DE3114351A1 - "oxindol-derivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel mit neuroanaboler wirkung" - Google Patents

"oxindol-derivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel mit neuroanaboler wirkung"

Info

Publication number
DE3114351A1
DE3114351A1 DE19813114351 DE3114351A DE3114351A1 DE 3114351 A1 DE3114351 A1 DE 3114351A1 DE 19813114351 DE19813114351 DE 19813114351 DE 3114351 A DE3114351 A DE 3114351A DE 3114351 A1 DE3114351 A1 DE 3114351A1
Authority
DE
Germany
Prior art keywords
formula
carbon atoms
alkyl
phenyl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19813114351
Other languages
German (de)
English (en)
Inventor
Hansjörg Dr. 6233 Kelkheim Kruse
Heinz Dr. 6000 Frankfurt Kuch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Priority to DE19813114351 priority Critical patent/DE3114351A1/de
Priority to ES82511097D priority patent/ES8307217A1/es
Priority to AT82102936T priority patent/ATE8387T1/de
Priority to DE8282102936T priority patent/DE3260356D1/de
Priority to NO821158A priority patent/NO821158L/no
Priority to EP82102936A priority patent/EP0062887B1/de
Priority to FI821218A priority patent/FI821218L/fi
Priority to GR67851A priority patent/GR75450B/el
Priority to DK162682A priority patent/DK162682A/da
Priority to US06/366,321 priority patent/US4542148A/en
Priority to NZ200259A priority patent/NZ200259A/en
Priority to PH27110A priority patent/PH19471A/en
Priority to PT74721A priority patent/PT74721B/pt
Priority to KR1019820001528A priority patent/KR830010069A/ko
Priority to HU821080A priority patent/HU186053B/hu
Priority to ZA822427A priority patent/ZA822427B/xx
Priority to AU82487/82A priority patent/AU548411B2/en
Priority to JP57057411A priority patent/JPS57179158A/ja
Priority to IL65466A priority patent/IL65466A0/xx
Publication of DE3114351A1 publication Critical patent/DE3114351A1/de
Priority to ES521198A priority patent/ES521198A0/es
Priority to US06/745,884 priority patent/US4614739A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Fats And Perfumes (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)
  • Lubricants (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE19813114351 1981-04-09 1981-04-09 "oxindol-derivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel mit neuroanaboler wirkung" Withdrawn DE3114351A1 (de)

Priority Applications (21)

Application Number Priority Date Filing Date Title
DE19813114351 DE3114351A1 (de) 1981-04-09 1981-04-09 "oxindol-derivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel mit neuroanaboler wirkung"
ES82511097D ES8307217A1 (es) 1981-04-09 1982-04-02 "procedimiento para la preparacion de derivados de oxindol".
AT82102936T ATE8387T1 (de) 1981-04-09 1982-04-06 Oxindol-derivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel mit neuroanaboler wirkung.
DE8282102936T DE3260356D1 (en) 1981-04-09 1982-04-06 Indolinone-2 derivatives, process for their preparation and neuro-anabolic mediums containing them
NO821158A NO821158L (no) 1981-04-09 1982-04-06 Oksindolderivater, fremgangsmaate til deres fremstilling og legemiddel med neuroanabol virkning som inneholder dem
EP82102936A EP0062887B1 (de) 1981-04-09 1982-04-06 Oxindol-Derivate, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel mit neuroanaboler Wirkung
FI821218A FI821218L (fi) 1981-04-09 1982-04-06 Oxindolderivat, foerfarande foer deras framstaellning och dessa innehaollande laekemedel med neuroanabolisk verkan
PH27110A PH19471A (en) 1981-04-09 1982-04-07 Oxindole derivatives and pharmaceutical composition containing them
DK162682A DK162682A (da) 1981-04-09 1982-04-07 Oxindolderivater,deres fremstilling og anvendelse
US06/366,321 US4542148A (en) 1981-04-09 1982-04-07 2-Oxo-3-phenyl indole derivatives, drugs having a neuroanabolic action containing them, and their use
NZ200259A NZ200259A (en) 1981-04-09 1982-04-07 Oxindole derivatives and pharmaceutical compositions
GR67851A GR75450B (enExample) 1981-04-09 1982-04-07
PT74721A PT74721B (de) 1981-04-09 1982-04-07 Oxindol-derivate verfahren zu ihrer herstellung und sie enthaltende arzneimittel mit neuroanaboler wirkung
KR1019820001528A KR830010069A (ko) 1981-04-09 1982-04-07 옥신돌 유도체의 제조방법
HU821080A HU186053B (en) 1981-04-09 1982-04-08 Process for preparing oxindole derivatives and pharmaceutical compositions containing such compounds with neuro-anabolic activity
ZA822427A ZA822427B (en) 1981-04-09 1982-04-08 Oxindole derivatives, processes for their preparation and drugs having a neuroanabolic action containing them
AU82487/82A AU548411B2 (en) 1981-04-09 1982-04-08 Oxindole derivatives
JP57057411A JPS57179158A (en) 1981-04-09 1982-04-08 Oxindole derivative
IL65466A IL65466A0 (en) 1981-04-09 1982-04-11 Oxindole derivatives,processes for their preparation and drugs having a neuroanabolic action containing them
ES521198A ES521198A0 (es) 1981-04-09 1983-03-30 Procedimiento para la preparacion de derivados de oxindol.
US06/745,884 US4614739A (en) 1981-04-09 1985-06-18 Oxindole derivatives, pharmaceutical compositions and use

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19813114351 DE3114351A1 (de) 1981-04-09 1981-04-09 "oxindol-derivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel mit neuroanaboler wirkung"

Publications (1)

Publication Number Publication Date
DE3114351A1 true DE3114351A1 (de) 1982-11-04

Family

ID=6129772

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19813114351 Withdrawn DE3114351A1 (de) 1981-04-09 1981-04-09 "oxindol-derivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel mit neuroanaboler wirkung"
DE8282102936T Expired DE3260356D1 (en) 1981-04-09 1982-04-06 Indolinone-2 derivatives, process for their preparation and neuro-anabolic mediums containing them

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE8282102936T Expired DE3260356D1 (en) 1981-04-09 1982-04-06 Indolinone-2 derivatives, process for their preparation and neuro-anabolic mediums containing them

Country Status (18)

Country Link
US (2) US4542148A (enExample)
EP (1) EP0062887B1 (enExample)
JP (1) JPS57179158A (enExample)
KR (1) KR830010069A (enExample)
AT (1) ATE8387T1 (enExample)
AU (1) AU548411B2 (enExample)
DE (2) DE3114351A1 (enExample)
DK (1) DK162682A (enExample)
ES (2) ES8307217A1 (enExample)
FI (1) FI821218L (enExample)
GR (1) GR75450B (enExample)
HU (1) HU186053B (enExample)
IL (1) IL65466A0 (enExample)
NO (1) NO821158L (enExample)
NZ (1) NZ200259A (enExample)
PH (1) PH19471A (enExample)
PT (1) PT74721B (enExample)
ZA (1) ZA822427B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4624963A (en) * 1984-04-11 1986-11-25 Hoechst Aktiengesellschaft Use of oxindole compounds for the treatment of epilepsy

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4619937A (en) * 1984-02-02 1986-10-28 Warner-Lambert Company Saturated bicyclic lactam acids and derivatives as cognition activators
US4686224A (en) * 1984-10-31 1987-08-11 Pfizer Inc. Oxindole antiinflammatory agents
DE3529994A1 (de) * 1985-08-22 1987-02-26 Hoechst Ag Indolinonderivate, verfahren zu ihrer herstellung, sie enthaltende arzneimittel und deren verwendung
DE69031649T2 (de) * 1989-07-25 1998-02-26 Taiho Pharmaceutical Co Ltd Oxoindolderivate
SE514737C2 (sv) * 1994-03-22 2001-04-09 Sandvik Ab Belagt skärverktyg av hårdmetall
US5565483A (en) * 1995-06-07 1996-10-15 Bristol-Myers Squibb Company 3-substituted oxindole derivatives as potassium channel modulators
TW457233B (en) * 1996-10-11 2001-10-01 Bristol Myers Squibb Co Preparation of 3-fluoro oxindole derivatives
US7790726B2 (en) * 2005-08-16 2010-09-07 Chemocentryx, Inc. Monocyclic and bicyclic compounds and methods of use
EP2046739B1 (en) * 2006-07-24 2015-08-26 UCB Biopharma SPRL Substituted aniline derivatives

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3573310A (en) * 1967-09-28 1971-03-30 Miles Lab 1-substituted derivatives of 2-indolinone
US3558653A (en) * 1968-05-20 1971-01-26 Searle & Co Dialkylaminoalkyl-indolines
JPS4876863A (enExample) * 1972-01-22 1973-10-16
US3975531A (en) * 1973-10-02 1976-08-17 A. H. Robins Company, Incorporated 4-(5- And 7-)benzoylindolin-2-ones and pharmaceutical uses thereof
US4080330A (en) * 1975-06-23 1978-03-21 Delmar Chemicals Limited Phenylindolines and process for their production
US4110465A (en) * 1977-11-25 1978-08-29 Eli Lilly And Company 7-amino and 7-alkanoylamino 2-oxo-3-phenylindolines

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4624963A (en) * 1984-04-11 1986-11-25 Hoechst Aktiengesellschaft Use of oxindole compounds for the treatment of epilepsy

Also Published As

Publication number Publication date
ATE8387T1 (de) 1984-07-15
JPS57179158A (en) 1982-11-04
IL65466A0 (en) 1982-07-30
KR830010069A (ko) 1983-12-26
ES511097A0 (es) 1983-06-16
DE3260356D1 (en) 1984-08-16
DK162682A (da) 1982-10-10
ZA822427B (en) 1983-02-23
NZ200259A (en) 1985-07-31
NO821158L (no) 1982-10-11
US4542148A (en) 1985-09-17
PT74721A (de) 1982-05-01
FI821218A7 (fi) 1982-10-10
PH19471A (en) 1986-05-14
AU548411B2 (en) 1985-12-12
EP0062887A1 (de) 1982-10-20
US4614739A (en) 1986-09-30
AU8248782A (en) 1983-04-21
ES8307217A1 (es) 1983-06-16
ES8401940A1 (es) 1984-01-01
ES521198A0 (es) 1984-01-01
EP0062887B1 (de) 1984-07-11
HU186053B (en) 1985-05-28
PT74721B (de) 1984-05-30
FI821218L (fi) 1982-10-10
GR75450B (enExample) 1984-07-19
FI821218A0 (fi) 1982-04-06

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Legal Events

Date Code Title Description
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