DE3162839D1 - Processes for substitution of aromatic organic compounds - Google Patents
Processes for substitution of aromatic organic compoundsInfo
- Publication number
- DE3162839D1 DE3162839D1 DE8181305885T DE3162839T DE3162839D1 DE 3162839 D1 DE3162839 D1 DE 3162839D1 DE 8181305885 T DE8181305885 T DE 8181305885T DE 3162839 T DE3162839 T DE 3162839T DE 3162839 D1 DE3162839 D1 DE 3162839D1
- Authority
- DE
- Germany
- Prior art keywords
- general formula
- chem
- optionally
- aromatic
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 3
- -1 aromatic organic compounds Chemical class 0.000 title abstract 2
- 238000006467 substitution reaction Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 239000003054 catalyst Substances 0.000 abstract 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 abstract 1
- 150000001342 alkaline earth metals Chemical group 0.000 abstract 1
- 150000001491 aromatic compounds Chemical class 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 235000019253 formic acid Nutrition 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052740 iodine Chemical group 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 125000003367 polycyclic group Chemical group 0.000 abstract 1
- 239000000376 reactant Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/32—Oxygen atoms
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
- B01J31/0201—Oxygen-containing compounds
- B01J31/0202—Alcohols or phenols
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
- B01J31/04—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing carboxylic acids or their salts
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/26—Catalysts comprising hydrides, coordination complexes or organic compounds containing in addition, inorganic metal compounds not provided for in groups B01J31/02 - B01J31/24
- B01J31/28—Catalysts comprising hydrides, coordination complexes or organic compounds containing in addition, inorganic metal compounds not provided for in groups B01J31/02 - B01J31/24 of the platinum group metals, iron group metals or copper
- B01J31/30—Halides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/16—Preparation of ethers by reaction of esters of mineral or organic acids with hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
- C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
- C07C45/515—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being an acetalised, ketalised hemi-acetalised, or hemi-ketalised hydroxyl group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/64—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of functional groups containing oxygen only in singly bound form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
- B01J2231/40—Substitution reactions at carbon centres, e.g. C-C or C-X, i.e. carbon-hetero atom, cross-coupling, C-H activation or ring-opening reactions
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Inorganic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Catalysts (AREA)
- Quinoline Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Detergent Compositions (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8040383 | 1980-12-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3162839D1 true DE3162839D1 (en) | 1984-04-26 |
Family
ID=10518031
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8181305885T Expired DE3162839D1 (en) | 1980-12-17 | 1981-12-15 | Processes for substitution of aromatic organic compounds |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US4422955A (enExample) |
| EP (1) | EP0057321B1 (enExample) |
| JP (1) | JPS57150442A (enExample) |
| AT (1) | ATE6771T1 (enExample) |
| AU (1) | AU7821581A (enExample) |
| CA (1) | CA1164849A (enExample) |
| DE (1) | DE3162839D1 (enExample) |
| DK (1) | DK557281A (enExample) |
| FI (1) | FI77015C (enExample) |
| GR (1) | GR76371B (enExample) |
| IE (1) | IE52060B1 (enExample) |
| NO (1) | NO155002C (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8515179D0 (en) * | 1985-06-14 | 1985-07-17 | Bp Chem Int Ltd | Preparation of phenolic ethers |
| DE3804522A1 (de) * | 1988-02-13 | 1989-08-24 | Hoechst Ag | Verfahren zur herstellung von thiophenethern |
| US4918241A (en) * | 1988-05-02 | 1990-04-17 | Eastman Kodak Company | Method of preparing aromatic ethers from iodoaromatic compounds |
| WO1999018057A1 (en) | 1997-10-06 | 1999-04-15 | Massachusetts Institute Of Technology | Preparation of diaryl ether by condensation reactions |
| US6124500A (en) * | 1998-03-09 | 2000-09-26 | Rohm And Haas Company | Process for synthesizing benzoic acids |
| US9394294B2 (en) | 2010-05-11 | 2016-07-19 | Demerx, Inc. | Methods and compositions for preparing and purifying noribogaine |
| US9586954B2 (en) | 2010-06-22 | 2017-03-07 | Demerx, Inc. | N-substituted noribogaine prodrugs |
| US8802832B2 (en) | 2010-06-22 | 2014-08-12 | Demerx, Inc. | Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier |
| CA2806232A1 (en) | 2010-07-23 | 2012-01-26 | Demerx, Inc. | Noribogaine compositions |
| EP2481740B1 (en) | 2011-01-26 | 2015-11-04 | DemeRx, Inc. | Methods and compositions for preparing noribogaine from voacangine |
| US9617274B1 (en) | 2011-08-26 | 2017-04-11 | Demerx, Inc. | Synthetic noribogaine |
| WO2013112673A1 (en) | 2012-01-25 | 2013-08-01 | Demerx, Inc. | Synthetic voacangine |
| EP2934541A4 (en) | 2012-12-20 | 2016-08-03 | Demerx Inc | SUBSTITUTED NORIBOGAIN |
| WO2019209607A1 (en) * | 2018-04-23 | 2019-10-31 | Merck Sharp & Dohme Corp. | Novel process for synthesis of a phenoxy diaminopyrimidine compound |
| WO2022036636A1 (zh) * | 2020-08-20 | 2022-02-24 | 江苏康龙医药有限公司 | 一种1,3,5-三甲氧基苯的制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3118001A (en) * | 1958-01-28 | 1964-01-14 | Hoechst Ag | Process for oxidizing olefins to aldehydes and ketones |
| US3609098A (en) * | 1969-08-21 | 1971-09-28 | Phillips Petroleum Co | Haloester and cuprous salt polymerization catalyst systems |
| BE789586A (fr) | 1972-03-27 | 1973-04-02 | Hoffmann La Roche | Procede pour la preparation de 3,4,5-trimethoxy-benzaldehyde |
| US4102933A (en) * | 1973-12-11 | 1978-07-25 | Oce-Andeno B.V. | Process for preparing a S-trialkoxy benzene |
| GB2025403A (en) * | 1978-03-09 | 1980-01-23 | Albright & Wilson | Improvements in and Relating to the Ullmann Reaction |
| US4218567A (en) * | 1978-05-30 | 1980-08-19 | Hoffmann-La Roche Inc. | Process for aromatic ethers |
| JPS5594329A (en) * | 1979-01-08 | 1980-07-17 | Koji Takeuchi | Preparation of 3,4,5-trihydroxy toluenealkyl ethers |
| FR2460283A1 (fr) * | 1979-07-03 | 1981-01-23 | Rhone Poulenc Ind | Procede de preparation d'ethers diaryliques |
-
1981
- 1981-12-03 AU AU78215/81A patent/AU7821581A/en not_active Abandoned
- 1981-12-04 US US06/327,714 patent/US4422955A/en not_active Expired - Fee Related
- 1981-12-15 AT AT81305885T patent/ATE6771T1/de not_active IP Right Cessation
- 1981-12-15 EP EP81305885A patent/EP0057321B1/en not_active Expired
- 1981-12-15 DE DE8181305885T patent/DE3162839D1/de not_active Expired
- 1981-12-16 NO NO814312A patent/NO155002C/no unknown
- 1981-12-16 FI FI814047A patent/FI77015C/fi not_active IP Right Cessation
- 1981-12-16 IE IE2963/81A patent/IE52060B1/en unknown
- 1981-12-16 CA CA000392482A patent/CA1164849A/en not_active Expired
- 1981-12-16 DK DK557281A patent/DK557281A/da not_active Application Discontinuation
- 1981-12-16 JP JP56203292A patent/JPS57150442A/ja active Granted
- 1981-12-17 GR GR66829A patent/GR76371B/el unknown
-
1983
- 1983-06-13 US US06/504,095 patent/US4495353A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPS57150442A (en) | 1982-09-17 |
| IE812963L (en) | 1982-06-17 |
| DK557281A (da) | 1982-06-18 |
| JPS6333424B2 (enExample) | 1988-07-05 |
| EP0057321A1 (en) | 1982-08-11 |
| FI77015C (fi) | 1989-01-10 |
| NO155002B (no) | 1986-10-20 |
| FI814047L (fi) | 1982-06-18 |
| CA1164849A (en) | 1984-04-03 |
| US4422955A (en) | 1983-12-27 |
| EP0057321B1 (en) | 1984-03-21 |
| NO814312L (no) | 1982-06-18 |
| IE52060B1 (en) | 1987-05-27 |
| NO155002C (no) | 1987-01-28 |
| ATE6771T1 (de) | 1984-04-15 |
| US4495353A (en) | 1985-01-22 |
| GR76371B (enExample) | 1984-08-06 |
| AU7821581A (en) | 1982-06-24 |
| FI77015B (fi) | 1988-09-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8327 | Change in the person/name/address of the patent owner |
Owner name: STERLING ORGANICS U.K. LTD., LONDON, GB |
|
| 8328 | Change in the person/name/address of the agent |
Free format text: FRHR. VON UEXKUELL, J., DIPL.-CHEM. DR.RER.NAT. GRAF ZU STOLBERG-WERNIGERODE, U., DIPL.-CHEM. DR.RER.NAT. SUCHANTKE, J., DIPL.-ING. HUBER, A., DIPL.-ING. VON KAMEKE, A., DIPL.-CHEM. DR.RER.NAT. VOELKER, I., DIPL.-BIOL., PAT.-ANW., 2000 HAMBURG |
|
| 8339 | Ceased/non-payment of the annual fee |