DE2752140A1 - INSECT DEPENDENT COMPLEX AND ITS APPLICATION - Google Patents

Description

2752ΊΑ0

The invention relates to an insect repellant complex or agent, in particular is used in the form of a Ühampoobehahrung and in particular for the destruction of and to prevent particularly resistant insects such as lice and fleas.

Various components are already known which can destroy this type of insect such as DDT, hexachlorocyclohexane or lindane. However, these products are generally in the form of powders and their increased toxicity makes their use dangerous through direct contact with mammalian skin.

However, pests such as lice and fleas prefer to infect young creatures (children, young dogs, young cats), these creatures being particularly sensitive to toxic substances.

On the other hand, it is known that certain acidic components in the form of liquids such as acetic acid are effective against insects and parasites are active, especially when these products are applied in concentrated solution with a pH close to 2 v / earth.

However, at such pH values, liquid products attack the skin of living beings in a sensitive way, so that one is forced to use them in a dilute solution, thereby reducing their effectiveness is considerably reduced.

The object of the invention is an insect-repellent complex or an insect-repellent agent which has these disadvantages does not have and its effect on the one hand is effective suppression the insects and parasites and, on the other hand, the prevention of their return to the treated areas or parts of the body enables.

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This complex or this agent, which is used in particular in the form of a shampoo treatment, comprises a large proportion of a wetting agent such as sodium, ammonium or triethanolamine lauryl sulfate, and it is characterized in that it contains from 1 to 25 vol. / o contains at least one organic acid with 2 to 8 carbon atoms, so that the pH of the whole is brought to a value below 4.5 and preferably below;), 5.

In particular, the complexes or agents according to the invention can contain 2 to 12% by volume of acetic acid and also 0.5 to 20% by volume and in particular 0.5 to 5 % by volume of insecticides or substances that act as parasite-killing agents derived from natural or synthetic substances, such as the extracts or essences of cloves, lavender, peppermint, marjoram, rosemary, linden blossom, juniper, lemon, lemon herb, thyme, Datura stramonium, Fidte, pyrethrum, pyrethrin and the essential oils from the Bark or leaves of Ceylon cinnamon.

In addition, the complexes according to the invention can advantageously contain an insecticidal or scar-forming substance, such as natural or synthetic camphor, in proportions by volume between 1.5 and 5% and preferably between 0.5 and 1.5 %.

To better show the advantages of the complexes according to the invention and to show the value of their mode of use, the following are examples of formulations which are the main uses of the complexes, examples of treatments carried out are also given.

For each formulation it should be noted that the proportion of Wetting agent or surfactant is essential.

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Indeed, it has surprisingly been found that the insecticidal effect of acetic acid can be considerably increased by adding of wetting agents such as sodium, ammonium or triethanolamine lauryl sulfate, the classic, cationic bases or non-ionic, in the classic way in the field of shampoo treatment products used is increased.

This plague position can be demonstrated with the help of the following test performed with weevils, ants, earwigs, lice and fleas:

The product made in the following examples was diluted to one third of its volume, followed by some Drops placed on each insect held between slats so that nearly three-quarters of the body of the insect was impregnated.

Then the required time was measured, after which the insect stopped moving. These times were compared with the times obtained with the aid of an aqueous acetic acid solution of the same pH value have been achieved.

The results found showed that the times averaged two to five times in the case of the shampoo treatment are less than in the case of pure acetic acid, namely 20 to 50 seconds instead of 1 to 3 minutes.

example 1

Hygienic shampoo, effective against lice in adults and children; the ratios are given in volumes.

- wetting agent (Texapant N 40, Henkel)

diluted to j> 0% 75 to 95 %

- Synthetic camphor 0.5 to 1.5%

- lemon herb 0.5 to 1.5 %

- acetic acid 5 to 10 %

- pH 1.8 to 2.2.

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Case 1 : There were two children aged 11 and 13 years,

whose hair carried a large colony of adult lice and nits, treated with a shampoo containing 1 % synthetic camphor, 1% lemon herb oil, 5% acetic acid and 93 ° / ° wetting agent (Texapant, diluted to 30%) (pH adjusted to 2 , 1) included.

Washing with the help of the shampoo was done at about 9 · ΟΟ in the morning Clock carried out. The shampoo became active for 15 minutes allowed to act, then a washing process was carried out with water.

An examination of the head showed that there was no adult at all Louse was more present and that the proportion of nits was reduced.

A new shampoo treatment was given 2, 4 and then 6 days later carried out, with no adult louse found at all became. The number of nits was in regular decrease.

New wash treatments were performed every week, at the end of 3 weeks the nits had completely disappeared.

Case 2: A young girl of 15 years old was observed to have lice swimming around her while bathing. She was treated with a powder containing 0.5 % lindane every evening, her head covered with a hood every night, and then washed with an ordinary shampoo every morning and combed with a dust comb. After 5 days, nits were still found in the hair.

A single shampoo treatment with the product specified in case 1 was sufficient to rid the hair of all parasites and to end the disgusting and uncomfortable treatment.

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Case 3: A little girl of 5 years had been treated for 3 weeks and Nissen was every evening with a powder based on 0.4 '/ o lindane and DDT 10%. They kept these insecticides in their hair all night under a hood of hair, and in the morning they did an ordinary shampoo wash followed by combing with a dust comb.

This little, blonde girl had particularly fine hair and numerous nits on her hair in extreme cases Manner priced.

A first treatment with the product according to the invention according to case 1 gave only a partial result. It was still necessary carry out two applications of the product in order to achieve a complete removal of the nits.

Example 2

Treatment of fleas, lice and ticks in dogs.

A shampoo was used which contained 6 % acetic acid, 1.5 % lemon herb and 1.5% clove essence as well as 91% wetting agent (Texapant), diluted to 30% (pH adjusted to 2).

A fully grown dachshund infected with fleas was treated .

Washing with a shampoo of the aforementioned animal formulation was carried out in the morning around 8:00 a.m. Against At 12 noon the dog no longer had any fleas and was no longer infested for 3 days despite an unfavorable environment.

A treatment that consisted of atomizing a lotion consisting of a solution of a thyme decoction of 25%, cider vinegar of 73 % and 2% of lemon herb made it possible to prevent any return of parasites until the area was completely disinfected (place and textiles) with the help of products of Example 3.

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Example $

Treatment of places and textiles (fabrics)

A shampoo consisting of 10% acetic acid, 2 % lemon herb essence and 2% camphor (pH adjusted to 1.8) was used.

In one that has not been used for some time and has been badly locked An increase in fleas was found in the room, which contained various objects and textiles.

After rearranging, items and the carpet that covered part of the floor and tiles were shampooed with the had been diluted in two times its volume of water, sprayed. Two hours later, the fleas gave no sign of life more of yourself.

In the same way coats, blankets, and coats have been used with success Baskets for dogs treated by using solutions of 5 cm Shampoo per liter of water have been treated.

In general, the mode of action of the products according to the invention is as follows: there is a shampoo treatment parts to be treated carried out with the aid of the complexes described above, the products are left for a time im generally between 1 to 10 minutes for living beings and between 5 to 20 minutes for objects.

It is rinsed thoroughly, removing the acetic acid or its Equivalents as well as the insects and parasites are carried away.

After washing, it is found that the insect repellant products remain in sufficient quantity to withstand new ones Protect infections.

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However, in many cases it is intended that the treatment be carried out by successive, separate washes up to to continue complete disappearance of larvae, as well as to carry out maintenance treatment, which atomizations or spray treatments of various essences of insecticides or the aforesaid products which act as parasite mifceles with or without camphor, but preferably without acetic acid, i.e. with lemon herb, clove essence, lavender, Peppermint, marjoram, rosemary, linden blossom, juniper, Include lemon, thyme, Datura stramonium, pyrethrum, or Ceylon cinnamon essential oil.

These atomization treatments permanently protect the objects between each Shainpoo treatment.

On the other hand, the insecticidal activity of a shampoo, which compared the in l ^r all the 1 Example 1 used corresponded, as compared to a powder preparation of lindane 15 wt .-% in the following manner:

1. Experiments on adult lice: Put 5 cm of pure shampoo into a beaker, then Five lice (pediculus humanus) are used here. Death occurs instantly. After the result is saved a further experiment was carried out in which the lice were left in the shampoo for only 10 seconds and then they were removed with a thin wooden spatula. They were put under a magnifying glass and it became the Death of the lice found.

In the same way, the experiments were repeated with the shampoo, diluted to 50%, then to 25 % in order to approximate the application concentration, which varied from 25 to 100%.

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Lice death was slower at these two dilutions and the lice removal test showed that the Lice stopped coming to life after 30 seconds.

The same tests were performed on the kind phtirius pubis with the same percentage of mortality of 100% after ^ O seconds. These tests are compiled in the following table in comparison with a lindane preparation as a powder of 15 %.

Table I.

Experiments on adult lice pediculus humanus: PERCENTAGE OF MORTALITY: After 10 see

R.S. 206 in

RS 206 diluted to 50 % RS 206 diluted to 25 % lindane powder, 15%

The same experiment was carried out on adult phtirius pubis lice with the same results.

2. Experiments on nits of pediculus humanus: It was very difficult to prove whether the nits really were killed by the product as it required a 2 to 5 week wait to be certain of their death; the fact of separating the nit from the hair to which it was stuck could be the damaging factor.

The experiment was carried out as follows: 10 hairs with the nits were removed from a child carrying nits and placed in beakers with the products of the experiments or with water for a period of 15 minutes and then stored at a temperature of 22 G.

ch 10 see after 30 seconds after 2 h 100 % 100 % 100 % 20 % 100 / o 100 ίο 0 % 100 % 100 / ό 0 % 0 % 50 %

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Certain nits were removed from the hair in the shampoo, others remained stuck on. The observations were made during Carried out for 5 weeks, the results are summarized in the following table II:

Tabel II 2. 3. 4th 5 Observations of the
the nits: Hatching
1 . week 0 0 0 0 H.S. 206 in 0 0 0 0 0 R.S. 206 diluted to 50 % 0 0 0 0 0 Lindane powder, 15 ° / £ ig 0

The same experiment was carried out on nits from phtirius pubis with the same results.

The product is therefore more active than a 15% lindane formulation.

The 0.4 and 0.8% lindane formulations have a insufficient effect to be used as a comparative product.

Furthermore, the bacteriostatic effect of the products according to the invention was demonstrated, even though they did not contain any commonly used bactericides such as methyl paraoxybenzoate, various tests showing that no bacterium developed in the pure or 50 % diluted product.

The examination to prove that the preparation was free from bacteria was before the interesting results obtained carried out.

The technique used was the following with the shampoo of Example 1:

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Λ) vaccination on normal culture medium,

2) Storage in the incubation oven at ^ 7 ° C for 48 hours then for 7 days.

The results are compiled in the following table III:

Table III

after 48 h after 7 days

pure shampoo O colonies 0 colonies

Shampoo diluted to 50 % 0 colonies 0 colonies

after vaccination with escherichia coli:

pure shampoo O colonies 0 colonies

Shampoo diluted to 50 % 0 colonies 0 colonies

Other applications and variants of the invention are readily possible for the person skilled in the art, in particular by replacing Equivalents for the different products described above, for example by replacing the acetic acid with homologous acids, however, it was found that the obtained Results can be slightly worse, especially with propionic acid and caprylic acid.

Finally, the increased toxicities can vary widely, which takes advantage of acetic acid, synergistically with it a wetting agent, which gives it an increased insecticidal effect, with its toxicity is always kept within limits that are perfectly compatible with their application when in contact with more sensitive ones Epidermes.

In fact, the po toxicity caused by application of the shampoo according to Example 1 in male RIVER mice with an average weight of 25 g was obtained for a maximum tolerated dose of 24 ml / kg and a lethal dose of 100 with a value of 40 ml / kg.

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The results do not allow the determination of the lethal dose 50. In comparison, it should be noted that that the lethal dose 50 for lindane observed in aqueous preparations administered orally in mice is about jjOO mg / kg.

Finally, it enabled the study of local skin tolerance, a local irritation index of 0.3 and thus to establish a low value, with attempts of repeated application to the ear of mice concluded that the shampoo was not irritating and repeated applications on depilated areas of Rabbits showed excellent tolerance.

Only experiments in the area of the eyes suggested that the shampoo had an irritant effect can, but this irritative effect is after a dilution, which corresponds to the application of the product, only very weak.

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Claims (1)

Claims Insect-repelling complex that can be used in the form of a hair wash and contains a wetting agent characterized in that it is 1 to 25% by volume at least one having 2 to 8 carbon atoms, contains organic acid, which brings the pH of the whole to a value below 4.5. 2. An insect repellant complex according to claim 1, characterized characterized in that it contains 2 to 12 vol .-% acetic acid, which increases the pH of the whole a value below 3.5 is brought. 3. insect repellant complex according to any one of claims 1 or 2, characterized in that it 0.5 to 20% by volume of natural or synthetic insecticidal or parasite-killing agents Contains substances of the type belonging to the class DR. C. MANITZ 'DIPL.-INC. M. FINSTERWALD
β MÖNCHEN 11, BOBERT-KOCH-STRASSt I
TEL. IOS9) 23 42 11. TELEX OS-99672 PATMF 809821/1026 DIPL.-INC. W. CR AMK O W 7 STUTTGART SO IBAD CANNSTATTI SEELBEKGSTR. 9S / S5. TEL. 10711) 86 73 61 CENTRAL TICKET OFFICE BAYER. VOLKSBANKEN MÖNCHEN. ACCOUNT NUMBER 7270 POST CHECK; MUNICH 77062-SOS 2 7 b2 14U the extracts or essences of cloves, lavender, peppermint, marjoram, rosemary, lime blossom, Juniper, lemon, lemon herb, thyme, Datura stramonium, spruce, pyrethrum, pyrethrin and the essential ones oil is formed from the bark or leaves of Ceylon cinnamon. Λ-. Complex according to claim 3 »characterized in that it contains 0.5 to 5 vol 1 .- / 6 lemon herb. 5 · Complex according to one of claims 1 to 4, characterized in that it is characterized t that it is a disinfectant and scarring substance of the synthetic or type contains natural camphor in proportions between 0.5 and 5 vol .- / 6. 6. Complex according to claim 5, characterized in that that it contains 0.5 to 1.5 Vo1 .-% camphor. 7- complex according to one of claims 1 to 6, characterized g e that the wetting agent is sodium lauryl sulfate. 8. Use of the complex according to any one of claims 1 to 7 for the removal of lice and flea-type insects by shampooing the infected parts of mammals. 9. Application of the complex according to one of claims 1 to 8 for disinfecting and suppressing insects in places or when treating infected tissues. 10. Complex according to claim ^, characterized in that « that the substances acting as insecticides and as parasitic agents are separated from the shampoo treatment can be used for preventive action against the insects. 809821/1026