AU548411B2 - Oxindole derivatives - Google Patents

Oxindole derivatives

Info

Publication number
AU548411B2
AU548411B2 AU82487/82A AU8248782A AU548411B2 AU 548411 B2 AU548411 B2 AU 548411B2 AU 82487/82 A AU82487/82 A AU 82487/82A AU 8248782 A AU8248782 A AU 8248782A AU 548411 B2 AU548411 B2 AU 548411B2
Authority
AU
Australia
Prior art keywords
oxindole derivatives
oxindole
derivatives
neuroanabolic
processes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU82487/82A
Other languages
English (en)
Other versions
AU8248782A (en
Inventor
Hansjorg Kruse
Heinz Kuch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of AU8248782A publication Critical patent/AU8248782A/en
Application granted granted Critical
Publication of AU548411B2 publication Critical patent/AU548411B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Fats And Perfumes (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)
  • Lubricants (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU82487/82A 1981-04-09 1982-04-08 Oxindole derivatives Ceased AU548411B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19813114351 DE3114351A1 (de) 1981-04-09 1981-04-09 "oxindol-derivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel mit neuroanaboler wirkung"
DE31143512 1981-04-09

Publications (2)

Publication Number Publication Date
AU8248782A AU8248782A (en) 1983-04-21
AU548411B2 true AU548411B2 (en) 1985-12-12

Family

ID=6129772

Family Applications (1)

Application Number Title Priority Date Filing Date
AU82487/82A Ceased AU548411B2 (en) 1981-04-09 1982-04-08 Oxindole derivatives

Country Status (18)

Country Link
US (2) US4542148A (enExample)
EP (1) EP0062887B1 (enExample)
JP (1) JPS57179158A (enExample)
KR (1) KR830010069A (enExample)
AT (1) ATE8387T1 (enExample)
AU (1) AU548411B2 (enExample)
DE (2) DE3114351A1 (enExample)
DK (1) DK162682A (enExample)
ES (2) ES8307217A1 (enExample)
FI (1) FI821218L (enExample)
GR (1) GR75450B (enExample)
HU (1) HU186053B (enExample)
IL (1) IL65466A0 (enExample)
NO (1) NO821158L (enExample)
NZ (1) NZ200259A (enExample)
PH (1) PH19471A (enExample)
PT (1) PT74721B (enExample)
ZA (1) ZA822427B (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4619937A (en) * 1984-02-02 1986-10-28 Warner-Lambert Company Saturated bicyclic lactam acids and derivatives as cognition activators
DE3413572A1 (de) * 1984-04-11 1985-10-24 Hoechst Ag, 6230 Frankfurt Oxindol-verbindungen zur behandlung der epilepsie
US4686224A (en) * 1984-10-31 1987-08-11 Pfizer Inc. Oxindole antiinflammatory agents
DE3529994A1 (de) * 1985-08-22 1987-02-26 Hoechst Ag Indolinonderivate, verfahren zu ihrer herstellung, sie enthaltende arzneimittel und deren verwendung
DE69031649T2 (de) * 1989-07-25 1998-02-26 Taiho Pharmaceutical Co Ltd Oxoindolderivate
SE514737C2 (sv) * 1994-03-22 2001-04-09 Sandvik Ab Belagt skärverktyg av hårdmetall
US5565483A (en) * 1995-06-07 1996-10-15 Bristol-Myers Squibb Company 3-substituted oxindole derivatives as potassium channel modulators
TW457233B (en) * 1996-10-11 2001-10-01 Bristol Myers Squibb Co Preparation of 3-fluoro oxindole derivatives
US7790726B2 (en) * 2005-08-16 2010-09-07 Chemocentryx, Inc. Monocyclic and bicyclic compounds and methods of use
EP2046739B1 (en) * 2006-07-24 2015-08-26 UCB Biopharma SPRL Substituted aniline derivatives

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3573310A (en) * 1967-09-28 1971-03-30 Miles Lab 1-substituted derivatives of 2-indolinone
US3558653A (en) * 1968-05-20 1971-01-26 Searle & Co Dialkylaminoalkyl-indolines
JPS4876863A (enExample) * 1972-01-22 1973-10-16
US3975531A (en) * 1973-10-02 1976-08-17 A. H. Robins Company, Incorporated 4-(5- And 7-)benzoylindolin-2-ones and pharmaceutical uses thereof
US4080330A (en) * 1975-06-23 1978-03-21 Delmar Chemicals Limited Phenylindolines and process for their production
US4110465A (en) * 1977-11-25 1978-08-29 Eli Lilly And Company 7-amino and 7-alkanoylamino 2-oxo-3-phenylindolines

Also Published As

Publication number Publication date
ATE8387T1 (de) 1984-07-15
JPS57179158A (en) 1982-11-04
IL65466A0 (en) 1982-07-30
KR830010069A (ko) 1983-12-26
ES511097A0 (es) 1983-06-16
DE3260356D1 (en) 1984-08-16
DK162682A (da) 1982-10-10
ZA822427B (en) 1983-02-23
NZ200259A (en) 1985-07-31
NO821158L (no) 1982-10-11
US4542148A (en) 1985-09-17
PT74721A (de) 1982-05-01
FI821218A7 (fi) 1982-10-10
PH19471A (en) 1986-05-14
EP0062887A1 (de) 1982-10-20
US4614739A (en) 1986-09-30
AU8248782A (en) 1983-04-21
ES8307217A1 (es) 1983-06-16
ES8401940A1 (es) 1984-01-01
ES521198A0 (es) 1984-01-01
EP0062887B1 (de) 1984-07-11
HU186053B (en) 1985-05-28
PT74721B (de) 1984-05-30
DE3114351A1 (de) 1982-11-04
FI821218L (fi) 1982-10-10
GR75450B (enExample) 1984-07-19
FI821218A0 (fi) 1982-04-06

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