DE3134923C1 - N-[N'-(2-Chloraethyl)-N'-nitroso-carbamoyl]-oligopeptidester und -amide und Verfahren zu ihrer Herstellung - Google Patents

N-[N'-(2-Chloraethyl)-N'-nitroso-carbamoyl]-oligopeptidester und -amide und Verfahren zu ihrer Herstellung

Info

Publication number
DE3134923C1
DE3134923C1 DE3134923A DE3134923A DE3134923C1 DE 3134923 C1 DE3134923 C1 DE 3134923C1 DE 3134923 A DE3134923 A DE 3134923A DE 3134923 A DE3134923 A DE 3134923A DE 3134923 C1 DE3134923 C1 DE 3134923C1
Authority
DE
Germany
Prior art keywords
deep
nitroso
chloroethyl
carbamoyl
low
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE3134923A
Other languages
German (de)
English (en)
Inventor
Gerhard Dr. 6902 Sandhausen Eisenbrand
Wei-ci Prof. Quing dao Tang
Otto Ing.(grad.) 6900 Heidelberg Zelesny
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
German Cancer Research Center
Original Assignee
German Cancer Research Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by German Cancer Research Center filed Critical German Cancer Research Center
Priority to DE3134923A priority Critical patent/DE3134923C1/de
Priority to GR69161A priority patent/GR76534B/el
Priority to YU01959/82A priority patent/YU195982A/xx
Priority to IL66689A priority patent/IL66689A/xx
Priority to ZA826481A priority patent/ZA826481B/xx
Priority to MC82EP8200191D priority patent/MC1526A1/xx
Priority to EP82108166A priority patent/EP0074103B1/de
Priority to DE8282108166T priority patent/DE3268831D1/de
Priority to FI830768A priority patent/FI830768A7/fi
Priority to PCT/EP1982/000191 priority patent/WO1983000860A1/de
Priority to AT82108166T priority patent/ATE17735T1/de
Priority to AU89009/82A priority patent/AU8900982A/en
Priority to HU823208A priority patent/HU190643B/hu
Priority to DD82243011A priority patent/DD209192A5/de
Priority to BR8207845A priority patent/BR8207845A/pt
Priority to JP57502693A priority patent/JPS58501769A/ja
Priority to DK77583A priority patent/DK77583A/da
Priority to NO831475A priority patent/NO831475L/no
Application granted granted Critical
Publication of DE3134923C1 publication Critical patent/DE3134923C1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
DE3134923A 1981-09-03 1981-09-03 N-[N'-(2-Chloraethyl)-N'-nitroso-carbamoyl]-oligopeptidester und -amide und Verfahren zu ihrer Herstellung Expired DE3134923C1 (de)

Priority Applications (18)

Application Number Priority Date Filing Date Title
DE3134923A DE3134923C1 (de) 1981-09-03 1981-09-03 N-[N'-(2-Chloraethyl)-N'-nitroso-carbamoyl]-oligopeptidester und -amide und Verfahren zu ihrer Herstellung
GR69161A GR76534B (cg-RX-API-DMAC10.html) 1981-09-03 1982-08-30
YU01959/82A YU195982A (en) 1981-09-03 1982-08-31 Process for preparing n-(n'-(2-chloroethyl)-n'-nitrosocarbamoyl)-oligopeptide esters or amides
IL66689A IL66689A (en) 1981-09-03 1982-09-01 N-(n'-chloroethyl-n'-nitrosocarbamoyl)-oligopeptide esters and amides and method for their preparation
PCT/EP1982/000191 WO1983000860A1 (en) 1981-09-03 1982-09-03 Oligopeptidic ester and amide n-adn'-(2-chlorethyl)-n'-nitroso-carbomoylbd and production method thereof
EP82108166A EP0074103B1 (de) 1981-09-03 1982-09-03 N-(N'-(2-Chloräthyl)-N'-nitroso-carbamoyl)- oligopeptidester und -amide und Verfahren zu ihrer Herstellung
DE8282108166T DE3268831D1 (en) 1981-09-03 1982-09-03 N-(n'-(2-chloroethyl)-n'-nitroso-carbamoyl)-oligopeptide esters and amides, and process for preparing them
FI830768A FI830768A7 (fi) 1981-09-03 1982-09-03 N-/N'-(2-kloorietyyli)-N'-nitroso- karbamoyyli/-oligopeptidiesteri ja -amidi ja menetelmä niiden valmistavalmistamiseksi.
ZA826481A ZA826481B (en) 1981-09-03 1982-09-03 N-(n'-(2-chloroethyl)-n'-nitroso-carbamoyl)-oligopeptide esters and amides,and their preparation
AT82108166T ATE17735T1 (de) 1981-09-03 1982-09-03 N-(n'-(2-chloraethyl)-n'-nitroso-carbamoyl)oligopeptidester und -amide und verfahren zu ihrer herstellung.
AU89009/82A AU8900982A (en) 1981-09-03 1982-09-03 Oligopeptidic ester and amide n-(n'-(2-chlorethyl)-n'- nitroso-carbomoyl) and production method thereof
HU823208A HU190643B (en) 1981-09-03 1982-09-03 Process for producing n-/n'/2-chloroethyl/-n'-nitrozo-carbomoy/-olygopeptidesters and amides
DD82243011A DD209192A5 (de) 1981-09-03 1982-09-03 Verfahren zur herstellung von n-(n'-(2-chloraethyl)-n'-nitroso-carbamoyl)-oligopeptidestern und -amiden
BR8207845A BR8207845A (pt) 1981-09-03 1982-09-03 Esteres e amidas n-(n'-(2-cloretilo)-n'-nitroso-carbamoil)-oligopeptidicos e processo para a preparacao dos mesmos
JP57502693A JPS58501769A (ja) 1981-09-03 1982-09-03 Ｎ−〔ｎ′−（２−クロルエチル）−ｎ′−ニトロソ−カルバモイル〕−オリゴペプチドエステルとアミドおよびそれらの製造方法
MC82EP8200191D MC1526A1 (fr) 1981-09-03 1982-09-03 Esters et amides de n-(n'-(2-chlorethyl)-n'-nitrosocarbamoyl)-oligopeptide et procede pour leur preparation
DK77583A DK77583A (da) 1981-09-03 1983-02-22 N-(n'-(2-chlorethyl)-n'-nitroso-carbamoyl)-oligopeptidestere og -amider samt fremgangsmaade til deres fremstilling
NO831475A NO831475L (no) 1981-09-03 1983-04-26 Fremgangsmaate ved fremstilling av n-(n`-(2-klorethyl)-n`-nitroso-carbamoyl)-oligopeptidestere og -amider

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3134923A DE3134923C1 (de) 1981-09-03 1981-09-03 N-[N'-(2-Chloraethyl)-N'-nitroso-carbamoyl]-oligopeptidester und -amide und Verfahren zu ihrer Herstellung

Publications (1)

Publication Number Publication Date
DE3134923C1 true DE3134923C1 (de) 1983-06-09

Family

ID=6140795

Family Applications (2)

Application Number Title Priority Date Filing Date
DE3134923A Expired DE3134923C1 (de) 1981-09-03 1981-09-03 N-[N'-(2-Chloraethyl)-N'-nitroso-carbamoyl]-oligopeptidester und -amide und Verfahren zu ihrer Herstellung
DE8282108166T Expired DE3268831D1 (en) 1981-09-03 1982-09-03 N-(n'-(2-chloroethyl)-n'-nitroso-carbamoyl)-oligopeptide esters and amides, and process for preparing them

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE8282108166T Expired DE3268831D1 (en) 1981-09-03 1982-09-03 N-(n'-(2-chloroethyl)-n'-nitroso-carbamoyl)-oligopeptide esters and amides, and process for preparing them

Country Status (17)

Country Link
EP (1) EP0074103B1 (cg-RX-API-DMAC10.html)
JP (1) JPS58501769A (cg-RX-API-DMAC10.html)
AT (1) ATE17735T1 (cg-RX-API-DMAC10.html)
AU (1) AU8900982A (cg-RX-API-DMAC10.html)
BR (1) BR8207845A (cg-RX-API-DMAC10.html)
DD (1) DD209192A5 (cg-RX-API-DMAC10.html)
DE (2) DE3134923C1 (cg-RX-API-DMAC10.html)
DK (1) DK77583A (cg-RX-API-DMAC10.html)
FI (1) FI830768A7 (cg-RX-API-DMAC10.html)
GR (1) GR76534B (cg-RX-API-DMAC10.html)
HU (1) HU190643B (cg-RX-API-DMAC10.html)
IL (1) IL66689A (cg-RX-API-DMAC10.html)
MC (1) MC1526A1 (cg-RX-API-DMAC10.html)
NO (1) NO831475L (cg-RX-API-DMAC10.html)
WO (1) WO1983000860A1 (cg-RX-API-DMAC10.html)
YU (1) YU195982A (cg-RX-API-DMAC10.html)
ZA (1) ZA826481B (cg-RX-API-DMAC10.html)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2987263A (en) * 1959-02-16 1961-06-06 William R Senn Apparatus for granulating phosphate rock fertilizer or the like
FR2540491A1 (fr) * 1983-02-08 1984-08-10 Centre Nat Rech Scient Nouvelles nitrosourees, leur procede de preparation et leur application therapeutique
JPS6288472A (ja) * 1985-10-14 1987-04-22 Sharp Corp フアクシミリの読取記録装置

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5113722A (en) * 1974-07-23 1976-02-03 Suami T Shinkina nitoroshinyosojudotaino seizoho

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NICHTS-ERMITTELT *

Also Published As

Publication number Publication date
DK77583A (da) 1983-03-17
NO831475L (no) 1983-04-26
IL66689A (en) 1986-02-28
ZA826481B (en) 1983-07-27
JPS58501769A (ja) 1983-10-20
MC1526A1 (fr) 1984-04-13
DK77583D0 (da) 1983-02-22
YU195982A (en) 1985-08-31
WO1983000860A1 (en) 1983-03-17
DE3268831D1 (en) 1986-03-13
FI830768A0 (fi) 1983-03-08
ATE17735T1 (de) 1986-02-15
DD209192A5 (de) 1984-04-25
AU8900982A (en) 1983-03-28
GR76534B (cg-RX-API-DMAC10.html) 1984-08-10
HU190643B (en) 1986-09-29
FI830768L (fi) 1983-03-08
EP0074103A1 (de) 1983-03-16
EP0074103B1 (de) 1986-01-29
FI830768A7 (fi) 1983-03-08
BR8207845A (pt) 1983-08-30

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Legal Events

Date Code Title Description
8100 Publication of patent without earlier publication of application
D1 Grant (no unexamined application published) patent law 81
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee