DE3365492D1 - Diphosphonic acid derivatives and pharmaceutical preparations containing them - Google Patents

Diphosphonic acid derivatives and pharmaceutical preparations containing them

Info

Publication number
DE3365492D1
DE3365492D1 DE8383100283T DE3365492T DE3365492D1 DE 3365492 D1 DE3365492 D1 DE 3365492D1 DE 8383100283 T DE8383100283 T DE 8383100283T DE 3365492 T DE3365492 T DE 3365492T DE 3365492 D1 DE3365492 D1 DE 3365492D1
Authority
DE
Germany
Prior art keywords
acid derivatives
pharmaceutical preparations
diphosphonic acid
preparations containing
diphosphonic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8383100283T
Other languages
German (de)
English (en)
Inventor
Helmut Dr Biere
Clemens Dr Rufer
Irmgard Dr Bottcher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19823203309 external-priority patent/DE3203309A1/de
Priority claimed from DE19823225468 external-priority patent/DE3225468A1/de
Application filed by Schering AG filed Critical Schering AG
Priority to DE8383100283T priority Critical patent/DE3365492D1/de
Application granted granted Critical
Publication of DE3365492D1 publication Critical patent/DE3365492D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids
    • C07F9/404—Esters of poly(thio)phosphonic acids containing hydroxy substituents in the hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/386—Polyphosphonic acids containing hydroxy substituents in the hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
    • C07F9/655345—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a five-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE8383100283T 1982-01-27 1983-01-14 Diphosphonic acid derivatives and pharmaceutical preparations containing them Expired DE3365492D1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE8383100283T DE3365492D1 (en) 1982-01-27 1983-01-14 Diphosphonic acid derivatives and pharmaceutical preparations containing them

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19823203309 DE3203309A1 (de) 1982-01-27 1982-01-27 Diphosphonsaeure-derivate und diese enthaltende pharmazeutische praeparate
DE19823225468 DE3225468A1 (de) 1982-07-05 1982-07-05 Diphosphonsaeure-derivate und diese enthaltende pharmazeutische praeparate
DE8383100283T DE3365492D1 (en) 1982-01-27 1983-01-14 Diphosphonic acid derivatives and pharmaceutical preparations containing them

Publications (1)

Publication Number Publication Date
DE3365492D1 true DE3365492D1 (en) 1986-10-02

Family

ID=25799266

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8383100283T Expired DE3365492D1 (en) 1982-01-27 1983-01-14 Diphosphonic acid derivatives and pharmaceutical preparations containing them

Country Status (10)

Country Link
US (1) US4473560A (enExample)
EP (1) EP0085321B1 (enExample)
AU (1) AU559513B2 (enExample)
CA (1) CA1202635A (enExample)
DE (1) DE3365492D1 (enExample)
DK (1) DK30083A (enExample)
ES (1) ES519322A0 (enExample)
FI (1) FI77041C (enExample)
GR (1) GR77145B (enExample)
IL (1) IL67763A0 (enExample)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3364638A (en) * 1965-08-02 1968-01-23 Johnson & Johnson Composite plastic and corrugated panel
FR2531088B1 (fr) * 1982-07-29 1987-08-28 Sanofi Sa Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation
DE3334211A1 (de) * 1983-09-22 1985-04-04 Henkel KGaA, 4000 Düsseldorf Dihydroxyalkandiphosphonsaeuren
DE3428524A1 (de) * 1984-08-02 1986-02-13 Boehringer Mannheim Gmbh, 6800 Mannheim Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
IL77243A (en) * 1984-12-21 1996-11-14 Procter & Gamble Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds
US4902679A (en) * 1985-12-13 1990-02-20 Norwich Eaton Pharmaceuticals, Inc. Methods of treating diseases with certain geminal diphosphonates
DE3623397A1 (de) * 1986-07-11 1988-01-14 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
DE3822650A1 (de) * 1988-07-05 1990-02-01 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
JPH0377894A (ja) * 1989-08-18 1991-04-03 Toray Ind Inc メチレンジホスホン酸化合物
US5227506A (en) * 1989-09-06 1993-07-13 Merck & Co., Inc. Acyloxymethyl esters of bisphosphonic acids as bone resorption inhibitors
US5204334A (en) * 1990-10-18 1993-04-20 Ciba-Geigy Corporation Benzoheterocyclylalkylaminoalkanediphosphonic acids, compositions thereof, and use thereof in the treatment of calcium metabolism disorders
EP0561948B1 (en) * 1990-12-07 1995-04-05 The Upjohn Company Phosphonic acid derivatives useful as antiinflammatory agents
US5217994A (en) * 1991-08-09 1993-06-08 Merck & Co., Inc. Method of inhibiting osteoclast-mediated bone resorption by administration of aminoalkyl-substituted phenyl derivatives
US5204350A (en) * 1991-08-09 1993-04-20 Merck & Co., Inc. Method of inhibiting osteoclast-mediated bone resorption by administration of n-heterocyclicalkyl-substituted phenyl derivatives
DK0594857T3 (da) * 1991-09-05 1998-10-07 Toray Industries Methandiphosphonsyrederivat, fremstilling deraf ogmedicinsk anvendelse deraf
FR2683528A1 (fr) * 1991-11-12 1993-05-14 Bretagne Occidentale Universit Prodrogues et analogues gem-bisphosphoniques d'antiinflammatoires non-sterouidiens de type arylacetique ou arylpropionique.
KR100272907B1 (ko) * 1992-07-10 2001-03-02 히라이 가쯔히꼬 메탄디포스폰산 유도체, 이의 제조방법 및 이의 의약 용도
TW393488B (en) * 1995-04-20 2000-06-11 Merck & Co Inc Process for making 1-hydrox-ybisphosphonates
RU2147299C1 (ru) * 1998-01-05 2000-04-10 Иркутский институт химии СО РАН Гидроксиэтиленбифосфонат полигексаметиленгуанидина, обладающий антисептическими и антидотными свойствами
FR2784031B1 (fr) * 1998-10-02 2002-02-01 Sanofi Elf Utilisation de derives de l'acide bisphosphonique pour la preparation d'un medicament destine au traitement des boiteries
CA2394650A1 (en) * 1999-12-17 2001-06-21 Chi B. Vu Novel heterocycles
AU2583901A (en) * 1999-12-17 2001-06-25 Ariad Pharmaceuticals, Inc. Proton pump inhibitors
IL150062A0 (en) 1999-12-17 2002-12-01 Ariad Pharma Inc Proton pump inhibitors
US20030036537A1 (en) * 2001-07-16 2003-02-20 Marc Lecouvey Bisphosphonate derivatives, their preparations and uses
EP1406910B1 (fr) 2001-07-16 2010-01-13 Universite Paris 13 Procedes de preparation de derives de bisphosphonates
FR2827289B1 (fr) * 2001-07-16 2004-07-23 Univ Paris 13 Nouveau derive d'acide diphosphonique, son application en therapeutique et procede de preparation
TW200413381A (en) 2002-11-04 2004-08-01 Hoffmann La Roche Novel amino-substituted dihydropyrimido [4,5-d]pyrimidinone derivatives, their manufacture and use as pharmaceutical agents
WO2005009348A2 (en) * 2003-06-25 2005-02-03 Ariad Pharmaceuticals, Inc. Substituted purine derivatives
WO2007109585A2 (en) * 2006-03-17 2007-09-27 The Board Of Trustees Of The University Of Illinois Bisphosphonate compounds and methods

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3664975A (en) * 1970-04-13 1972-05-23 Monsanto Co Flame resistant polyurethane prepared by adding an ethane diphosphonate into the urethane-forming mixture
US4069246A (en) * 1971-12-31 1978-01-17 Henkel Kommanditgesellschaft Auf Aktien Production of 1-hydroxy-alkane-1,1-diphosphonic acids
GB2043072B (en) * 1979-02-13 1983-11-23 Symphar Sa Diphosphonate compounds
EP0084822B1 (de) * 1982-01-27 1986-01-08 Schering Aktiengesellschaft Diphosphonsäure-Derivate und diese enthaltende pharmazeutische Präparate

Also Published As

Publication number Publication date
AU1074383A (en) 1983-08-04
DK30083A (da) 1983-07-28
FI830299A0 (fi) 1983-01-27
FI77041B (fi) 1988-09-30
GR77145B (enExample) 1984-09-07
ES8400118A1 (es) 1983-11-01
AU559513B2 (en) 1987-03-12
ES519322A0 (es) 1983-11-01
IL67763A0 (en) 1983-05-15
DK30083D0 (da) 1983-01-26
EP0085321A2 (de) 1983-08-10
US4473560A (en) 1984-09-25
EP0085321A3 (en) 1983-08-17
FI77041C (fi) 1989-01-10
EP0085321B1 (de) 1986-08-27
FI830299L (fi) 1983-07-28
CA1202635A (en) 1986-04-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: SCHERING AG, 13353 BERLIN, DE

8339 Ceased/non-payment of the annual fee