DE3475074D1 - N6-substituted diarylalkyl adenosines, processes for their production and pharmaceutical compositions comprising the same - Google Patents
N6-substituted diarylalkyl adenosines, processes for their production and pharmaceutical compositions comprising the sameInfo
- Publication number
- DE3475074D1 DE3475074D1 DE8484305047T DE3475074T DE3475074D1 DE 3475074 D1 DE3475074 D1 DE 3475074D1 DE 8484305047 T DE8484305047 T DE 8484305047T DE 3475074 T DE3475074 T DE 3475074T DE 3475074 D1 DE3475074 D1 DE 3475074D1
- Authority
- DE
- Germany
- Prior art keywords
- adenosines
- processes
- production
- same
- pharmaceutical compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/22—Pteridine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US51928483A | 1983-08-01 | 1983-08-01 | |
US62194384A | 1984-06-22 | 1984-06-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3475074D1 true DE3475074D1 (en) | 1988-12-15 |
Family
ID=27059783
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8484305047T Expired DE3475074D1 (en) | 1983-08-01 | 1984-07-25 | N6-substituted diarylalkyl adenosines, processes for their production and pharmaceutical compositions comprising the same |
Country Status (14)
Country | Link |
---|---|
EP (2) | EP0251339A3 (de) |
AU (1) | AU570058B2 (de) |
CA (1) | CA1239397A (de) |
DE (1) | DE3475074D1 (de) |
DK (1) | DK159855C (de) |
ES (1) | ES8604258A1 (de) |
FI (1) | FI77666C (de) |
GR (1) | GR82224B (de) |
HU (1) | HUT34990A (de) |
IL (1) | IL72422A (de) |
NO (1) | NO158876C (de) |
NZ (1) | NZ209064A (de) |
PH (2) | PH21507A (de) |
PT (1) | PT79008B (de) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0655756B2 (ja) * | 1984-04-18 | 1994-07-27 | ネルソン・リサ−チ・アンド・デベロツプメント・カンパニ− | 心臓血管拡張薬としてのn−6置換アデノシン誘導体 |
US4657897A (en) * | 1984-06-22 | 1987-04-14 | Warner-Lambert Company | N6 -substituted adenosines for treating pain |
US4582823A (en) * | 1984-08-15 | 1986-04-15 | Warner-Lambert Company | Method for treating schizophrenia and medicaments therefor |
AU577743B2 (en) * | 1984-10-26 | 1988-09-29 | Warner-Lambert Company | N6-benzopyrano and benzothiopyrano adenosines |
US4738954A (en) * | 1985-11-06 | 1988-04-19 | Warner-Lambert Company | Novel N6 -substituted-5'-oxidized adenosine analogs |
US4755594A (en) * | 1986-01-31 | 1988-07-05 | Warner-Lambert Company | N6 -substituted adenosines |
AU8274187A (en) * | 1986-10-31 | 1988-05-25 | Warner-Lambert Company | Heteroaromatic derivatives of adenosine |
WO1988003147A1 (en) * | 1986-10-31 | 1988-05-05 | Warner-Lambert Company | Selected n6-substituted adenosines having selective a2 binding activity |
US4908441A (en) * | 1988-07-19 | 1990-03-13 | Warner-Lambert Company | Deoxyadenosine compounds and methods of making and using the same |
GB2226027B (en) * | 1988-12-13 | 1992-05-20 | Sandoz Ltd | Adenosine derivatives,their production and use |
US5561134A (en) * | 1990-09-25 | 1996-10-01 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties |
FR2687678B1 (fr) * | 1992-01-31 | 1995-03-31 | Union Pharma Scient Appl | Nouveaux derives de l'adenosine, leurs procedes de preparation, compositions pharmaceutiques les contenant. |
GB9301000D0 (en) * | 1993-01-20 | 1993-03-10 | Glaxo Group Ltd | Chemical compounds |
TW528755B (en) | 1996-12-24 | 2003-04-21 | Glaxo Group Ltd | 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives |
YU44900A (sh) | 1998-01-31 | 2003-01-31 | Glaxo Group Limited | Derivati 2-(purin-9-il)tetrahidrofuran-3,4-diola |
KR20010071591A (ko) | 1998-06-23 | 2001-07-28 | 그레이엄 브레레톤, 레슬리 에드워즈 | 2-(퓨린-9-일)-테트라히드로푸란-3,4-디올 유도체 |
AR049384A1 (es) | 2004-05-24 | 2006-07-26 | Glaxo Group Ltd | Derivados de purina |
GB0514809D0 (en) | 2005-07-19 | 2005-08-24 | Glaxo Group Ltd | Compounds |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB116580A (en) * | 1917-07-07 | 1918-06-20 | Thomas Camk | Improvements in Air-lifs for Sewage Sludge. |
NL128629C (de) * | 1966-05-07 | |||
DE1795828A1 (de) * | 1966-12-21 | 1975-11-27 | Boehringer Mannheim Gmbh | Adenosinderivate |
DE1670265A1 (de) * | 1967-08-25 | 1971-01-28 | Boehringer Mannheim Gmbh | 2-Amino-Adenosinderivate und Verfahren zu deren Herstellung |
DE2052596A1 (de) * | 1970-10-27 | 1972-05-04 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neuartige Verwendung von N(6)-substituierten Adenosin-Derivaten |
DE2406587A1 (de) * | 1974-02-12 | 1975-08-21 | Klinge Co Chem Pharm Fab | Hypolipaemisch wirksame adenosinderivate |
US4501735A (en) * | 1983-12-05 | 1985-02-26 | Warner-Lambert Company | N6-(1- and 2-benzocycloalkyl) adenosines |
-
1984
- 1984-07-11 CA CA000458620A patent/CA1239397A/en not_active Expired
- 1984-07-16 IL IL72422A patent/IL72422A/xx unknown
- 1984-07-18 AU AU30782/84A patent/AU570058B2/en not_active Ceased
- 1984-07-23 GR GR75404A patent/GR82224B/el unknown
- 1984-07-25 EP EP87110557A patent/EP0251339A3/de not_active Withdrawn
- 1984-07-25 DE DE8484305047T patent/DE3475074D1/de not_active Expired
- 1984-07-25 EP EP84305047A patent/EP0139358B1/de not_active Expired
- 1984-07-30 FI FI843013A patent/FI77666C/fi not_active IP Right Cessation
- 1984-07-31 ES ES534752A patent/ES8604258A1/es not_active Expired
- 1984-07-31 NO NO843084A patent/NO158876C/no unknown
- 1984-07-31 HU HU842928A patent/HUT34990A/hu unknown
- 1984-07-31 DK DK371584A patent/DK159855C/da not_active IP Right Cessation
- 1984-07-31 NZ NZ209064A patent/NZ209064A/xx unknown
- 1984-07-31 PH PH31050A patent/PH21507A/en unknown
- 1984-08-01 PT PT79008A patent/PT79008B/pt not_active IP Right Cessation
-
1985
- 1985-09-23 PH PH32883A patent/PH21388A/en unknown
Also Published As
Publication number | Publication date |
---|---|
HUT34990A (en) | 1985-05-28 |
NO843084L (no) | 1985-02-04 |
IL72422A (en) | 1988-08-31 |
DK371584A (da) | 1985-02-02 |
AU570058B2 (en) | 1988-03-03 |
ES534752A0 (es) | 1986-01-16 |
NO158876C (no) | 1988-11-09 |
FI843013A (fi) | 1985-02-02 |
NO158876B (no) | 1988-08-01 |
FI843013A0 (fi) | 1984-07-30 |
EP0139358A2 (de) | 1985-05-02 |
DK159855B (da) | 1990-12-17 |
FI77666C (fi) | 1989-04-10 |
PT79008B (en) | 1986-09-08 |
IL72422A0 (en) | 1984-11-30 |
DK371584D0 (da) | 1984-07-31 |
DK159855C (da) | 1991-05-13 |
PH21388A (en) | 1987-10-15 |
EP0139358B1 (de) | 1988-11-09 |
FI77666B (fi) | 1988-12-30 |
ES8604258A1 (es) | 1986-01-16 |
AU3078284A (en) | 1985-02-07 |
GR82224B (de) | 1984-12-13 |
PT79008A (en) | 1984-09-01 |
EP0251339A3 (de) | 1989-07-26 |
EP0139358A3 (en) | 1985-10-09 |
NZ209064A (en) | 1989-02-24 |
CA1239397A (en) | 1988-07-19 |
PH21507A (en) | 1987-11-10 |
EP0251339A2 (de) | 1988-01-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |