DE3485240D1 - Methoden zur ermittlung der lebensfaehigkeit von zellen und vorrichtung zu ihrer durchfuehrung. - Google Patents

Methoden zur ermittlung der lebensfaehigkeit von zellen und vorrichtung zu ihrer durchfuehrung.

Info

Publication number
DE3485240D1
DE3485240D1 DE8484900685T DE3485240T DE3485240D1 DE 3485240 D1 DE3485240 D1 DE 3485240D1 DE 8484900685 T DE8484900685 T DE 8484900685T DE 3485240 T DE3485240 T DE 3485240T DE 3485240 D1 DE3485240 D1 DE 3485240D1
Authority
DE
Germany
Prior art keywords
vitability
cells
implementation
determining
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8484900685T
Other languages
English (en)
Inventor
M Rotman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ANALYTICAL BIOSYSTEMS CORP., WARWICK, R.I., US
Original Assignee
Brown University Research Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brown University Research Foundation Inc filed Critical Brown University Research Foundation Inc
Application granted granted Critical
Publication of DE3485240D1 publication Critical patent/DE3485240D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/16—Microfluidic devices; Capillary tubes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/808—Optical sensing apparatus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/811—Interferon
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • Y10T436/255—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.] including use of a solid sorbent, semipermeable membrane, or liquid extraction

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Sustainable Development (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Toxicology (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
DE8484900685T 1983-02-04 1984-01-12 Methoden zur ermittlung der lebensfaehigkeit von zellen und vorrichtung zu ihrer durchfuehrung. Expired - Fee Related DE3485240D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/463,669 US4559299A (en) 1983-02-04 1983-02-04 Cytotoxicity assays in cell culturing devices
PCT/US1984/000046 WO1984003047A1 (en) 1983-02-04 1984-01-12 Cytotoxicity assays in artificial organs

Publications (1)

Publication Number Publication Date
DE3485240D1 true DE3485240D1 (de) 1991-12-12

Family

ID=23840911

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8484900685T Expired - Fee Related DE3485240D1 (de) 1983-02-04 1984-01-12 Methoden zur ermittlung der lebensfaehigkeit von zellen und vorrichtung zu ihrer durchfuehrung.

Country Status (5)

Country Link
US (1) US4559299A (de)
EP (1) EP0138833B1 (de)
JP (1) JPH0611236B2 (de)
DE (1) DE3485240D1 (de)
WO (1) WO1984003047A1 (de)

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US4734372A (en) * 1983-02-04 1988-03-29 Brown University Research Foundation Cell culturing methods and apparatus
DE3515753C2 (de) * 1985-05-02 1987-03-05 Hans 4156 Willich Preisendanz Verfahren zur Bestimmung der Wirkung von Chemotherapeutika auf das Wachstum von Mikroorganismen und/oder Zellen und Verwendung einer Vorrichtung mit mehreren Kammern zu seiner Durchführung
US4671938A (en) * 1985-09-09 1987-06-09 Ciba-Corning Diagnostics, Corp. Immunoassay apparatus
US4844869A (en) * 1985-09-09 1989-07-04 Ord, Inc. Immunoassay apparatus
US5286646A (en) * 1985-11-25 1994-02-15 Boehringer Mannheim Gmbh Method for mammalian cell culture
US4937182A (en) * 1985-12-19 1990-06-26 Peralta Cancer Research Institute Method for predicting chemosensitivity of anti-cancer drugs
US4816395A (en) * 1985-12-19 1989-03-28 Peralta Cancer Research Institute Method for predicting chemosensitivity of anti-cancer drugs
US4894342A (en) * 1986-05-12 1990-01-16 C. D. Medical, Inc. Bioreactor system
US4889812A (en) * 1986-05-12 1989-12-26 C. D. Medical, Inc. Bioreactor apparatus
US4859584A (en) * 1986-10-31 1989-08-22 Smithkline Beckman Corporation Cell growth rate determination by measurement of changes in cyanine dye levels in plasma membranes
KR950013951B1 (ko) * 1986-11-06 1995-11-18 토마스 제퍼슨 유니버시티 보철(prostheric) 표면의 내피 세포 적용범위(coverage) 결정방법
EP0272791A3 (de) * 1986-11-17 1989-06-28 Oncotech Verfahren zur Kontrollierung und Verhinderung des angewöhnten Widerstandes gegen Chemotherapie bei Menschen
US5001051A (en) * 1986-12-12 1991-03-19 Regents Of The University Of California Dose critical in-vivo detection of anti-cancer drug levels in blood
US4835102A (en) * 1987-03-31 1989-05-30 Eugene Bell Tissue equivalent test systems
US4839292B1 (en) * 1987-09-11 1994-09-13 Joseph G Cremonese Cell culture flask utilizing membrane barrier
DE3733636C1 (de) * 1987-10-05 1989-04-20 Schott Glaswerke Verfahren zum Vermehren von Zellen,insbesondere bei der Pruefung von Behandlungssubstanzen auf Wirksamkeit
US5081035A (en) * 1988-04-18 1992-01-14 The University Of Michigan Bioreactor system
SE464763B (sv) * 1989-10-05 1991-06-10 Gunnar Engstroem Metod och anordning foer att studera cellers/cellaggregats reaktionsmoenster vid perfusion med ett testmedium
CA2027694C (en) * 1989-10-20 2002-03-05 Tadashi Matsunaga Process and apparatus for detecting sensitized leukocyte or antigen
US5242806A (en) * 1990-05-07 1993-09-07 Baxter Diagnostics Inc. Method for conducting the cytotoxicity assays on tumor cells
EP0571525A1 (de) * 1991-02-11 1993-12-01 OMMAYA, Ayub K. Durch spinale flüssigkeit angetriebenes, künstliches organ
US5222982A (en) * 1991-02-11 1993-06-29 Ommaya Ayub K Spinal fluid driven artificial organ
US5435307A (en) * 1991-03-29 1995-07-25 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Surface fluorescent monitor
US5656492A (en) * 1993-02-12 1997-08-12 Brigham And Women's Hospital, Inc. Cell induction device
EP0817965A1 (de) * 1995-03-31 1998-01-14 Novo Nordisk A/S Verfahren zur identifizierung biologisch aktiver substanzen durch ihre wirkung auf lebenden zellen
US5962317A (en) * 1995-10-18 1999-10-05 The Johns Hopkins University School Of Medicine Dosage modeling system
US6287848B1 (en) 1995-10-18 2001-09-11 Johns Hopkins University Dosage modeling system
ATE250666T1 (de) * 1996-06-04 2003-10-15 Sulzer Orthopedics Ltd Verfahren zur herstellung von knorpelgewebe und von implantaten
US20040072722A1 (en) 2002-10-10 2004-04-15 Kornblith Paul L. Methods for assessing efficacy of chemotherapeutic agents
US20040023375A1 (en) * 2002-07-30 2004-02-05 Precision Therapeutics, Inc. Method for preparing cell cultures from biological specimens for chemotherapeutic and other assays
US5728541A (en) * 1996-07-12 1998-03-17 Precision Therapeutics, Inc. Method for preparing cell cultures from biologial specimens for chemotherapeutic and other assays
US20030013115A1 (en) * 1997-06-16 2003-01-16 Diversa Corporation, A Delaware Corporation Capillary array-based sample screening
ATE220564T1 (de) 1997-08-14 2002-08-15 Sulzer Innotec Ag Zusammensetzung und vorrichtung zur reparatur von knorpelgewebe in vivo bestehend aus nanokapseln mit osteoinduktiven und/oder chondroinduktiven faktoren
AU1174401A (en) * 1999-11-10 2001-06-06 Yoreh Biotechnologies Ltd. In-vitro assay for assessment of cytotoxicity of a candidate agent
US7622562B2 (en) 2002-06-26 2009-11-24 Zimmer Orthobiologics, Inc. Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue
AU2003278564A1 (en) * 2002-10-23 2004-05-13 Yissum Research Development Company Of The Hebrew University Of Jerusalem In vitro test for studying compound predicting pharmacologic and/or pharmacokinetic and/or pharmacodynamic parameters of a compound
US20070048732A1 (en) * 2005-08-30 2007-03-01 Hepahope, Inc. Chemosensitivity tester
US20050130254A1 (en) 2003-12-16 2005-06-16 Park Sung-Soo Drug testing system with bio-artificial liver
CA2620215A1 (en) * 2005-08-24 2007-03-01 Hepahope, Inc. Novel enhanced processes for drug testing and screening using human tissue
WO2007028146A2 (en) * 2005-09-01 2007-03-08 Precision Therapeutics, Inc. Chemo-sensitivity assays using tumor cells exhibiting persistent phenotypic characteristics
MX2013005301A (es) * 2010-11-12 2013-12-06 Abbvie Inc Metodo y sistema optico de alto rendimiento para determinar el efecto de una sustancia de prueba sobre celulas vivas.
WO2012140325A1 (en) 2011-04-15 2012-10-18 Aalto University Foundation In vitro test method for implant materials
DE102014106423A1 (de) 2014-05-08 2015-11-12 Universitätsklinikum Jena Verfahren und Vorrichtungen zur In-vitro-Herstellung von Anordnungen von Zellschichten

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US2996426A (en) * 1958-04-28 1961-08-15 Diamond Alkali Co Pesticidal composition
US3065148A (en) * 1959-07-14 1962-11-20 Technicon Instr Method and apparatus for use in conducting studies on cells
US3476514A (en) * 1966-09-09 1969-11-04 Daniel Roth Cancer cytoscreening
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ATE12520T1 (de) * 1980-12-05 1985-04-15 Battelle Memorial Institute Verfahren zum beobachten der entwicklung von mikroorganismen.
SE448881B (sv) * 1981-03-12 1987-03-23 Erik Walum Apparat for genomforandet av perfusionsodling av en eller flera cellkulturer samt forfarande for perfusionsodling av en eller flera cellkulturer
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Also Published As

Publication number Publication date
JPH0611236B2 (ja) 1994-02-16
EP0138833A1 (de) 1985-05-02
WO1984003047A1 (en) 1984-08-16
EP0138833B1 (de) 1991-11-06
JPS60500699A (ja) 1985-05-16
EP0138833A4 (de) 1987-12-09
US4559299A (en) 1985-12-17

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: ANALYTICAL BIOSYSTEMS CORP., WARWICK, R.I., US

8339 Ceased/non-payment of the annual fee