DE3366963D1 - Process for assaying the activity of tissue plasminogen activator, and kit suitable for use in said process - Google Patents

Process for assaying the activity of tissue plasminogen activator, and kit suitable for use in said process

Info

Publication number
DE3366963D1
DE3366963D1 DE8383200670T DE3366963T DE3366963D1 DE 3366963 D1 DE3366963 D1 DE 3366963D1 DE 8383200670 T DE8383200670 T DE 8383200670T DE 3366963 T DE3366963 T DE 3366963T DE 3366963 D1 DE3366963 D1 DE 3366963D1
Authority
DE
Germany
Prior art keywords
plasmin
fibrinogen
assaying
activity
fibrin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8383200670T
Other languages
English (en)
Inventor
Johan Hendrikus Verheijen
Willem Nieuwenhuizen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nederlandse Organisatie voor Toegepast Natuurwetenschappelijk Onderzoek TNO
Original Assignee
Nederlandse Organisatie voor Toegepast Natuurwetenschappelijk Onderzoek TNO
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nederlandse Organisatie voor Toegepast Natuurwetenschappelijk Onderzoek TNO filed Critical Nederlandse Organisatie voor Toegepast Natuurwetenschappelijk Onderzoek TNO
Application granted granted Critical
Publication of DE3366963D1 publication Critical patent/DE3366963D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
    • C12Q2337/10—Anilides
    • C12Q2337/12—Para-Nitroanilides p-NA
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/745—Assays involving non-enzymic blood coagulation factors
    • G01N2333/75—Fibrin; Fibrinogen
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/968—Plasmin, i.e. fibrinolysin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/972—Plasminogen activators
    • G01N2333/9726—Tissue plasminogen activator

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Neurosurgery (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE8383200670T 1982-05-13 1983-05-09 Process for assaying the activity of tissue plasminogen activator, and kit suitable for use in said process Expired DE3366963D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL8201987A NL8201987A (nl) 1982-05-13 1982-05-13 Werkwijze voor het bepalen van de activiteit van plasminogeenactivator van het weefseltype, alsmede voor gebruik bij deze werkwijze geschikte combinatie van het "kit"-type.

Publications (1)

Publication Number Publication Date
DE3366963D1 true DE3366963D1 (en) 1986-11-20

Family

ID=19839733

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8383200670T Expired DE3366963D1 (en) 1982-05-13 1983-05-09 Process for assaying the activity of tissue plasminogen activator, and kit suitable for use in said process

Country Status (6)

Country Link
US (1) US4563420A (de)
EP (1) EP0094720B1 (de)
JP (1) JPS58209999A (de)
AT (1) ATE22928T1 (de)
DE (1) DE3366963D1 (de)
NL (1) NL8201987A (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1254119A (en) * 1984-07-20 1989-05-16 Lloyd A. Schick Single step protease inhibitor assay
DE3430906A1 (de) * 1984-08-22 1986-02-27 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur bestimmung von fibrinmonomer in plasma
US4753879A (en) * 1984-08-27 1988-06-28 Biogen N.V. Modified tissue plasminogen activators
DE3512909A1 (de) * 1985-04-11 1986-10-23 Behringwerke Ag, 3550 Marburg Verfahren zur bestimmung von plasminogenaktivatoren (pa)
US5096811A (en) * 1986-03-12 1992-03-17 Genentech, Inc. Novel assay system for measuring human plasminogen actuator activity
AT388618B (de) * 1987-05-05 1989-08-10 Binder Bernd Dr Verfahren zur quantitativen bestimmung von funktion und antigener konzentration einer in einer biologischen fluessigkeit enthaltenen substanz
US5312745A (en) * 1987-06-18 1994-05-17 Chromogenix Ab Determination of components active in proteolysis
SE8702556D0 (sv) * 1987-06-18 1987-06-18 Kabivitrum Ab Bestemning av vid proteolys aktiva komponenter
JP2520424B2 (ja) * 1987-07-03 1996-07-31 帝人株式会社 血液線溶活性の測定方法
US5114845A (en) * 1987-07-06 1992-05-19 Biopool International, Inc. Assays for plasminogen activator inhibitor and soluble fibrin
EP0576039A3 (en) * 1987-07-06 1994-06-08 Biopool Int Inc Method of determining tissue plasminogen activator activity in biological fluids
EP0576038B1 (de) * 1987-07-06 1999-10-06 Biopool International, Inc. Verfahren zur Messung von Gewebeplasminogenaktivator, Antithrombin-III und lösliches Fibrin
US5206140A (en) * 1988-06-24 1993-04-27 Research Corporation Technologies, Inc. Assay for soluble crosslinked fibrin polymers
NL8802710A (nl) * 1988-11-04 1990-06-01 Tno Werkwijze voor het bepalen van een enzym en daarvoor geschikte kit en stof.
DE3843422A1 (de) * 1988-12-23 1990-06-28 Behringwerke Ag Verfahren zur bestimmung der plasminogenaktivator-aktivitaet in alpha-2-antiplasmin-haltigen proben
FI91777C (fi) * 1990-04-02 1994-08-10 Elomit Oy Menetelmä plasmiiniaktiivisuuden määrittämiseksi
AU644205B2 (en) * 1990-08-23 1993-12-02 New York Blood Center, Inc., The Assays using a soluble fibrin-like monomer
WO2000065349A2 (en) * 1999-04-28 2000-11-02 Cardiogenics Inc. Method for determining plasminogen activator inhibitor
AU2006281969B2 (en) * 2005-08-12 2011-10-06 Biopower Systems Pty. Ltd. A mooring

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2431342C3 (de) * 1973-07-27 1978-10-26 Behringwerke Ag, 3550 Marburg Verfahren zur Messung des Plasminogengehaltes durch Bestimmung der Bildung von Fibrin in einer Probe
SE407571B (sv) * 1975-07-11 1979-04-02 Kabi Ab Nya kromogena enzymsubstrat for serinproteaser
CH634662A5 (de) * 1976-05-28 1983-02-15 Pentapharm Ag Verwendung von tripeptidderivaten zur quantitativen bestimmung von plasminogen-aktivatoren.

Also Published As

Publication number Publication date
JPS58209999A (ja) 1983-12-07
JPH0417640B2 (de) 1992-03-26
US4563420A (en) 1986-01-07
EP0094720A1 (de) 1983-11-23
ATE22928T1 (de) 1986-11-15
NL8201987A (nl) 1983-12-01
EP0094720B1 (de) 1986-10-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee