DE2606533A1 - Xylitol for treatment of caries and pre-carious conditions - remineralises the tooth substance and reduces carious lesions (BE190876) - Google Patents

Abstract

A therapeutic agent for the treatment of caries and precarious conditions contg. xylite, as active ingredient, and a carrier is new. Xylite used regularly as a therapeutic agent significantly reduces the formation of caries and remineralises the tooth substance. The xylite must be brought into direct contact with the teeth for at least 2 min., pref. at least 5 min., esp. at least 10 min. Suitable product forms are chewing gum, tablets, pastilles, sweets, gumdrops, mouth washes or sprays, toothpaste.

Description

Therapeutic Agent The present invention relates to a therapeutic agent Means intended for the treatment of tooth decay and precarious conditions is.

The term "tooth decay" is, as usual, mostly under Discoloration (brown discoloration) accompanying softening of the tooth enamel and dentin to understand, while under the term "precarious states such states too." understand which, if continued, will eventually turn into tooth decay, such as tooth enamel lesions, Tooth enamel fissures and incipient interproximal caries lesions. The caries formation is accompanied by demineralization of the tooth substance.

The present invention is based on the finding that xylitol, with regular use, a significant effect in terms of a reduction the formation of caries and in particular a remineralization of the tooth substance.

Xylitol was already used as a tooth-friendly or non-cariogenic sugar substitute known in food and beverages. It had been found that neither xylitol promotes the growth of cariogenic bacteria, yet degraded by cariogenic bacteria is and therefore, in contrast to sucrose, gentle on the teeth or non-cariogenic can be viewed.

With this prior art it was surprising to find that Xylitol, if used regularly and as part of a therapy, has a significant impact Effect in terms of a reduction in the formation of caries and, in particular, a remineralization the tooth substance (reversal of caries lesions).

The therapeutic according to the invention, based on the above knowledge Means is intended for the treatment of tooth decay and precarious conditions, whereby one xylitol or a substance containing xylitol regularly and in the sense of a therapy administered into the oral cavity and brought into effective contact with the tooth surfaces.

"Effective contact" here means one to achieve what is desired Effect both long enough in time measured contact, as well as a with regard to to understand its intensity of sufficient contact.

As far as the timing of the contact is concerned, it is necessary to that this contact lasts for a longer period of time, i.e. per administration during at least 2 minutes, preferably for at least 5 minutes, especially during at least 10 minutes.

The intensity of the contact between the xylitol or the xylitol-htien Substance can be reinforced mechanically, u.zw.

depending on the form in which the xylitol is administered, for example by intensive chewing (in the case of chewing gum containing xylitol) or intensive Rinsing (in the case of a mouthwash containing xylitol) or by intensive brushing (in the case of toothpaste containing xylitol).

The xylitol or the xylitol-containing substance is, in the sense of a regular Use, expediently several times, for example about 3 to 10 times, in particular applied about 3-6 times a day. It is particularly useful to use the xylitol or the Substance containing xylitol to be used essentially after every meal, i.e. to administer and bring into effective contact with the tooth surfaces.

Administration can take place in a wide variety of forms, with those forms are preferred which satisfy both in terms of time and duration Ensure the most effective contact possible in terms of intensity. Examples of suitable ones Forms of xylitol-containing substances are chewing gum, sucking tablets, lozenges, candies, Gumdrops or the like, as well as oral and dental care products, e.g. mouthwashes, mouth sprays and toothpastes.

Such a chewing gum can, for example, have the following composition have: 25-30% o gum base 15-20% o gum arabic 50-70 xylitol 0.5-1.5o plasticizer (e.g. glycerine) 0.4-1% edible acid (e.g. citric acid) 0.2-1% flavoring substances.

A lozenge can have the following composition: Xylitol 68.5 mg microcrystalline cellulose 75 mg magnesium stearate 1.5 mg gumdrops can as usual e.g. using gum arabic, gelatin, licorice extract, Glycerin, eucalyptus oil, menthol, peppermint oil, flavorings and a sweetener be prepared, where xylitol is used as a sweetener in an amount of 30% by weight, based on the total gumdrop mass.

A mouthwash can be composed as follows: zinc chloride 2,4 g menthol 0.8 g xylitol 140.0 g formaldehyde solution 0.4 ml clove oil 0.4 ml cint oil 1.6 ml of ethanol 1.6 ml of distilled water to 1000 ml of an oral spray concentrate can have the following composition: xylitol 4.5 g peppermint oil .0.5 g water 5 ml glycerine 10 ml alcohol 100 ml This concentrate is used to make a Sprays using freon in the ratio of 40: 60% (concentrate: freon) As an example of a xylitol-containing toothpaste, a pasta of the following composition the following are mentioned: carboxymethyl cellulose 2% glycerine 20% Xylitol 13 % Dist. Water 30.5% calcium carbonate 5% dicalcium phosphate 25% vaseline oil 1 P TEXAPON (Wetting agent consisting of sodium salts of sulfated CetyT and myristyl alcohol) 1 Flavorings 1% Saccharin 0.025% The lower limit for the one in question Treatment amount of xylitol administered per day is about 3 g.

In the case of treatment with chewing gum, this corresponds to a chewing gum weight of 3g and a xylitol content of 50% in the chewing gum, a daily consumption of 2 pieces of chewing gum. Preferably, however, at least 3, in particular at least 6 pieces of chewing gum, which equates to a daily xylitol dose of 4.5 g or

9 g. The upper limit of the amount of administered daily Xylitol is in those cases where the xylitol does not get into the gastrointestinal tract (mouthwash, Toothpaste) not critical. In those cases where. the xylitol in the gastrointestinal tract reaches (chewing gum, tablets, gumdrops or the like.) The upper limit of the daily administrable dose of xylitol is determined by its tolerability. As stated generally occur with daily doses of about 100 or even 120 g no symptoms of intolerance, while at higher doses in some cases diarrhea can occur.

In a particularly expedient manner, by means of the therapeutic agent achievable effect, namely the treatment of tooth decay and Precarious states with remineralization of the caries lesions thereby achieved will, that you have at least 3, preferably at least 6 pieces of xylitol-containing chewing gum administered daily and the xylitol contained therein by chewing during at least 5 minutes, preferably for at least 10 minutes, in contact with the tooth surfaces brings.

In this case, a chewing gum is advantageously used, which at least Contains 20% by weight, preferably at least 40% by weight, for example about 50% by weight, xylitol.

The inventive therapeutic agents contain xylitol as effective substance. The xylitol content of such preparations can generally be at least a minimum 10% by weight, preferably at least 20% by weight and particularly preferably at least 40 % By weight, for example about 50% by weight.

These preparations can, for example, take the form of chewing gum, lozenges, Pastilles, candies, gumdrops and the like.

or in the form of oral or dental care products, for example Mouthwash, mouth spray, or toothpaste.

The effect that can be achieved according to the invention, namely remineralization of caries lesions, occurs not only when the treatment with the inventive therapeutic agents are carried out with a simultaneous sucrose-free diet, but also with a completely normal diet, i.e. when using sucrose-containing ones Food.

This was found in various large-scale tests.

In one of these experiments 102 people (dental students) divided into 2 groups, which differ in terms of gender, age, body weight, Body size, eating habits, tooth condition at the beginning of the experiment and the like corresponded. These subjects were asked to maintain their previous Eating habits, chewing 4-7 pieces of gum per day, u.zw. evenly Spread over the whole day and preferably one piece at a time immediately afterwards every meal. The chewing time should be 10-20 minutes, each of the pieces of chewing gum weighed 5 g and contained 50% by weight sucrose or xylitol.

One of the two groups received the sucrose gum and the others the xylitol chewing gum.

At the end of the test period, i.e. after one year, the test subjects had of the xylitol group 4.5 chewing gum per day and the subjects of the sucrose group 4.0 chewing gum consumed per day. The frequency of intake of sucrose was for the xylitol group 4.94 and for the sucrose group 4.24 per day.

The test results obtained after 6 months and 1 year are summarized in the following table: Average increase in Number of lesions Sucrose group xylitol group After 6 months 2.34-0.29 After 1 year 3.02-1.04 "Average increase in the number of ions" is to be understood here as the average difference between those cases in which a caries lesion occurs and those cases in which a caries lesion disappears with remineralization of the tooth substance. The above results clearly show that in the sucrose group there was a strong increase in caries, while in the xylitol group there was a significant decrease in the number of caries lesions due to remineralization of the tooth substance.

Claims (8)

Claims 1) Process for the preparation of a for the therapy of tooth decay and precarious states of certain therapeutic agents, characterized in that one mixes xylitol with a carrier material. 2) Method according to claim 1, for the preparation of a therapeutic Means in the form of chewing gum, tablets, lastillen, candies, gumdrops and the like, 3) The method of claim 1 for the manufacture of a therapeutic agent in In the form of a dental care product, for example mouthwash, mouth sprays or toothpaste. 4) Method according to claim 1, 2 or 3, characterized in that one, calculated on the total weight of the therapeutic agent, the xylitol in one Amount of at least 20% by weight, preferably at least 40 total, for example 50 % By weight, used. 0 therapeutic agent for the treatment of tooth decay and precarious conditions, characterized in that it is xylitol as the active substance, in addition to a carrier material contains. 6) Therapeutic agent according to claim 5, characterized in that that it is in the form of a dentifrice, such as a mouthwash, mouth spray or toothpaste is present. 7) Therapeutic agent according to claim 5, characterized in that that it is in the form of chewing gum, tablets, lozenges, candies, gumdrops or the like. 8) Therapeutic agent according to claim 5, 6 or 7, characterized in that that it, calculated on its total weight, is at least 20% by weight, preferably at least Contains 40% by weight, for example 50% by weight, xylitol.