DE3120312C2 - Verfahren zur Herstellung von Darm-Glucagon-Antigenen und deren Verwendung - Google Patents

Verfahren zur Herstellung von Darm-Glucagon-Antigenen und deren Verwendung

Info

Publication number
DE3120312C2
DE3120312C2 DE3120312A DE3120312A DE3120312C2 DE 3120312 C2 DE3120312 C2 DE 3120312C2 DE 3120312 A DE3120312 A DE 3120312A DE 3120312 A DE3120312 A DE 3120312A DE 3120312 C2 DE3120312 C2 DE 3120312C2
Authority
DE
Germany
Prior art keywords
asn
peptide
lys
arg
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE3120312A
Other languages
German (de)
English (en)
Other versions
DE3120312A1 (de
Inventor
Noboru Shizuoka Yanaihara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Publication of DE3120312A1 publication Critical patent/DE3120312A1/de
Application granted granted Critical
Publication of DE3120312C2 publication Critical patent/DE3120312C2/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/822—Identified hapten
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/823—Immunogenic carrier or carrier per se
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/806—Antigenic peptides or proteins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE3120312A 1980-05-21 1981-05-21 Verfahren zur Herstellung von Darm-Glucagon-Antigenen und deren Verwendung Expired DE3120312C2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6804080A JPS56163456A (en) 1980-05-21 1980-05-21 Preparation of antigen

Publications (2)

Publication Number Publication Date
DE3120312A1 DE3120312A1 (de) 1982-03-04
DE3120312C2 true DE3120312C2 (de) 1985-08-29

Family

ID=13362282

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3120312A Expired DE3120312C2 (de) 1980-05-21 1981-05-21 Verfahren zur Herstellung von Darm-Glucagon-Antigenen und deren Verwendung

Country Status (8)

Country Link
US (1) US4407965A (ref)
JP (1) JPS56163456A (ref)
BE (1) BE888906A (ref)
DE (1) DE3120312C2 (ref)
DK (1) DK159163C (ref)
FR (1) FR2482861A1 (ref)
GB (1) GB2079289B (ref)
SE (1) SE454301B (ref)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1249395A (en) * 1982-09-30 1989-01-24 Tetsuya Tachikawa Human leukemia virus-related peptides, a process for production thereof, antibodies of the peptides and a process for production of the antibodies
CA1256795A (en) * 1983-12-28 1989-07-04 Dennis A. Carson Anti-idiotype antibodies induced by synthetic polypeptides
US4545985A (en) * 1984-01-26 1985-10-08 The United States Of America As Represented By The Secretary, Dept. Of Health And Human Services Pseudomonas exotoxin conjugate immunotoxins
GB2160312B (en) * 1984-04-13 1987-09-16 South African Inventions Adjuvant for immunisation
US5116725A (en) * 1984-08-08 1992-05-26 Scripps Clinic And Research Foundation Assay for Epstein-Barr virus infection with solid phase bound synthetic polypeptides
US4654419A (en) * 1984-08-08 1987-03-31 Scripps Clinic And Research Foundation Synthetic polypeptides and antibodies related to epstein-barr virus nuclear antigen
ATE71150T1 (de) * 1984-09-19 1992-01-15 Univ California Retrovirale polypeptide in zusammenhang mit menschlicher transformation.
US4732863A (en) * 1984-12-31 1988-03-22 University Of New Mexico PEG-modified antibody with reduced affinity for cell surface Fc receptors
JPH0792458B2 (ja) * 1986-03-14 1995-10-09 郁男 山科 糖鎖特異抗体アツセイプレ−ト及びその製造方法
US5202270A (en) * 1986-05-15 1993-04-13 Abbott Laboratories Cocaine and cocaine metabolites assay tracers, immunogens and antibodies
US6919076B1 (en) 1998-01-20 2005-07-19 Pericor Science, Inc. Conjugates of agents and transglutaminase substrate linking molecules
US6958148B1 (en) 1998-01-20 2005-10-25 Pericor Science, Inc. Linkage of agents to body tissue using microparticles and transglutaminase
KR20170062466A (ko) 2014-09-16 2017-06-07 리제너론 파마슈티칼스 인코포레이티드 항-글루카곤 항체 및 그것의 사용
MA46089A (fr) 2016-08-30 2019-07-10 Regeneron Pharma Procédés de traitement de la résistance à l'insuline grave par interférence avec la signalisation du récepteur du glucagon
US20190248888A1 (en) 2016-10-20 2019-08-15 Regeneron Pharmaceuticals, Inc. Methods of lowering blood glucose levels
CA3071387A1 (en) 2017-08-22 2019-02-28 Regeneron Pharmaceuticals, Inc. Methods of treating urea cycle disorders by interfering with glucagon receptor signaling

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5836308B2 (ja) * 1977-02-10 1983-08-08 大塚製薬株式会社 抗体の製造方法
US4206199A (en) * 1977-07-22 1980-06-03 Takeda Chemical Industries, Ltd. Novel glucagon fragment and its derivatives

Also Published As

Publication number Publication date
BE888906A (fr) 1981-11-23
US4407965A (en) 1983-10-04
GB2079289A (en) 1982-01-20
DK159163C (da) 1991-02-11
FR2482861A1 (fr) 1981-11-27
GB2079289B (en) 1983-10-26
JPS56163456A (en) 1981-12-16
DK159163B (da) 1990-09-10
SE454301B (sv) 1988-04-18
FR2482861B1 (ref) 1983-09-09
DK222081A (da) 1981-11-22
JPS6223822B2 (ref) 1987-05-25
SE8103198L (sv) 1981-11-22
DE3120312A1 (de) 1982-03-04

Similar Documents

Publication Publication Date Title
DE3120312C2 (de) Verfahren zur Herstellung von Darm-Glucagon-Antigenen und deren Verwendung
DE3211263C2 (ref)
DE69006306T2 (de) Synthetische peptide des konjugates von ubiquitin und histon h2a.
EP0783522B1 (de) PEPTIDE AUS DER SEQUENZ DES hPTH (1-37)
DE2717741C2 (ref)
DE2858718C2 (ref)
DE214709T1 (de) Synthetisches peptid und verfahren fuer dessen benutzung zum nachweis von antikoerpern zu htlv-iii, diagnose von aids und pre-aids-bedingungen und als impfstoffe.
DE69132864T2 (de) Antikörper gegen hypophysäre adenylatzyklase aktivierende peptid-pacap, hybridome und bestimmung von pacap
DE69228277T2 (de) PACAP-Derivate mit c-AMP-produzierenden Eigenschaften
EP0379949A2 (de) Verfahren zur Bestimmung von HIV-Antikörpern
EP0331126A2 (de) Verfahren zur Bestimmung eines Proteins nach dem Prinzip des Fluoreszenz-Polarisations Immunoassays
DE69504620T2 (de) Monoklonaler Antikörper gegen menschliches Glicentin, Hybridoma zur Herstellung dieses Antikörpers und Testverfahren für menschliches Glicentin unter Verwendung dieses Antikörpers
EP0329994B1 (de) Immunogen und seine Verwendung zur Gewinnung von Antikörpern gegen Hämoglobin A1C
DE3881467T2 (de) Vasokonstriktor-Peptid.
DE3039122A1 (de) Glucagonfragment und seine verwendung
EP0124779A2 (de) Radioimmunverfahren für Thymosin beta 4
DE68927283T2 (de) HCG-Peptide zur Verwendung in Antikörper-Reinigungsverfahren
DE2364883C2 (de) Des-Lys↑2↑↑9↑-Ala↑3↑↑0↑-Schweine- und -Rinderinsulin, Verfahren zu deren Herstellung und diese Insuline enthaltende injizierbare Präparate
DE3040825A1 (de) Neues tridekapeptid, verfahren zu seiner herstellung und verwendung
DE3014582C2 (ref)
DE69014042T2 (de) Verfahren zur Herstellung von menschlichem Osteocalcin.
Blache et al. Development of an oxyntomodulin/glicentin C-terminal radioimmunoassay using a “thiol-maleoyl” coupling method for preparing the immunogen
DE2505712A1 (de) Traegergebundene sowie biologisch aktive peptide und herstellungsverfahren dafuer
DE2804566A1 (de) Polypeptide, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
DE68925365T2 (de) PEPTIDE, DIE EPITOPE AUF R-IFN-BETA REPRÄSENTIEREN, ANTIKöRPER DAGEGEN, UND IHRE ANWENDUNG

Legal Events

Date Code Title Description
OP8 Request for examination as to paragraph 44 patent law
8125 Change of the main classification

Ipc: C07C103/52

8126 Change of the secondary classification

Free format text: A61K 37/02 G01N 33/54

D2 Grant after examination
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee