DE2814316A1 - CHEWING GUM MASSES AND METHOD FOR THE PRODUCTION THEREOF - Google Patents

Description

The invention relates to chewing gum compositions and a process for their manufacture.

Fluorine is for the internal mineral structure of the teeth in the development stage before eruption of teeth is absolutely necessary, and it is no less necessary to protect the teeth locally, namely from the time the teeth erupted, in that the fluorine strengthens the enamel and opposes it makes it less susceptible to attack by acids that cause tooth decay. The fluorine contributes to the formation of Inhibit or slow down caries-causing acids by acting directly on the bacterial enzymes and on the Microbial body of the dental plaque acts.

35

Currently the cariostatic effect of fluorine,

XI / 17

ÖU9840 / 1122

2874316

- 4 - B 8836

whether this is brought about by ingesting fluorine (internally) or by applying it locally (locally) is proven and recognized to a large extent. This effect takes place in relation to the tooth on a crystal-chemical basis and in relation to saliva and dental plaque by biochemical means.

The fluorine acts on the tooth in the development stage before or after the eruption of the teeth by causing the mineral structure of the tooth a) by forming fluoroapatite and b) by increasing the "crystallinity" of the Calcium phosphates and their precipitation in the most stable form, the form of hydroxyapatite, reinforced.

This effect leads to the tooth enamel as a result a better, mineral structure is more resistant to external agents and less Maintains solubility in the acids that cause tooth decay.

In addition, thanks to its anti-enzymatic properties, the fluorine has the effect of blocking or blocking Reduction of salivary enzymes and consequently an inhibition or limitation of the formation of cariogenic acids, which severely attack the tooth enamel.

The dental plaque or bacterial coating of the tooth (plaque) is the deposit that forms at the base of the tooth crown on the gumline and that builds up despite daily dental care Renewed very quickly between brushing your teeth. This sticky coating is made from modified salivary proteins, which are made insoluble, made up of mucopolysaccharides and countless microbial bodies.

The fluorine accumulates in the dental plaque, whereby it, like

809840/1 122

28U316

- 5 - B 8836

has recently been shown to be 95% in a bound, nonionic form in this coating, especially in an the inside of the microbe bodies bound form, and as a result of this accumulation can its effect in terms of inhibition the enzymes and the prevention of the formation of caries-causing acids develop fully.

Another property of plaque against which the fluorine is effective is the ability of the plaque to penetrate the effect of bacterial enzymes (glucosyltransferases or fructosyltransferases) from sugars that are ingested have been made from glucose or fructose, both as a result of hydrolysis of the glycosidic bond of the Sucrose is formed, which is known to under certain conditions of ingestion (biting and repeated ingestion of sweets, sticky sweets, "bed treats1") the most strongly cariogenic sugar is reserve polysaccharides to synthesize. Glucose becomes dextran and fructose becomes fructosans as polysaccharides educated.

This ability of the enzymes to create reserve sugar, which is then gradually broken down, has the result that locally an acidic milieu is maintained, the prolonged exposure to a progressive dissolution of the mineral Tooth enamel leads to salts (pH <5.5).

In concentrations of 10 ppm or more, the fluorine prevents the synthesis of these polysaccharides.
30th

In addition, the locally applied fluorine stimulates the growth and metabolism of those that lead to acid formation Ifeime of the dental plaque very severely hindered. This effect is known for a long time and is consistent with what has been said above regarding the anti-enzymatic effect of fluorine was mentioned.

809840/1122

28U316

- 6 - B 8836

This bacteriostatic effect makes local fluorine concentrations on the order of 10 ppm to 20 ppm is required.

One can draw the conclusion that the direct and local, biochemical action of fluorine on the saliva and the dental plaque in the stage after the eruption of the teeth by a) its anti-enzymatic and b) its bacteriostatic Properties thanks to its ability to show itself in dental plaque accumulate, which makes the fluorine concentration an effective Can reach order of magnitude, in particular that the fluorine is concentrated in the microbial bodies themselves.

This double property leads to a significant reduction in even to an inhibition of the locally occurring acidity leading to caries formation.

The fluorine can be applied in different ways, namely in the internal way and the local way.

It has been shown that a tablet which is sucked before being swallowed with the same fluorine concentration is much more effective than swallowing the same tablet straight away.

This result is explained by the fact that the fluorine, which in the former case is concentrated in the saliva, thanks to its affinity for the mineral salts of the tooth enamel and for the dental plaque despite the short period Contact time quickly adhere to this and, through a local effect, the tooth faster and better than on the inner one Can protect paths alone.

This mode of administration therefore offers the advantage that the two possibilities of the preventive effect of the

8098 AO / 1122

- 7 - B 8836

Fluorine against caries can be combined with each other, namely the application from the inside and the local application, in the meantime it has been shown that from the stage of eruption of the teeth to the local application of fluorine, if not more important than the usual way.

In connection with the facts described above Considerations have of course been given to the use of a carrier which allows it to be used before Swallowing, maintaining prolonged contact of the active element in the mouth. As it turned out chewing gum, especially for children and adolescents, is the ideal vehicle for this mode of administration of fluorine. Chewing gum actually allows the fluorine to penetrate through the mechanical action of chewing to ease the enamel through direct contact in a simple and pleasant way.

However, chewing gum masses usually contain carbohydrates that are highly cariogenic (such as sucrose and glucose) as basic ingredients, which is in contrast to the task of preventing dental caries by adding fluorine to the chewing gum .

This contradiction led to the idea that a suitable chewing gum races at the same time anticariogenic (through the Fluorine, its active ingredient) and non-cariogenic (in relation to its basic ingredient must be »

It is therefore the object of the invention to a) in a chewing gum to mix in a suitable dose of fluorine as a caries-inhibiting component and b) the cariogenic ones that are commonly used To replace components of a chewing gum with substances, which have the same quality as sweeteners and especially the same sweetening power, but which do not cause tooth decay are.

809 840/1122

28U316

- 8 - B 8836

These sugar substitutes are made up of the three below specified, naturally occurring sweeteners selected:

from xylitol, a pentitol of the formula C ₁ -H ₁₀ O ₁ - (Molecular

b ι λ 5

weight 152.15), which is derived from xylose and in many Fruits, grains and vegetables occur,

the end . L-sorbose, a ketohexose with the formula CgH .. _Og (molecular weight 180), which occurs naturally in occurs in rowan berries, and

from D-sorbitol with the formula C ₆ H ₁₄ O ₆ (molecular weight 182), which occurs naturally in many types of berries.

These sucrose substitutes show against the usual Carbohydrates used for the production of chewing gum have fundamental differences in relation to them biological behavior towards the enzymes in saliva and dental plaque as well as towards those that cause tooth decay Oral microorganisms such as Streptococcus mutans, mitis, salivarius, lactis, sanguis and Actynomyces viscosus etc., which leads to the fact that neither xylitol nor sorbose or sorbitol by these bacterial agents and their enzymes used or fermented.

Knowing these bacterial agents and theirs Enzymes for the formation of dental plaque, for its growth and its metabolic activities, which are based on the biochemical Area responsible for the caries process, especially through the enzymatic breakdown of carbohydrates and reserve carbohydrates that are ingested with food, this breakdown leading to the formation of cariogenic acids which has a high degree of demineralization on the tooth enamel.

809840/1122

28H316

B 8836

rend are absolutely necessary, the obvious interest in a Such a chewing gum formulation consists of xylitol, sorbose or sorbitol instead of the sugar commonly used (Sucrose) and which contains glucose.

The inventive method for producing a chewing gum composition is characterized in that one in the Introduces mass as the sole ingredients with sweetener effect xylitol and L-sorbose or xylitol and D-sorbitol and that one mixing in a compound containing ionized fluorine in the form of a water-soluble fluoride in an appropriate dose, where a rubber is used as the basic component, which is free of any alkaline earth metal, in order to ensure the precipitation of the To prevent fluoride ion in the form of an insoluble and therefore inactive salt. The invention also relates to chewing gum masses produced by this process.

It is clear that any ingredient used in a chewing gum formulation of the present invention is chemical Elements or compounds must be free that are capable of forming insoluble fluorides. The most important Representatives of such elements are the alkaline earths, especially the calcium ion.

For a more detailed explanation of the invention, some of the invention Formulations given as an example:

Chewing gum formulation A. B. C. D. Flavor (sufficient amount) 30th Sodium fluoride (ng) 7.143 10.0 15.80 22.12 Rubber as a base 20.0 30.0 20.0 30.0 component (g) Xylitol (g) 10.0 53.0 68.0 10.0 L-sorbose (g) 68.0 10.0 10.0 53.0 35 Petroleum jelly (g) 0.1 0.5 0.1 0.5 Glycerine (g) 1.0 5.0 1.0 5.0

809840/1122

28H316

- ίο -

B 8836

Formulations A and B correspond to an amount of sodium fluoride of 0.250 mg per chewing gum, i.e. H. an F quantity of 0.113 mg, being a single chewing gum of the formulation A weighs 3.50 g and formulation B chewing gum weighs 2.50 g. The formulations C and D correspond to an amount of sodium fluoride of 0.553 mg per chewing gum, i.e. H. an F ~ amount of 0.250 mg, the individual chewing gum formulation C weighs 3.50 g; and the individual formulation D chewing gum weighs 2.50 g.

Chewing gum formulation 0 E. 0 F. 0 G Sodium fluoride (mg) 0 , 250 0 , 250 1 , 553 Xylitol (g) 1 , 170 0 , 867 0 , 530 Sorbitol (g) , 530 , 833 , 170 Flavored gum as a basic component (ad 2.50 g)

The inventive method for producing the chewing gum mass is explained in more detail below with an example:

In a kneader (Werner type), the non-border by a water bath to a temperature 65 ⁰ C is heated, the previously comminuted rubber as a principal ingredient is under

25 slowly kneading. When the gum has become sufficiently soft and homogeneous, the petroleum jelly and / or the glycerin will become and a portion of the sorbose or sorbitol previously sieved is added. You wait a few minutes for the correct mixing is achieved, then the heating is stopped and the rest of the sorbitol or sorbose and that Xylitol in powder form, also sieved, and the sodium fluoride continuously mixed in.

Then the flavoring is added at the same time as the sufficient amount of sorbose or sorbitol that has been set aside

809840/1 1 22

28U316

- 11 - B 8836

End of operation added. Kneading is continued until complete homogenization is achieved.

The paste is then treated for gum shaping and conditioning.

The chewing gum compositions according to the invention contain xylitol and sorbose or xylitol and sorbitol in an amount which varies between 45% by weight and 90% by weight.
10

The weight ratio of xylitol to sorbose or sorbitol is between 1:10 and 10: 1.

The amount of fluorine contained in a chewing gum ingested whole can vary depending on the total weight of the Chewing gums vary, however, between the fixed limits of 0.250 mg to 0.553 mg of sodium fluoride, which is a content of elemental fluorine corresponds to between 0.113 mg and 0.250 mg per chewing gum. In contrast, the amount of xylitol and Sorbose or xylitol and sorbitol depending on the total weight of the chewing gum and the composition of the basic ingredient vary over a wide range, e.g. B. between 0.250 g and 2.40 g.

80 9 840/1 122

Claims (10)

10 claims 1. Chewing gum mass, characterized in that it is a Contains all alkaline earth free gum as a basic ingredient, a water-soluble fluorine salt and xylitol. 2. chewing gum composition according to claim 1, characterized in that that it contains xylitol mixed with sorbose or sorbitol. 3. Chewing gum composition according to claim 1 or 2, characterized in that it mixes xylitol with sorbose or sorbitol contains, this mixture being present in an amount of 45% by weight to 90% by weight. 4. chewing gum composition according to claim 3, characterized in that it contains xylitol in a weight ratio of 1:10 to 10i1 to contain sorbose or sorbitol. 5. chewing gum composition according to one of the preceding claims, characterized in that it is in the form of a chewing gum for ingestion and in an amount of fluorine from 0.113 mg to 0.250 mg and a mixture of xylitol and Contains sorbose or sorbitol in an amount of 0.250 g to 2.40 g. 6. Chewing gum composition according to claim 5 in the form of a chewing gum ^{XI / 17} 809840/1122 ORIGINAL! WSFECT 28H316 - 2 - B 8836 for ingestion as a whole, characterized in that it contains 0.250 mg of sodium fluoride, 0.867 g of xylitol, 0.833 g of sorbitol and contains an alkaline earth free flavored gum in an amount such that the chewing gum has a total weight of 2.50 g. 7. A method for producing a chewing gum composition according to any one of the preceding claims, characterized in that that in a rubber free of any alkaline earths as a basic component, after slowly kneading at 65 ° C., a water-soluble rubber Fluorine salt, xylitol and L-sorbose or sorbitol mixed in . 8. The method according to claim 7, characterized in that 45 wt .-% to 90 wt .-% of a mixture in the mass Introduces xylitol and sorbose or sorbitol. 9. The method according to claim 7 or 8, characterized in that xylitol in a weight ratio of 1:10 to 10: 1 mixed into sorbose or sorbitol. H U 9 8 A 0/1 1 2 2