DE3378634D1 - Pharmaceutically active pteridine derivatives - Google Patents

Pharmaceutically active pteridine derivatives

Info

Publication number
DE3378634D1
DE3378634D1 DE8383109291T DE3378634T DE3378634D1 DE 3378634 D1 DE3378634 D1 DE 3378634D1 DE 8383109291 T DE8383109291 T DE 8383109291T DE 3378634 T DE3378634 T DE 3378634T DE 3378634 D1 DE3378634 D1 DE 3378634D1
Authority
DE
Germany
Prior art keywords
pharmaceutically active
pteridine derivatives
active pteridine
derivatives
pharmaceutically
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8383109291T
Other languages
English (en)
Inventor
Charles Adam Nichol
Jr John Frederick Reinhard
Cary Keith Smith
Eric Cleveland Bigham
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB838318833A external-priority patent/GB8318833D0/en
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Application granted granted Critical
Publication of DE3378634D1 publication Critical patent/DE3378634D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE8383109291T 1982-09-20 1983-09-19 Pharmaceutically active pteridine derivatives Expired DE3378634D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8226688 1982-09-20
GB838318833A GB8318833D0 (en) 1983-07-12 1983-07-12 Chemical compounds

Publications (1)

Publication Number Publication Date
DE3378634D1 true DE3378634D1 (en) 1989-01-12

Family

ID=26283872

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8383109291T Expired DE3378634D1 (en) 1982-09-20 1983-09-19 Pharmaceutically active pteridine derivatives

Country Status (5)

Country Link
EP (1) EP0108890B1 (de)
AU (1) AU572792B2 (de)
CA (1) CA1288099C (de)
DE (1) DE3378634D1 (de)
DK (1) DK426083A (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5196533A (en) * 1983-04-11 1993-03-23 South Alabama Medical Science Foundation, Usa Cyclization of 5 amino-pyrimidines to quinoid 6,6 disubstituted dihydropteridines
JPS61277618A (ja) * 1985-06-04 1986-12-08 Suntory Ltd 自閉症治療剤
US5198547A (en) * 1992-03-16 1993-03-30 South Alabama Medical Science Foundation, Usa Process for N5-formylating tetrahydropteridines
EP0674627A1 (de) * 1992-12-18 1995-10-04 The Wellcome Foundation Limited Pyrimidin-, pyridin-, pteridinon- und indazolderivate als enzyminhibitoren
GB9226377D0 (en) * 1992-12-18 1993-02-10 Babbedge Rachel C Pharmaceutical compositions
DE4418096A1 (de) * 1994-05-24 1995-11-30 Cassella Ag Verwendung von Pteridin-Derivaten als Hemmstoffe der NO-Synthase
JP4306825B2 (ja) 1998-02-27 2009-08-05 アスビオファーマ株式会社 インスリン抵抗性が関与する血管機能異常を伴う疾患の予防または治療剤
US7276506B2 (en) 1998-12-28 2007-10-02 4 Aza Bioscience Nv Immunosuppressive effects of pteridine derivatives
ES2229803T3 (es) * 1998-12-28 2005-04-16 4 Aza Bioscience Nv Efectos inmunosupresivos de derivados de pteridina.
AU2004291149C1 (en) * 2003-11-17 2021-01-21 Biomarin Pharmaceutical Inc. Methods and Compositions for the Treatment of Metabolic Disorders
US8003126B2 (en) 2004-11-17 2011-08-23 Biomarin Pharmaceutical Inc. Stable tablet formulation
US10144736B2 (en) 2006-07-20 2018-12-04 Gilead Sciences, Inc. Substituted pteridines useful for the treatment and prevention of viral infections
PT3321265T (pt) 2015-03-04 2020-07-07 Gilead Sciences Inc Compostos 4,6-diamino-pirido[3,2-d]pirimidina compounds e a sua utilização como moduladores de receptores do tipo toll
JP6746776B2 (ja) 2016-09-02 2020-08-26 ギリアード サイエンシーズ， インコーポレイテッド Ｔｏｌｌ様受容体調節剤化合物
ES2826748T3 (es) 2016-09-02 2021-05-19 Gilead Sciences Inc Derivados de 4,6-diamino-pirido[3,2-d]pirimidina como moduladores de receptores de tipo Toll
TW202212339A (zh) 2019-04-17 2022-04-01 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TWI751516B (zh) 2019-04-17 2022-01-01 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TW202115056A (zh) 2019-06-28 2021-04-16 美商基利科學股份有限公司 類鐸受體調節劑化合物的製備方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1293541A (en) * 1969-03-18 1972-10-18 John Alexander Blair Folic acid derivatives
BE787236A (fr) * 1971-08-05 1973-02-05 Wellcome Found Compositions de potentialisation
JPS5883691A (ja) * 1981-11-13 1983-05-19 Kanegafuchi Chem Ind Co Ltd １′，２′−ジアシル−（６ｒ，ｓ）−５，６，７，８−テトラヒドロ−ｌ−ビオプテリンおよびその製法

Also Published As

Publication number Publication date
AU1925683A (en) 1984-03-29
DK426083A (da) 1984-03-21
EP0108890A2 (de) 1984-05-23
AU572792B2 (en) 1988-05-19
CA1288099C (en) 1991-08-27
DK426083D0 (da) 1983-09-19
EP0108890A3 (en) 1985-10-02
EP0108890B1 (de) 1988-12-07

Similar Documents

Publication Publication Date Title
GB2146989B (en) Pharmaceutically active hydroxypyridones
DE3368057D1 (en) Pharmaceutically active aminobenzopyrans
ZA837598B (en) Therapeutically useful 1-phenyl-2-piperidinoalkanol derivatives
GB8403540D0 (en) Pharmacologically active compounds
GB2127402B (en) Pharmaceutically active carbostyril derivatives
ZA832549B (en) Pharmaceutically active compounds
DE3378634D1 (en) Pharmaceutically active pteridine derivatives
DE3275540D1 (en) Pharmaceutically active (3-aminopropoxy)-bibenzyl derivatives
PT86000A (en) Pharmaceutically active compounds
ZA841567B (en) Pharmacologically active tripeptide derivatives
GB2130220B (en) Pharmacologically active peptides
DE3174163D1 (en) Pharmaceutically active compounds
GB2126581B (en) Herbicidally active furodioxole derivatives
GB2072173B (en) Pharmaceutically active amino-acid derivatives
GB2116175B (en) Fungicidally active benzohydrol derivatives
GB2016012B (en) Pharmaceutically active decahydro-isoquinoline derivatives
EP0366614A3 (en) Pharmaceutically active dithioketene derivatives
GB2136436B (en) Pharmacologically active tripeptide derivatives
ZA824165B (en) Pharmaceutically active compounds
GB2098477B (en) Pharmaceutically active material
GB2131024B (en) New therapeutically useful alkylbenzylidene derivatives
GB2150134B (en) Pharmaceutically active 1,1-diphenyl-4-isobutylamino-1-1butanol and derivatives thereof
DE3264904D1 (en) Pharmacologically active naphthotriazole derivatives
GB8315520D0 (en) Pharmaceutically active heterocycles
GB8328415D0 (en) Pharmaceutically active compounds

Legal Events

Date Code Title Description
8364 No opposition during term of opposition