DE2656746C2 - Verwendung von beladenen Erythrozyten - Google Patents

Verwendung von beladenen Erythrozyten

Info

Publication number
DE2656746C2
DE2656746C2 DE2656746A DE2656746A DE2656746C2 DE 2656746 C2 DE2656746 C2 DE 2656746C2 DE 2656746 A DE2656746 A DE 2656746A DE 2656746 A DE2656746 A DE 2656746A DE 2656746 C2 DE2656746 C2 DE 2656746C2
Authority
DE
Germany
Prior art keywords
cells
loaded
substances
solution
methotrexate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2656746A
Other languages
German (de)
English (en)
Other versions
DE2656746A1 (de
Inventor
Karin 5100 Aachen Bock
Hermann Josef 5170 Jülich Buers
Günter Dr. 5170 Jülich Pilwat
Ulrich Prof. Dr. Zimmermann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Forschungszentrum Juelich GmbH
Original Assignee
Kernforschungsanlage Juelich GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kernforschungsanlage Juelich GmbH filed Critical Kernforschungsanlage Juelich GmbH
Priority to DE2656746A priority Critical patent/DE2656746C2/de
Priority to CH1378877A priority patent/CH632928A5/de
Priority to SE7713946A priority patent/SE445296B/sv
Priority to IL53596A priority patent/IL53596A/xx
Priority to US05/860,570 priority patent/US4289756A/en
Priority to FR7737673A priority patent/FR2374045A1/fr
Priority to JP14998577A priority patent/JPS5375385A/ja
Priority to GB52188/77A priority patent/GB1557649A/en
Publication of DE2656746A1 publication Critical patent/DE2656746A1/de
Application granted granted Critical
Publication of DE2656746C2 publication Critical patent/DE2656746C2/de
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals
    • A61K9/5068—Cell membranes or bacterial membranes enclosing drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/18—Erythrocytes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/101666—Particle count or volume standard or control [e.g., platelet count standards, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/107497—Preparation composition [e.g., lysing or precipitation, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/108331—Preservative, buffer, anticoagulant or diluent

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Botany (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE2656746A 1976-12-15 1976-12-15 Verwendung von beladenen Erythrozyten Expired DE2656746C2 (de)

Priority Applications (8)

Application Number Priority Date Filing Date Title
DE2656746A DE2656746C2 (de) 1976-12-15 1976-12-15 Verwendung von beladenen Erythrozyten
CH1378877A CH632928A5 (de) 1976-12-15 1977-11-11 Verfahren zur herstellung einer masse von in einer physiologischen loesung suspendierten beladenen zellen.
SE7713946A SE445296B (sv) 1976-12-15 1977-12-08 Sett att i en fysiologisk losning framstella en suspension av med metotrexat belastade blodceller
IL53596A IL53596A (en) 1976-12-15 1977-12-13 Biological cells externally modified for controlled release,in the spleen and/or liver,of pharmaceutically active substances comprised therein,their preparation and pharmaceutical compositions containing them
US05/860,570 US4289756A (en) 1976-12-15 1977-12-14 Physiological preparation containing loaded cells of expanded volume in suspension, for preferential accumulation in spleen and liver
FR7737673A FR2374045A1 (fr) 1976-12-15 1977-12-14 Procede pour la preparation d'une masse de cellules chargees en suspension dans une solution physiologique
JP14998577A JPS5375385A (en) 1976-12-15 1977-12-15 Production of assembled substance of load cell suspended in phisiological solution
GB52188/77A GB1557649A (en) 1976-12-15 1977-12-15 Loaded cells

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2656746A DE2656746C2 (de) 1976-12-15 1976-12-15 Verwendung von beladenen Erythrozyten

Publications (2)

Publication Number Publication Date
DE2656746A1 DE2656746A1 (de) 1978-06-29
DE2656746C2 true DE2656746C2 (de) 1986-06-26

Family

ID=5995573

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2656746A Expired DE2656746C2 (de) 1976-12-15 1976-12-15 Verwendung von beladenen Erythrozyten

Country Status (8)

Country Link
US (1) US4289756A (en:Method)
JP (1) JPS5375385A (en:Method)
CH (1) CH632928A5 (en:Method)
DE (1) DE2656746C2 (en:Method)
FR (1) FR2374045A1 (en:Method)
GB (1) GB1557649A (en:Method)
IL (1) IL53596A (en:Method)
SE (1) SE445296B (en:Method)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2655801C2 (de) * 1976-12-09 1986-06-26 Kernforschungsanlage Jülich GmbH, 5170 Jülich Injizierbare Suspension von Membranvesikeln aus Erythrozyten und Verfahren zur Herstellung der Suspension
US4403038A (en) * 1979-04-11 1983-09-06 Toshio Asakura Buffered serum substitute for blood oxygen analyzer
US4358394A (en) * 1979-05-07 1982-11-09 Coulter Electronics, Inc. Process for preparing whole blood reference controls having long term stability
US4489162A (en) * 1981-12-21 1984-12-18 American Hospital Supply Corporation Fresh blood (unfixed) hematology control
FR2529463B1 (fr) * 1982-07-05 1986-01-10 Centre Nat Rech Scient Procede et dispositif pour l'encapsulation dans les erythrocytes d'au moins une substance a activite biologique, notamment des effecteurs allosteriques de l'hemoglobine et erythrocytes ainsi obtenus
US4478824A (en) * 1983-08-08 1984-10-23 Franco Robert S Method for altering red blood cell function and survival
EP0266418A4 (en) * 1986-05-09 1989-02-13 Electropore Inc DEVICE AND METHOD FOR FORMING PORES IN VESICLES, AND METHOD FOR CHARGING AND MELTING.
US4906576A (en) * 1986-05-09 1990-03-06 Electropore, Inc. High speed, high power apparatus for vesicle prealignment, poration, loading and fusion in uniform electric fields and method therefor
US4923814A (en) * 1986-05-09 1990-05-08 Electropore, Inc. High speed, high power apparatus for vesicle prealignment, poration, loading and fusion in uniform electric fields and method therefor
US4931276A (en) * 1987-10-30 1990-06-05 Franco Robert S Method for introducing desired agents into red blood cells
CA1327174C (en) * 1988-10-05 1994-02-22 Youssef Mouneimne Electro-insertion of proteins into animal cell membranes
US5236835A (en) * 1988-10-05 1993-08-17 Hapgood, C.V. Electro insertion of proteins into red cell membranes
US5443813A (en) * 1991-06-06 1995-08-22 Associated Universities, Inc. Loading and conjugating cavity biostructures
US5173158A (en) * 1991-07-22 1992-12-22 Schmukler Robert E Apparatus and methods for electroporation and electrofusion
WO1993018397A1 (en) * 1992-03-02 1993-09-16 Streck Laboratories, Inc. Reference control for use with manual and flow cytometric reticulocyte counting devices
EP0882448B1 (en) * 1997-05-05 2005-01-12 DIDECO S.r.l. Method of encapsulating biologically active agents within erythrocytes and apparatus therefor
EP1663158A2 (en) * 2003-06-24 2006-06-07 Baxter International Inc. Specific delivery of drugs to the brain
US8986736B2 (en) * 2003-06-24 2015-03-24 Baxter International Inc. Method for delivering particulate drugs to tissues
CA2554246A1 (en) * 2004-01-29 2005-08-11 Baxter International Inc. Nanosuspensions of anti-retroviral agents for increased central nervous system delivery
KR20070037444A (ko) * 2004-06-15 2007-04-04 백스터 인터내셔널 인코포레이티드 고체 미립자성 치료제의 생체외 적용방법
DE102004054536A1 (de) * 2004-11-06 2006-05-11 Capsulution Nanoscience Ag Multimodal veränderte Zellen als zellulare Darreichungsformen für aktive Substanzen und als diagnostische Zellpartikel
BRPI0909780B1 (pt) 2008-03-05 2022-05-03 Baxter International Inc Suspensão contendo uma partícula com superfície modificada, composição farmacêutica compreendendo a referida suspensão, método para aprimorar a absorção celular de um agente ativo, uso de partículas com superfície modificada, e método de preparação de uma partícula com superfície modificada
US10952965B2 (en) * 2009-05-15 2021-03-23 Baxter International Inc. Compositions and methods for drug delivery

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3887698A (en) * 1973-03-12 1975-06-03 Univ Leland Stanford Junior Sacs with epitopic sites on walls enclosing stable free radicals
DE2326224C3 (de) 1973-05-23 1975-11-13 Kernforschungsanlage Juelich Gmbh, 5170 Juelich Verfahren zum Abtrenne», von durch chemische oder physikalisch^ Eigenschaften ausgezeichneten ionisierten Stoffen aus einer wäßrigen Lösung
DE2326191B2 (de) 1973-05-23 1978-03-30 Hutschenreuther Ag, 8672 Selb Verfahren zum Herstellen eines Reliefdekors auf keramischen Erzeugnissen
DE2326161C2 (de) * 1973-05-23 1986-07-17 Kernforschungsanlage Jülich GmbH, 5170 Jülich Verfahren zum Aufbau oder zum Abbau von durch chemische Eigenschaften ausgezeichneten, in einer wäßrigen Lösung enthaltenen Stoffen
GB1481480A (en) * 1974-02-02 1977-07-27 Kernforschungsanlage Juelich Process and apparatus for increasing the permeability of the membrane of cells of organisms
DE2655801C2 (de) * 1976-12-09 1986-06-26 Kernforschungsanlage Jülich GmbH, 5170 Jülich Injizierbare Suspension von Membranvesikeln aus Erythrozyten und Verfahren zur Herstellung der Suspension

Also Published As

Publication number Publication date
US4289756A (en) 1981-09-15
SE445296B (sv) 1986-06-16
JPS5375385A (en) 1978-07-04
FR2374045B1 (en:Method) 1981-06-26
FR2374045A1 (fr) 1978-07-13
IL53596A (en) 1981-06-29
GB1557649A (en) 1979-12-12
IL53596A0 (en) 1978-03-10
SE7713946L (sv) 1978-06-16
CH632928A5 (de) 1982-11-15
DE2656746A1 (de) 1978-06-29

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Legal Events

Date Code Title Description
OAP Request for examination filed
OD Request for examination
D2 Grant after examination
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee