DE336732C - Process for the production of completely debittered glycosides from the Cascara Sagrada bark - Google Patents

Process for the production of completely debittered glycosides from the Cascara Sagrada bark

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Publication number
DE336732C
DE336732C DE1919336732D DE336732DD DE336732C DE 336732 C DE336732 C DE 336732C DE 1919336732 D DE1919336732 D DE 1919336732D DE 336732D D DE336732D D DE 336732DD DE 336732 C DE336732 C DE 336732C
Authority
DE
Germany
Prior art keywords
debittered
glycosides
completely
bark
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE1919336732D
Other languages
German (de)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CHEMISCHE FABRIKEN
Franz Fritzsche & Co
Original Assignee
CHEMISCHE FABRIKEN
Franz Fritzsche & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CHEMISCHE FABRIKEN, Franz Fritzsche & Co filed Critical CHEMISCHE FABRIKEN
Application granted granted Critical
Publication of DE336732C publication Critical patent/DE336732C/en
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

Verfahren zur Herstellung von vollständig entbtterten Glykosiden aus--der Cascara Sagrada-Rinde. Es ist bekannt, daß es gelingt, mit Hilfe von gebrannter Magnesia oder Zinkoxyd aus Cascara-Sagrada-Rinde entbitterte Extrakte zu erhalten. Einesteils wird aber die Entbitterung nicht vollständig erreicht, andernteils werden beim Arbeiten mit gebrannter Magnesia 'auch wirksame Methylanthrachinone ausgefällt, die nicht mehr in den bei der Extraktbereitung verwendeten Lösungsmitteln löslich sind. Den nach beiden Verfahren hergestellten Extrakten haftet aber der Nachteil an, daß diese nicht von den Ballaststoffen befreit sind, und daß dieselben daher bei ihrer therapeutischen Verwendung Reizwirkungen zeigen.Process for the production of completely peeled glycosides from Cascara Sagrada bark. It is known that it succeeds with the help of fired Magnesia or zinc oxide from Cascara Sagrada bark to obtain debittered extracts. On the one hand, however, the debittering is not fully achieved, on the other hand, it is achieved when working with burnt magnesia, effective methylanthraquinones are also precipitated, which are no longer soluble in the solvents used in the preparation of the extract are. However, the extracts produced by both processes have the disadvantage indicate that these are not exempt from dietary fiber, and that they are therefore the same show irritant effects in their therapeutic use.

Aus der Patentschrift 2o755o ist ein Verfahren zur Gewinnung der in der Cascararinde enthaltenen Glykoside bekannt, nach welchem zwar die unwirksamen Ballaststoffe der Rinde durch Bleiazetat und Bleiessig entfernt werden, schließlich aber eine bittere Trockensubstanz gewonnen wird, wie in dem Beispiel der Patentschrift zum Ausdruck gebracht wird, indem im ersten Absatze, etwa in der Mitte, gesagt wird, daß der Rückstand, welcher das Produkt bildet, einen »ziemlich bitteren Geschmack« hat. Daraus ist ersichtlich, daß die Anwendung des Bleioxyds in basischem Bleiazetat eine vollständige Ent bitterung des Endproduktes nicht erzielen kann.From the patent specification 2o755o a method for obtaining the in the glycosides contained in the cascara bark, according to which the ineffective ones Fiber is removed from the bark by lead acetate and lead acetic acid, eventually but a bitter dry substance is obtained, as in the example of the patent is expressed by saying in the first paragraph, roughly in the middle, that the residue which forms the product has a "rather bitter taste" Has. It can be seen from this that the use of lead oxide in basic lead acetate a complete de-bittering of the end product cannot be achieved.

Demgegenüber wurde nun gefunden, daß es überraschenderweise gelingt, durch geeignete Behandlung zu einem vollständig entbitterten, von Ballaststoffen befreiten, wasserlöslichen Präparat zu gelangen, das die Gesamtglykoside der Cascara Sagrada enthält.In contrast, it has now been found that, surprisingly, it succeeds by appropriate treatment to a completely debittered, of fiber released, water-soluble preparation containing the total glycosides of Cascara Contains Sagrada.

Unsere Erfindung besteht darin, daß bei der bekannten Extraktion der Cascara-Sagrada-Rinde Mennige, das ist eine Verbindung von Bleioxyd mit Bleisuperoxyd, zugefügt wird und alle Arbeiten bis zur schließlichen Gewinnung des die Glykoside enthaltenden Trockenpräparates ohne jede Erwärmung ausgeführt werden. Beispiel.Our invention consists in the fact that in the known extraction Cascara-Sagrada-Bark Red lead, that is a combination of lead oxide with lead superoxide, is added and all work up to the eventual recovery of the glycosides containing dry preparations can be carried out without any heating. Example.

Auf bekannte Weise stellt man einen kalten Auszug der Cascararinde dar. Im hohen Vakuum werden die Auszüge zu einem dünnen Extrakt konzentriert und nun ohne Erwärmen mit Mennige so lange gerührt, bis vollkommene Entbitterung eingetreten ist. Sobald dieser Punkt erreicht ist, wird das Produkt durch Filtrieren von der Mennige befreit und das Filtrat nach den bekannten Methoden der Glykosidreinigung (s. Hagers Handbuch der pharmaceutischen Praxis und Schmidt, Lehrbuch der pharmaceutischen Chemie) behandelt und schließlich noch im hohen Vakuum zur Trockne eingedampft.A cold extract of the cascara bark is made in a well-known manner In a high vacuum, the extracts are concentrated into a thin extract and Stirred with red lead without heating until it is completely debittered is. Once this point is reached, the product is filtered off from the Red lead freed and the filtrate according to the known methods of glycoside purification (See Hagers Handbuch der pharmaceutischen Praxis and Schmidt, textbook of pharmaceutischen Chemistry) and finally evaporated to dryness in a high vacuum.

Das Endprodukt ist vollkommen entbittert und enthält die wirksamen Glykoside der Cascara Sagrada.The end product is completely debittered and contains the effective ones Glycosides of the Cascara Sagrada.

Der technische Fortschritt des Verfahrens beruht in der größeren Verwendbarkeit des Produktes die dadurch zum Ausdruck kommt, daß die vollkommen entbitterten Glykoside überall da zur Verwendung kommen können, wo dienoch bitteren oder ziemlich bitteren Glylzoside bei der Einnahme durch den Mund zurückgewiesen' dederi; `The technical progress of the process is based on the greater usability of the product which is expressed by the fact that the completely debittered glycosides can be used anywhere where they are still bitter or rather bitter glylzoside when ingested by mouth rejected 'dederi; `

Claims (1)

.`E:T@ F y d"-A #,R, erC H V erfhren@,_ zür: re.@stellung von v o I 1- ständig entbitterten Glykosiden aus der Cascara-Sagrada-Rinde in wasserlöslicher
und von Ballaststoffen befreiter Form, dadurch gekennzeichnet, daß man die kalten Auszüge mit Mennige bis zur vollständigen Entbitterung behandelt und nach Entfernung der Mennige die Filtrate nach bekannten Methoden der Glykosidreinigung auf Trockensubstanz ohne jede Erwärmung verarbeitet. .`E: T @ F yd "-A #, R, erC H V erfhren @, _ zu: right @ position of vo I 1- constantly debittered glycosides from the Cascara sagrada bark in water soluble
and form freed from roughage, characterized in that the cold extracts are treated with red lead until they are completely debittered and, after the red lead has been removed, the filtrates are processed to dry matter by known methods of glycoside purification without any heating.
DE1919336732D 1919-06-20 1919-06-20 Process for the production of completely debittered glycosides from the Cascara Sagrada bark Expired DE336732C (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE336732T 1919-06-20

Publications (1)

Publication Number Publication Date
DE336732C true DE336732C (en) 1921-05-11

Family

ID=6220693

Family Applications (1)

Application Number Title Priority Date Filing Date
DE1919336732D Expired DE336732C (en) 1919-06-20 1919-06-20 Process for the production of completely debittered glycosides from the Cascara Sagrada bark

Country Status (1)

Country Link
DE (1) DE336732C (en)

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