DE3464495D1 - Modified (80-113) beta interferons - Google Patents

Modified (80-113) beta interferons

Info

Publication number
DE3464495D1
DE3464495D1 DE8484107456T DE3464495T DE3464495D1 DE 3464495 D1 DE3464495 D1 DE 3464495D1 DE 8484107456 T DE8484107456 T DE 8484107456T DE 3464495 T DE3464495 T DE 3464495T DE 3464495 D1 DE3464495 D1 DE 3464495D1
Authority
DE
Germany
Prior art keywords
modified
beta interferons
interferons
beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8484107456T
Other languages
English (en)
Inventor
Leslie D Bell
Paul G Boseley
John C Smith
Michael Houghton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Application granted granted Critical
Publication of DE3464495D1 publication Critical patent/DE3464495D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/565—IFN-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/811—Interferon
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/14—Lymphokine; related peptides
    • Y10S930/142—Interferon

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
DE8484107456T 1983-07-01 1984-06-28 Modified (80-113) beta interferons Expired DE3464495D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB838317880A GB8317880D0 (en) 1983-07-01 1983-07-01 Structure and synthesis of interferons

Publications (1)

Publication Number Publication Date
DE3464495D1 true DE3464495D1 (en) 1987-08-06

Family

ID=10545098

Family Applications (4)

Application Number Title Priority Date Filing Date
DE8484107456T Expired DE3464495D1 (en) 1983-07-01 1984-06-28 Modified (80-113) beta interferons
DE8484107457T Expired DE3463511D1 (en) 1983-07-01 1984-06-28 Modified (115-145) beta interferons
DE8484107458T Expired DE3466992D1 (en) 1983-07-01 1984-06-28 Modified (1-28) beta interferons
DE8484107498T Expired DE3466993D1 (en) 1983-07-01 1984-06-28 Modified (1-56) beta interferons

Family Applications After (3)

Application Number Title Priority Date Filing Date
DE8484107457T Expired DE3463511D1 (en) 1983-07-01 1984-06-28 Modified (115-145) beta interferons
DE8484107458T Expired DE3466992D1 (en) 1983-07-01 1984-06-28 Modified (1-28) beta interferons
DE8484107498T Expired DE3466993D1 (en) 1983-07-01 1984-06-28 Modified (1-56) beta interferons

Country Status (6)

Country Link
US (4) US4793995A (de)
EP (4) EP0131816B1 (de)
JP (4) JPS60100599A (de)
AU (4) AU577790B2 (de)
DE (4) DE3464495D1 (de)
GB (1) GB8317880D0 (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4588585A (en) * 1982-10-19 1986-05-13 Cetus Corporation Human recombinant cysteine depleted interferon-β muteins
NZ208309A (en) * 1983-06-01 1988-04-29 Hoffmann La Roche Recombinant leukocyte, fibroblast, or immune interferons (rifn-#a#, b or #g#) with one cys residue replaced
GB8317880D0 (en) * 1983-07-01 1983-08-03 Searle & Co Structure and synthesis of interferons
GB8334102D0 (en) * 1983-12-21 1984-02-01 Searle & Co Interferons with cysteine pattern
US4530787A (en) * 1984-03-28 1985-07-23 Cetus Corporation Controlled oxidation of microbially produced cysteine-containing proteins
GB8412564D0 (en) * 1984-05-17 1984-06-20 Searle & Co Structure and properties
US4752585A (en) * 1985-12-17 1988-06-21 Cetus Corporation Oxidation-resistant muteins
US4885166A (en) * 1985-06-11 1989-12-05 Ciba-Geigy Corporation Hybrid interferons
US5963288A (en) * 1987-08-20 1999-10-05 Semiconductor Energy Laboratory Co., Ltd. Liquid crystal device having sealant and spacers made from the same material
EP0260350B1 (de) * 1986-09-05 1992-02-12 Cetus Oncology Corporation Oxidationsresistente Muteine von beta-Interferon, deren Herstellung und diese Muteine enthaltende Präparate
US4904584A (en) * 1987-12-23 1990-02-27 Genetics Institute, Inc. Site-specific homogeneous modification of polypeptides
US6682896B1 (en) * 1988-10-14 2004-01-27 Schering Aktiengesellschaft Peptides representing epitopic sites on r-IFN-β, antibodies thereto and uses thereof
US5545723A (en) * 1994-03-15 1996-08-13 Biogen Inc. Muteins of IFN-β
US6753165B1 (en) * 1999-01-14 2004-06-22 Bolder Biotechnology, Inc. Methods for making proteins containing free cysteine residues
US20080076706A1 (en) 1997-07-14 2008-03-27 Bolder Biotechnology, Inc. Derivatives of Growth Hormone and Related Proteins, and Methods of Use Thereof
DE69838552T2 (de) * 1997-07-14 2008-05-21 Bolder Biotechnology, Inc., Louisville Derivate des wachstumshormons und verwandte proteine
US6525185B1 (en) 1998-05-07 2003-02-25 Affymetrix, Inc. Polymorphisms associated with hypertension
US8288126B2 (en) 1999-01-14 2012-10-16 Bolder Biotechnology, Inc. Methods for making proteins containing free cysteine residues
US6514729B1 (en) * 1999-05-12 2003-02-04 Xencor, Inc. Recombinant interferon-beta muteins
US20040091967A1 (en) * 2001-02-05 2004-05-13 Kohler Ranier H Regulation of human histone acetyltranseferase
EP1366075B1 (de) 2001-02-27 2009-05-27 Maxygen Aps Neue interferon-beta-ähnliche moleküle
BR0208041A (pt) * 2001-03-15 2004-02-25 Merck Patent Gmbh Interferon beta modificado com imunogenicidade reduzida
US6887462B2 (en) 2001-04-09 2005-05-03 Chiron Corporation HSA-free formulations of interferon-beta
CA2497151A1 (en) * 2002-08-29 2004-03-11 Cytocure Llc Methods for up-regulating antigen expression in tumors
CA2498319A1 (en) * 2002-09-09 2004-03-18 Nautilus Biotech Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
US20050054053A1 (en) * 2002-10-01 2005-03-10 Xencor, Inc. Interferon variants with improved properties
US20040175359A1 (en) * 2002-11-12 2004-09-09 Desjarlais John Rudolph Novel proteins with antiviral, antineoplastic, and/or immunomodulatory activity
TW200716749A (en) * 2005-05-19 2007-05-01 Schering Ag Interferon-beta gene therapy using an improved, regulated expression system
DOP2006000116A (es) * 2005-05-19 2007-01-31 Schering Ag Sistema mejorado de expresión regulada y sus usos.
US20070179113A1 (en) * 2005-05-19 2007-08-02 Schering Aktiengesellachaft GM-CSF gene therapy for Crohn's disease using an improved regulated expression system
US20080076729A1 (en) * 2005-05-19 2008-03-27 Schering Aktiengesellachaft Interferon-beta gene therapy using an improved, regulated expression system
US20080003202A1 (en) * 2006-03-28 2008-01-03 Thierry Guyon Modified interferon-beta (IFN-beta) polypeptides
WO2008125222A2 (en) * 2007-04-11 2008-10-23 Bayer Schering Pharma Aktiengesellschaft New modulation molecules for an improved regulated expression system
BRPI0810622A2 (pt) * 2007-05-02 2020-10-13 Ambrx, Inc. polipeptídeos de interferon beta modificados e seus usos
EP2207890A4 (de) * 2007-10-05 2010-12-15 Barofold Inc Hochdruckbehandlung aggregierter interferone
CN101918026B (zh) 2007-11-20 2016-03-02 Ambrx公司 经修饰胰岛素多肽和其用途
JP4911373B2 (ja) 2009-11-26 2012-04-04 横河電機株式会社 Ｘ線測定装置
MA34521B1 (fr) 2010-08-17 2013-09-02 Ambrx Inc Polypeptides de relaxine modifiés et leurs utilisations

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES506955A0 (es) * 1980-11-10 1983-02-01 Genentech Inc Un procedimiento para producir un polipeptido antiviral.
US4414150A (en) * 1980-11-10 1983-11-08 Genentech, Inc. Hybrid human leukocyte interferons
WO1983002461A1 (en) * 1982-01-19 1983-07-21 Cetus Corp Multiclass hybrid interferons
US4588585A (en) * 1982-10-19 1986-05-13 Cetus Corporation Human recombinant cysteine depleted interferon-β muteins
GB8317880D0 (en) * 1983-07-01 1983-08-03 Searle & Co Structure and synthesis of interferons

Also Published As

Publication number Publication date
JPS60214800A (ja) 1985-10-28
US4753795A (en) 1988-06-28
JPS60143000A (ja) 1985-07-29
AU577789B2 (en) 1988-10-06
EP0130566A1 (de) 1985-01-09
AU577790B2 (en) 1988-10-06
US4738845A (en) 1988-04-19
EP0130565B1 (de) 1987-05-06
AU577791B2 (en) 1988-10-06
AU2998484A (en) 1985-01-03
US4738844A (en) 1988-04-19
JPS60100599A (ja) 1985-06-04
GB8317880D0 (en) 1983-08-03
AU2998284A (en) 1985-01-03
EP0130564B1 (de) 1987-07-01
EP0130564A1 (de) 1985-01-09
DE3466992D1 (en) 1987-12-03
DE3463511D1 (en) 1987-06-11
JPS60105700A (ja) 1985-06-11
EP0130565A1 (de) 1985-01-09
AU2998184A (en) 1985-01-03
DE3466993D1 (en) 1987-12-03
AU2998384A (en) 1985-01-03
US4793995A (en) 1988-12-27
EP0131816A1 (de) 1985-01-23
EP0130566B1 (de) 1987-10-28
EP0131816B1 (de) 1987-10-28
AU577792B2 (en) 1988-10-06

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee