DE2307904A1 - Verwendung von katalasefreien oder katalsearmen glucoseoxidase-praeparaten als zytostatikum fuer maligne zellen - Google Patents
Verwendung von katalasefreien oder katalsearmen glucoseoxidase-praeparaten als zytostatikum fuer maligne zellenInfo
- Publication number
- DE2307904A1 DE2307904A1 DE19732307904 DE2307904A DE2307904A1 DE 2307904 A1 DE2307904 A1 DE 2307904A1 DE 19732307904 DE19732307904 DE 19732307904 DE 2307904 A DE2307904 A DE 2307904A DE 2307904 A1 DE2307904 A1 DE 2307904A1
- Authority
- DE
- Germany
- Prior art keywords
- catalase
- glucose oxidase
- cells
- low
- free
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108010015776 Glucose oxidase Proteins 0.000 title claims description 46
- 239000004366 Glucose oxidase Substances 0.000 title claims description 46
- 229940116332 glucose oxidase Drugs 0.000 title claims description 46
- 235000019420 glucose oxidase Nutrition 0.000 title claims description 46
- 238000002360 preparation method Methods 0.000 title claims description 12
- 102000016938 Catalase Human genes 0.000 claims description 18
- 108010053835 Catalase Proteins 0.000 claims description 18
- 230000003211 malignant effect Effects 0.000 claims description 13
- 230000000694 effects Effects 0.000 claims description 9
- 238000001727 in vivo Methods 0.000 claims description 8
- 239000000824 cytostatic agent Substances 0.000 claims description 6
- 238000000338 in vitro Methods 0.000 claims description 4
- 230000001085 cytostatic effect Effects 0.000 claims description 3
- 230000004069 differentiation Effects 0.000 claims description 2
- 230000010261 cell growth Effects 0.000 claims 3
- 239000000825 pharmaceutical preparation Substances 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 206010003445 Ascites Diseases 0.000 description 22
- 210000004027 cell Anatomy 0.000 description 20
- 241001465754 Metazoa Species 0.000 description 17
- 206010028980 Neoplasm Diseases 0.000 description 11
- 238000000034 method Methods 0.000 description 7
- 241000699666 Mus <mouse, genus> Species 0.000 description 6
- 230000004083 survival effect Effects 0.000 description 6
- 201000009030 Carcinoma Diseases 0.000 description 5
- 241000699670 Mus sp. Species 0.000 description 5
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 230000006378 damage Effects 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 230000004614 tumor growth Effects 0.000 description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
- 241000228150 Penicillium chrysogenum Species 0.000 description 3
- 230000006536 aerobic glycolysis Effects 0.000 description 3
- 230000006538 anaerobic glycolysis Effects 0.000 description 3
- 201000011510 cancer Diseases 0.000 description 3
- 229960001031 glucose Drugs 0.000 description 3
- 239000008103 glucose Substances 0.000 description 3
- 230000005764 inhibitory process Effects 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 description 2
- 229930182555 Penicillin Natural products 0.000 description 2
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 239000006285 cell suspension Substances 0.000 description 2
- 210000003850 cellular structure Anatomy 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 229940088598 enzyme Drugs 0.000 description 2
- 208000025036 lymphosarcoma Diseases 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 229940049954 penicillin Drugs 0.000 description 2
- 238000002054 transplantation Methods 0.000 description 2
- 238000011282 treatment Methods 0.000 description 2
- 210000004881 tumor cell Anatomy 0.000 description 2
- 230000005748 tumor development Effects 0.000 description 2
- JRBJSXQPQWSCCF-UHFFFAOYSA-N 3,3'-Dimethoxybenzidine Chemical compound C1=C(N)C(OC)=CC(C=2C=C(OC)C(N)=CC=2)=C1 JRBJSXQPQWSCCF-UHFFFAOYSA-N 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
- PHOQVHQSTUBQQK-SQOUGZDYSA-N D-glucono-1,5-lactone Chemical compound OC[C@H]1OC(=O)[C@H](O)[C@@H](O)[C@@H]1O PHOQVHQSTUBQQK-SQOUGZDYSA-N 0.000 description 1
- 206010027476 Metastases Diseases 0.000 description 1
- 241000896238 Oidium Species 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 102000003992 Peroxidases Human genes 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 208000005718 Stomach Neoplasms Diseases 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- WQZGKKKJIJFFOK-UKLRSMCWSA-N dextrose-2-13c Chemical compound OC[C@H]1OC(O)[13C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-UKLRSMCWSA-N 0.000 description 1
- 238000002224 dissection Methods 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 125000004072 flavinyl group Chemical group 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 206010017758 gastric cancer Diseases 0.000 description 1
- 229960003681 gluconolactone Drugs 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000036210 malignancy Effects 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 201000011549 stomach cancer Diseases 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000005740 tumor formation Effects 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/44—Oxidoreductases (1)
- A61K38/443—Oxidoreductases (1) acting on CH-OH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19732307904 DE2307904A1 (de) | 1973-02-17 | 1973-02-17 | Verwendung von katalasefreien oder katalsearmen glucoseoxidase-praeparaten als zytostatikum fuer maligne zellen |
| NL7401888A NL7401888A (enExample) | 1973-02-17 | 1974-02-12 | |
| FR7405286A FR2218088B1 (enExample) | 1973-02-17 | 1974-02-15 | |
| JP49018164A JPS5029717A (enExample) | 1973-02-17 | 1974-02-16 | |
| GB733474A GB1466981A (en) | 1973-02-17 | 1974-02-18 | Glucose oxidase preparations and their use |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19732307904 DE2307904A1 (de) | 1973-02-17 | 1973-02-17 | Verwendung von katalasefreien oder katalsearmen glucoseoxidase-praeparaten als zytostatikum fuer maligne zellen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2307904A1 true DE2307904A1 (de) | 1974-08-29 |
Family
ID=5872247
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19732307904 Pending DE2307904A1 (de) | 1973-02-17 | 1973-02-17 | Verwendung von katalasefreien oder katalsearmen glucoseoxidase-praeparaten als zytostatikum fuer maligne zellen |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JPS5029717A (enExample) |
| DE (1) | DE2307904A1 (enExample) |
| FR (1) | FR2218088B1 (enExample) |
| GB (1) | GB1466981A (enExample) |
| NL (1) | NL7401888A (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2484870A1 (fr) * | 1980-06-19 | 1981-12-24 | Jagenberg Werke Ag | Dispositif de reglage de l'epaisseur d'application lors de l'enduction de bandes de materiau continues |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4486408A (en) * | 1981-04-07 | 1984-12-04 | Kiel Johnathan L | Insoluble crosslinked cytotoxic oxidase-peroxidase system |
-
1973
- 1973-02-17 DE DE19732307904 patent/DE2307904A1/de active Pending
-
1974
- 1974-02-12 NL NL7401888A patent/NL7401888A/xx unknown
- 1974-02-15 FR FR7405286A patent/FR2218088B1/fr not_active Expired
- 1974-02-16 JP JP49018164A patent/JPS5029717A/ja active Pending
- 1974-02-18 GB GB733474A patent/GB1466981A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2484870A1 (fr) * | 1980-06-19 | 1981-12-24 | Jagenberg Werke Ag | Dispositif de reglage de l'epaisseur d'application lors de l'enduction de bandes de materiau continues |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5029717A (enExample) | 1975-03-25 |
| NL7401888A (enExample) | 1974-08-20 |
| FR2218088A1 (enExample) | 1974-09-13 |
| GB1466981A (en) | 1977-03-16 |
| FR2218088B1 (enExample) | 1978-01-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Wigglesworth | A theory of tracheal respiration in insects | |
| Leyden et al. | Urinary ammonia and ammonia-producing microorganisms in infants with and without diaper dermatitis | |
| DE2000133A1 (de) | Enzymloesung | |
| Davies et al. | Dehydrogenations by brain tissue. The effects of narcotics | |
| Riker et al. | Atypical and pathological multiplication of cells approached through studies on crown gall | |
| Tizard et al. | The generation of toxic activity from Trypanosoma congolense | |
| DE897316C (de) | Verfahren zur Herstellung von Vitamin B | |
| Martin et al. | Insulin secretion in glucosamine-induced hyperglycemia in rats | |
| DE2307904A1 (de) | Verwendung von katalasefreien oder katalsearmen glucoseoxidase-praeparaten als zytostatikum fuer maligne zellen | |
| Eriksson et al. | Impact of topical metronidazole on the skin and colon microflora in patients with rosacea | |
| DE1768575C3 (de) | 0-(5-Indanyl)-m,N-dimethylthionocarbanilat, Verfahren zu dessen Herstellung und dieses enthaltende Arzneimittel | |
| Barnett | The reduction of nitrate in mixtures of minced grass and water | |
| Parkes et al. | Storage of testicular tissue at very low temperatures | |
| DE1717100A1 (de) | Verfahren zur Herstellung von anticarcinomatoesen Praeparaten haemolytischer Streptococcen | |
| Harris et al. | Cholinesterases and contractility of cat irides: effect of echothiophate iodide | |
| Hogan et al. | Differentiation of the antidermatitis factor | |
| Clayton | Hydrogen cyanide fumigation | |
| AT163656B (de) | Verfahren zur Herstellung eines Heil- und/oder Vorbeugungsmittels zur Bekämpfung der Nosemaseuche der Bienen | |
| SU1268167A1 (ru) | Способ получени препарата строфантина | |
| DE949685C (de) | Abtoeten oder Hemmen von Mikroorganismen | |
| Litwack et al. | Modification of Lysozyme Thermostability by Cytochrome c Preparations. | |
| GB2094623A (en) | Compositions containing hydrogen peroxide | |
| Hurst et al. | Calcium Cyanamide and other Artificial Fertilisers in the Treatment of Soil infected with Heterodera schachtii | |
| Livingston | Some physiological aspects of soil toxicity | |
| AT234900B (de) | Verfahren zur Herstellung eines neuen fungiziden Mittels |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OHA | Expiration of time for request for examination |