DE2209477A1 - Verfahren zur herstellung von festem, freifliessendem cholinchlorid - Google Patents
Verfahren zur herstellung von festem, freifliessendem cholinchloridInfo
- Publication number
- DE2209477A1 DE2209477A1 DE2209477A DE2209477A DE2209477A1 DE 2209477 A1 DE2209477 A1 DE 2209477A1 DE 2209477 A DE2209477 A DE 2209477A DE 2209477 A DE2209477 A DE 2209477A DE 2209477 A1 DE2209477 A1 DE 2209477A1
- Authority
- DE
- Germany
- Prior art keywords
- choline chloride
- silica
- powder
- spray
- free
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000001763 2-hydroxyethyl(trimethyl)azanium Substances 0.000 title claims description 30
- 235000019743 Choline chloride Nutrition 0.000 title claims description 30
- 229960003178 choline chloride Drugs 0.000 title claims description 30
- SGMZJAMFUVOLNK-UHFFFAOYSA-M choline chloride Chemical compound [Cl-].C[N+](C)(C)CCO SGMZJAMFUVOLNK-UHFFFAOYSA-M 0.000 title claims description 30
- 238000000034 method Methods 0.000 title claims description 21
- 239000007787 solid Substances 0.000 title description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 59
- 239000000377 silicon dioxide Substances 0.000 claims description 28
- 239000000843 powder Substances 0.000 claims description 24
- 239000000243 solution Substances 0.000 claims description 13
- 239000007789 gas Substances 0.000 claims description 12
- 238000002156 mixing Methods 0.000 claims description 12
- 238000001694 spray drying Methods 0.000 claims description 8
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 239000007864 aqueous solution Substances 0.000 claims description 2
- 239000012159 carrier gas Substances 0.000 claims description 2
- 230000002209 hydrophobic effect Effects 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 238000001816 cooling Methods 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 239000007921 spray Substances 0.000 description 4
- 238000001035 drying Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 241000269980 Pleuronectidae Species 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 241000209140 Triticum Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 239000000112 cooling gas Substances 0.000 description 1
- 239000011363 dried mixture Substances 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 235000013312 flour Nutrition 0.000 description 1
- 230000009969 flowable effect Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 239000006194 liquid suspension Substances 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000006199 nebulizer Substances 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/30—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic using agents to prevent the granules sticking together; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Silicon Compounds (AREA)
- Medicinal Preparation (AREA)
- Treating Waste Gases (AREA)
- Gas Separation By Absorption (AREA)
Priority Applications (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BE795866D BE795866A (fr) | 1972-02-29 | Procede de preparation de chlorure de choline solide a ecoulement libre | |
| DE2209477A DE2209477A1 (de) | 1972-02-29 | 1972-02-29 | Verfahren zur herstellung von festem, freifliessendem cholinchlorid |
| IT20455/73A IT989015B (it) | 1972-02-29 | 1973-02-15 | Processo per la preparazione di cloruro di colina solido e libe ramente scorrevole |
| NL7302587A NL7302587A (enrdf_load_stackoverflow) | 1972-02-29 | 1973-02-23 | |
| HUBA2878A HU165009B (enrdf_load_stackoverflow) | 1972-02-29 | 1973-02-23 | |
| IL41620A IL41620A (en) | 1972-02-29 | 1973-02-26 | The manufacture of solid free flowing choline chloride powders |
| SU1887169A SU476747A3 (ru) | 1972-02-29 | 1973-02-27 | Способ получени холинхлорида |
| GB948473A GB1412204A (en) | 1972-02-29 | 1973-02-27 | Manufacture of solid freeflowing choline chloride |
| DD169081A DD105206A5 (enrdf_load_stackoverflow) | 1972-02-29 | 1973-02-27 | |
| JP48022764A JPS4898013A (enrdf_load_stackoverflow) | 1972-02-29 | 1973-02-27 | |
| AT176273A AT335405B (de) | 1972-02-29 | 1973-02-28 | Verfahren zur herstellung von freifliessendem, konzentriertem cholinchloridpulver |
| FR7307139A FR2174170B1 (enrdf_load_stackoverflow) | 1972-02-29 | 1973-02-28 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2209477A DE2209477A1 (de) | 1972-02-29 | 1972-02-29 | Verfahren zur herstellung von festem, freifliessendem cholinchlorid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2209477A1 true DE2209477A1 (de) | 1973-09-06 |
Family
ID=5837392
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2209477A Pending DE2209477A1 (de) | 1972-02-29 | 1972-02-29 | Verfahren zur herstellung von festem, freifliessendem cholinchlorid |
Country Status (12)
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0158120A1 (de) * | 1984-03-13 | 1985-10-16 | BASF Aktiengesellschaft | Verfahren zur Herstellung von fliessfähigen Cholinchlorid-Kieselsäure-Pulvern |
| EP0253212A3 (en) * | 1986-07-16 | 1989-07-12 | Basf Aktiengesellschaft | Process for preparing a non-dusting, free flowing choline chloride powder |
| DE19825687A1 (de) * | 1998-06-09 | 1999-12-16 | Degussa | Wirkstoffkonzentrat |
| WO2004094595A2 (en) | 2003-04-17 | 2004-11-04 | Alnylam Pharmaceuticals Inc. | MODIFIED iRNA AGENTS |
| WO2004094345A2 (en) | 2003-04-17 | 2004-11-04 | Alnylam Pharmaceuticals Inc. | Protected monomers |
| WO2010072842A1 (en) | 2008-12-24 | 2010-07-01 | Taminco | Process for preparing a free-flowing powder containing a deliquescent quaternary ammonium compound |
| EP2216407A2 (en) | 2003-03-07 | 2010-08-11 | Alnylam Pharmaceuticals, Inc. | Therapeutic Compositions |
| WO2011109427A2 (en) | 2010-03-01 | 2011-09-09 | Alnylam Pharmaceuticals, Inc. | Improving the biological activity of sirna through modulation of its thermodynamic profile |
| WO2016057693A1 (en) | 2014-10-10 | 2016-04-14 | Alnylam Pharmaceuticals, Inc. | Methods and compositions for inhalation delivery of conjugated oligonucleotide |
| EP3141265A1 (en) | 2007-12-04 | 2017-03-15 | Alnylam Pharmaceuticals, Inc. | Carbohydrate conjugates as delivery agents for oligonucleotides |
| US9700529B2 (en) | 2002-05-03 | 2017-07-11 | Nektar Therapeutics | Particulate materials |
| EP3604533A1 (en) | 2008-04-11 | 2020-02-05 | Arbutus Biopharma Corporation | Site-specific delivery of nucleic acids by combining targeting ligands with endosomolytic components |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4218768A1 (de) * | 1992-06-06 | 1993-12-09 | Basf Ag | Verfahren zur Herstellung von Cholinchlorid enthaltenden Pulvern, diese Pulver und ihre Verwendung |
| US5766668A (en) * | 1995-03-27 | 1998-06-16 | Chinook Group, Inc. | Method for synthesizing chloride based feed precursor and product resulting therefrom |
| CN105876164A (zh) * | 2016-06-17 | 2016-08-24 | 山东奥克特化工有限公司 | 一种氯化胆碱粉剂的制取方法及制取装置 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1642998B2 (de) * | 1967-03-23 | 1973-05-17 | Verfahren zur verhinderung der agglomeration feinteiliger, 1ulverfoermiger stoffe |
-
0
- BE BE795866D patent/BE795866A/xx unknown
-
1972
- 1972-02-29 DE DE2209477A patent/DE2209477A1/de active Pending
-
1973
- 1973-02-15 IT IT20455/73A patent/IT989015B/it active
- 1973-02-23 HU HUBA2878A patent/HU165009B/hu unknown
- 1973-02-23 NL NL7302587A patent/NL7302587A/xx unknown
- 1973-02-26 IL IL41620A patent/IL41620A/xx unknown
- 1973-02-27 JP JP48022764A patent/JPS4898013A/ja active Pending
- 1973-02-27 GB GB948473A patent/GB1412204A/en not_active Expired
- 1973-02-27 SU SU1887169A patent/SU476747A3/ru active
- 1973-02-27 DD DD169081A patent/DD105206A5/xx unknown
- 1973-02-28 FR FR7307139A patent/FR2174170B1/fr not_active Expired
- 1973-02-28 AT AT176273A patent/AT335405B/de not_active IP Right Cessation
Cited By (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0158120A1 (de) * | 1984-03-13 | 1985-10-16 | BASF Aktiengesellschaft | Verfahren zur Herstellung von fliessfähigen Cholinchlorid-Kieselsäure-Pulvern |
| US4775540A (en) * | 1984-03-13 | 1988-10-04 | Basf Aktiengesellschaft | Preparation of pourable choline chloride/silica powders |
| EP0253212A3 (en) * | 1986-07-16 | 1989-07-12 | Basf Aktiengesellschaft | Process for preparing a non-dusting, free flowing choline chloride powder |
| SG81999A1 (en) * | 1998-06-09 | 2001-07-24 | Degussa | Active-substance concentrate |
| EP0963702A3 (de) * | 1998-06-09 | 2000-07-19 | Degussa-Hüls Aktiengesellschaft | Wirkstoffkonzentrat |
| US6177124B1 (en) | 1998-06-09 | 2001-01-23 | Degussa- H{umlaut over (u)}ls Aktiengesellschaft | Active-substance concentrate |
| DE19825687A1 (de) * | 1998-06-09 | 1999-12-16 | Degussa | Wirkstoffkonzentrat |
| US9700529B2 (en) | 2002-05-03 | 2017-07-11 | Nektar Therapeutics | Particulate materials |
| US10945972B2 (en) | 2002-05-03 | 2021-03-16 | Nektar Therapeutics | Particulate materials |
| US10188614B2 (en) | 2002-05-03 | 2019-01-29 | Nektar Therapeutics | Particulate materials |
| EP3450559A1 (en) | 2003-03-07 | 2019-03-06 | Alnylam Pharmaceuticals, Inc. | Therapeutic compositions |
| EP2216407A2 (en) | 2003-03-07 | 2010-08-11 | Alnylam Pharmaceuticals, Inc. | Therapeutic Compositions |
| EP2239329A1 (en) | 2003-03-07 | 2010-10-13 | Alnylam Pharmaceuticals, Inc. | Therapeutic compositions |
| WO2004094595A2 (en) | 2003-04-17 | 2004-11-04 | Alnylam Pharmaceuticals Inc. | MODIFIED iRNA AGENTS |
| EP2660322A2 (en) | 2003-04-17 | 2013-11-06 | Alnylam Pharmaceuticals Inc. | Modified iRNA agents |
| EP2664672A1 (en) | 2003-04-17 | 2013-11-20 | Alnylam Pharmaceuticals Inc. | Modified iRNA agents |
| EP2666858A1 (en) | 2003-04-17 | 2013-11-27 | Alnylam Pharmaceuticals Inc. | Modified iRNA agents |
| EP2669377A2 (en) | 2003-04-17 | 2013-12-04 | Alnylam Pharmaceuticals Inc. | Modified iRNA agents |
| WO2004094345A2 (en) | 2003-04-17 | 2004-11-04 | Alnylam Pharmaceuticals Inc. | Protected monomers |
| EP4321177A2 (en) | 2007-12-04 | 2024-02-14 | Alnylam Pharmaceuticals, Inc. | Carbohydrate conjugates as delivery agents for oligonucleotides |
| EP3141265A1 (en) | 2007-12-04 | 2017-03-15 | Alnylam Pharmaceuticals, Inc. | Carbohydrate conjugates as delivery agents for oligonucleotides |
| EP4223299A2 (en) | 2007-12-04 | 2023-08-09 | Alnylam Pharmaceuticals, Inc. | Carbohydrate conjugates as delivery agents for oligonucleotides |
| EP3705125A1 (en) | 2007-12-04 | 2020-09-09 | Alnylam Pharmaceuticals, Inc. | Carbohydrate conjugates as delivery agents for oligonucleotides |
| EP3604533A1 (en) | 2008-04-11 | 2020-02-05 | Arbutus Biopharma Corporation | Site-specific delivery of nucleic acids by combining targeting ligands with endosomolytic components |
| WO2010072842A1 (en) | 2008-12-24 | 2010-07-01 | Taminco | Process for preparing a free-flowing powder containing a deliquescent quaternary ammonium compound |
| EP2206440A1 (en) | 2008-12-24 | 2010-07-14 | Taminco | Process for preparing a free-flowing powder containing a deliquescent quaternary ammonium compound |
| WO2011109427A2 (en) | 2010-03-01 | 2011-09-09 | Alnylam Pharmaceuticals, Inc. | Improving the biological activity of sirna through modulation of its thermodynamic profile |
| WO2016057693A1 (en) | 2014-10-10 | 2016-04-14 | Alnylam Pharmaceuticals, Inc. | Methods and compositions for inhalation delivery of conjugated oligonucleotide |
Also Published As
| Publication number | Publication date |
|---|---|
| BE795866A (fr) | 1973-08-23 |
| AT335405B (de) | 1977-03-10 |
| ATA176273A (de) | 1976-07-15 |
| IL41620A (en) | 1975-10-15 |
| HU165009B (enrdf_load_stackoverflow) | 1974-06-28 |
| IT989015B (it) | 1975-05-20 |
| GB1412204A (en) | 1975-10-29 |
| FR2174170B1 (enrdf_load_stackoverflow) | 1977-12-30 |
| DD105206A5 (enrdf_load_stackoverflow) | 1974-04-12 |
| FR2174170A1 (enrdf_load_stackoverflow) | 1973-10-12 |
| NL7302587A (enrdf_load_stackoverflow) | 1973-08-31 |
| IL41620A0 (en) | 1973-04-30 |
| SU476747A3 (ru) | 1975-07-05 |
| JPS4898013A (enrdf_load_stackoverflow) | 1973-12-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OHN | Withdrawal |