DE2146429A1 - Vorrichtung und Verfahren zur Züchtung von Kulturen - Google Patents
Vorrichtung und Verfahren zur Züchtung von KulturenInfo
- Publication number
- DE2146429A1 DE2146429A1 DE19712146429 DE2146429A DE2146429A1 DE 2146429 A1 DE2146429 A1 DE 2146429A1 DE 19712146429 DE19712146429 DE 19712146429 DE 2146429 A DE2146429 A DE 2146429A DE 2146429 A1 DE2146429 A1 DE 2146429A1
- Authority
- DE
- Germany
- Prior art keywords
- tubes
- culture
- opening
- vessel
- plates
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims description 10
- 239000007788 liquid Substances 0.000 claims description 15
- 239000002356 single layer Substances 0.000 claims description 8
- 239000006194 liquid suspension Substances 0.000 claims description 7
- 238000005096 rolling process Methods 0.000 claims description 5
- 230000007246 mechanism Effects 0.000 claims description 3
- 230000001105 regulatory effect Effects 0.000 claims description 2
- 238000009629 microbiological culture Methods 0.000 claims 2
- 206010035148 Plague Diseases 0.000 claims 1
- 241000607479 Yersinia pestis Species 0.000 claims 1
- 239000007789 gas Substances 0.000 description 18
- 241000700605 Viruses Species 0.000 description 16
- 239000002609 medium Substances 0.000 description 14
- 235000015097 nutrients Nutrition 0.000 description 12
- 238000004519 manufacturing process Methods 0.000 description 6
- 230000008901 benefit Effects 0.000 description 5
- 239000001963 growth medium Substances 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 4
- 229910000831 Steel Inorganic materials 0.000 description 4
- 238000004113 cell culture Methods 0.000 description 4
- 239000012530 fluid Substances 0.000 description 4
- 239000011521 glass Substances 0.000 description 4
- 239000010959 steel Substances 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- 229960005486 vaccine Drugs 0.000 description 4
- 229920001875 Ebonite Polymers 0.000 description 3
- 239000000427 antigen Substances 0.000 description 3
- 102000036639 antigens Human genes 0.000 description 3
- 108091007433 antigens Proteins 0.000 description 3
- 230000033228 biological regulation Effects 0.000 description 3
- 238000011109 contamination Methods 0.000 description 3
- 238000009826 distribution Methods 0.000 description 3
- 230000005484 gravity Effects 0.000 description 3
- 238000012423 maintenance Methods 0.000 description 3
- 230000002906 microbiologic effect Effects 0.000 description 3
- 239000004033 plastic Substances 0.000 description 3
- 229920003023 plastic Polymers 0.000 description 3
- 229920001296 polysiloxane Polymers 0.000 description 3
- 239000004677 Nylon Substances 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 229910052782 aluminium Inorganic materials 0.000 description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
- 229910002092 carbon dioxide Inorganic materials 0.000 description 2
- 239000001569 carbon dioxide Substances 0.000 description 2
- 230000010261 cell growth Effects 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 239000010410 layer Substances 0.000 description 2
- 230000033001 locomotion Effects 0.000 description 2
- 239000002207 metabolite Substances 0.000 description 2
- 229920001778 nylon Polymers 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 description 1
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 235000009161 Espostoa lanata Nutrition 0.000 description 1
- 240000001624 Espostoa lanata Species 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 description 1
- 239000003855 balanced salt solution Substances 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 230000031018 biological processes and functions Effects 0.000 description 1
- 239000005388 borosilicate glass Substances 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 244000309466 calf Species 0.000 description 1
- 239000006143 cell culture medium Substances 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 229940030156 cell vaccine Drugs 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000013043 chemical agent Substances 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 238000005553 drilling Methods 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000005357 flat glass Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 210000001161 mammalian embryo Anatomy 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 239000005297 pyrex Substances 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 239000003566 sealing material Substances 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000004114 suspension culture Methods 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 229960004854 viral vaccine Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
- C12M25/10—Hollow fibers or tubes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
- C12M27/14—Rotation or movement of the cells support, e.g. rotated hollow fibers
Landscapes
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Sustainable Development (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB4443270A GB1369593A (en) | 1970-09-17 | 1970-09-17 | Culture apparatus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2146429A1 true DE2146429A1 (de) | 1972-03-23 |
Family
ID=10433269
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19712146429 Pending DE2146429A1 (de) | 1970-09-17 | 1971-09-16 | Vorrichtung und Verfahren zur Züchtung von Kulturen |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US3827943A (enExample) |
| AU (1) | AU461211B2 (enExample) |
| BE (1) | BE772637A (enExample) |
| CA (1) | CA937883A (enExample) |
| CH (1) | CH531042A (enExample) |
| DE (1) | DE2146429A1 (enExample) |
| DK (1) | DK133310C (enExample) |
| FR (1) | FR2107748A5 (enExample) |
| GB (1) | GB1369593A (enExample) |
| HU (1) | HU163461B (enExample) |
| IL (1) | IL37664A (enExample) |
| IT (1) | IT942175B (enExample) |
| NL (1) | NL7112827A (enExample) |
| SE (1) | SE398358B (enExample) |
| ZA (1) | ZA715909B (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4033825A (en) * | 1973-05-31 | 1977-07-05 | Instrumentation Laboratory, Inc. | Cell culture system |
| US4144136A (en) * | 1977-06-06 | 1979-03-13 | Institut Armand-Frappier | Apparatus for cellular culture |
| CH635868A5 (de) * | 1977-08-16 | 1983-04-29 | Chemap Ag | Vorrichtung zur zuechtung von gewebezellen. |
| US4184922A (en) * | 1977-11-11 | 1980-01-22 | The Government Of The United States | Dual circuit, woven artificial capillary bundle for cell culture |
| US4296204A (en) * | 1978-01-25 | 1981-10-20 | Merck & Co., Inc. | Use of motionless mixer as cell culture propagator |
| JPS5564795A (en) * | 1978-11-10 | 1980-05-15 | Olympus Optical Co Ltd | Method and apparatus for culturing living tissue or cell |
| US4415670A (en) * | 1980-07-07 | 1983-11-15 | Merck & Co., Inc. | Motionless mixer as cell culture propagator |
| US4317886A (en) * | 1980-08-11 | 1982-03-02 | Becton, Dickinson And Company | Multiple interior surface roller bottle |
| US4385115A (en) * | 1980-10-22 | 1983-05-24 | Hoffmann-La Roche Inc. | Diagnostics testing devices and processes |
| US4514499A (en) * | 1983-02-04 | 1985-04-30 | Corning Glass Works | Cell culture using a monolithic support |
| US5240854A (en) * | 1989-06-05 | 1993-08-31 | Berry Eric S | Continuous high-density cell culture system |
| US5437998A (en) * | 1993-09-09 | 1995-08-01 | Synthecon, Inc. | Gas permeable bioreactor and method of use |
| US6066497A (en) * | 1994-08-16 | 2000-05-23 | Powell Biological Machines Limited | Cell culture apparatus |
| KR0129833B1 (ko) * | 1994-11-09 | 1998-04-04 | 박성수 | 조직 배양 방법 및 장치 |
| US6001642A (en) * | 1998-06-29 | 1999-12-14 | Wyle Laboratories, Inc. Life Sciences | Bioreactor and cell culturing processes using the bioreactor |
| WO2002034875A1 (en) | 2000-10-24 | 2002-05-02 | Alexander Robert Powell | Cell culture apparatus |
| KR20020088848A (ko) * | 2001-05-21 | 2002-11-29 | (주)코아바이오텍 | 세포배양관 및 이를 이용한 대량 세포배양기 |
| US20040029266A1 (en) * | 2002-08-09 | 2004-02-12 | Emilio Barbera-Guillem | Cell and tissue culture device |
| US20040265997A1 (en) * | 2003-06-27 | 2004-12-30 | Park Sung-Soo | Bio-artificial liver system |
| US7514256B2 (en) * | 2005-02-11 | 2009-04-07 | Emilio Barbera-Guillem | Bioreactor for selectively controlling the molecular diffusion between fluids |
| CN101247732B (zh) * | 2005-09-02 | 2011-02-16 | 特洛伊·D.·亚希科夫斯基 | 酒瓶旋转装置 |
-
1970
- 1970-09-17 GB GB4443270A patent/GB1369593A/en not_active Expired
-
1971
- 1971-09-03 ZA ZA715909A patent/ZA715909B/xx unknown
- 1971-09-06 IL IL37664A patent/IL37664A/xx unknown
- 1971-09-09 US US00179032A patent/US3827943A/en not_active Expired - Lifetime
- 1971-09-10 AU AU33341/71A patent/AU461211B2/en not_active Expired
- 1971-09-15 BE BE772637A patent/BE772637A/xx unknown
- 1971-09-15 IT IT52899/71A patent/IT942175B/it active
- 1971-09-16 FR FR7133395A patent/FR2107748A5/fr not_active Expired
- 1971-09-16 DK DK453671A patent/DK133310C/da active
- 1971-09-16 CA CA123071A patent/CA937883A/en not_active Expired
- 1971-09-16 SE SE7111738A patent/SE398358B/xx unknown
- 1971-09-16 DE DE19712146429 patent/DE2146429A1/de active Pending
- 1971-09-17 HU HUWE445A patent/HU163461B/hu unknown
- 1971-09-17 NL NL7112827A patent/NL7112827A/xx unknown
- 1971-09-17 CH CH1364171A patent/CH531042A/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US3827943A (en) | 1974-08-06 |
| DK133310C (da) | 1976-09-20 |
| IT942175B (it) | 1973-03-20 |
| CH531042A (de) | 1972-11-30 |
| FR2107748A5 (enExample) | 1972-05-05 |
| DK133310B (da) | 1976-04-26 |
| AU461211B2 (en) | 1975-05-22 |
| CA937883A (en) | 1973-12-04 |
| IL37664A0 (en) | 1971-11-29 |
| GB1369593A (en) | 1974-10-09 |
| AU3334171A (en) | 1973-03-15 |
| HU163461B (enExample) | 1973-08-28 |
| BE772637A (fr) | 1972-03-15 |
| SE398358B (sv) | 1977-12-19 |
| IL37664A (en) | 1974-11-29 |
| NL7112827A (enExample) | 1972-03-21 |
| ZA715909B (en) | 1973-04-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OHA | Expiration of time for request for examination |