DE2705454A1 - Derivate von aryl-1(1h)chinazolon-4, verfahren zur herstellung dieser derivate, diese derivate enthaltende pharmazeutische zubereitungen sowie verwendung dieser derivate - Google Patents
Derivate von aryl-1(1h)chinazolon-4, verfahren zur herstellung dieser derivate, diese derivate enthaltende pharmazeutische zubereitungen sowie verwendung dieser derivateInfo
- Publication number
- DE2705454A1 DE2705454A1 DE19772705454 DE2705454A DE2705454A1 DE 2705454 A1 DE2705454 A1 DE 2705454A1 DE 19772705454 DE19772705454 DE 19772705454 DE 2705454 A DE2705454 A DE 2705454A DE 2705454 A1 DE2705454 A1 DE 2705454A1
- Authority
- DE
- Germany
- Prior art keywords
- deep
- derivatives
- general formula
- quinazolone
- radical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- 239000000203 mixture Substances 0.000 claims description 31
- 150000001875 compounds Chemical class 0.000 claims description 19
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 claims description 12
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 12
- XHXFXVLFKHQFAL-UHFFFAOYSA-N phosphoryl trichloride Chemical compound ClP(Cl)(Cl)=O XHXFXVLFKHQFAL-UHFFFAOYSA-N 0.000 claims description 12
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 11
- -1 alkyl radical Chemical class 0.000 claims description 10
- 229910052739 hydrogen Inorganic materials 0.000 claims description 10
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- 238000002360 preparation method Methods 0.000 claims description 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 6
- 238000006243 chemical reaction Methods 0.000 claims description 6
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims description 6
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- 229910052731 fluorine Inorganic materials 0.000 claims description 4
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- BLNWTAHYTCHDJH-UHFFFAOYSA-O hydroxy(oxo)azanium Chemical compound O[NH+]=O BLNWTAHYTCHDJH-UHFFFAOYSA-O 0.000 claims description 4
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LU74369A LU74369A1 (enrdf_load_stackoverflow) | 1976-02-18 | 1976-02-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2705454A1 true DE2705454A1 (de) | 1977-08-25 |
Family
ID=19728157
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19772705454 Pending DE2705454A1 (de) | 1976-02-18 | 1977-02-10 | Derivate von aryl-1(1h)chinazolon-4, verfahren zur herstellung dieser derivate, diese derivate enthaltende pharmazeutische zubereitungen sowie verwendung dieser derivate |
Country Status (5)
| Country | Link |
|---|---|
| BE (1) | BE850979A (enrdf_load_stackoverflow) |
| DE (1) | DE2705454A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2348921A1 (enrdf_load_stackoverflow) |
| LU (1) | LU74369A1 (enrdf_load_stackoverflow) |
| NL (1) | NL7701655A (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015534959A (ja) * | 2012-10-19 | 2015-12-07 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | Ｓｙｋの阻害剤 |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2539476C (en) * | 2003-09-23 | 2011-04-19 | Merck & Co., Inc. | Quinazoline potassium channel inhibitors |
-
1976
- 1976-02-18 LU LU74369A patent/LU74369A1/xx unknown
-
1977
- 1977-02-01 BE BE174568A patent/BE850979A/xx unknown
- 1977-02-10 DE DE19772705454 patent/DE2705454A1/de active Pending
- 1977-02-16 NL NL7701655A patent/NL7701655A/xx not_active Application Discontinuation
- 1977-02-18 FR FR7704791A patent/FR2348921A1/fr not_active Withdrawn
Non-Patent Citations (7)
| Title |
|---|
| A. Chatterjee in "J. Indian Chem. Soc."46, 1969, 103/104 |
| P.F. JUBY in "J. Med. Chem." 11 (1968) 111, H.M. Blatter et al in "J. Org. Chem." 30 (1965) 1020, A. Chatterjee et al in "J. Ind. Chem." 46 (1969) 103 und J.P. Osselaere |
| Robert und Nezamis in "Proc. Soc. Exp. Biol. Med.", 99 (1958) 443 |
| S. Somasekhara et al in "Current Sciences" 33, 1964, 52 |
| Siegmund, Cadmus und Lu in "Proc. Soc. Exp. Biol. Med.", 95 (1957) 729 |
| W.J. Irwin in "J. Chem. Soc. Perkin Trans." 1, 1972, 353 |
| Winter, Risley und Nuss in "Proc. Soc. exp. Biol. Med.", 111, 1962, 544 |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015534959A (ja) * | 2012-10-19 | 2015-12-07 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | Ｓｙｋの阻害剤 |
| US10112928B2 (en) | 2012-10-19 | 2018-10-30 | Hoffmann-La Roche Inc. | Inhibitors of SYK |
Also Published As
| Publication number | Publication date |
|---|---|
| NL7701655A (nl) | 1977-08-22 |
| FR2348921A1 (fr) | 1977-11-18 |
| LU74369A1 (enrdf_load_stackoverflow) | 1977-09-12 |
| BE850979A (fr) | 1977-08-01 |
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