DE3371337D1 - Nitroimidazole radiosensitizers and pharmaceutical compositions thereof - Google Patents

Nitroimidazole radiosensitizers and pharmaceutical compositions thereof

Info

Publication number
DE3371337D1
DE3371337D1 DE8383902516T DE3371337T DE3371337D1 DE 3371337 D1 DE3371337 D1 DE 3371337D1 DE 8383902516 T DE8383902516 T DE 8383902516T DE 3371337 T DE3371337 T DE 3371337T DE 3371337 D1 DE3371337 D1 DE 3371337D1
Authority
DE
Germany
Prior art keywords
pharmaceutical compositions
nitroimidazole radiosensitizers
radiosensitizers
nitroimidazole
pharmaceutical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8383902516T
Other languages
German (de)
English (en)
Inventor
Krishna C Agrawal
Masakazu Sakaguchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Corp
Original Assignee
Research Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research Corp filed Critical Research Corp
Application granted granted Critical
Publication of DE3371337D1 publication Critical patent/DE3371337D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE8383902516T 1982-02-08 1983-02-07 Nitroimidazole radiosensitizers and pharmaceutical compositions thereof Expired DE3371337D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/346,914 US4462992A (en) 1982-02-08 1982-02-08 Nitroimidazole radiosensitizers for hypoxic tumor cells and compositions thereof
PCT/US1983/000165 WO1983002774A1 (en) 1982-02-08 1983-02-07 Nitroimidazole radiosensitizers and composition thereof

Publications (1)

Publication Number Publication Date
DE3371337D1 true DE3371337D1 (en) 1987-06-11

Family

ID=23361561

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8383902516T Expired DE3371337D1 (en) 1982-02-08 1983-02-07 Nitroimidazole radiosensitizers and pharmaceutical compositions thereof

Country Status (10)

Country Link
US (1) US4462992A (oth)
EP (1) EP0100363B1 (oth)
JP (1) JPS59500130A (oth)
CA (1) CA1197854A (oth)
DE (1) DE3371337D1 (oth)
DK (1) DK422083A (oth)
GR (1) GR78100B (oth)
IE (1) IE830233L (oth)
IT (1) IT1163086B (oth)
WO (1) WO1983002774A1 (oth)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3682723D1 (de) * 1985-08-15 1992-01-16 Asahi Denka Kogyo Kk Strahlungssensibilisator.
US4758669A (en) * 1986-05-05 1988-07-19 Radiation Oncology Center Research And Development Corporation 4-(nitrone aryl) dihydropyridines
JPH0819111B2 (ja) * 1987-10-22 1996-02-28 ポーラ化成工業株式会社 ２―ニトロイミダゾール誘導体及びこれを有効成分とする放射線増感剤
GB8728418D0 (en) * 1987-12-04 1988-01-13 Jenkins T C Nitro-substituted aromatic/hetero-aromatic compounds for use in cancer treatment
IT1226100B (it) * 1988-07-07 1990-12-10 Dompe Farmaceutici Spa Derivati benzimidazolici farmacologicamente attivi.
US5036096A (en) * 1988-11-25 1991-07-30 Warner-Lambert Company Aziridino derivatives of nitroimidazoles and pharmaceutical compositions of selected derivatives
US5036089A (en) * 1988-11-25 1991-07-30 Warner-Lambert Company 2-oxazolidinone derivatives of nitroimidazoles and pharmaceutical compositions useful as sensitizing agents
US4954515A (en) * 1988-11-25 1990-09-04 Warner-Lambert Company Haloalkylaminomethyl-2-nitro-1H-imidazoles
CA1339130C (en) * 1989-08-18 1997-07-29 Leonard Irving Wiebe Markers of tissue hypoxia
KR927003539A (ko) * 1990-01-26 1992-12-18 스즈끼 쯔네시 2-니트로 이미다졸 유도체, 그의 제조방법 및 이를 유효성분으로 하는 방사선 증감제
US5808091A (en) 1991-10-29 1998-09-15 Bracco International B.V. Rhenium and technetium complexes containing a hypoxia localizing moiety
WO1994014778A1 (fr) * 1992-12-18 1994-07-07 Pola Chemical Industries, Inc. Derive optiquement actif de 2-nitroimidazole, son procede de production, et intermediaire pour sa production
US5486360A (en) * 1993-04-22 1996-01-23 St. Joseph Health Centre Method of treating tumour cells using catalase
US5608110A (en) * 1993-06-15 1997-03-04 Bracco International B.V. Heteroatom-bearing ligands and metal complexes thereof
WO1995009844A1 (en) * 1993-10-04 1995-04-13 Board Of Regents, The University Of Texas System Rapid synthesis and use of 18f-fluoromisonidazole and analogs
US5700825A (en) * 1995-03-31 1997-12-23 Florida State University Radiosensitizing diamines and their pharmaceutical preparations
US6060604A (en) * 1995-03-31 2000-05-09 Florida State University Pharmaceutical compounds comprising polyamines substituted with electron-affinic groups
US6331286B1 (en) 1998-12-21 2001-12-18 Photogen, Inc. Methods for high energy phototherapeutics
US8974363B2 (en) * 1997-12-11 2015-03-10 Provectus Pharmatech, Inc. Topical medicaments and methods for photodynamic treatment of disease
US20090117199A1 (en) * 1998-08-06 2009-05-07 Scott Timothy C Method of treatment of cancer
US8557298B2 (en) * 1998-08-06 2013-10-15 Provectus Pharmatech, Inc. Medicaments for chemotherapeutic treatment of disease
US20020001567A1 (en) * 1998-12-21 2002-01-03 Photogen, Inc. Intracorporeal medicaments for high energy phototherapeutic treatment of disease
US8470296B2 (en) * 1998-12-21 2013-06-25 Provectus Pharmatech, Inc. Intracorporeal medicaments for high energy phototherapeutic treatment of disease
US7384623B1 (en) 1998-12-21 2008-06-10 Provectus Pharmatech, Inc. High energy phototherapeutic agents
US20030216758A1 (en) * 2001-12-28 2003-11-20 Angiotech Pharmaceuticals, Inc. Coated surgical patches
EP2181704B1 (en) 2002-12-30 2015-05-06 Angiotech International Ag Drug delivery from rapid gelling polymer composition
JP5297815B2 (ja) 2007-01-26 2013-09-25 株式会社ポーラファルマ 医薬組成物
US8703188B1 (en) 2012-11-19 2014-04-22 Azanta A/S Dispersible tablet

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3646057A (en) * 1969-04-06 1972-02-29 Hoffmann La Roche 2-nitroimidazoles
US4199592A (en) * 1978-08-29 1980-04-22 E. I. Du Pont De Nemours And Company Antiinflammatory 4,5-diaryl-2-nitroimidazoles
US4282232A (en) * 1979-04-26 1981-08-04 Research Corporation Nitroimidazole radiosensitizers for hypoxic tumor cells and compositions thereof
US4371540A (en) * 1979-09-14 1983-02-01 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Nitroimidazoles of low toxicity and high activity as radiosensitizers of hypoxic tumor cells

Also Published As

Publication number Publication date
EP0100363A1 (en) 1984-02-15
US4462992A (en) 1984-07-31
IE830233L (en) 1983-08-08
DK422083D0 (da) 1983-09-16
EP0100363B1 (en) 1987-05-06
EP0100363A4 (en) 1984-06-13
WO1983002774A1 (en) 1983-08-18
IT8319481A0 (it) 1983-02-08
IT1163086B (it) 1987-04-08
DK422083A (da) 1983-09-16
CA1197854A (en) 1985-12-10
JPS59500130A (ja) 1984-01-26
GR78100B (oth) 1984-09-26

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee