ATE51620T1 - 3-(4-piperidinyl)-1,2-benzisothiazole und deren derivate, verfahren zu ihrer herstellung und verwendung als arzneimittel. - Google Patents
3-(4-piperidinyl)-1,2-benzisothiazole und deren derivate, verfahren zu ihrer herstellung und verwendung als arzneimittel.Info
- Publication number
- ATE51620T1 ATE51620T1 AT84106037T AT84106037T ATE51620T1 AT E51620 T1 ATE51620 T1 AT E51620T1 AT 84106037 T AT84106037 T AT 84106037T AT 84106037 T AT84106037 T AT 84106037T AT E51620 T1 ATE51620 T1 AT E51620T1
- Authority
- AT
- Austria
- Prior art keywords
- piperidinyl
- benzisothiazole
- derivatives
- manufacture
- medicinal products
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- RUGIEMXPGXHGET-UHFFFAOYSA-N 3-piperidin-4-yl-1,2-benzothiazole Chemical compound C1CNCCC1C1=NSC2=CC=CC=C12 RUGIEMXPGXHGET-UHFFFAOYSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/499,583 US4458076A (en) | 1983-05-31 | 1983-05-31 | 3-(4-Piperidinyl)-1,2-benzisothiazoles |
| EP84106037A EP0127167B1 (de) | 1983-05-31 | 1984-05-28 | 3-(4-Piperidinyl)-1,2-benzisothiazole und deren Derivate, Verfahren zu ihrer Herstellung und Verwendung als Arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE51620T1 true ATE51620T1 (de) | 1990-04-15 |
Family
ID=23985830
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT84106037T ATE51620T1 (de) | 1983-05-31 | 1984-05-28 | 3-(4-piperidinyl)-1,2-benzisothiazole und deren derivate, verfahren zu ihrer herstellung und verwendung als arzneimittel. |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US4458076A (de) |
| EP (1) | EP0127167B1 (de) |
| JP (1) | JPS59227882A (de) |
| AT (1) | ATE51620T1 (de) |
| DE (1) | DE3481840D1 (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4528292A (en) * | 1984-04-23 | 1985-07-09 | Hoechst-Roussel Pharmaceuticals Inc. | Antihypertensive 1,2-benzisothiazole piperidines |
| EP0192935B1 (de) * | 1985-01-23 | 1991-02-27 | Hoechst-Roussel Pharmaceuticals Incorporated | 3-Piperidinyl- 1H-Indazole, Verfahren zu deren Herstellung und deren Anwendung als Arzneimittel |
| US4804663A (en) * | 1985-03-27 | 1989-02-14 | Janssen Pharmaceutica N.V. | 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles |
| IE58370B1 (en) * | 1985-04-10 | 1993-09-08 | Lundbeck & Co As H | Indole derivatives |
| FR2581993B1 (fr) * | 1985-05-14 | 1988-03-18 | Synthelabo | Derives de (benzoyl-4 piperidino)-2 phenyl-1 alcanols, leur preparation et leur application en therapeutique |
| FR2610929B1 (fr) * | 1987-02-13 | 1989-06-23 | Roussel Uclaf | Derives de la benzimidazol-2-one, leurs sels, procede de preparation, application a titre de medicaments, compositions les renfermant et intermediaires |
| FR2621588B1 (fr) * | 1987-10-08 | 1991-05-24 | Roussel Uclaf | Nouveaux derives de la 1,1-dioxo 1,2-benzoisothiazol 3-one, leur procede de preparation et leur application comme medicaments |
| HU207310B (en) * | 1988-12-02 | 1993-03-29 | Pfizer | Process for producing aryl-piperidine derivatives |
| US5776963A (en) * | 1989-05-19 | 1998-07-07 | Hoechst Marion Roussel, Inc. | 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility |
| DE69021645T2 (de) * | 1989-05-19 | 1996-02-22 | Hoechst-Roussel Pharmaceuticals Inc., Somerville, N.J. | N-(aryloxyalkyl)heteroarylpiperidine und -heteroarylpiperazine, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikamente. |
| US5364866A (en) * | 1989-05-19 | 1994-11-15 | Hoechst-Roussel Pharmaceuticals, Inc. | Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analetics |
| US5561128A (en) * | 1989-05-19 | 1996-10-01 | Hoechst-Roussel Pharmaceuticals, Inc. | N-[(4-(heteroaryl)-1-piperidinyl)alkyl]-10,11-dihydro-5H-dibenz[B,F]azepines and related compounds and their therapeutic utility |
| US5147881A (en) * | 1990-11-14 | 1992-09-15 | Pfizer Inc | 4-(1,2-benzisoxazolyl)piperidine antipsychotic agents |
| US5750542A (en) * | 1993-09-28 | 1998-05-12 | Pfizer | Benzisoxazole and benzisothizole derivatives as cholinesterase inhibitors |
| US5378714A (en) * | 1991-11-27 | 1995-01-03 | Novo Nordisk A/S | Antipsychotic piperidine derivatives |
| US5532240A (en) * | 1991-12-26 | 1996-07-02 | Yoshitomi Pharmaceutical Industries, Ltd. | Condensed thiophene compound and pharmaceutical use thereof |
| RO119224B1 (ro) * | 1993-11-19 | 2004-06-30 | Janssenápharmaceuticaán.V. | Compoziţie farmaceutică pentru tratamentul unor afecţiuni psihotice şi utilizarea acesteia |
| FR2749304B1 (fr) * | 1996-06-04 | 1998-06-26 | Adir | Nouveaux derives du 3-(piperid-4-yl)1,2-benzisoxazole et du 3-(piperazin-4-yl)1,2-benzisoxazole, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent |
| US20050232995A1 (en) | 2002-07-29 | 2005-10-20 | Yam Nyomi V | Methods and dosage forms for controlled delivery of paliperidone and risperidone |
| AR055099A1 (es) * | 2005-07-28 | 2007-08-08 | Alza Corp | Formulaciones liquidas para la administracion controlada de derivados de bencisoxazol |
| ES2374200T3 (es) * | 2007-08-21 | 2012-02-14 | Teva Pharmaceutical Industries Ltd. | Formulación de liberación prolongada de paliperidona. |
| WO2010082110A2 (en) * | 2009-01-13 | 2010-07-22 | Cadila Pharmaceuticals Ltd | Novel process for preparing pure 6-fluoro-3-piperidin-4-yl-1,2-benzisoxazole hydrochloride and its conversion to paliperidone |
| CN101693711B (zh) * | 2009-10-23 | 2011-08-17 | 杜玉民 | 一种3-(1-哌嗪基)-1,2-苯并异噻唑衍生物及其合成方法和用途 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1265824A (de) * | 1968-03-28 | 1972-03-08 | ||
| US4104388A (en) * | 1977-05-23 | 1978-08-01 | E. R. Squibb & Sons, Inc. | 3-Substituted benzisothiazole, 1,1-dioxides |
| ES475100A1 (es) * | 1977-11-21 | 1979-12-01 | Hoechst Ag | Un metodo para preparar acidos 1,2-benzisoxazoloxiaceticos |
| US4147698A (en) * | 1978-07-13 | 1979-04-03 | E. R. Squibb & Sons, Inc. | 3-(Heterocyclicalkylamino)benzisothiazole-1,1-dioxides |
| US4140693A (en) * | 1978-02-03 | 1979-02-20 | E. R. Squibb & Sons, Inc. | Substituted 2,3-dihydro-1,2,4-triazolo [4,3-b][1,2]benzisothiazol-3-amine, 5,5, dioxides |
| US4148798A (en) * | 1978-02-03 | 1979-04-10 | E. R. Squibb & Sons, Inc. | [(1,1-dioxo-1,2-benzisothiazol-3-yl)amino]alkanoic acids and esters thereof |
| US4166910A (en) * | 1978-07-13 | 1979-09-04 | E. R. Squibb & Sons, Inc. | 3-(Nitrogen containing heterocyclic)amino) benzisothiazole-1,1-dioxide |
| DE3018108A1 (de) * | 1980-05-12 | 1981-11-19 | Basf Ag, 6700 Ludwigshafen | Verfahren zur herstellung von 1,2-benzisothhiazolen |
| US4355037A (en) * | 1981-11-12 | 1982-10-19 | Hoechst-Roussel Pharmaceuticals | 3-(4-Piperidyl)-1,2-benzisoxales |
| US4352811A (en) * | 1981-11-12 | 1982-10-05 | Hoechst-Roussel Pharmaceuticals Inc. | 3-(1-Substituted-4-piperidyl)-1,2-benzisoxazoles |
-
1983
- 1983-05-31 US US06/499,583 patent/US4458076A/en not_active Expired - Lifetime
-
1984
- 1984-05-28 DE DE8484106037T patent/DE3481840D1/de not_active Expired - Fee Related
- 1984-05-28 EP EP84106037A patent/EP0127167B1/de not_active Expired - Lifetime
- 1984-05-28 AT AT84106037T patent/ATE51620T1/de not_active IP Right Cessation
- 1984-05-30 JP JP59108723A patent/JPS59227882A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE3481840D1 (de) | 1990-05-10 |
| EP0127167A3 (en) | 1987-01-14 |
| EP0127167A2 (de) | 1984-12-05 |
| JPS59227882A (ja) | 1984-12-21 |
| US4458076A (en) | 1984-07-03 |
| EP0127167B1 (de) | 1990-04-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |