DE3365900D1 - Nitrosourea derivatives, process for their preparation and pharmaceutical compositions containing them - Google Patents

Nitrosourea derivatives, process for their preparation and pharmaceutical compositions containing them

Info

Publication number
DE3365900D1
DE3365900D1 DE8383402209T DE3365900T DE3365900D1 DE 3365900 D1 DE3365900 D1 DE 3365900D1 DE 8383402209 T DE8383402209 T DE 8383402209T DE 3365900 T DE3365900 T DE 3365900T DE 3365900 D1 DE3365900 D1 DE 3365900D1
Authority
DE
Germany
Prior art keywords
pharmaceutical compositions
preparation
compositions containing
alkyl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8383402209T
Other languages
German (de)
English (en)
Inventor
Gilbert Lavielle
Claude Dr Cudennec
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Application granted granted Critical
Publication of DE3365900D1 publication Critical patent/DE3365900D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/3804—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se) not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
DE8383402209T 1982-11-17 1983-11-16 Nitrosourea derivatives, process for their preparation and pharmaceutical compositions containing them Expired DE3365900D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8219199A FR2536075B1 (fr) 1982-11-17 1982-11-17 Nouveaux derives de la nitrosouree, leur procede de preparation et les compositions pharmaceutiques les renfermant

Publications (1)

Publication Number Publication Date
DE3365900D1 true DE3365900D1 (en) 1986-10-09

Family

ID=9279241

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8383402209T Expired DE3365900D1 (en) 1982-11-17 1983-11-16 Nitrosourea derivatives, process for their preparation and pharmaceutical compositions containing them

Country Status (19)

Country Link
US (1) US4567169A (fr)
EP (1) EP0117959B1 (fr)
JP (1) JPS59106497A (fr)
AT (1) ATE21905T1 (fr)
AU (1) AU557139B2 (fr)
CA (1) CA1204442A (fr)
DE (1) DE3365900D1 (fr)
DK (1) DK169340B1 (fr)
ES (1) ES527353A0 (fr)
FR (1) FR2536075B1 (fr)
IE (1) IE56259B1 (fr)
IL (1) IL70253A (fr)
MA (1) MA19952A1 (fr)
NO (1) NO163409C (fr)
NZ (1) NZ206293A (fr)
OA (1) OA07589A (fr)
PT (1) PT77666B (fr)
SU (1) SU1303024A3 (fr)
ZA (1) ZA838558B (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2567129B1 (fr) * 1984-07-06 1986-12-05 Adir Nouveaux derives de l'oxaazaphosphorine, leur procede de preparation et les compositions pharmaceutiques les renfermant
IT1246778B (it) * 1991-04-12 1994-11-26 Boehringer Mannheim Italia Nitrosocarbamoil derivati di acidi gem-difosfonici, un processo per la loro preparazione e composizioni farmaceutiche che li contengono
US5298499A (en) * 1991-07-05 1994-03-29 Research Triangle Institute S-2-(substituted ethylamino)ethyl phosphorothioates
AU7737896A (en) * 1995-11-20 1997-06-11 Sepracor, Inc. Antineoplastic methods and compositions employing (+)-fotemustine
WO1997018819A1 (fr) * 1995-11-20 1997-05-29 Sepracor, Inc. Procedes et compositions antineoplasiques utilisant une (-)-fotemustine optiquement pure
US20040072889A1 (en) * 1997-04-21 2004-04-15 Pharmacia Corporation Method of using a COX-2 inhibitor and an alkylating-type antineoplastic agent as a combination therapy in the treatment of neoplasia
CN100365002C (zh) * 2004-06-02 2008-01-30 上海医药科技发展有限公司 注射用福莫司汀制备工艺
AT501496B1 (de) * 2005-02-21 2007-03-15 Iep Gmbh Verfahren zur enantioselektiven enzymatischen reduktion von ketoverbindungen
CN102311456A (zh) * 2011-07-08 2012-01-11 山东睿鹰先锋制药有限公司 一种福莫司汀原料药的合成方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3920733A (en) * 1973-08-06 1975-11-18 Monsanto Co Ureidoalkylphosphonic acids

Also Published As

Publication number Publication date
IL70253A0 (en) 1984-02-29
ES8501772A1 (es) 1984-12-01
NO834214L (no) 1984-05-18
EP0117959B1 (fr) 1986-09-03
AU2143683A (en) 1984-05-24
PT77666B (fr) 1986-05-12
IE56259B1 (en) 1991-06-05
NO163409B (no) 1990-02-12
OA07589A (fr) 1985-03-31
SU1303024A3 (ru) 1987-04-07
DK524283D0 (da) 1983-11-16
AU557139B2 (en) 1986-12-04
IL70253A (en) 1986-10-31
EP0117959A3 (en) 1984-11-14
PT77666A (fr) 1983-12-01
US4567169A (en) 1986-01-28
JPS6411637B2 (fr) 1989-02-27
ZA838558B (en) 1984-07-25
CA1204442A (fr) 1986-05-13
EP0117959A2 (fr) 1984-09-12
DK524283A (da) 1984-05-18
DK169340B1 (da) 1994-10-10
ATE21905T1 (de) 1986-09-15
FR2536075A1 (fr) 1984-05-18
JPS59106497A (ja) 1984-06-20
ES527353A0 (es) 1984-12-01
IE832680L (en) 1984-05-17
NZ206293A (en) 1987-02-20
NO163409C (no) 1990-05-23
FR2536075B1 (fr) 1985-07-05
MA19952A1 (fr) 1984-07-01

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Legal Events

Date Code Title Description
8328 Change in the person/name/address of the agent

Free format text: TER MEER, N., DIPL.-CHEM. DR.RER.NAT. MUELLER, F., DIPL.-ING., 8000 MUENCHEN STEINMEISTER, H., DIPL.-ING., PAT.-ANW., 4800 BIELEFELD

8364 No opposition during term of opposition