DE3209127C2 - - Google Patents
Info
- Publication number
- DE3209127C2 DE3209127C2 DE3209127A DE3209127A DE3209127C2 DE 3209127 C2 DE3209127 C2 DE 3209127C2 DE 3209127 A DE3209127 A DE 3209127A DE 3209127 A DE3209127 A DE 3209127A DE 3209127 C2 DE3209127 C2 DE 3209127C2
- Authority
- DE
- Germany
- Prior art keywords
- cells
- capsules
- medium
- membranes
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/565—IFN-beta
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0012—Cell encapsulation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/126—Immunoprotecting barriers, e.g. jackets, diffusion chambers
- A61K2035/128—Immunoprotecting barriers, e.g. jackets, diffusion chambers capsules, e.g. microcapsules
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/30—Synthetic polymers
- C12N2533/32—Polylysine, polyornithine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/70—Polysaccharides
- C12N2533/74—Alginate
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Toxicology (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24358381A | 1981-03-13 | 1981-03-13 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3209127A1 DE3209127A1 (de) | 1982-12-09 |
DE3209127C2 true DE3209127C2 (xx) | 1988-02-04 |
Family
ID=22919321
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE19823209127 Granted DE3209127A1 (de) | 1981-03-13 | 1982-03-12 | Verfahren und system zur herstellung von durch lebende zellen erzeugten substanzen |
Country Status (11)
Country | Link |
---|---|
JP (2) | JPS5816693A (xx) |
BE (1) | BE892479A (xx) |
CA (1) | CA1172961A (xx) |
CH (1) | CH654328A5 (xx) |
DE (1) | DE3209127A1 (xx) |
DK (1) | DK112282A (xx) |
FR (1) | FR2503183B1 (xx) |
GB (1) | GB2094833B (xx) |
IT (1) | IT1150682B (xx) |
NO (1) | NO163060C (xx) |
SE (1) | SE454780B (xx) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4229526A1 (de) * | 1992-09-07 | 1994-03-10 | Juergen Dr Schrezenmeir | Vorrichtung zur Aufnahme und zum Einbringen von biologisch aktiven Geweben oder Zellen in den menschlichen Körper |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NO161446C (no) * | 1981-03-13 | 1989-08-16 | Damon Biotech Inc | Fremgangsmaate for dyrking av celler som er avhengige av forankring. |
US4582799A (en) * | 1983-04-15 | 1986-04-15 | Damon Biotech, Inc. | Process for recovering nonsecreted substances produced by cells |
CA1196862A (en) * | 1983-06-01 | 1985-11-19 | Anthony M.F. Sun | Microencapsulation of living tissue and cells |
JPS6025929A (ja) * | 1983-07-20 | 1985-02-08 | ザ・スト−ル・リサ−チ・アンド・デイベロツプメント・コ−ポレ−シヨン | カプセル化細胞、その製造方法および用途 |
JPS60141281A (ja) * | 1983-12-28 | 1985-07-26 | Meiji Milk Prod Co Ltd | 菌体顆粒の製造方法及び装置 |
EP0152898B1 (en) * | 1984-02-15 | 1990-01-17 | Massachusetts Institute Of Technology | Process for encapsulation and encapsulated active material system( |
JPS60175539A (ja) * | 1984-02-23 | 1985-09-09 | Snow Brand Milk Prod Co Ltd | カプセル体およびその製造法 |
GR851626B (xx) * | 1984-07-05 | 1985-11-26 | Genentech Inc | |
US5672347A (en) * | 1984-07-05 | 1997-09-30 | Genentech, Inc. | Tumor necrosis factor antagonists and their use |
US6686455B1 (en) | 1984-07-05 | 2004-02-03 | Genentech, Inc. | Tumor necrosis factor |
CA1241598A (en) * | 1984-07-11 | 1988-09-06 | Connaught Laboratories Limited | Droplet generation |
EP0199362A3 (en) * | 1985-04-26 | 1987-10-07 | Massachusetts Institute Of Technology | System and apparatus for delayed and pulsed release of biologically active substances |
CA1265443A (en) * | 1985-09-18 | 1990-02-06 | Elieser Gorelik | Assays for chemotherapeutic agents |
DE3534983A1 (de) * | 1985-10-01 | 1987-04-02 | Sturge John & E Ltd | Komplexe immobilisierte biokatalysatoren sowie ihre herstellung und anwendung |
JPS62166891A (ja) * | 1986-01-20 | 1987-07-23 | Snow Brand Milk Prod Co Ltd | 細胞培養による有用物質の製造方法 |
WO1987004367A1 (en) * | 1986-01-23 | 1987-07-30 | Ltl Associates | Covalent membranes |
DE3615043A1 (de) * | 1986-05-03 | 1987-11-05 | Hoechst Ag | Verfahren zur verkapselung von biologisch aktivem material |
IL79052A0 (en) * | 1986-06-06 | 1986-11-30 | Univ Ramot | Device and process for production of alginate-shell beads containing biologically active material |
JP2530690Y2 (ja) * | 1986-08-28 | 1997-03-26 | カシオ計算機株式会社 | 電子楽器 |
US5420242A (en) * | 1986-10-22 | 1995-05-30 | Kaare M. Gautvik | Production of human parathyroid hormone from microorganisms |
EP1114865B1 (en) | 1986-10-22 | 2004-01-21 | Allelix Biopharmaceuticals Inc. | Production of human parathyroid hormone |
US5010010A (en) * | 1986-10-22 | 1991-04-23 | Selmer-Sande, A.S. | Production of human parathyroid hormone from microorganisms |
AU614747B2 (en) * | 1987-04-22 | 1991-09-12 | Michael Bay | Cell culture of anchorage dependent cells, materials and products |
JPS6414225U (xx) * | 1987-07-15 | 1989-01-25 | ||
JPH025797U (xx) * | 1988-06-23 | 1990-01-16 | ||
WO1991010470A1 (en) * | 1990-01-08 | 1991-07-25 | Brown University Research Foundation | Devices and methods for enhanced delivery of active factors |
DK0585368T3 (da) * | 1991-04-25 | 1998-03-16 | Univ Brown Res Found | Implanterbart biokompatibelt immunisolatorisk vehikel til afgivelse af udvalgte terapeutiske produkter |
US5800829A (en) * | 1991-04-25 | 1998-09-01 | Brown University Research Foundation | Methods for coextruding immunoisolatory implantable vehicles with a biocompatible jacket and a biocompatible matrix core |
US5908623A (en) * | 1993-08-12 | 1999-06-01 | Cytotherapeutics, Inc. | Compositions and methods for the delivery of biologically active molecules using genetically altered cells contained in biocompatible immunoisolatory capsules |
EP0802800B1 (en) * | 1993-08-12 | 2002-06-12 | Neurotech S.A. | Biocompatible immunoisolatory capsules containing genetically altered cells for the delivery of biologically active molecules |
US5550050A (en) * | 1994-04-15 | 1996-08-27 | Cytotherapeutics, Inc. | Method for implanting encapsulated cells in a host |
DE4426396A1 (de) * | 1994-07-26 | 1996-02-01 | Ulrich Prof Dr Zimmermann | Verfahren zur Herstellung konzentrierter Lösungen von mikroverkapselten Zellen oder von suspendierten Wirkstoffen in mikroverkapselter Form |
US5916790A (en) * | 1995-03-03 | 1999-06-29 | Metabolex, Inc. | Encapsulation compositions, and methods |
SE9702401D0 (sv) | 1997-06-19 | 1997-06-19 | Astra Ab | Pharmaceutical use |
EP2673357A2 (en) * | 2011-02-07 | 2013-12-18 | Life Technologies Corporation | Compositions and methods for stabilizing susceptible compounds |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4324683A (en) * | 1975-08-20 | 1982-04-13 | Damon Corporation | Encapsulation of labile biological material |
US4352883A (en) * | 1979-03-28 | 1982-10-05 | Damon Corporation | Encapsulation of biological material |
NO161446C (no) * | 1981-03-13 | 1989-08-16 | Damon Biotech Inc | Fremgangsmaate for dyrking av celler som er avhengige av forankring. |
NO158284C (no) * | 1981-03-13 | 1988-08-17 | Damon Biotech Inc | Fremgangsmaate for selektiv oppbrytning av en permeabel membran. |
-
1982
- 1982-03-11 NO NO820794A patent/NO163060C/no unknown
- 1982-03-12 DK DK112282A patent/DK112282A/da not_active Application Discontinuation
- 1982-03-12 CH CH1575/82A patent/CH654328A5/de not_active IP Right Cessation
- 1982-03-12 CA CA000398218A patent/CA1172961A/en not_active Expired
- 1982-03-12 DE DE19823209127 patent/DE3209127A1/de active Granted
- 1982-03-12 SE SE8201554A patent/SE454780B/sv not_active IP Right Cessation
- 1982-03-12 FR FR8204242A patent/FR2503183B1/fr not_active Expired
- 1982-03-12 JP JP57038238A patent/JPS5816693A/ja active Granted
- 1982-03-12 GB GB8207309A patent/GB2094833B/en not_active Expired
- 1982-03-12 IT IT20140/82A patent/IT1150682B/it active
- 1982-03-12 BE BE0/207559A patent/BE892479A/fr not_active IP Right Cessation
-
1985
- 1985-08-22 JP JP60184995A patent/JPS6188893A/ja active Granted
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4229526A1 (de) * | 1992-09-07 | 1994-03-10 | Juergen Dr Schrezenmeir | Vorrichtung zur Aufnahme und zum Einbringen von biologisch aktiven Geweben oder Zellen in den menschlichen Körper |
DE4229526B4 (de) * | 1992-09-07 | 2006-02-16 | Schrezenmeir, Jürgen, Dr. | Vorrichtung zur Aufnahme und zum Einbringen von biologisch aktiven Geweben oder Zellen in den menschlichen Körper |
Also Published As
Publication number | Publication date |
---|---|
JPS6244919B2 (xx) | 1987-09-24 |
SE454780B (sv) | 1988-05-30 |
JPS6157288B2 (xx) | 1986-12-06 |
DE3209127A1 (de) | 1982-12-09 |
IT1150682B (it) | 1986-12-17 |
FR2503183B1 (fr) | 1985-11-08 |
JPS6188893A (ja) | 1986-05-07 |
IT8220140A0 (it) | 1982-03-12 |
JPS5816693A (ja) | 1983-01-31 |
CH654328A5 (de) | 1986-02-14 |
FR2503183A1 (fr) | 1982-10-08 |
NO820794L (no) | 1982-09-14 |
GB2094833B (en) | 1984-06-20 |
SE8201554L (sv) | 1982-09-14 |
NO163060C (no) | 1990-03-28 |
NO163060B (no) | 1989-12-18 |
CA1172961A (en) | 1984-08-21 |
GB2094833A (en) | 1982-09-22 |
DK112282A (da) | 1982-09-14 |
BE892479A (fr) | 1982-07-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE3209127C2 (xx) | ||
DE3209098C2 (xx) | ||
DE69531821T2 (de) | Mehrlagige alginatbeschichtungen von biologischen geweben für die transplantation | |
DE69221484T2 (de) | Implantierbare, biokompatible immunisolator-trägersubstanz zum abgeben ausgesuchter, therapeutischer produkte | |
DE3012233C2 (xx) | ||
DE3209045C2 (de) | Verfahren zum selektiven Aufbrechen permeabler Membranen | |
DE69330716T2 (de) | Nicht faserige, mit alginat beschichtete transplantate sowie herstellungs- und anwendungssvefahren dafür | |
DE3509202A1 (de) | Verfahren zur induktion einer immunantwort durch immunisierung mit eingekapselten antigen erzeugenden zellen | |
DE3027105C2 (xx) | ||
DE69430054T2 (de) | Verfahren zum einbetten von tierkulturzellen | |
DE69633189T2 (de) | Fester Träger zur Verwendung in der Zellkultivierung, insbesondere für die Kultivierung von Leberzellen, Bioreaktor, welcher den festen Träger enthält, und die Verwendung davon in einem biologisch-künstlichen Lebersystem | |
DE102004017473A1 (de) | Verfahren zur Differenzierung von Stammzellen in Zellen, die ein pankreatisches Hormon produzieren | |
DE3504715C2 (xx) | ||
DE69109744T2 (de) | Kultur- und Nachweisverfahren für sterile filtrierbare selbständig replizierende biologische Partikel. | |
DE3432143A1 (de) | Verfahren zur einkapselung eines einzuhuellenden materials | |
DE3414083A1 (de) | Verfahren zur gewinnung von durch lebende zellen produzierten, nicht sekretierten substanzen | |
WO2000024420A1 (de) | Verfahren zur herstellung eines antiviralen mittels | |
DE10307925A1 (de) | Träger für eine Zellkultur und Verfahren zur Kultivierung von Zellen | |
DE69425707T2 (de) | Medien für die isolierung und stabilisierung von zellen | |
DE3925680C2 (xx) | ||
DE3504748C2 (xx) | ||
WO2003080122A1 (de) | Verfahren und mittel zur herstellung therapeutisch wirksamer blutzusammensetzungen | |
DE69723264T2 (de) | Verfahren und medium zur zellzüchtung, so erhaltene zellzusammensetzung und ihre anwendungen als produktionssystem und als forschungsmodell | |
EP0396597A1 (de) | Verfahren zur herstellung eines therapeutisch aktiven, insbesondere zur wundheilung oder zur behandlung in der geriatrie verwendbaren wirkstoffes und ein einen solchen wirkstoff enthaltendes therapeutisches präparat | |
DE19707910A1 (de) | Träger für Zellkulturen |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8110 | Request for examination paragraph 44 | ||
8127 | New person/name/address of the applicant |
Owner name: DAMON BIOTECH, INC., NEEDHAM HEIGHTS, MASS., US |
|
D2 | Grant after examination | ||
8363 | Opposition against the patent | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: ABBOTT BIOTECH, INC. (N.D.GES.D.STAATES DELAWARE), |
|
8328 | Change in the person/name/address of the agent |
Free format text: BEETZ JUN., R., DIPL.-ING. DR.-ING. TIMPE, W., DR.-ING. SIEGFRIED, J., DIPL.-ING. SCHMITT-FUMIAN, W., PROF. DIPL.-CHEM. DR.RER.NAT. MAYR, C., DIPL.-PHYS.DR.RER.NAT., PAT.-ANWAELTE, 8000 MUENCHEN |
|
8365 | Fully valid after opposition proceedings | ||
8339 | Ceased/non-payment of the annual fee |