DE3504421A1 - Neue 11ss-phenyl-gonane, deren herstellung und diese enthaltende pharmazeutische praeparate - Google Patents

Neue 11ss-phenyl-gonane, deren herstellung und diese enthaltende pharmazeutische praeparate

Info

Publication number
DE3504421A1
DE3504421A1 DE19853504421 DE3504421A DE3504421A1 DE 3504421 A1 DE3504421 A1 DE 3504421A1 DE 19853504421 DE19853504421 DE 19853504421 DE 3504421 A DE3504421 A DE 3504421A DE 3504421 A1 DE3504421 A1 DE 3504421A1
Authority
DE
Germany
Prior art keywords
hydroxy
methyl
estradien
alkyl
propynyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19853504421
Other languages
German (de)
English (en)
Inventor
Sybille Dipl.-Biol. Dr. Beier
Walter Dr. Elger
David Dr. Henderson
Günter Dr. Neef
Eckhard Dr. Ottow
Ralph Dr. 1000 Berlin Rhode
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Priority to DE19853504421 priority Critical patent/DE3504421A1/de
Priority to NZ214998A priority patent/NZ214998A/xx
Priority to AU52913/86A priority patent/AU580843B2/en
Priority to IL77762A priority patent/IL77762A/xx
Priority to CN86100994A priority patent/CN1033753C/zh
Priority to ES551625A priority patent/ES8701778A1/es
Priority to DK056086A priority patent/DK161709C/da
Priority to GR860342A priority patent/GR860342B/el
Priority to PT81969A priority patent/PT81969B/pt
Priority to DD86286860A priority patent/DD261166A5/de
Priority to AT86101548T priority patent/ATE45956T1/de
Priority to CA000501252A priority patent/CA1310630C/en
Priority to NO860425A priority patent/NO171994C/no
Priority to HU86499A priority patent/HU194904B/hu
Priority to IE33486A priority patent/IE58149B1/en
Priority to DE8686101548T priority patent/DE3665307D1/de
Priority to EP86101548A priority patent/EP0190759B1/de
Priority to JP61024260A priority patent/JPS61183296A/ja
Priority to ZA86936A priority patent/ZA86936B/xx
Priority to US06/827,050 priority patent/US5089635A/en
Priority to FI860559A priority patent/FI85377C/fi
Publication of DE3504421A1 publication Critical patent/DE3504421A1/de
Priority to NO864209A priority patent/NO170285C/no
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J15/00—Stereochemically pure steroids containing carbon, hydrogen, halogen or oxygen having a partially or totally inverted skeleton, e.g. retrosteroids, L-isomers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • C07J1/0088—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
    • C07J1/0096—Alkynyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/001—Lactones
    • C07J21/003—Lactones at position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE19853504421 1985-02-07 1985-02-07 Neue 11ss-phenyl-gonane, deren herstellung und diese enthaltende pharmazeutische praeparate Withdrawn DE3504421A1 (de)

Priority Applications (22)

Application Number Priority Date Filing Date Title
DE19853504421 DE3504421A1 (de) 1985-02-07 1985-02-07 Neue 11ss-phenyl-gonane, deren herstellung und diese enthaltende pharmazeutische praeparate
NZ214998A NZ214998A (en) 1985-02-07 1986-01-31 13-(methyl or ethyl)-11-beta-phenyl-gonane derivatives; preparatory processes and pharmaceutical compositions
AU52913/86A AU580843B2 (en) 1985-02-07 1986-01-31 11``-phenyl-gonanes, their manufacture and pharmaceutical preparations containing them
IL77762A IL77762A (en) 1985-02-07 1986-02-02 11beta-phenyl gonane derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
CN86100994A CN1033753C (zh) 1985-02-07 1986-02-03 11β-苯基-甾烷的制备方法
ES551625A ES8701778A1 (es) 1985-02-07 1986-02-04 Procedimiento para la preparacion de 13-alquil-ll b -fenil-gonamos
DK056086A DK161709C (da) 1985-02-07 1986-02-05 13-alkyl-11beta-phenylgonaner, fremgangsmaade til deres fremstilling og farmaceutiske praeparater indeholdende dem samt deres anvendelse til fremstilling af laegemidler
GR860342A GR860342B (en) 1985-02-07 1986-02-05 11b- phenyl-gonane their preparation and pharmaceutical preparations containing them
PT81969A PT81969B (pt) 1985-02-07 1986-02-05 Processo para preparacao de 11 beta-fenil-esteroides e de composicoes farmaceuticas que os contem
CA000501252A CA1310630C (en) 1985-02-07 1986-02-06 11.beta.-PHENYL-GONANES, THEIR MANUFACTURE AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM
EP86101548A EP0190759B1 (de) 1985-02-07 1986-02-06 11 Beta-Phenyl-Gonane, deren Herstellung und diese enthaltende pharmazeutische Präparate
DD86286860A DD261166A5 (de) 1985-02-07 1986-02-06 Verfahren zur herstellung von 11beta-phenyl-genanen
NO860425A NO171994C (no) 1985-02-07 1986-02-06 Fremgangsmaate for fremstilling av dihydroxylerte 11beta-(4-acetylfenyl)-17beta-hydroxy-17alfa-(1-propynyl)-4,9-estradien-3-oner
HU86499A HU194904B (en) 1985-02-07 1986-02-06 Process for producing 11-beta-phenyl-gonanes and pharmaceutical compositions containing them
IE33486A IE58149B1 (en) 1985-02-07 1986-02-06 11 beta-phenyl-gonanes,their manufacture and pharmaceutical preparations containing them
DE8686101548T DE3665307D1 (en) 1985-02-07 1986-02-06 11-beta phenyl gonanes, their preparation and pharmaceutical compositions containing them
AT86101548T ATE45956T1 (de) 1985-02-07 1986-02-06 11 beta-phenyl-gonane, deren herstellung und diese enthaltende pharmazeutische praeparate.
JP61024260A JPS61183296A (ja) 1985-02-07 1986-02-07 １１β―フェニル―ゴナン及びその製法
ZA86936A ZA86936B (en) 1985-02-07 1986-02-07 11beta-phenyl-gonanes,their manufacture and pharmaceutical preparations containing them
US06/827,050 US5089635A (en) 1985-02-07 1986-02-07 11 β-phenyl-gonanes, their manufacture and pharmaceutical preparations containing them
FI860559A FI85377C (fi) 1985-02-07 1986-02-07 Foerfarande foer framstaellning av terapeutiskt aktiva 13-alkyl-11 -fenylgonaner.
NO864209A NO170285C (no) 1985-02-07 1986-10-21 13-alkyl-llbeta-fenyl-gonaner, og antikonsepsjonsmiddel inneholdende disse

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19853504421 DE3504421A1 (de) 1985-02-07 1985-02-07 Neue 11ss-phenyl-gonane, deren herstellung und diese enthaltende pharmazeutische praeparate

Publications (1)

Publication Number Publication Date
DE3504421A1 true DE3504421A1 (de) 1986-08-07

Family

ID=6262067

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19853504421 Withdrawn DE3504421A1 (de) 1985-02-07 1985-02-07 Neue 11ss-phenyl-gonane, deren herstellung und diese enthaltende pharmazeutische praeparate

Country Status (4)

Country Link
JP (1) JPS61183296A (enrdf_load_stackoverflow)
DD (1) DD261166A5 (enrdf_load_stackoverflow)
DE (1) DE3504421A1 (enrdf_load_stackoverflow)
ZA (1) ZA86936B (enrdf_load_stackoverflow)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4332284A1 (de) * 1993-09-20 1995-03-23 Jenapharm Gmbh Neue 11-Benzaldoxim-17beta-methoxy-17alpha-methoxymethyl-estradien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
RU2137777C1 (ru) * 1993-09-20 1999-09-20 Йенафарм ГмбХ ПРОИЗВОДНЫЕ 11β-БЕНЗАЛЬДОКСИМ-ЭСТРА-4,9-ДИЕНА, СПОСОБ ИХ ПОЛУЧЕНИЯ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ
WO2001044267A1 (de) * 1999-12-15 2001-06-21 Jenapharm Gmbh & Co. Kg 11-β-PHENYLESTRADIEN-DERIVATE MIT FLUORALKYLGRUPPEN IN DER AROMATISCHEN SEITENKETTE, DEREN HERSTELLUNG UND DIESE VERBINDUNGEN ENTHALTENDE PHARMAZEUTISCHE ZUSAMMENSETZUNGEN
WO2004014935A1 (de) * 2002-08-02 2004-02-19 Schering Aktiengesellschaft Progesteronrezeptormodulatoren mit erhöhter antigonadotroper aktivität für die weibliche fertilitätskontrolle und hormonersatztherapie
BG64735B1 (bg) * 1998-03-03 2006-01-31 Jenapharm Gmbh & Co. Kg S-заместени тиолови естери на 11бета-бензалдоксим-естра-4,9-диен-въглеродна киселина, метод за тяхното получаване и фармацевтични препарати, съдържащи тези съединения
DE102006018869A1 (de) * 2006-04-13 2007-10-18 Bayer Schering Pharma Ag 17alpha-substituierte 4-(3-Oxoestra-4,9-dien-11beta-yl)-benzoesäure, deren Derivate und Verfahren zu ihrer Herstellung
US7550451B2 (en) 2002-08-02 2009-06-23 Bayer Schering Pharma Ag Progesterone receptor modulators with increased antigonadotropic activity for female birth control and hormone replacement therapy
US7759330B2 (en) 1996-05-01 2010-07-20 The United States Of America As Represented By The Department Of Health And Human Services 21-substituted progesterone derivatives as new antiprogestational agents
CN102471366A (zh) * 2009-07-20 2012-05-23 拜耳医药股份有限公司 17-羟基-17-五氟乙基雌-4,9(10)-二烯11-苯亚甲基衍生物、其制备方法及其用于治疗疾病的用途
US8569276B2 (en) * 1996-05-01 2013-10-29 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Structural modification of 19-norprogesterone I: 17-α-substituted-11-β-substituted-4-aryl and 21-substituted 19-norpregnadienedione as new antiprogestational agents

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE396197T1 (de) * 2000-03-17 2008-06-15 Us Gov Health & Human Serv 17-alpha-substituierte-11-beta-substituierte-4- aryl und 21-substituierte 19-norpregnadienedione mit antigestagener aktivität
DE102009034526A1 (de) * 2009-07-21 2011-02-10 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-ethinylphenyl-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten
DE102009034525A1 (de) * 2009-07-21 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2377418A1 (fr) * 1977-01-13 1978-08-11 Roussel Uclaf Nouveaux derives steroides 4,9-dieniques 11b-substitues, leur procede de preparation et leur application comme medicaments
ZA8231B (en) * 1981-01-09 1982-11-24 Roussel Uclaf New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained
DE3231827A1 (de) * 1982-08-24 1984-03-01 Schering AG, 1000 Berlin und 4709 Bergkamen 11ss-aryl-17(alpha)-alkinyl-17ss-hydroxy-4,9(10)- estradien-3-on-derivate, deren herstellung und diese enthaltende pharmazeutische praeparate

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4332284A1 (de) * 1993-09-20 1995-03-23 Jenapharm Gmbh Neue 11-Benzaldoxim-17beta-methoxy-17alpha-methoxymethyl-estradien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
RU2137777C1 (ru) * 1993-09-20 1999-09-20 Йенафарм ГмбХ ПРОИЗВОДНЫЕ 11β-БЕНЗАЛЬДОКСИМ-ЭСТРА-4,9-ДИЕНА, СПОСОБ ИХ ПОЛУЧЕНИЯ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ
US7759330B2 (en) 1996-05-01 2010-07-20 The United States Of America As Represented By The Department Of Health And Human Services 21-substituted progesterone derivatives as new antiprogestational agents
US8003629B2 (en) 1996-05-01 2011-08-23 The United States Of America As Represented By The Secretary, Department Of Health And Human Services 21-substituted progesterone derivatives as new antiprogestational agents
US8569276B2 (en) * 1996-05-01 2013-10-29 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Structural modification of 19-norprogesterone I: 17-α-substituted-11-β-substituted-4-aryl and 21-substituted 19-norpregnadienedione as new antiprogestational agents
BG64735B1 (bg) * 1998-03-03 2006-01-31 Jenapharm Gmbh & Co. Kg S-заместени тиолови естери на 11бета-бензалдоксим-естра-4,9-диен-въглеродна киселина, метод за тяхното получаване и фармацевтични препарати, съдържащи тези съединения
WO2001044267A1 (de) * 1999-12-15 2001-06-21 Jenapharm Gmbh & Co. Kg 11-β-PHENYLESTRADIEN-DERIVATE MIT FLUORALKYLGRUPPEN IN DER AROMATISCHEN SEITENKETTE, DEREN HERSTELLUNG UND DIESE VERBINDUNGEN ENTHALTENDE PHARMAZEUTISCHE ZUSAMMENSETZUNGEN
WO2004014935A1 (de) * 2002-08-02 2004-02-19 Schering Aktiengesellschaft Progesteronrezeptormodulatoren mit erhöhter antigonadotroper aktivität für die weibliche fertilitätskontrolle und hormonersatztherapie
US7550451B2 (en) 2002-08-02 2009-06-23 Bayer Schering Pharma Ag Progesterone receptor modulators with increased antigonadotropic activity for female birth control and hormone replacement therapy
DE102006018869A1 (de) * 2006-04-13 2007-10-18 Bayer Schering Pharma Ag 17alpha-substituierte 4-(3-Oxoestra-4,9-dien-11beta-yl)-benzoesäure, deren Derivate und Verfahren zu ihrer Herstellung
CN102471366A (zh) * 2009-07-20 2012-05-23 拜耳医药股份有限公司 17-羟基-17-五氟乙基雌-4,9(10)-二烯11-苯亚甲基衍生物、其制备方法及其用于治疗疾病的用途
CN102471366B (zh) * 2009-07-20 2015-12-16 拜耳知识产权有限责任公司 17-羟基-17-五氟乙基雌-4，9(10)-二烯11-苯亚甲基衍生物、其制备方法及其用于治疗疾病的用途

Also Published As

Publication number Publication date
JPH0437080B2 (enrdf_load_stackoverflow) 1992-06-18
ZA86936B (en) 1986-09-24
DD261166A5 (de) 1988-10-19
JPS61183296A (ja) 1986-08-15

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