DE2742509A1 - Piperazinylpyridine, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zubereitungen - Google Patents

Piperazinylpyridine, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zubereitungen

Info

Publication number
DE2742509A1
DE2742509A1 DE19772742509 DE2742509A DE2742509A1 DE 2742509 A1 DE2742509 A1 DE 2742509A1 DE 19772742509 DE19772742509 DE 19772742509 DE 2742509 A DE2742509 A DE 2742509A DE 2742509 A1 DE2742509 A1 DE 2742509A1
Authority
DE
Germany
Prior art keywords
hydrogen
halogen
acid
compound
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19772742509
Other languages
German (de)
English (en)
Inventor
Jun William Carl Lumma
Walfred Spencer Saari
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE2742509A1 publication Critical patent/DE2742509A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
DE19772742509 1976-09-24 1977-09-21 Piperazinylpyridine, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zubereitungen Withdrawn DE2742509A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/726,713 US4078063A (en) 1976-09-24 1976-09-24 Piperazinylpyridines

Publications (1)

Publication Number Publication Date
DE2742509A1 true DE2742509A1 (de) 1978-03-30

Family

ID=24919705

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19772742509 Withdrawn DE2742509A1 (de) 1976-09-24 1977-09-21 Piperazinylpyridine, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zubereitungen

Country Status (8)

Country Link
US (1) US4078063A (enExample)
JP (1) JPS5340784A (enExample)
DE (1) DE2742509A1 (enExample)
DK (1) DK403577A (enExample)
FR (1) FR2365567A1 (enExample)
GB (1) GB1557637A (enExample)
NL (1) NL7709948A (enExample)
SE (1) SE7710145L (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0580465A1 (fr) * 1992-06-25 1994-01-26 Sanofi Nouvelle utilisation thérapeutique d'hétérocyclyl-pipérazines comme 5-HT3 agonistes et nouveaux dérivés

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179563A (en) * 1978-05-19 1979-12-18 Warner-Lambert Company 3-Aryloxy-substituted-aminopyridines and methods for their production
PH18686A (en) * 1981-05-26 1985-08-29 Merck & Co Inc 1-(3 halo-2-pyridinyl) piperazine
US4456604A (en) * 1981-05-26 1984-06-26 Merck & Co., Inc. 1-(3-Halo-2-pyridinyl) piperazine
US4442103A (en) * 1981-05-26 1984-04-10 Merck & Co., Inc. Treating sedation with 1-(3-substituted-2-pyridinyl) piperazines
US4381302A (en) * 1981-05-26 1983-04-26 Merck & Co., Inc. (6aα,10aα,11aα)-2-(2-Pyridinyl)-1,3,4,6,6a,7,8,9,10,10a,11,11a-dodecahydro-2H-pyrazino]1,2-b]isoquinoline and derivatives
US4367335A (en) * 1981-08-03 1983-01-04 Mead Johnson & Company Thiazolidinylalkylene piperazine derivatives
US4376772A (en) * 1981-12-09 1983-03-15 Merck & Co., Inc. Use of piperazinyl-imidazo[1,2-a]pyrazines in sedation
US4506074A (en) * 1982-11-08 1985-03-19 Merck & Co., Inc. 2-[2-Pyridinyloxy(thio or amino)methyl]-1H-imidazoles and derivatives
US4505918A (en) * 1982-11-08 1985-03-19 Merck & Co., Inc. 4-[2-Pyridinylthio(oxy or amino)methyl]-1H-imidazoles and derivatives
JPS59146772A (ja) * 1983-02-09 1984-08-22 凸版印刷株式会社 搬送用ロボツト
JPS60146692A (ja) * 1983-12-29 1985-08-02 凸版印刷株式会社 搬送用ロボツト
FR2573075B1 (fr) * 1984-09-14 1987-03-20 Innothera Lab Sa Nouvelles (pyridyl-2)-1 piperazines, leur procede de preparation et leur application en therapeutique
JPH0665203A (ja) * 1992-06-25 1994-03-08 Elf Sanofi ピペラジンのヘテロ環誘導体
SE0004245D0 (sv) * 2000-11-20 2000-11-20 Pharmacia Ab Novel compounds and their use
SE0201544D0 (sv) * 2002-05-17 2002-05-17 Biovitrum Ab Novel compounds and thier use
US20050245533A1 (en) * 2004-04-29 2005-11-03 Hoff Ethan D Inhibitors of the 11-beta-hydroxysteroid dehydrogenaseType 1 enzyme and their therapeutic application
WO2015078799A1 (en) * 2013-11-27 2015-06-04 Bayer Pharma Aktiengesellschaft Glucose transport inhibitors

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2636032A (en) * 1949-04-12 1953-04-21 Abbott Lab N, n'-disubstituted piperazines and process of preparing same
US3306903A (en) * 1965-10-07 1967-02-28 Council Scient Ind Res 1-aminopyridyl-4-(phenyl or pyridyl)-piperazines and intermediates
CH493558A (de) * 1968-02-21 1970-07-15 Geigy Ag J R Verfahren zur Herstellung von neuen Imidazolidinonderivaten
US3862157A (en) * 1969-10-02 1975-01-21 Therachemie Chem Therapeut 2-(dialkylamino, pyrrolidino or piperidino)-3-amino-5-nitro pyridines
US3980652A (en) * 1970-11-11 1976-09-14 A. Christiaens Societe Anonyme 2-(4-Methyl-piperazino)-3 or 5 cyano pyridine
GB1368948A (en) * 1970-11-11 1974-10-02 Manuf Prod Pharma Pyridine derivatives
GB1391007A (en) * 1971-06-17 1975-04-16 Ciba Geigy Ag Imidazolidinone derivatives and processes for the production thereof
DE2230392A1 (de) * 1972-06-22 1974-01-31 Cassella Farbwerke Mainkur Ag Substituierte pyridinverbindungen und verfahren zu ihrer herstellung
US3798324A (en) * 1972-12-21 1974-03-19 Miles Lab Method for controlling tremor symptomatic of parkinsonism utilizing 1-(2-pyridyl)piperazine
US3773951A (en) * 1972-12-21 1973-11-20 Miles Lab Method of treating depression with 1-(2-pyridyl)piperazine

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0580465A1 (fr) * 1992-06-25 1994-01-26 Sanofi Nouvelle utilisation thérapeutique d'hétérocyclyl-pipérazines comme 5-HT3 agonistes et nouveaux dérivés

Also Published As

Publication number Publication date
FR2365567A1 (fr) 1978-04-21
SE7710145L (sv) 1978-03-25
NL7709948A (nl) 1978-03-29
JPS5340784A (en) 1978-04-13
FR2365567B1 (enExample) 1980-06-13
GB1557637A (en) 1979-12-12
US4078063A (en) 1978-03-07
DK403577A (da) 1978-03-25

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Legal Events

Date Code Title Description
8139 Disposal/non-payment of the annual fee