DE2963600D1 - Piperazine methane imine derivatives, methods for their preparation and their therapeutical use - Google Patents

Piperazine methane imine derivatives, methods for their preparation and their therapeutical use

Info

Publication number
DE2963600D1
DE2963600D1 DE7979400214T DE2963600T DE2963600D1 DE 2963600 D1 DE2963600 D1 DE 2963600D1 DE 7979400214 T DE7979400214 T DE 7979400214T DE 2963600 T DE2963600 T DE 2963600T DE 2963600 D1 DE2963600 D1 DE 2963600D1
Authority
DE
Germany
Prior art keywords
preparation
methods
imine derivatives
therapeutical use
methane imine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE7979400214T
Other languages
English (en)
Inventor
Jean-Claude Pascal
Henri Pinhas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laroche Navarron SA
Original Assignee
Laroche Navarron SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laroche Navarron SA filed Critical Laroche Navarron SA
Application granted granted Critical
Publication of DE2963600D1 publication Critical patent/DE2963600D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/225—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/195—Radicals derived from nitrogen analogues of carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE7979400214T 1978-04-27 1979-04-03 Piperazine methane imine derivatives, methods for their preparation and their therapeutical use Expired DE2963600D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1674478 1978-04-27

Publications (1)

Publication Number Publication Date
DE2963600D1 true DE2963600D1 (en) 1982-10-28

Family

ID=10082882

Family Applications (1)

Application Number Title Priority Date Filing Date
DE7979400214T Expired DE2963600D1 (en) 1978-04-27 1979-04-03 Piperazine methane imine derivatives, methods for their preparation and their therapeutical use

Country Status (16)

Country Link
US (1) US4259334A (de)
EP (1) EP0005385B1 (de)
JP (1) JPS55370A (de)
AT (1) AT375358B (de)
AU (1) AU521238B2 (de)
CA (1) CA1127156A (de)
CS (1) CS226185B2 (de)
DE (1) DE2963600D1 (de)
ES (2) ES480637A0 (de)
FI (1) FI69841C (de)
HU (1) HU178272B (de)
IE (1) IE47950B1 (de)
NZ (1) NZ190293A (de)
OA (1) OA06247A (de)
PH (1) PH15270A (de)
ZA (1) ZA791944B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4400381A (en) * 1981-07-31 1983-08-23 Laroche-Navarron, S.A. Piperazine derivatives of theophylline
US4374837A (en) * 1981-07-31 1983-02-22 Laroche Navarron, S.A. Piperazine derivatives of theobromine
US4515947A (en) * 1982-08-11 1985-05-07 Eastman Kodak Company Cyanoalkylpiperazines and methods for their preparation and use
US4713382A (en) * 1985-05-30 1987-12-15 Syntex (U.S.A.) Inc. N-phenyl-4-phenyl-1-piperazinecarboxamidines and related compounds as antiarrhythmic agents
EP1216988A4 (de) * 1999-09-28 2005-04-20 Nihon Nohyaku Co Ltd Thioalkylamin-derivate und verfahren zu ihrer herstellung

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1810836A1 (de) * 1967-12-28 1970-01-08 Chinoin Gyogyszer Es Vegyeszet Neue Benzamidinderivate und Verfahren zur Herstellung derselben
US4115569A (en) * 1971-11-19 1978-09-19 Hoechst Aktiengesellschaft Cyclic diamine derivatives
SE397088B (sv) * 1972-06-17 1977-10-17 Sumitomo Chemical Co Forfarande for framstellning av nya 2-propanolderivat
US3793322A (en) * 1972-12-15 1974-02-19 Usv Pharma Corp 1,4-disubstituted piperazines

Also Published As

Publication number Publication date
CA1127156A (en) 1982-07-06
AU4633179A (en) 1979-11-01
JPS55370A (en) 1980-01-05
HU178272B (en) 1982-04-28
ZA791944B (en) 1980-04-30
IE47950B1 (en) 1984-07-25
ES8100282A1 (es) 1980-11-01
ES480637A0 (es) 1980-11-01
AT375358B (de) 1984-07-25
AU521238B2 (en) 1982-03-25
EP0005385A1 (de) 1979-11-14
ES488835A0 (es) 1981-03-16
FI69841B (fi) 1985-12-31
EP0005385B1 (de) 1982-09-01
OA06247A (fr) 1981-06-30
US4259334A (en) 1981-03-31
CS226185B2 (en) 1984-03-19
PH15270A (en) 1982-11-02
FI791350A (fi) 1979-10-28
IE790872L (en) 1978-10-27
FI69841C (fi) 1986-05-26
ES8103740A1 (es) 1981-03-16
ATA291379A (de) 1983-12-15
NZ190293A (en) 1980-11-28

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Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee