IT1163086B - Radiosensibilizzatori di nitroimmidazolo per cellule tumorali ipossiche e loro composizioni - Google Patents
Radiosensibilizzatori di nitroimmidazolo per cellule tumorali ipossiche e loro composizioniInfo
- Publication number
- IT1163086B IT1163086B IT19481/83A IT1948183A IT1163086B IT 1163086 B IT1163086 B IT 1163086B IT 19481/83 A IT19481/83 A IT 19481/83A IT 1948183 A IT1948183 A IT 1948183A IT 1163086 B IT1163086 B IT 1163086B
- Authority
- IT
- Italy
- Prior art keywords
- nitroimmidazole
- radiosensitizers
- compositions
- cancer cells
- hypoxic cancer
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/91—Nitro radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/346,914 US4462992A (en) | 1982-02-08 | 1982-02-08 | Nitroimidazole radiosensitizers for hypoxic tumor cells and compositions thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IT8319481A0 IT8319481A0 (it) | 1983-02-08 |
| IT1163086B true IT1163086B (it) | 1987-04-08 |
Family
ID=23361561
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT19481/83A IT1163086B (it) | 1982-02-08 | 1983-02-08 | Radiosensibilizzatori di nitroimmidazolo per cellule tumorali ipossiche e loro composizioni |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4462992A (it) |
| EP (1) | EP0100363B1 (it) |
| JP (1) | JPS59500130A (it) |
| CA (1) | CA1197854A (it) |
| DE (1) | DE3371337D1 (it) |
| DK (1) | DK422083A (it) |
| GR (1) | GR78100B (it) |
| IE (1) | IE830233L (it) |
| IT (1) | IT1163086B (it) |
| WO (1) | WO1983002774A1 (it) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3682723D1 (de) * | 1985-08-15 | 1992-01-16 | Asahi Denka Kogyo Kk | Strahlungssensibilisator. |
| US4758669A (en) * | 1986-05-05 | 1988-07-19 | Radiation Oncology Center Research And Development Corporation | 4-(nitrone aryl) dihydropyridines |
| JPH0819111B2 (ja) * | 1987-10-22 | 1996-02-28 | ポーラ化成工業株式会社 | ２―ニトロイミダゾール誘導体及びこれを有効成分とする放射線増感剤 |
| GB8728418D0 (en) * | 1987-12-04 | 1988-01-13 | Jenkins T C | Nitro-substituted aromatic/hetero-aromatic compounds for use in cancer treatment |
| IT1226100B (it) * | 1988-07-07 | 1990-12-10 | Dompe Farmaceutici Spa | Derivati benzimidazolici farmacologicamente attivi. |
| US5036089A (en) * | 1988-11-25 | 1991-07-30 | Warner-Lambert Company | 2-oxazolidinone derivatives of nitroimidazoles and pharmaceutical compositions useful as sensitizing agents |
| US5036096A (en) * | 1988-11-25 | 1991-07-30 | Warner-Lambert Company | Aziridino derivatives of nitroimidazoles and pharmaceutical compositions of selected derivatives |
| US4954515A (en) * | 1988-11-25 | 1990-09-04 | Warner-Lambert Company | Haloalkylaminomethyl-2-nitro-1H-imidazoles |
| CA1339130C (en) * | 1989-08-18 | 1997-07-29 | Leonard Irving Wiebe | Markers of tissue hypoxia |
| JP2626727B2 (ja) * | 1990-01-26 | 1997-07-02 | ポーラ化成工業株式会社 | ２―ニトロイミダゾール誘導体、その製造法及びこれを有効成分とする放射線増感剤 |
| US5808091A (en) * | 1991-10-29 | 1998-09-15 | Bracco International B.V. | Rhenium and technetium complexes containing a hypoxia localizing moiety |
| WO1994014778A1 (en) * | 1992-12-18 | 1994-07-07 | Pola Chemical Industries, Inc. | Optically active 2-nitroimidazole derivative, process for producing the same, and intermediate for producing the same |
| US5486360A (en) * | 1993-04-22 | 1996-01-23 | St. Joseph Health Centre | Method of treating tumour cells using catalase |
| US5608110A (en) * | 1993-06-15 | 1997-03-04 | Bracco International B.V. | Heteroatom-bearing ligands and metal complexes thereof |
| WO1995009844A1 (en) * | 1993-10-04 | 1995-04-13 | Board Of Regents, The University Of Texas System | Rapid synthesis and use of 18f-fluoromisonidazole and analogs |
| US5700825A (en) * | 1995-03-31 | 1997-12-23 | Florida State University | Radiosensitizing diamines and their pharmaceutical preparations |
| US6060604A (en) * | 1995-03-31 | 2000-05-09 | Florida State University | Pharmaceutical compounds comprising polyamines substituted with electron-affinic groups |
| US6331286B1 (en) | 1998-12-21 | 2001-12-18 | Photogen, Inc. | Methods for high energy phototherapeutics |
| US8974363B2 (en) * | 1997-12-11 | 2015-03-10 | Provectus Pharmatech, Inc. | Topical medicaments and methods for photodynamic treatment of disease |
| US8557298B2 (en) * | 1998-08-06 | 2013-10-15 | Provectus Pharmatech, Inc. | Medicaments for chemotherapeutic treatment of disease |
| US20090117199A1 (en) * | 1998-08-06 | 2009-05-07 | Scott Timothy C | Method of treatment of cancer |
| US8470296B2 (en) * | 1998-12-21 | 2013-06-25 | Provectus Pharmatech, Inc. | Intracorporeal medicaments for high energy phototherapeutic treatment of disease |
| US7384623B1 (en) | 1998-12-21 | 2008-06-10 | Provectus Pharmatech, Inc. | High energy phototherapeutic agents |
| US20020001567A1 (en) * | 1998-12-21 | 2002-01-03 | Photogen, Inc. | Intracorporeal medicaments for high energy phototherapeutic treatment of disease |
| US20030216758A1 (en) * | 2001-12-28 | 2003-11-20 | Angiotech Pharmaceuticals, Inc. | Coated surgical patches |
| EP1594459B1 (en) | 2002-12-30 | 2010-02-17 | Angiotech International Ag | Drug delivery from rapid gelling polymer composition |
| CN101621997B (zh) * | 2007-01-26 | 2013-05-08 | 株式会社宝丽制药 | 医药组合物 |
| US8703188B1 (en) | 2012-11-19 | 2014-04-22 | Azanta A/S | Dispersible tablet |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3646057A (en) * | 1969-04-06 | 1972-02-29 | Hoffmann La Roche | 2-nitroimidazoles |
| US4199592A (en) * | 1978-08-29 | 1980-04-22 | E. I. Du Pont De Nemours And Company | Antiinflammatory 4,5-diaryl-2-nitroimidazoles |
| US4282232A (en) * | 1979-04-26 | 1981-08-04 | Research Corporation | Nitroimidazole radiosensitizers for hypoxic tumor cells and compositions thereof |
| US4371540A (en) * | 1979-09-14 | 1983-02-01 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Nitroimidazoles of low toxicity and high activity as radiosensitizers of hypoxic tumor cells |
-
1982
- 1982-02-08 US US06/346,914 patent/US4462992A/en not_active Expired - Fee Related
-
1983
- 1983-02-04 CA CA000420931A patent/CA1197854A/en not_active Expired
- 1983-02-07 JP JP83500881A patent/JPS59500130A/ja active Pending
- 1983-02-07 IE IE830233A patent/IE830233L/xx unknown
- 1983-02-07 DE DE8383902516T patent/DE3371337D1/de not_active Expired
- 1983-02-07 WO PCT/US1983/000165 patent/WO1983002774A1/en active IP Right Grant
- 1983-02-07 EP EP83902516A patent/EP0100363B1/en not_active Expired
- 1983-02-07 GR GR70441A patent/GR78100B/el unknown
- 1983-02-08 IT IT19481/83A patent/IT1163086B/it active
- 1983-09-16 DK DK422083A patent/DK422083A/da not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US4462992A (en) | 1984-07-31 |
| IT8319481A0 (it) | 1983-02-08 |
| CA1197854A (en) | 1985-12-10 |
| EP0100363A1 (en) | 1984-02-15 |
| DK422083D0 (da) | 1983-09-16 |
| IE830233L (en) | 1983-08-08 |
| EP0100363B1 (en) | 1987-05-06 |
| JPS59500130A (ja) | 1984-01-26 |
| WO1983002774A1 (en) | 1983-08-18 |
| DK422083A (da) | 1983-09-16 |
| DE3371337D1 (en) | 1987-06-11 |
| GR78100B (it) | 1984-09-26 |
| EP0100363A4 (en) | 1984-06-13 |
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