DE3170608D1 - Phen(alk)oxy-substituted oxirane-carboxylic acids, process for their preparation, their use and drugs containing them - Google Patents

Phen(alk)oxy-substituted oxirane-carboxylic acids, process for their preparation, their use and drugs containing them

Info

Publication number
DE3170608D1
DE3170608D1 DE8181106556T DE3170608T DE3170608D1 DE 3170608 D1 DE3170608 D1 DE 3170608D1 DE 8181106556 T DE8181106556 T DE 8181106556T DE 3170608 T DE3170608 T DE 3170608T DE 3170608 D1 DE3170608 D1 DE 3170608D1
Authority
DE
Germany
Prior art keywords
phen
alk
oxy
preparation
carboxylic acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8181106556T
Other languages
German (de)
English (en)
Inventor
Klaus Eistetter
Gerhard Ludwig
Erich Rapp
Horst Wolf
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
WOLF, HORST P.O., DR., 7753 ALLENSBACH, DE
Original Assignee
Byk Gulden Lomberg Chemische Fabrik GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Byk Gulden Lomberg Chemische Fabrik GmbH filed Critical Byk Gulden Lomberg Chemische Fabrik GmbH
Application granted granted Critical
Publication of DE3170608D1 publication Critical patent/DE3170608D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/17—Unsaturated ethers containing halogen
    • C07C43/174—Unsaturated ethers containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/178—Unsaturated ethers containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/225—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/257—Ethers having an ether-oxygen atom bound to carbon atoms both belonging to six-membered aromatic rings
    • C07C43/29—Ethers having an ether-oxygen atom bound to carbon atoms both belonging to six-membered aromatic rings containing halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE8181106556T 1980-08-25 1981-08-24 Phen(alk)oxy-substituted oxirane-carboxylic acids, process for their preparation, their use and drugs containing them Expired DE3170608D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH639780 1980-08-25
CH152681 1981-03-06

Publications (1)

Publication Number Publication Date
DE3170608D1 true DE3170608D1 (en) 1985-06-27

Family

ID=25687902

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8181106556T Expired DE3170608D1 (en) 1980-08-25 1981-08-24 Phen(alk)oxy-substituted oxirane-carboxylic acids, process for their preparation, their use and drugs containing them

Country Status (16)

Country Link
US (1) US4337267A (en:Method)
EP (1) EP0046590B1 (en:Method)
JP (1) JPS6059914B2 (en:Method)
AU (1) AU549447B2 (en:Method)
CA (1) CA1167050A (en:Method)
DE (1) DE3170608D1 (en:Method)
DK (1) DK171890B1 (en:Method)
ES (1) ES8300730A1 (en:Method)
GR (1) GR75741B (en:Method)
IE (1) IE51534B1 (en:Method)
IL (1) IL63627A (en:Method)
NZ (1) NZ198136A (en:Method)
PH (1) PH21847A (en:Method)
PT (1) PT73563B (en:Method)
WO (1) WO1982000643A1 (en:Method)
YU (1) YU206681A (en:Method)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0231367B1 (de) * 1985-08-02 1991-07-24 Wolf, Horst P.O., Dr. Verwendung von oxirancarbonsäuren zur behandlung der hyperlipämie
EP0283168A3 (en) * 1987-03-16 1989-06-14 American Home Products Corporation Fluorooxirane carboxylates
US4788304A (en) * 1987-12-07 1988-11-29 American Home Products Corporation Phospholipase A2 inhibitors
DE3906953A1 (de) * 1989-03-04 1990-09-20 Byk Gulden Lomberg Chem Fab Verfahren zur herstellung optisch reiner oxirancarbonsaeuren
US5545672A (en) * 1993-02-11 1996-08-13 The University Of Texas System Treatment of insulin resistance and type 2 diabetes mellitus with a thiol protease inhibitor
IS4164A (is) * 1993-06-11 1994-12-12 Ab Astra Efnasambönd sem hindra flæði magasýru
US5556863A (en) * 1993-06-11 1996-09-17 Astra Aktiebolag Compound for gastric acid secretion inhibition
KR980009260A (ko) * 1996-07-02 1998-04-30 주상섭 오시란카르복실산 유도체 및 그의 제조방법
KR19980028082A (ko) * 1996-10-21 1998-07-15 김박광 혈당 강하 작용을 갖는 신규 옥시란 카복실산의 유도체, 그 제조방법 및 이를 함유하는 당뇨병 치료제
DE19705718A1 (de) * 1997-02-14 1998-08-20 Horst P O Dr Wolf Neue Oxirancarbonsäuren zur Behandlung des Diabetes Typ 2 und anderer insulinresistenter Zustände
US5932763A (en) * 1997-05-15 1999-08-03 Bayer Corporation Inhibition of matrix metalloproteases by 2-(ω-arolalkyl)-4-biaryl-4-oxobutyric acids
DE10115938A1 (de) 2001-03-30 2002-10-10 Medigene Ag Ges Fuer Molekular Verfahren zur Herstellung von Oxirancarbonsäuren und Derivaten davon
ES2400683T3 (es) * 2001-09-26 2013-04-11 Emisphere Technologies, Inc. Método de preparación de ácidos fenoi-alcanoicos y sales de los mismos mediante un producto intermedio de dicarboxilato
JP2006519229A (ja) * 2003-02-13 2006-08-24 アルバート・アインシュタイン・カレッジ・オヴ・メディシン・オヴ・イェシヴァ・ユニヴァーシティ 視床下部内の長鎖脂肪アシルＣｏＡレベルの変調による摂食量およびグルコース産生量の調節
WO2006041922A2 (en) * 2004-10-08 2006-04-20 Dara Biosciences, Inc. Agents and methods for administration to the central nervous system
WO2006088875A2 (en) * 2005-02-14 2006-08-24 Albert Einstein College Of Medicine Of Yeshiva University Intranasal administration of modulators of hypothalamic atp-sensitive potassium channels
CA2766282C (en) 2008-06-27 2021-03-02 Meta-Iq Aps Inhibitors of carnitin-palmitoyl-transferase-1 for the treatment and prevention of disorders caused by delipidation of neural tissue
ES2879826T3 (es) 2015-06-15 2021-11-23 Nmd Pharma As Compuestos para su uso en el tratamiento de trastornos neuromusculares
US11147788B2 (en) 2017-12-14 2021-10-19 Nmd Pharma A/S Compounds for the treatment of neuromuscular disorders
US11730714B2 (en) 2017-12-14 2023-08-22 Nmd Pharma A/S Compounds for the treatment of neuromuscular disorders
US10385028B2 (en) 2017-12-14 2019-08-20 Nmd Pharma A/S Compounds for the treatment of neuromuscular disorders
US11591284B2 (en) 2017-12-14 2023-02-28 Nmd Pharma A/S Compounds for the treatment of neuromuscular disorders

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1551078A (en) * 1975-09-22 1979-08-22 Mcneilab Inc Alkyl-substituted glycidates and thioglycidates
US4196300A (en) * 1975-09-22 1980-04-01 Mcneilabs, Inc. α-Alkyl-substituted glycidates and thioglycidates
US4132719A (en) * 1978-04-20 1979-01-02 Mcneilab Inc. Dibromoalkylglycidic acid derivatives
US4132720A (en) * 1978-04-20 1979-01-02 Mcneil Laboratories, Inc. Alkenylglycidic acid derivatives
ATE3291T1 (de) * 1979-09-07 1983-05-15 Byk Gulden Lomberg Chemische Fabrik Gmbh Substituierte oxirancarbonsaeuren, verfahren zu ihrer herstellung, ihre verwendung und sie enthaltende arzneimittel.

Also Published As

Publication number Publication date
PH21847A (en) 1988-03-17
PT73563B (en) 1983-07-14
IE811931L (en) 1982-02-25
JPS6059914B2 (ja) 1985-12-27
EP0046590A2 (de) 1982-03-03
PT73563A (en) 1981-09-01
DK183882A (da) 1982-04-23
YU206681A (en) 1983-10-31
NZ198136A (en) 1983-12-16
AU7447581A (en) 1982-03-04
IL63627A0 (en) 1981-11-30
EP0046590A3 (en) 1982-04-07
CA1167050A (en) 1984-05-08
JPS57501233A (en:Method) 1982-07-15
AU549447B2 (en) 1986-01-30
ES504922A0 (es) 1982-11-16
WO1982000643A1 (en) 1982-03-04
IL63627A (en) 1984-11-30
EP0046590B1 (de) 1985-05-22
DK171890B1 (da) 1997-08-04
GR75741B (en:Method) 1984-08-02
US4337267A (en) 1982-06-29
IE51534B1 (en) 1987-01-07
ES8300730A1 (es) 1982-11-16

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: WOLF, HORST P.O., DR., 7753 ALLENSBACH, DE

8339 Ceased/non-payment of the annual fee