DE2522090A1 - Pyrimidinol-verbindungen und verfahren zu ihrer herstellung - Google Patents
Pyrimidinol-verbindungen und verfahren zu ihrer herstellungInfo
- Publication number
- DE2522090A1 DE2522090A1 DE19752522090 DE2522090A DE2522090A1 DE 2522090 A1 DE2522090 A1 DE 2522090A1 DE 19752522090 DE19752522090 DE 19752522090 DE 2522090 A DE2522090 A DE 2522090A DE 2522090 A1 DE2522090 A1 DE 2522090A1
- Authority
- DE
- Germany
- Prior art keywords
- pyrimidinol
- amino
- ethyl
- iodo
- acid addition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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- 229910052794 bromium Inorganic materials 0.000 claims description 8
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 8
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- 125000001246 bromo group Chemical group Br* 0.000 claims description 6
- 229910052740 iodine Chemical group 0.000 claims description 6
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 4
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- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 3
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- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229940068968 polysorbate 80 Drugs 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 239000001294 propane Substances 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 239000011253 protective coating Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 239000004208 shellac Substances 0.000 description 1
- 229940113147 shellac Drugs 0.000 description 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
- 235000013874 shellac Nutrition 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 238000011146 sterile filtration Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 206010044325 trachoma Diseases 0.000 description 1
- 238000009827 uniform distribution Methods 0.000 description 1
- 239000010913 used oil Substances 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
- 235000021419 vinegar Nutrition 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 235000012431 wafers Nutrition 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000010497 wheat germ oil Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/473,013 US3956302A (en) | 1974-05-24 | 1974-05-24 | Substituted pyrimidines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2522090A1 true DE2522090A1 (de) | 1975-12-04 |
Family
ID=23877827
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19752522090 Withdrawn DE2522090A1 (de) | 1974-05-24 | 1975-05-17 | Pyrimidinol-verbindungen und verfahren zu ihrer herstellung |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US3956302A (en, 2012) |
| JP (1) | JPS511484A (en, 2012) |
| BE (1) | BE829417A (en, 2012) |
| CA (1) | CA1031777A (en, 2012) |
| CH (1) | CH610309A5 (en, 2012) |
| DE (1) | DE2522090A1 (en, 2012) |
| FR (1) | FR2271825B1 (en, 2012) |
| NL (1) | NL7505879A (en, 2012) |
| ZA (1) | ZA752761B (en, 2012) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2409980A1 (en) | 2005-04-14 | 2012-01-25 | Applied Biosystems, LLC | 3'modified oligonucleotides containing pseudoisocytosine nucleobase derivatives and applications thereof as primers or probes |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5434157A (en) * | 1979-03-19 | 1995-07-18 | The Upjohn Company | 6-aryl pyrimidine compounds and method for treating viral infections and inducing interferon production |
| US4507302A (en) * | 1979-03-19 | 1985-03-26 | The Upjohn Company | Method for treating arthritis with 6-aryl pyrimidine compounds |
| US5002951A (en) * | 1979-03-19 | 1991-03-26 | The Upjohn Company | Method for treating bacterial and protozoal infections |
| US5554617A (en) * | 1979-09-28 | 1996-09-10 | The Upjohn Company | Method for treating cancer with 6-aryl pyrimidine compounds |
| US4308272A (en) * | 1980-10-03 | 1981-12-29 | The Upjohn Company | Process for treating hypertension |
| US4460589A (en) * | 1980-10-03 | 1984-07-17 | The Upjohn Company | Process for treating hypertension |
| US4593096A (en) * | 1982-06-09 | 1986-06-03 | The Upjohn Company | Novel compounds and process for treating hypertension |
| EP0111440A1 (en) * | 1982-10-15 | 1984-06-20 | Ciba-Geigy Ag | 2-Aminopyrimidines, their production and use |
| IT1305313B1 (it) * | 1998-07-17 | 2001-05-04 | Colla Paolo | 3,4 - diidro- 6- benzil-4-oxopirimidine sostituite e relativo processodi produzione e impiego nella terapia delle infezioni da hiv-1. |
| WO2002040021A2 (en) | 2000-11-17 | 2002-05-23 | Idenix (Cayman) Limited | Methods for inhibiting the transmission of hiv using topically applied substituted 6-benzyl-4-oxopyrimidines |
| CN114644594B (zh) * | 2022-03-24 | 2024-06-11 | 郑州猫眼农业科技有限公司 | 5-溴-2-氯嘧啶的制备方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3554784A (en) | 1967-06-05 | 1971-01-12 | Procter & Gamble | Softening of textile materials |
-
1974
- 1974-05-24 US US05/473,013 patent/US3956302A/en not_active Expired - Lifetime
-
1975
- 1975-04-24 CA CA225,370A patent/CA1031777A/en not_active Expired
- 1975-04-29 ZA ZA00752761A patent/ZA752761B/xx unknown
- 1975-04-29 CH CH547075A patent/CH610309A5/xx not_active IP Right Cessation
- 1975-05-17 DE DE19752522090 patent/DE2522090A1/de not_active Withdrawn
- 1975-05-20 NL NL7505879A patent/NL7505879A/xx not_active Application Discontinuation
- 1975-05-23 JP JP50061804A patent/JPS511484A/ja active Pending
- 1975-05-23 FR FR7516235A patent/FR2271825B1/fr not_active Expired
- 1975-05-23 BE BE156645A patent/BE829417A/xx unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2409980A1 (en) | 2005-04-14 | 2012-01-25 | Applied Biosystems, LLC | 3'modified oligonucleotides containing pseudoisocytosine nucleobase derivatives and applications thereof as primers or probes |
Also Published As
| Publication number | Publication date |
|---|---|
| ZA752761B (en) | 1976-04-28 |
| FR2271825B1 (en, 2012) | 1981-12-04 |
| NL7505879A (nl) | 1975-11-26 |
| FR2271825A1 (en, 2012) | 1975-12-19 |
| CH610309A5 (en, 2012) | 1979-04-12 |
| US3956302A (en) | 1976-05-11 |
| JPS511484A (en, 2012) | 1976-01-08 |
| BE829417A (fr) | 1975-11-24 |
| CA1031777A (en) | 1978-05-23 |
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Legal Events
| Date | Code | Title | Description |
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| 8130 | Withdrawal |