DE2800954A1 - Derivate des meta-trifluoromethylphenylpiperazins und deren verwendung als arzneimittel - Google Patents

Derivate des meta-trifluoromethylphenylpiperazins und deren verwendung als arzneimittel

Info

Publication number
DE2800954A1
DE2800954A1 DE19782800954 DE2800954A DE2800954A1 DE 2800954 A1 DE2800954 A1 DE 2800954A1 DE 19782800954 DE19782800954 DE 19782800954 DE 2800954 A DE2800954 A DE 2800954A DE 2800954 A1 DE2800954 A1 DE 2800954A1
Authority
DE
Germany
Prior art keywords
piperazino
oxo
phenyl
trifluoromethyl
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE19782800954
Other languages
German (de)
English (en)
Inventor
Maurice Joullie
Lucien Dr Med Lakah
Gabriel Dr Maillard
Yves Robert Alain Pascal
Christian Jean Marie Warolin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
METABIO JOULLIE MEUDON FA
Original Assignee
METABIO JOULLIE MEUDON FA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by METABIO JOULLIE MEUDON FA filed Critical METABIO JOULLIE MEUDON FA
Publication of DE2800954A1 publication Critical patent/DE2800954A1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C07D295/116—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings with the doubly bound oxygen or sulfur atoms directly attached to a carbocyclic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE19782800954 1977-01-14 1978-01-11 Derivate des meta-trifluoromethylphenylpiperazins und deren verwendung als arzneimittel Pending DE2800954A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1539/77A GB1560271A (en) 1977-01-14 1977-01-14 Therapeutically useful m-trifluoromethylphenylpiperazine derivatives

Publications (1)

Publication Number Publication Date
DE2800954A1 true DE2800954A1 (de) 1978-07-20

Family

ID=9723745

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19782800954 Pending DE2800954A1 (de) 1977-01-14 1978-01-11 Derivate des meta-trifluoromethylphenylpiperazins und deren verwendung als arzneimittel

Country Status (14)

Country Link
US (1) US4203986A (US06299757-20011009-C00006.png)
JP (1) JPS5439085A (US06299757-20011009-C00006.png)
AU (1) AU512266B2 (US06299757-20011009-C00006.png)
BE (1) BE867030A (US06299757-20011009-C00006.png)
DE (1) DE2800954A1 (US06299757-20011009-C00006.png)
ES (1) ES465939A1 (US06299757-20011009-C00006.png)
FI (1) FI780034A (US06299757-20011009-C00006.png)
FR (1) FR2377392A1 (US06299757-20011009-C00006.png)
GB (1) GB1560271A (US06299757-20011009-C00006.png)
IT (1) IT7823355A0 (US06299757-20011009-C00006.png)
LU (1) LU79968A1 (US06299757-20011009-C00006.png)
NZ (1) NZ186189A (US06299757-20011009-C00006.png)
SE (1) SE7806466L (US06299757-20011009-C00006.png)
ZA (1) ZA78124B (US06299757-20011009-C00006.png)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4518712A (en) * 1980-06-30 1985-05-21 Taiho Pharmaceutical Company Limited Piperazine derivative and analgesic composition containing the same
US4699910A (en) * 1983-02-28 1987-10-13 Boehringer Ingelheim Kg N-(3-trifluoromethyl-phenyl)-N'-propargyl-piperazine and salts thereof useful as analgesics

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI864570A0 (fi) * 1986-11-11 1986-11-11 Farmos Oy Terapeutiskt anvaendbar foerening.
US4882330A (en) * 1986-11-21 1989-11-21 A. H. Robins Company, Incorporated 1-aryloxy-4-[((4-aryl)-1-piperazinyl]-2-butanols useful as antiallergy agents
DK78692D0 (da) * 1992-06-12 1992-06-12 Lundbeck & Co As H Dimere piperidin- og piperazinderivater
WO1999000366A1 (fr) * 1997-06-27 1999-01-07 Nippon Kayaku Kabushiki Kaisha Medicaments pour le traitement/la prevention des mictions frequentes et de l'incontinence urinaire, et derives de tropone
SE9904723D0 (sv) 1999-12-22 1999-12-22 Carlsson A Research Ab New modulators of dopamine neurotransmission II
USRE46117E1 (en) 1999-12-22 2016-08-23 Teva Pharmaceuticals International Gmbh Modulators of dopamine neurotransmission
SE9904724D0 (sv) * 1999-12-22 1999-12-22 Carlsson A Research Ab New modulators of dopamine neurotransmission I
DE10161809A1 (de) * 2001-12-14 2003-06-26 Gruenenthal Gmbh Arzneimittel enthaltend N,N'-disubstituierte Piperazin-Verbindungen
DE10161644A1 (de) * 2001-12-14 2003-06-26 Gruenenthal Gmbh N,N'-disubstituierte Piperazin-Verbindungen
UY28538A1 (es) * 2003-09-26 2005-04-29 Vertex Pharma Derivados de fenil-piperazina como moduladores de receptores muscarínicos
DE602005017784D1 (de) 2004-06-08 2009-12-31 Nsab, Filial Af Neurosearch Sweden Ab Neue disubstituierte phenylpiperidine als modulatoren der dopamin- und serotoninneurotransmission
US7851629B2 (en) 2004-06-08 2010-12-14 Nsab, Filial Af Neurosearch Sweden Ab, Sverige Disubstituted phenylpiperidines as modulators of dopamine and serotonin neurotransmission
DK1773772T3 (da) 2004-06-08 2010-09-13 Nsab Af Neurosearch Sweden Ab Nye disubstituerede phenylpiperidiner/piperaziner som modulatorer af dopaminneurotransmission
HUE029790T2 (hu) 2004-10-13 2017-04-28 Teva Pharmaceuticals Int Gmbh Eljárás 4-(3-metánszulfonil-fenil)-l-N-propil-piperidin elõállítására
SE529246C2 (sv) 2005-10-13 2007-06-12 Neurosearch Sweden Ab Nya disubstituerade fenyl-piperidiner som modulatorer för dopaminneurotransmission
TW201041868A (en) * 2009-03-20 2010-12-01 Intervet Int Bv Anthelmintic agents and their use
BRPI1003506B1 (pt) 2010-09-24 2019-12-03 Ache Int Bvi Ltd composto alquil-piperazino-fenil-4(3h)quinazolinonas e uso do composto alquil-piperazino-fenil-4(3h)quinazolinonas associado aos receptores serotoninérgicos 5-ht1a e 5-ht2a
UY34503A (es) 2011-12-08 2013-07-31 Ivax Int Gmbh ?sal de bromhidrato de pridopidina?

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3163649A (en) * 1964-12-29 Substituteb phenyl-piperazine
US3028390A (en) * 1959-02-04 1962-04-03 Parke Davis & Co Substituted piperazine compounds and process for producing the same
GB948766A (en) * 1959-10-20 1964-02-05 May & Baker Ltd Trifluoromethylphenylpiperazine derivatives
US3253989A (en) * 1963-02-11 1966-05-31 American Cyanamid Co Process for producing anorexia
US3637705A (en) * 1968-10-01 1972-01-25 Abbott Lab N-3 4-dihalo phenyl piperazines
US3770743A (en) * 1971-03-08 1973-11-06 Cutter Lab 1-(1,3-dioxolan-4-yl-alkyl)-piperazines and piperazine alkane diols
FR2201084B1 (US06299757-20011009-C00006.png) * 1972-09-29 1975-10-31 Bouchara Emile
GB1437868A (en) * 1973-05-09 1976-06-03 Synthelabo Arylpiperazinoalkyl esters

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4518712A (en) * 1980-06-30 1985-05-21 Taiho Pharmaceutical Company Limited Piperazine derivative and analgesic composition containing the same
US4699910A (en) * 1983-02-28 1987-10-13 Boehringer Ingelheim Kg N-(3-trifluoromethyl-phenyl)-N'-propargyl-piperazine and salts thereof useful as analgesics

Also Published As

Publication number Publication date
ZA78124B (en) 1978-12-27
GB1560271A (en) 1980-02-06
SE7806466L (sv) 1979-06-22
LU79968A1 (fr) 1979-04-09
AU3229078A (en) 1979-07-19
ES465939A1 (es) 1978-09-16
NZ186189A (en) 1979-06-19
US4203986A (en) 1980-05-20
FI780034A (fi) 1978-07-15
BE867030A (fr) 1978-11-13
IT7823355A0 (it) 1978-05-12
AU512266B2 (en) 1980-10-02
JPS5439085A (en) 1979-03-24
FR2377392B1 (US06299757-20011009-C00006.png) 1980-08-22
FR2377392A1 (fr) 1978-08-11

Similar Documents

Publication Publication Date Title
DE2800954A1 (de) Derivate des meta-trifluoromethylphenylpiperazins und deren verwendung als arzneimittel
DE2635853C2 (de) Pyrrolidin-2-on-Derivate und diese enthaltende Arzneimittel
DE2702119C2 (de) Substituierte Anilinoacetamidoxim-Derivate und diese enthaltende Arzneimittel
DD202715A5 (de) Verfahren zur herstellung von substituierten derivaten des pyridazin
DE2163911B2 (de) 2-Aminomethyl-phenole, Verfahren zur Herstellung derselben und diese enthaltende Arzneimittel
DE1695837B2 (de) Stickstoffheterocyclen enthaltende Di- und Triphenylpropylpiperazine, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
DD213213A5 (de) Verfahren zur herstellung von 4-methyl-6-phenyl-pyridazin-derivaten
CH642966A5 (en) 1-(2-Chlorophenyl)-4-[2-(1,3,4,5-tetrahydro-7,8-dimethoxy-2-benzox epin-1-yl)ethyl]piperazine and pharmacologically acceptable acid addition salts thereof
DE69127285T2 (de) Verwendung von verbindungen zur behandlung von altersbedingtem gedächtnisschwund und anderen kognitiven störungen
CH647515A5 (de) Substituierte s-triazinone bzw. thione.
DE2307536C3 (de) 2-Methylamino-4-(4-methylpiperazino)-5-methylthio-6-chlorpyrünidin, Verfahren zu dessen Herstellung und dieses enthaltende Arzneimittel
DE2137988C3 (de) Norpinanderivate, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel
DE1901519A1 (de) Chinazolinylharnstoffe
DE2719607C2 (US06299757-20011009-C00006.png)
AT343643B (de) Verfahren zur herstellung von neuen naphthylsubstituierten ketonen
DD209457A5 (de) Verfahren zur herstellung von 4-piperazinyl-4-phenyl-chinazolin-derivaten
DE2534963A1 (de) Piperazino-pyrimidine und diese verbindungen enthaltende arzneimittel
DE3611427A1 (de) Bis-tertiaerbutylamino-substituierte 1,3,5-triazinderivate, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und ihre verwendung
DE1518311B1 (de) N-(2-Diaethylaminoaethyl)-2-methoxy-3,4- bzw. 4,5-methylendioxybenzamid und deren pharmakologisch nicht giftige Saeureadditionssalze
DE1695785C3 (de) 2-Aminomethyl-beitzofurane, Verfahren zu deren Herstellung sowie diese Verbindungen enthaltende Präparate
DE2749075C2 (US06299757-20011009-C00006.png)
DE2410982C3 (de) Arzneimitel mit Sedativ- und Tranquilizer-Wirkung
DE1695043C2 (de) Pharmazeutische Zusammensetzungen mit sedativen und tranquillisierenden Eigenschaften
DE2237407A1 (de) Magnesiumsalze, ihre verwendung und verfahren zu ihrer herstellung
DE3239719T1 (de) Uracil-Derivate, Verfahren zu ihrer Herstellung und dieselben enthaltende pharmazeutische Zusammensetzungen

Legal Events

Date Code Title Description
OD Request for examination
OI Miscellaneous see part 1
OI Miscellaneous see part 1
OHN Withdrawal