DE3481840D1 - 3-(4-piperidinyl)-1,2-benzisothiazole und deren derivate, verfahren zu ihrer herstellung und verwendung als arzneimittel. - Google Patents

3-(4-piperidinyl)-1,2-benzisothiazole und deren derivate, verfahren zu ihrer herstellung und verwendung als arzneimittel.

Info

Publication number
DE3481840D1
DE3481840D1 DE8484106037T DE3481840T DE3481840D1 DE 3481840 D1 DE3481840 D1 DE 3481840D1 DE 8484106037 T DE8484106037 T DE 8484106037T DE 3481840 T DE3481840 T DE 3481840T DE 3481840 D1 DE3481840 D1 DE 3481840D1
Authority
DE
Germany
Prior art keywords
piperidinyl
benzisothiazole
derivatives
production
medicinal product
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8484106037T
Other languages
English (en)
Inventor
Joseph T Strupczewski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Hoechst Roussel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharmaceuticals Inc filed Critical Hoechst Roussel Pharmaceuticals Inc
Application granted granted Critical
Publication of DE3481840D1 publication Critical patent/DE3481840D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
DE8484106037T 1983-05-31 1984-05-28 3-(4-piperidinyl)-1,2-benzisothiazole und deren derivate, verfahren zu ihrer herstellung und verwendung als arzneimittel. Expired - Fee Related DE3481840D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/499,583 US4458076A (en) 1983-05-31 1983-05-31 3-(4-Piperidinyl)-1,2-benzisothiazoles

Publications (1)

Publication Number Publication Date
DE3481840D1 true DE3481840D1 (de) 1990-05-10

Family

ID=23985830

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8484106037T Expired - Fee Related DE3481840D1 (de) 1983-05-31 1984-05-28 3-(4-piperidinyl)-1,2-benzisothiazole und deren derivate, verfahren zu ihrer herstellung und verwendung als arzneimittel.

Country Status (5)

Country Link
US (1) US4458076A (de)
EP (1) EP0127167B1 (de)
JP (1) JPS59227882A (de)
AT (1) ATE51620T1 (de)
DE (1) DE3481840D1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4528292A (en) * 1984-04-23 1985-07-09 Hoechst-Roussel Pharmaceuticals Inc. Antihypertensive 1,2-benzisothiazole piperidines
EP0192935B1 (de) * 1985-01-23 1991-02-27 Hoechst-Roussel Pharmaceuticals Incorporated 3-Piperidinyl- 1H-Indazole, Verfahren zu deren Herstellung und deren Anwendung als Arzneimittel
US4804663A (en) * 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
IE58370B1 (en) * 1985-04-10 1993-09-08 Lundbeck & Co As H Indole derivatives
FR2581993B1 (fr) * 1985-05-14 1988-03-18 Synthelabo Derives de (benzoyl-4 piperidino)-2 phenyl-1 alcanols, leur preparation et leur application en therapeutique
FR2610929B1 (fr) * 1987-02-13 1989-06-23 Roussel Uclaf Derives de la benzimidazol-2-one, leurs sels, procede de preparation, application a titre de medicaments, compositions les renfermant et intermediaires
FR2621588B1 (fr) * 1987-10-08 1991-05-24 Roussel Uclaf Nouveaux derives de la 1,1-dioxo 1,2-benzoisothiazol 3-one, leur procede de preparation et leur application comme medicaments
HU207310B (en) * 1988-12-02 1993-03-29 Pfizer Process for producing aryl-piperidine derivatives
US5776963A (en) * 1989-05-19 1998-07-07 Hoechst Marion Roussel, Inc. 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility
ATE126512T1 (de) * 1989-05-19 1995-09-15 Hoechst Roussel Pharma N-(aryloxyalkyl)heteroarylpiperidine und - heteroarylpiperazine, verfahren zu ihrer herstellung und ihre verwendung als medikamente.
US5561128A (en) * 1989-05-19 1996-10-01 Hoechst-Roussel Pharmaceuticals, Inc. N-[(4-(heteroaryl)-1-piperidinyl)alkyl]-10,11-dihydro-5H-dibenz[B,F]azepines and related compounds and their therapeutic utility
US5364866A (en) * 1989-05-19 1994-11-15 Hoechst-Roussel Pharmaceuticals, Inc. Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analetics
US5147881A (en) * 1990-11-14 1992-09-15 Pfizer Inc 4-(1,2-benzisoxazolyl)piperidine antipsychotic agents
US5750542A (en) 1993-09-28 1998-05-12 Pfizer Benzisoxazole and benzisothizole derivatives as cholinesterase inhibitors
US5378714A (en) * 1991-11-27 1995-01-03 Novo Nordisk A/S Antipsychotic piperidine derivatives
US5532240A (en) * 1991-12-26 1996-07-02 Yoshitomi Pharmaceutical Industries, Ltd. Condensed thiophene compound and pharmaceutical use thereof
KR100354270B1 (ko) * 1993-11-19 2003-02-11 알커메스 컨트롤드 테라포이틱스 인코퍼레이티드 Ii 마이크로캡슐화된3-피페리디닐-치환된1,2-벤즈이속사졸및1,2-벤즈이소티아졸
FR2749304B1 (fr) * 1996-06-04 1998-06-26 Adir Nouveaux derives du 3-(piperid-4-yl)1,2-benzisoxazole et du 3-(piperazin-4-yl)1,2-benzisoxazole, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
US20050232995A1 (en) 2002-07-29 2005-10-20 Yam Nyomi V Methods and dosage forms for controlled delivery of paliperidone and risperidone
AR055099A1 (es) * 2005-07-28 2007-08-08 Alza Corp Formulaciones liquidas para la administracion controlada de derivados de bencisoxazol
PT2079446E (pt) * 2007-08-21 2011-12-23 Teva Pharma Formulação de libertação sustida de paliperidona
WO2010082110A2 (en) * 2009-01-13 2010-07-22 Cadila Pharmaceuticals Ltd Novel process for preparing pure 6-fluoro-3-piperidin-4-yl-1,2-benzisoxazole hydrochloride and its conversion to paliperidone
CN101693711B (zh) * 2009-10-23 2011-08-17 杜玉民 一种3-(1-哌嗪基)-1,2-苯并异噻唑衍生物及其合成方法和用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1265824A (de) * 1968-03-28 1972-03-08
US4104388A (en) * 1977-05-23 1978-08-01 E. R. Squibb & Sons, Inc. 3-Substituted benzisothiazole, 1,1-dioxides
ES475100A1 (es) * 1977-11-21 1979-12-01 Hoechst Ag Un metodo para preparar acidos 1,2-benzisoxazoloxiaceticos
US4140693A (en) * 1978-02-03 1979-02-20 E. R. Squibb & Sons, Inc. Substituted 2,3-dihydro-1,2,4-triazolo [4,3-b][1,2]benzisothiazol-3-amine, 5,5, dioxides
US4148798A (en) * 1978-02-03 1979-04-10 E. R. Squibb & Sons, Inc. [(1,1-dioxo-1,2-benzisothiazol-3-yl)amino]alkanoic acids and esters thereof
US4147698A (en) * 1978-07-13 1979-04-03 E. R. Squibb & Sons, Inc. 3-(Heterocyclicalkylamino)benzisothiazole-1,1-dioxides
US4166910A (en) * 1978-07-13 1979-09-04 E. R. Squibb & Sons, Inc. 3-(Nitrogen containing heterocyclic)amino) benzisothiazole-1,1-dioxide
DE3018108A1 (de) * 1980-05-12 1981-11-19 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung von 1,2-benzisothhiazolen
US4355037A (en) * 1981-11-12 1982-10-19 Hoechst-Roussel Pharmaceuticals 3-(4-Piperidyl)-1,2-benzisoxales
US4352811A (en) * 1981-11-12 1982-10-05 Hoechst-Roussel Pharmaceuticals Inc. 3-(1-Substituted-4-piperidyl)-1,2-benzisoxazoles

Also Published As

Publication number Publication date
US4458076A (en) 1984-07-03
EP0127167B1 (de) 1990-04-04
JPS59227882A (ja) 1984-12-21
EP0127167A2 (de) 1984-12-05
ATE51620T1 (de) 1990-04-15
EP0127167A3 (en) 1987-01-14

Similar Documents

Publication Publication Date Title
DE3481840D1 (de) 3-(4-piperidinyl)-1,2-benzisothiazole und deren derivate, verfahren zu ihrer herstellung und verwendung als arzneimittel.
ES8506658A1 (es) Procedimiento para la preparacion de 3-(1-sustituido-4-piperidil)-1, 2-bencisoxazoles
DE68914488D1 (de) 2-(2-Hydroxy-3-phenoxypropylamino)ethylphenoxyacetamide, Verfahren und Zwischenprodukte zu deren Herstellung.
DE3764828D1 (de) Derivate von n-alpha-arylsulfonylaminoacyl-p-amidino-phenylalaninamiden, verfahren zu deren herstellung, deren verwendung als arzneimittel und deren zwischenverbindungen.
ATE47139T1 (de) 3-(piperidinyl)- und 3-(pyrrolidinyl)-1hindazole, ein verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
ATE108453T1 (de) Benzopyridopiperidin, -piperidyliden und - piperazin-verbindungen, zusammensetzungen, methoden zur herstellung und verwendung.
ATE128143T1 (de) 17-beta-substituierte-4-aza-5-alpha-androstan-3 one-derivate und verfahren zu ihrer herstellung.
ES8507519A1 (es) Un procedimiento para la preparacion de 3-(4-piperidil)-1, 2-bencisoxazoles
ES8203888A1 (es) Procedimiento para la obtencion de dihidropiridinas susti- tuidas en la posicion 4 del hetero-anillo
ATE8623T1 (de) Derivate des 3,4,5-trihydroxypiperidins, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel sowie in der tierernaehrung.
ATE4642T1 (de) 2-hydroxyalkyl-3,4,5-trihydroxypiperidine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
DE59102986D1 (de) Heterocyclisch substituierte Dihydropyridine, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln.
ATE34172T1 (de) 6-fluor-3-(3-(1-heterocyclo)propyl)-1,2benzisoxazole, verfahren zu ihrer herstellung, deren pharmazeutische zusammensetzungen und ihre verwendung als arzneimittel.
ATE4117T1 (de) Pseudotrisaccharide, ihre herstellung und verwendung als arzneimittel.
PT75726A (en) 1-<3-(6-fluoro-1,2-benzisoxazol-3-yl)propyl>-4-(substituted)-piperazines and piperidines a process for the preparation thereof pharmaceutical compositions containing the same and their use as medicaments
ATE2794T1 (de) 1-n-alkylsisomicin-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
PT70560A (de) 1,3,4-thiadiazol-2-carbonsaure-derivate verfahren zur herstellung dieser verbindungen sowie diese enthaltende fungizide und nematizide mittel
ATE13669T1 (de) 4-aryloxy-3-phenylpiperidin-derivate, zwischenprodukte, verfahren zur herstellung solcher verbindungen und ihre verwendung als arzneimittel.
PT84618A (de) Bis-tertiaerbutylamino-substituierte 1,3,5-triazinderivate verfahren zu ihrer herstellung diese verbindungen enthaltende arzneimittel und ihre verwendung
DE3785987T2 (de) Imidazol-derivate und deren salze, verfahren zu deren herstellung, deren anwendung als arzneimittel und deren zusammensetzungen.
DE3774367D1 (de) Oxolabdane, verfahren zu deren herstellung und deren verwendung als arzneimittel.
DE68907857D1 (de) Beta-d-phenylthioxyloside, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
PT81427B (de) 3,4-diazolderivate verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3865547D1 (de) Aminopropanolderivate von 3-(3'-hydroxyphenyl)-1-propanon-verbindungen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel.
ATE4714T1 (de) Imidazolyl-indeno-thiophene, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee