DE2365720A1 - Cyclische phosphorsaeureester von 1,n hoch 6-aethenoadenosinen - Google Patents

Cyclische phosphorsaeureester von 1,n hoch 6-aethenoadenosinen

Info

Publication number
DE2365720A1
DE2365720A1 DE2365720*A DE2365720A DE2365720A1 DE 2365720 A1 DE2365720 A1 DE 2365720A1 DE 2365720 A DE2365720 A DE 2365720A DE 2365720 A1 DE2365720 A1 DE 2365720A1
Authority
DE
Germany
Prior art keywords
cyclic
phosphoric acid
hydrogen
acid ester
deoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE2365720*A
Other languages
German (de)
English (en)
Inventor
Tsuyoshi Kawanabe
Minoru Machida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Publication of DE2365720A1 publication Critical patent/DE2365720A1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/02—Saturated compounds having —CHO groups bound to acyclic carbon atoms or to hydrogen
    • C07C47/14—Saturated compounds having —CHO groups bound to acyclic carbon atoms or to hydrogen containing halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE2365720*A 1972-10-10 1973-10-09 Cyclische phosphorsaeureester von 1,n hoch 6-aethenoadenosinen Pending DE2365720A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29588972A 1972-10-10 1972-10-10
US378220A US3872098A (en) 1972-10-10 1973-07-11 1,n{hu 6{b ethenoadenosine cyclophosphate compounds

Publications (1)

Publication Number Publication Date
DE2365720A1 true DE2365720A1 (de) 1976-01-15

Family

ID=26969389

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19732350608 Pending DE2350608A1 (de) 1972-10-10 1973-10-09 Cyclische phosphorsaeureester von l,n hoch 6-aethenoadenosinen
DE2365720*A Pending DE2365720A1 (de) 1972-10-10 1973-10-09 Cyclische phosphorsaeureester von 1,n hoch 6-aethenoadenosinen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE19732350608 Pending DE2350608A1 (de) 1972-10-10 1973-10-09 Cyclische phosphorsaeureester von l,n hoch 6-aethenoadenosinen

Country Status (5)

Country Link
US (1) US3872098A (cg-RX-API-DMAC10.html)
JP (1) JPS4986398A (cg-RX-API-DMAC10.html)
DE (2) DE2350608A1 (cg-RX-API-DMAC10.html)
FR (1) FR2201897A1 (cg-RX-API-DMAC10.html)
GB (1) GB1438574A (cg-RX-API-DMAC10.html)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3516953A1 (de) * 1984-05-11 1985-11-14 Kikkoman Corp., Noda Verfahren zur herstellung von n(pfeil hoch)6(pfeil hoch)-substituiertem 3',5'-cyclischen adenosinmonophosphat oder eines salzes davon
US5086176A (en) * 1989-03-29 1992-02-04 Merrell Dow Pharmaceuticals Inc. Tricyclic fused adenine derivatives

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3960840A (en) * 1972-12-29 1976-06-01 University Of Illinois Foundaton Fluorescent derivatives of adenine-containing compounds
US4058659A (en) * 1974-05-31 1977-11-15 Icn Pharmaceuticals, Inc. 6,8-Disubstituted purine derivatives of 9-β-D-ribofuranosyl 3',5'-cyclic phosphate
US4048307A (en) * 1974-12-26 1977-09-13 Asahi Kasei Kogyo Kabushiki Kaisha Cyclic adenosine monophosphate 8-substituted derivatives
JPS5312892A (en) * 1976-07-23 1978-02-04 Kikkoman Corp Novel 1,n6-etheno-2-substituted-adenosine-3,5-cyclic phosphoric acid and its preparation
JPS5841895A (ja) * 1981-09-04 1983-03-11 Yamasa Shoyu Co Ltd ７−オキソピリド〔２，１−ｉ〕プリンリボヌクレオシド誘導体およびその合成法
US20040186282A1 (en) * 2003-03-20 2004-09-23 Chait Edward M. Synthesis and method of purification of cyclic nucleotide derivatives
KR20110128947A (ko) * 2009-03-20 2011-11-30 앨리오스 바이오파마 인크. 치환된 뉴클레오시드 및 뉴클레오티드 유사체
SG188497A1 (en) 2010-09-22 2013-05-31 Alios Biopharma Inc Substituted nucleotide analogs
HK1203075A1 (en) 2011-12-22 2015-10-16 艾丽奥斯生物制药有限公司 Substituted phosphorothioate nucleotide analogs
EP2828277A1 (en) 2012-03-21 2015-01-28 Vertex Pharmaceuticals Incorporated Solid forms of a thiophosphoramidate nucleotide prodrug
HK1203356A1 (en) 2012-03-22 2015-10-30 艾丽奥斯生物制药有限公司 Pharmaceutical combinations comprising a thionucleotide analog

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE738543A (cg-RX-API-DMAC10.html) * 1968-09-10 1970-03-09
US3558595A (en) * 1969-02-28 1971-01-26 Syntex Corp 2'-cyclic esters and 5'-cyclic esters of 3'-deoxy - 3' - dihydroxyphosphinylmethyl - beta - d - ribofuranosylnucleoside derivatives and intermediates therefor

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3516953A1 (de) * 1984-05-11 1985-11-14 Kikkoman Corp., Noda Verfahren zur herstellung von n(pfeil hoch)6(pfeil hoch)-substituiertem 3',5'-cyclischen adenosinmonophosphat oder eines salzes davon
US5086176A (en) * 1989-03-29 1992-02-04 Merrell Dow Pharmaceuticals Inc. Tricyclic fused adenine derivatives

Also Published As

Publication number Publication date
US3872098A (en) 1975-03-18
FR2201897A1 (cg-RX-API-DMAC10.html) 1974-05-03
JPS4986398A (cg-RX-API-DMAC10.html) 1974-08-19
GB1438574A (en) 1976-06-09
DE2350608A1 (de) 1974-04-25

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