DE2137213A1 - Kunststoffkapseln und Verfahren zu deren Herstellung - Google Patents
Kunststoffkapseln und Verfahren zu deren HerstellungInfo
- Publication number
- DE2137213A1 DE2137213A1 DE19712137213 DE2137213A DE2137213A1 DE 2137213 A1 DE2137213 A1 DE 2137213A1 DE 19712137213 DE19712137213 DE 19712137213 DE 2137213 A DE2137213 A DE 2137213A DE 2137213 A1 DE2137213 A1 DE 2137213A1
- Authority
- DE
- Germany
- Prior art keywords
- cellulose
- capsules
- mixture
- plastic
- acetate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002775 capsule Substances 0.000 title claims description 32
- 229920003023 plastic Polymers 0.000 title claims description 14
- 239000004033 plastic Substances 0.000 title claims description 14
- 238000000034 method Methods 0.000 title description 6
- 238000004519 manufacturing process Methods 0.000 title description 2
- 239000000203 mixture Substances 0.000 claims description 28
- -1 polyoxyethylene Polymers 0.000 claims description 12
- LDHQCZJRKDOVOX-NSCUHMNNSA-N crotonic acid Chemical compound C\C=C\C(O)=O LDHQCZJRKDOVOX-NSCUHMNNSA-N 0.000 claims description 10
- 239000003814 drug Substances 0.000 claims description 10
- 229940079593 drug Drugs 0.000 claims description 10
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 9
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 9
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 9
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 9
- 239000000654 additive Substances 0.000 claims description 7
- 229920001577 copolymer Polymers 0.000 claims description 7
- DQEFEBPAPFSJLV-UHFFFAOYSA-N Cellulose propionate Chemical compound CCC(=O)OCC1OC(OC(=O)CC)C(OC(=O)CC)C(OC(=O)CC)C1OC1C(OC(=O)CC)C(OC(=O)CC)C(OC(=O)CC)C(COC(=O)CC)O1 DQEFEBPAPFSJLV-UHFFFAOYSA-N 0.000 claims description 6
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims description 6
- 229920002678 cellulose Chemical class 0.000 claims description 6
- 239000001913 cellulose Chemical class 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 5
- 229920002689 polyvinyl acetate Polymers 0.000 claims description 5
- 239000011118 polyvinyl acetate Substances 0.000 claims description 5
- 229920002494 Zein Polymers 0.000 claims description 4
- LDHQCZJRKDOVOX-UHFFFAOYSA-N trans-crotonic acid Natural products CC=CC(O)=O LDHQCZJRKDOVOX-UHFFFAOYSA-N 0.000 claims description 4
- 239000005019 zein Substances 0.000 claims description 4
- 229940093612 zein Drugs 0.000 claims description 4
- 229920000623 Cellulose acetate phthalate Polymers 0.000 claims description 3
- 229920002125 Sokalan® Polymers 0.000 claims description 3
- 229920002301 cellulose acetate Polymers 0.000 claims description 3
- 229940081734 cellulose acetate phthalate Drugs 0.000 claims description 3
- 239000004014 plasticizer Substances 0.000 claims description 3
- 239000004584 polyacrylic acid Substances 0.000 claims description 3
- 239000001856 Ethyl cellulose Substances 0.000 claims description 2
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 2
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical class CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims description 2
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims description 2
- 239000000853 adhesive Substances 0.000 claims description 2
- 230000000181 anti-adherent effect Effects 0.000 claims description 2
- 239000003963 antioxidant agent Substances 0.000 claims description 2
- 229920006218 cellulose propionate Polymers 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims description 2
- 229920001249 ethyl cellulose Polymers 0.000 claims description 2
- 235000019325 ethyl cellulose Nutrition 0.000 claims description 2
- 239000000945 filler Substances 0.000 claims description 2
- 230000000996 additive effect Effects 0.000 claims 1
- 238000001746 injection moulding Methods 0.000 description 15
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 14
- 210000004051 gastric juice Anatomy 0.000 description 10
- ZTHYODDOHIVTJV-UHFFFAOYSA-N Propyl gallate Chemical compound CCCOC(=O)C1=CC(O)=C(O)C(O)=C1 ZTHYODDOHIVTJV-UHFFFAOYSA-N 0.000 description 8
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 8
- 235000021355 Stearic acid Nutrition 0.000 description 7
- 230000000968 intestinal effect Effects 0.000 description 7
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 7
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 7
- 239000008117 stearic acid Substances 0.000 description 7
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 6
- 239000008119 colloidal silica Substances 0.000 description 6
- LHGVFZTZFXWLCP-UHFFFAOYSA-N guaiacol Chemical group COC1=CC=CC=C1O LHGVFZTZFXWLCP-UHFFFAOYSA-N 0.000 description 5
- 210000000936 intestine Anatomy 0.000 description 4
- 229920000642 polymer Polymers 0.000 description 4
- 239000000473 propyl gallate Substances 0.000 description 4
- 229940075579 propyl gallate Drugs 0.000 description 4
- 235000010388 propyl gallate Nutrition 0.000 description 4
- 210000002784 stomach Anatomy 0.000 description 4
- 229910002012 Aerosil® Inorganic materials 0.000 description 3
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 description 3
- 239000008187 granular material Substances 0.000 description 3
- LYRFLYHAGKPMFH-UHFFFAOYSA-N octadecanamide Chemical compound CCCCCCCCCCCCCCCCCC(N)=O LYRFLYHAGKPMFH-UHFFFAOYSA-N 0.000 description 3
- GAMPNQJDUFQVQO-UHFFFAOYSA-N acetic acid;phthalic acid Chemical compound CC(O)=O.OC(=O)C1=CC=CC=C1C(O)=O GAMPNQJDUFQVQO-UHFFFAOYSA-N 0.000 description 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Natural products OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 2
- 239000001069 triethyl citrate Substances 0.000 description 2
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 2
- 235000013769 triethyl citrate Nutrition 0.000 description 2
- DWKNOLCXIFYNFV-HSZRJFAPSA-N 2-[[(2r)-1-[1-[(4-chloro-3-methylphenyl)methyl]piperidin-4-yl]-5-oxopyrrolidine-2-carbonyl]amino]-n,n,6-trimethylpyridine-4-carboxamide Chemical compound CN(C)C(=O)C1=CC(C)=NC(NC(=O)[C@@H]2N(C(=O)CC2)C2CCN(CC=3C=C(C)C(Cl)=CC=3)CC2)=C1 DWKNOLCXIFYNFV-HSZRJFAPSA-N 0.000 description 1
- 239000004925 Acrylic resin Substances 0.000 description 1
- 229920000178 Acrylic resin Polymers 0.000 description 1
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 1
- 229920013683 Celanese Polymers 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 1
- UGZICOVULPINFH-UHFFFAOYSA-N acetic acid;butanoic acid Chemical compound CC(O)=O.CCCC(O)=O UGZICOVULPINFH-UHFFFAOYSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 229920006217 cellulose acetate butyrate Polymers 0.000 description 1
- 238000000748 compression moulding Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 238000007872 degassing Methods 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
- 229920013821 hydroxy alkyl cellulose Polymers 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000004413 injection moulding compound Substances 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- FATBGEAMYMYZAF-KTKRTIGZSA-N oleamide Chemical compound CCCCCCCC\C=C/CCCCCCCC(N)=O FATBGEAMYMYZAF-KTKRTIGZSA-N 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000003856 thermoforming Methods 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
- 239000004416 thermosoftening plastic Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L1/00—Compositions of cellulose, modified cellulose or cellulose derivatives
- C08L1/08—Cellulose derivatives
- C08L1/26—Cellulose ethers
- C08L1/28—Alkyl ethers
- C08L1/284—Alkyl ethers with hydroxylated hydrocarbon radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7027830A FR2135021A2 (en) | 1970-07-28 | 1970-07-28 | Medicine capsules - dissolving in intestine with wall consisting of two polymers eg hydroxypropylcellulose and cellulose acetophthalat |
| FR7027831A FR2100561A2 (en) | 1970-07-28 | 1970-07-28 | Medicine capsules - dissolving in intestine with wall consisting of two polymers eg hydroxypropylcellulose and cellulose acetophthalat |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2137213A1 true DE2137213A1 (de) | 1972-03-16 |
Family
ID=26215867
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19712137213 Pending DE2137213A1 (de) | 1970-07-28 | 1971-07-24 | Kunststoffkapseln und Verfahren zu deren Herstellung |
Country Status (7)
| Country | Link |
|---|---|
| BE (1) | BE770162A (OSRAM) |
| CA (1) | CA944689A (OSRAM) |
| CH (1) | CH540046A (OSRAM) |
| DE (1) | DE2137213A1 (OSRAM) |
| GB (1) | GB1355324A (OSRAM) |
| IT (1) | IT1044956B (OSRAM) |
| NL (1) | NL7110361A (OSRAM) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2555972A1 (fr) * | 1983-10-20 | 1985-06-07 | Warner Lambert Co | Capsules et autres articles moules sous pression, utilisables notamment pour les applications pharmaceutiques |
| FR2583638A1 (fr) * | 1985-06-24 | 1986-12-26 | Ciba Geigy Ag | Formes de presentation solides, aptes a la conservation revetues d'une pellicule elastique |
| EP0180287A3 (en) * | 1984-10-23 | 1987-04-29 | Shin-Etsu Chemical Co., Ltd. | A cellulose ether composition and a hard medicinal capsule prepared therefrom |
| EP0090600B1 (en) * | 1982-03-26 | 1987-07-22 | Warner-Lambert Company | Method for molding capsules |
| EP0513542A3 (en) * | 1991-04-23 | 1993-03-31 | Robert J. Petcavich | Disposable recyclable plastic articles and moldable synthetic resin blends for making the same |
| WO1996004338A1 (en) * | 1994-08-03 | 1996-02-15 | Kimberly-Clark Worldwide, Inc. | Water-dispersible thermoplastic composition and articles thereof |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19958007A1 (de) | 1999-12-02 | 2001-06-07 | Roehm Gmbh | Spritzgußverfahren für (Meth)acrylat-Copolymere mit teritiären Ammoniumgruppen |
| GB0102342D0 (en) * | 2001-01-30 | 2001-03-14 | Smithkline Beecham Plc | Pharmaceutical formulation |
| EP3354335A1 (en) | 2010-10-26 | 2018-08-01 | Capsugel Belgium NV | Bulk enteric capsule shells |
| JP6626712B2 (ja) * | 2012-05-02 | 2019-12-25 | キャプシュゲル・ベルジウム・エヌ・ヴィ | 放出制御ポリマーの水性分散液並びにそのシェル及びカプセル |
| EP3065720A1 (en) | 2013-11-04 | 2016-09-14 | Capsugel Belgium NV | Methods and systems for improved bioavailability of active pharmaceutical ingredients including esomeprazole |
-
1971
- 1971-07-13 CA CA118,132*7A patent/CA944689A/en not_active Expired
- 1971-07-16 BE BE770162A patent/BE770162A/xx unknown
- 1971-07-19 GB GB3373171A patent/GB1355324A/en not_active Expired
- 1971-07-24 DE DE19712137213 patent/DE2137213A1/de active Pending
- 1971-07-27 IT IT6952371A patent/IT1044956B/it active
- 1971-07-27 NL NL7110361A patent/NL7110361A/xx unknown
- 1971-07-27 CH CH1108271A patent/CH540046A/fr not_active IP Right Cessation
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0090600B1 (en) * | 1982-03-26 | 1987-07-22 | Warner-Lambert Company | Method for molding capsules |
| FR2555972A1 (fr) * | 1983-10-20 | 1985-06-07 | Warner Lambert Co | Capsules et autres articles moules sous pression, utilisables notamment pour les applications pharmaceutiques |
| EP0180287A3 (en) * | 1984-10-23 | 1987-04-29 | Shin-Etsu Chemical Co., Ltd. | A cellulose ether composition and a hard medicinal capsule prepared therefrom |
| FR2583638A1 (fr) * | 1985-06-24 | 1986-12-26 | Ciba Geigy Ag | Formes de presentation solides, aptes a la conservation revetues d'une pellicule elastique |
| EP0513542A3 (en) * | 1991-04-23 | 1993-03-31 | Robert J. Petcavich | Disposable recyclable plastic articles and moldable synthetic resin blends for making the same |
| WO1996004338A1 (en) * | 1994-08-03 | 1996-02-15 | Kimberly-Clark Worldwide, Inc. | Water-dispersible thermoplastic composition and articles thereof |
| FR2723744A1 (fr) * | 1994-08-03 | 1996-02-23 | Kimberly Clark Co | Composition thermoplastique hydro-dispersable et articles fabriques a partir de celle-ci |
Also Published As
| Publication number | Publication date |
|---|---|
| CA944689A (en) | 1974-04-02 |
| IT1044956B (it) | 1980-04-21 |
| CH540046A (fr) | 1973-08-15 |
| GB1355324A (en) | 1974-06-05 |
| BE770162A (fr) | 1971-12-01 |
| NL7110361A (OSRAM) | 1972-02-01 |
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