DE3262880D1 - Tricyclic ethers, process for their preparation and their use in pharmaceutical preparations - Google Patents
Tricyclic ethers, process for their preparation and their use in pharmaceutical preparationsInfo
- Publication number
- DE3262880D1 DE3262880D1 DE8282401567T DE3262880T DE3262880D1 DE 3262880 D1 DE3262880 D1 DE 3262880D1 DE 8282401567 T DE8282401567 T DE 8282401567T DE 3262880 T DE3262880 T DE 3262880T DE 3262880 D1 DE3262880 D1 DE 3262880D1
- Authority
- DE
- Germany
- Prior art keywords
- group
- lower alkyl
- preparation
- pharmaceutical preparations
- different
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000002170 ethers Chemical class 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 229940005513 antidepressants Drugs 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 125000004193 piperazinyl group Chemical group 0.000 abstract 1
- -1 pyrrolidino, piperidino Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/02—Seven-membered rings
- C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D313/12—[b,e]-condensed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/16—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D267/18—[b, e]-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Anesthesiology (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyrane Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Luminescent Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8116347A FR2512024A1 (fr) | 1981-08-27 | 1981-08-27 | Ethers tricycliques, leur preparation et les compositions pharmaceutiques les contenant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3262880D1 true DE3262880D1 (en) | 1985-05-09 |
Family
ID=9261704
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8282401567T Expired DE3262880D1 (en) | 1981-08-27 | 1982-08-24 | Tricyclic ethers, process for their preparation and their use in pharmaceutical preparations |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4496557A (enExample) |
| EP (1) | EP0074304B1 (enExample) |
| JP (1) | JPS5874673A (enExample) |
| AT (1) | ATE12497T1 (enExample) |
| AU (1) | AU8773082A (enExample) |
| CA (1) | CA1227481A (enExample) |
| DE (1) | DE3262880D1 (enExample) |
| ES (1) | ES515232A0 (enExample) |
| FR (1) | FR2512024A1 (enExample) |
| GR (1) | GR77595B (enExample) |
| IL (1) | IL66650A (enExample) |
| NZ (1) | NZ201740A (enExample) |
| PT (1) | PT75471B (enExample) |
| ZA (1) | ZA826252B (enExample) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8500273D0 (sv) * | 1985-01-22 | 1985-01-22 | Leo Ab | Nya tricykliska foreningar, kompositioner innehallande sadana foreningar, framstellningsforfaranden och behandlingsmetoder |
| EP0332246A1 (en) * | 1988-03-11 | 1989-09-13 | Akzo N.V. | Tricyclic amine derivatives |
| US5180736A (en) * | 1989-03-23 | 1993-01-19 | Warner-Lambert Company | Polycyclic amines useful as cerebrovascular agents |
| US5006536A (en) * | 1989-12-26 | 1991-04-09 | Hoechst-Roussel Pharmaceuticals Inc. | Thienobenzoxepins and analgesic compositions thereof |
| US5260319A (en) * | 1989-12-26 | 1993-11-09 | Hoechst-Roussel Pharmaceuticals Incorporated | Thienobenzoxepins and naphthothiophenes |
| US5574173A (en) * | 1993-12-06 | 1996-11-12 | Schering Corporation | Tricyclic derivatives, compositions and methods of use |
| EP0726265B1 (de) * | 1995-02-08 | 2001-07-25 | Novartis AG | Antineurodegenerativ wirksame 10-Aminoaliphatyl-dibenz- b,f oxepine |
| US5698551A (en) * | 1995-04-07 | 1997-12-16 | Novo Nordisk A/S | Heterocyclic compounds |
| US8565372B2 (en) | 2003-11-26 | 2013-10-22 | Hologic, Inc | System and method for low dose tomosynthesis |
| US8571289B2 (en) | 2002-11-27 | 2013-10-29 | Hologic, Inc. | System and method for generating a 2D image from a tomosynthesis data set |
| US7616801B2 (en) | 2002-11-27 | 2009-11-10 | Hologic, Inc. | Image handling and display in x-ray mammography and tomosynthesis |
| US10638994B2 (en) | 2002-11-27 | 2020-05-05 | Hologic, Inc. | X-ray mammography with tomosynthesis |
| US7123684B2 (en) | 2002-11-27 | 2006-10-17 | Hologic, Inc. | Full field mammography with tissue exposure control, tomosynthesis, and dynamic field of view processing |
| US7577282B2 (en) | 2002-11-27 | 2009-08-18 | Hologic, Inc. | Image handling and display in X-ray mammography and tomosynthesis |
| US8768026B2 (en) | 2003-11-26 | 2014-07-01 | Hologic, Inc. | X-ray imaging with x-ray markers that provide adjunct information but preserve image quality |
| US7662082B2 (en) | 2004-11-05 | 2010-02-16 | Theragenics Corporation | Expandable brachytherapy device |
| EP2602743B1 (en) | 2004-11-15 | 2014-11-05 | Hologic, Inc. | Matching geometry generation and display of mammograms and tomosynthesis images |
| US7869563B2 (en) * | 2004-11-26 | 2011-01-11 | Hologic, Inc. | Integrated multi-mode mammography/tomosynthesis x-ray system and method |
| US7245694B2 (en) | 2005-08-15 | 2007-07-17 | Hologic, Inc. | X-ray mammography/tomosynthesis of patient's breast |
| US8079946B2 (en) | 2005-11-18 | 2011-12-20 | Senorx, Inc. | Asymmetrical irradiation of a body cavity |
| WO2007095330A2 (en) | 2006-02-15 | 2007-08-23 | Hologic Inc | Breast biopsy and needle localization using tomosynthesis systems |
| US7630533B2 (en) | 2007-09-20 | 2009-12-08 | Hologic, Inc. | Breast tomosynthesis with display of highlighted suspected calcifications |
| US7991106B2 (en) * | 2008-08-29 | 2011-08-02 | Hologic, Inc. | Multi-mode tomosynthesis/mammography gain calibration and image correction using gain map information from selected projection angles |
| WO2010028208A1 (en) | 2008-09-04 | 2010-03-11 | Hologic, Inc. | Integrated multi-mode mammography/tomosynthesis x-ray system and method |
| US9579524B2 (en) | 2009-02-11 | 2017-02-28 | Hologic, Inc. | Flexible multi-lumen brachytherapy device |
| US9248311B2 (en) | 2009-02-11 | 2016-02-02 | Hologic, Inc. | System and method for modifying a flexibility of a brachythereapy catheter |
| US8170320B2 (en) * | 2009-03-03 | 2012-05-01 | Hologic, Inc. | Mammography/tomosynthesis systems and methods automatically deriving breast characteristics from breast x-ray images and automatically adjusting image processing parameters accordingly |
| US10207126B2 (en) | 2009-05-11 | 2019-02-19 | Cytyc Corporation | Lumen visualization and identification system for multi-lumen balloon catheter |
| US10595954B2 (en) | 2009-10-08 | 2020-03-24 | Hologic, Inc. | Needle breast biopsy system and method for use |
| US9352172B2 (en) | 2010-09-30 | 2016-05-31 | Hologic, Inc. | Using a guide member to facilitate brachytherapy device swap |
| WO2012048000A2 (en) | 2010-10-05 | 2012-04-12 | Hologic, Inc. | Upright x-ray breast imaging with a ct mode, multiple tomosynthesis modes, and a mammography mode |
| WO2012071429A1 (en) | 2010-11-26 | 2012-05-31 | Hologic, Inc. | User interface for medical image review workstation |
| US10342992B2 (en) | 2011-01-06 | 2019-07-09 | Hologic, Inc. | Orienting a brachytherapy applicator |
| CA2829349C (en) | 2011-03-08 | 2021-02-09 | Hologic, Inc. | System and method for dual energy and/or contrast enhanced breast imaging for screening, diagnosis and biopsy |
| US11259759B2 (en) | 2011-11-18 | 2022-03-01 | Hologic Inc. | X-ray mammography and/or breast tomosynthesis using a compression paddle |
| EP2782505B1 (en) | 2011-11-27 | 2020-04-22 | Hologic, Inc. | System and method for generating a 2d image using mammography and/or tomosynthesis image data |
| ES2641456T3 (es) | 2012-02-13 | 2017-11-10 | Hologic, Inc. | Sistema y método para navegar por una pila de tomosíntesis usando datos de imágenes sintetizadas |
| JP6388347B2 (ja) | 2013-03-15 | 2018-09-12 | ホロジック, インコーポレイテッドHologic, Inc. | 腹臥位におけるトモシンセシス誘導生検 |
| CN105451657A (zh) | 2013-03-15 | 2016-03-30 | 霍罗吉克公司 | 用于导航断层合成堆叠的包括自动聚焦的系统和方法 |
| KR102264462B1 (ko) | 2013-10-09 | 2021-06-15 | 홀로직, 인크. | 편평화된 유방의 두께 방향을 포함하는 공간 해상도를 향상시키는 x선 유방 영상합성 |
| JP2016533803A (ja) | 2013-10-24 | 2016-11-04 | アンドリュー ピー． スミス， | Ｘ線誘導胸部生検をナビゲートするためのシステムおよび方法 |
| JP6506769B2 (ja) | 2014-02-28 | 2019-04-24 | ホロジック, インコーポレイテッドHologic, Inc. | トモシンセシス画像スラブを生成し表示するためのシステムおよび方法 |
| JP6749322B2 (ja) | 2014-11-07 | 2020-09-02 | ホロジック, インコーポレイテッドHologic, Inc. | マンモグラフィ／トモシンセシスｘ線システムのための枢動パドル装置 |
| JP7085492B2 (ja) | 2016-04-22 | 2022-06-16 | ホロジック，インコーポレイテッド | アドレス指定可能なアレイを使用する偏移焦点ｘ線システムを用いるトモシンセシス |
| CN117838159A (zh) | 2016-11-08 | 2024-04-09 | 豪洛捷公司 | 使用弯曲的压缩元件进行成像 |
| WO2018183548A1 (en) | 2017-03-30 | 2018-10-04 | Hologic, Inc. | System and method for hierarchical multi-level feature image synthesis and representation |
| CN110662489B (zh) | 2017-03-30 | 2024-08-02 | 豪洛捷公司 | 用于靶向对象增强以生成合成乳房组织图像的系统和方法 |
| US11455754B2 (en) | 2017-03-30 | 2022-09-27 | Hologic, Inc. | System and method for synthesizing low-dimensional image data from high-dimensional image data using an object grid enhancement |
| US11403483B2 (en) | 2017-06-20 | 2022-08-02 | Hologic, Inc. | Dynamic self-learning medical image method and system |
| AU2018313272B2 (en) | 2017-08-11 | 2024-01-11 | Hologic, Inc. | Breast compression paddle with access corners |
| JP2020530346A (ja) | 2017-08-11 | 2020-10-22 | ホロジック, インコーポレイテッドHologic, Inc. | 膨張可能ジャケットを有する乳房圧迫パドル |
| EP3668404B1 (en) | 2017-08-16 | 2022-07-06 | Hologic, Inc. | Techniques for breast imaging patient motion artifact compensation |
| EP3449835B1 (en) | 2017-08-22 | 2023-01-11 | Hologic, Inc. | Computed tomography system and method for imaging multiple anatomical targets |
| US11090017B2 (en) | 2018-09-13 | 2021-08-17 | Hologic, Inc. | Generating synthesized projection images for 3D breast tomosynthesis or multi-mode x-ray breast imaging |
| EP3856031B1 (en) | 2018-09-24 | 2025-06-11 | Hologic, Inc. | Breast mapping and abnormality localization |
| AU2019346527B2 (en) | 2018-09-28 | 2025-03-06 | Hologic, Inc. | System and method for synthetic breast tissue image generation by high density element suppression |
| EP3884499A1 (en) | 2018-11-25 | 2021-09-29 | Hologic, Inc. | Multimodality hanging protocols |
| CN113574609A (zh) | 2019-03-29 | 2021-10-29 | 豪洛捷公司 | 剪切触发的数字图像报告生成 |
| EP3832689A3 (en) | 2019-12-05 | 2021-08-11 | Hologic, Inc. | Systems and methods for improved x-ray tube life |
| CN115003228A (zh) | 2020-01-24 | 2022-09-02 | 豪洛捷公司 | 可水平移位的泡沫乳房压缩桨 |
| US11471118B2 (en) | 2020-03-27 | 2022-10-18 | Hologic, Inc. | System and method for tracking x-ray tube focal spot position |
| JP2024514268A (ja) | 2021-04-26 | 2024-03-29 | ホロジック， インコーポレイテッド | 発泡体圧迫要素の厚さを測定するためのシステムおよび方法 |
| US11786191B2 (en) | 2021-05-17 | 2023-10-17 | Hologic, Inc. | Contrast-enhanced tomosynthesis with a copper filter |
| US12186119B2 (en) | 2021-10-05 | 2025-01-07 | Hologic, Inc. | Interactive model interface for image selection in medical imaging systems |
| US12254586B2 (en) | 2021-10-25 | 2025-03-18 | Hologic, Inc. | Auto-focus tool for multimodality image review |
| WO2023097279A1 (en) | 2021-11-29 | 2023-06-01 | Hologic, Inc. | Systems and methods for correlating objects of interest |
| US12414217B2 (en) | 2022-02-07 | 2025-09-09 | Hologic, Inc. | Systems and methods for adaptively controlling filament current in an X-ray tube |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3609167A (en) * | 1962-04-02 | 1971-09-28 | Smith Kline French Lab | IBENZO{8 b,e{9 {0 THIEPINES |
| NL125253C (enExample) * | 1963-12-05 | |||
| NL152845B (nl) * | 1966-03-11 | 1977-04-15 | Boehringer Mannheim Gmbh | Werkwijze voor het bereiden van een geneesmiddel met een psychotrope en bloedsomloopstimulerende werking, alsmede het aldus verkregen gevormde geneesmiddel, en werkwijze voor het bereiden van een geneeskrachtig omega,omega-difenylalkylaminederivaat. |
| FR1518226A (fr) * | 1966-04-09 | 1968-03-22 | Boehringer & Soehne Gmbh | Procédé pour la préparation de dérivés tricy cliques n-alcoylés de l'acétamide |
| US4463001A (en) * | 1980-10-20 | 1984-07-31 | Farmitalia Carlo Erba S.P.A. | 6-Substituted 6H-dibenzo[b,d]pyran derivatives and process for their preparation |
-
1981
- 1981-08-27 FR FR8116347A patent/FR2512024A1/fr active Granted
-
1982
- 1982-08-16 US US06/408,451 patent/US4496557A/en not_active Expired - Fee Related
- 1982-08-20 CA CA000409886A patent/CA1227481A/fr not_active Expired
- 1982-08-24 AT AT82401567T patent/ATE12497T1/de active
- 1982-08-24 EP EP82401567A patent/EP0074304B1/fr not_active Expired
- 1982-08-24 DE DE8282401567T patent/DE3262880D1/de not_active Expired
- 1982-08-25 GR GR69103A patent/GR77595B/el unknown
- 1982-08-25 ES ES515232A patent/ES515232A0/es active Granted
- 1982-08-26 PT PT75471A patent/PT75471B/pt unknown
- 1982-08-26 ZA ZA826252A patent/ZA826252B/xx unknown
- 1982-08-26 AU AU87730/82A patent/AU8773082A/en not_active Abandoned
- 1982-08-26 JP JP57148452A patent/JPS5874673A/ja active Granted
- 1982-08-26 IL IL66650A patent/IL66650A/xx unknown
- 1982-08-27 NZ NZ201740A patent/NZ201740A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE12497T1 (de) | 1985-04-15 |
| CA1227481A (fr) | 1987-09-29 |
| GR77595B (enExample) | 1984-09-25 |
| IL66650A (en) | 1985-08-30 |
| IL66650A0 (en) | 1982-12-31 |
| ZA826252B (en) | 1983-07-27 |
| PT75471B (fr) | 1984-11-19 |
| FR2512024A1 (fr) | 1983-03-04 |
| EP0074304B1 (fr) | 1985-04-03 |
| ES8400422A1 (es) | 1983-11-01 |
| JPS5874673A (ja) | 1983-05-06 |
| FR2512024B1 (enExample) | 1984-01-06 |
| US4496557A (en) | 1985-01-29 |
| ES515232A0 (es) | 1983-11-01 |
| NZ201740A (en) | 1985-05-31 |
| AU8773082A (en) | 1983-03-03 |
| JPS6129950B2 (enExample) | 1986-07-10 |
| EP0074304A1 (fr) | 1983-03-16 |
| PT75471A (fr) | 1982-09-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8339 | Ceased/non-payment of the annual fee |