DE2745948A1 - Prodrug-verbindungen von steroiden, verfahren zur herstellung derselben und ihre verwendung in arzneimitteln mit anti-inflammatorischer wirkung - Google Patents
Prodrug-verbindungen von steroiden, verfahren zur herstellung derselben und ihre verwendung in arzneimitteln mit anti-inflammatorischer wirkungInfo
- Publication number
- DE2745948A1 DE2745948A1 DE19772745948 DE2745948A DE2745948A1 DE 2745948 A1 DE2745948 A1 DE 2745948A1 DE 19772745948 DE19772745948 DE 19772745948 DE 2745948 A DE2745948 A DE 2745948A DE 2745948 A1 DE2745948 A1 DE 2745948A1
- Authority
- DE
- Germany
- Prior art keywords
- spiro
- group
- thiazolidine
- pregnen
- llß
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
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- 235000002906 tartaric acid Nutrition 0.000 description 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1
- 229960003604 testosterone Drugs 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 150000003548 thiazolidines Chemical class 0.000 description 1
- 125000001984 thiazolidinyl group Chemical group 0.000 description 1
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- 239000001993 wax Substances 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/006—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton spiro-condensed
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/731,373 US4069322A (en) | 1976-10-12 | 1976-10-12 | Pro-drugs for the improved delivery of certain selected anti-inflammatory steroids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2745948A1 true DE2745948A1 (de) | 1978-04-13 |
Family
ID=24939222
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19772745948 Ceased DE2745948A1 (de) | 1976-10-12 | 1977-10-12 | Prodrug-verbindungen von steroiden, verfahren zur herstellung derselben und ihre verwendung in arzneimitteln mit anti-inflammatorischer wirkung |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4069322A (OSRAM) |
| JP (1) | JPS5392753A (OSRAM) |
| AU (1) | AU513155B2 (OSRAM) |
| BE (1) | BE859613A (OSRAM) |
| CA (1) | CA1100482A (OSRAM) |
| DE (1) | DE2745948A1 (OSRAM) |
| FR (1) | FR2367777A1 (OSRAM) |
| GB (1) | GB1589787A (OSRAM) |
| SE (1) | SE433220B (OSRAM) |
| ZA (1) | ZA776014B (OSRAM) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4235887A (en) * | 1977-04-13 | 1980-11-25 | The Upjohn Company | Process for therapeutic treatment |
| US4221787A (en) * | 1978-03-28 | 1980-09-09 | Interx Research Corporation | Esteramide prodrugs of anti-inflammatory corticosteroids |
| US4279900A (en) * | 1978-07-13 | 1981-07-21 | Intrex Research Corporation | Prodrugs for the improved delivery of halogen-containing glucocorticosteroids |
| US4213978A (en) * | 1978-12-05 | 1980-07-22 | Interx Research Corporation | Anti-acne and anti-seborrhea prodrug derivatives of progesterone |
| US4268441A (en) * | 1979-03-13 | 1981-05-19 | Interx Research Corporation | Prodrugs for improved bioavailability of certain Δ4 -3-ketosteroidal sex hormones |
| ATE126695T1 (de) * | 1982-05-18 | 1995-09-15 | Univ Florida | Gehirnspezifische arzneimittelabgabe. |
| WO1984004041A1 (en) * | 1983-04-14 | 1984-10-25 | Univ California | Colon-specific drug delivery system |
| US5886162A (en) * | 1989-11-03 | 1999-03-23 | Research Foundation Of State University Of New York | Lipophilic diakylaminomethylene prodrug derivatives for the inhibition of replication of viruses |
| US5061700A (en) * | 1989-11-16 | 1991-10-29 | Gordon Jay Dow | Glyceryl acetate ointment vehicles |
| CN116023425B (zh) * | 2023-03-28 | 2023-06-20 | 南京师范大学 | 曲安西龙衍生物及其医药用途 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB959377A (en) * | 1959-10-12 | 1964-06-03 | Scherico Ltd | Dioxy steroids and processes for their preparation |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH432513A (de) * | 1961-06-13 | 1967-03-31 | Vismara Francesco Spa | Verfahren zur Herstellung neuer, 1'-substituierter 17a,21-(1'-Alkoxy)-methylendioxysteroide |
| US3119816A (en) * | 1961-12-19 | 1964-01-28 | Shionogi & Co | 2'-substituted thiazolo[5', 4'-16, 17] steroid of androstane series |
| GB1043347A (en) * | 1963-05-10 | 1966-09-21 | Glaxo Lab Ltd | 17,21-orthoesters of steroids |
| IT1056712B (it) * | 1967-04-01 | 1982-02-20 | Vismara F Spa | Derivati steroidali |
-
1976
- 1976-10-12 US US05/731,373 patent/US4069322A/en not_active Expired - Lifetime
-
1977
- 1977-10-07 ZA ZA00776014A patent/ZA776014B/xx unknown
- 1977-10-11 AU AU29572/77A patent/AU513155B2/en not_active Expired
- 1977-10-11 SE SE7711385A patent/SE433220B/xx not_active IP Right Cessation
- 1977-10-11 CA CA288,679A patent/CA1100482A/en not_active Expired
- 1977-10-11 GB GB42298/77A patent/GB1589787A/en not_active Expired
- 1977-10-12 BE BE2056332A patent/BE859613A/xx not_active IP Right Cessation
- 1977-10-12 JP JP12291277A patent/JPS5392753A/ja active Pending
- 1977-10-12 FR FR7730746A patent/FR2367777A1/fr active Granted
- 1977-10-12 DE DE19772745948 patent/DE2745948A1/de not_active Ceased
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB959377A (en) * | 1959-10-12 | 1964-06-03 | Scherico Ltd | Dioxy steroids and processes for their preparation |
Non-Patent Citations (2)
| Title |
|---|
| Antiinflammatory Agents, Vol. 1, S.270, 1974, Acad. Press, New York * |
| J. Am. Chem. Soc., 70, S.3094-3097, 1948 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CA1100482A (en) | 1981-05-05 |
| AU513155B2 (en) | 1980-11-20 |
| JPS5392753A (en) | 1978-08-15 |
| AU2957277A (en) | 1979-04-26 |
| FR2367777B1 (OSRAM) | 1980-10-17 |
| US4069322A (en) | 1978-01-17 |
| ZA776014B (en) | 1978-05-30 |
| FR2367777A1 (fr) | 1978-05-12 |
| GB1589787A (en) | 1981-05-20 |
| SE433220B (sv) | 1984-05-14 |
| SE7711385L (sv) | 1978-04-13 |
| BE859613A (fr) | 1978-02-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8110 | Request for examination paragraph 44 | ||
| 8131 | Rejection |