DE2137043B2 - Verfahren zur Herstellung von Enzympräparaten - Google Patents
Verfahren zur Herstellung von EnzympräparatenInfo
- Publication number
- DE2137043B2 DE2137043B2 DE19712137043 DE2137043A DE2137043B2 DE 2137043 B2 DE2137043 B2 DE 2137043B2 DE 19712137043 DE19712137043 DE 19712137043 DE 2137043 A DE2137043 A DE 2137043A DE 2137043 B2 DE2137043 B2 DE 2137043B2
- Authority
- DE
- Germany
- Prior art keywords
- enzyme
- powder
- pellets
- spheronization
- substances
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 238000000034 method Methods 0.000 title claims description 23
- 229940079919 digestives enzyme preparation Drugs 0.000 title claims 5
- 238000004519 manufacturing process Methods 0.000 title claims 4
- 102000004190 Enzymes Human genes 0.000 claims description 28
- 108090000790 Enzymes Proteins 0.000 claims description 28
- 229940088598 enzyme Drugs 0.000 claims description 28
- 239000000203 mixture Substances 0.000 claims description 15
- 239000000843 powder Substances 0.000 claims description 14
- 239000000126 substance Substances 0.000 claims description 14
- 239000002245 particle Substances 0.000 claims description 11
- 239000008188 pellet Substances 0.000 claims description 10
- 238000005563 spheronization Methods 0.000 claims description 10
- 108091005804 Peptidases Proteins 0.000 claims description 7
- 230000002797 proteolythic effect Effects 0.000 claims description 7
- 239000004382 Amylase Substances 0.000 claims description 6
- 102000035195 Peptidases Human genes 0.000 claims description 6
- 238000001125 extrusion Methods 0.000 claims description 6
- 150000002191 fatty alcohols Chemical class 0.000 claims description 5
- 230000008018 melting Effects 0.000 claims description 5
- 238000002844 melting Methods 0.000 claims description 5
- 239000003381 stabilizer Substances 0.000 claims description 5
- 108010065511 Amylases Proteins 0.000 claims description 4
- 102000013142 Amylases Human genes 0.000 claims description 4
- 235000019418 amylase Nutrition 0.000 claims description 4
- 239000003599 detergent Substances 0.000 claims description 4
- 230000000694 effects Effects 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims description 3
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 claims description 3
- 241000193830 Bacillus <bacterium> Species 0.000 claims description 2
- 108010010803 Gelatin Proteins 0.000 claims description 2
- 108010073178 Glucan 1,4-alpha-Glucosidase Proteins 0.000 claims description 2
- 102000001554 Hemoglobins Human genes 0.000 claims description 2
- 108010054147 Hemoglobins Proteins 0.000 claims description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 2
- 239000000654 additive Substances 0.000 claims description 2
- 239000004202 carbamide Substances 0.000 claims description 2
- 239000005018 casein Substances 0.000 claims description 2
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims description 2
- 235000021240 caseins Nutrition 0.000 claims description 2
- 239000012141 concentrate Substances 0.000 claims description 2
- 229920000159 gelatin Polymers 0.000 claims description 2
- 239000008273 gelatin Substances 0.000 claims description 2
- 235000019322 gelatine Nutrition 0.000 claims description 2
- 235000011852 gelatine desserts Nutrition 0.000 claims description 2
- 239000000463 material Substances 0.000 claims description 2
- 235000015097 nutrients Nutrition 0.000 claims description 2
- 239000004033 plastic Substances 0.000 claims description 2
- 229920003023 plastic Polymers 0.000 claims description 2
- 241000894007 species Species 0.000 claims description 2
- 239000000758 substrate Substances 0.000 claims description 2
- 239000007787 solid Substances 0.000 claims 5
- 230000015572 biosynthetic process Effects 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 235000014113 dietary fatty acids Nutrition 0.000 claims 3
- 239000000194 fatty acid Substances 0.000 claims 3
- 229930195729 fatty acid Natural products 0.000 claims 3
- 150000004665 fatty acids Chemical class 0.000 claims 3
- 230000001737 promoting effect Effects 0.000 claims 3
- AGNTUZCMJBTHOG-UHFFFAOYSA-N 3-[3-(2,3-dihydroxypropoxy)-2-hydroxypropoxy]propane-1,2-diol Chemical class OCC(O)COCC(O)COCC(O)CO AGNTUZCMJBTHOG-UHFFFAOYSA-N 0.000 claims 2
- 239000011324 bead Substances 0.000 claims 2
- 239000010695 polyglycol Substances 0.000 claims 2
- 229920000151 polyglycol Polymers 0.000 claims 2
- 239000001993 wax Substances 0.000 claims 2
- 241000283690 Bos taurus Species 0.000 claims 1
- 102000004195 Isomerases Human genes 0.000 claims 1
- 108090000769 Isomerases Proteins 0.000 claims 1
- 239000004365 Protease Substances 0.000 claims 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 1
- 125000002877 alkyl aryl group Chemical group 0.000 claims 1
- 229930195733 hydrocarbon Natural products 0.000 claims 1
- 150000002430 hydrocarbons Chemical class 0.000 claims 1
- 229910052809 inorganic oxide Inorganic materials 0.000 claims 1
- 229910017053 inorganic salt Inorganic materials 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 8
- 239000007795 chemical reaction product Substances 0.000 description 7
- 239000000047 product Substances 0.000 description 7
- 102000005158 Subtilisins Human genes 0.000 description 5
- 108010056079 Subtilisins Proteins 0.000 description 5
- 239000002202 Polyethylene glycol Substances 0.000 description 4
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 4
- 229920001223 polyethylene glycol Polymers 0.000 description 4
- 239000011780 sodium chloride Substances 0.000 description 4
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 3
- 235000012438 extruded product Nutrition 0.000 description 3
- 230000002538 fungal effect Effects 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 229910002012 Aerosil® Inorganic materials 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 239000012736 aqueous medium Substances 0.000 description 2
- 235000013339 cereals Nutrition 0.000 description 2
- 230000002255 enzymatic effect Effects 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 229940057847 polyethylene glycol 600 Drugs 0.000 description 2
- 238000010298 pulverizing process Methods 0.000 description 2
- 229910052938 sodium sulfate Inorganic materials 0.000 description 2
- 235000011152 sodium sulphate Nutrition 0.000 description 2
- 235000019832 sodium triphosphate Nutrition 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 239000004408 titanium dioxide Substances 0.000 description 2
- 108010084185 Cellulases Proteins 0.000 description 1
- 102000005575 Cellulases Human genes 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 108090001060 Lipase Proteins 0.000 description 1
- 102000004882 Lipase Human genes 0.000 description 1
- 239000004367 Lipase Substances 0.000 description 1
- 229920000881 Modified starch Polymers 0.000 description 1
- 108010059820 Polygalacturonase Proteins 0.000 description 1
- -1 Sodium chloride Chemical class 0.000 description 1
- 108700040099 Xylose isomerases Proteins 0.000 description 1
- 229940025131 amylases Drugs 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000000701 coagulant Substances 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 108010093305 exopolygalacturonase Proteins 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 108010002430 hemicellulase Proteins 0.000 description 1
- 235000019421 lipase Nutrition 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000019426 modified starch Nutrition 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 229940093429 polyethylene glycol 6000 Drugs 0.000 description 1
- 235000019833 protease Nutrition 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- RYCLIXPGLDDLTM-UHFFFAOYSA-J tetrapotassium;phosphonato phosphate Chemical compound [K+].[K+].[K+].[K+].[O-]P([O-])(=O)OP([O-])([O-])=O RYCLIXPGLDDLTM-UHFFFAOYSA-J 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
- C11D3/38672—Granulated or coated enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/98—Preparation of granular or free-flowing enzyme compositions
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Detergent Compositions (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3656370A GB1361387A (en) | 1970-07-28 | 1970-07-28 | Production of enzyme preparations |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE2137043A1 DE2137043A1 (de) | 1972-02-03 |
| DE2137043B2 true DE2137043B2 (de) | 1980-05-22 |
Family
ID=10389282
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19712137043 Ceased DE2137043B2 (de) | 1970-07-28 | 1971-07-24 | Verfahren zur Herstellung von Enzympräparaten |
Country Status (4)
| Country | Link |
|---|---|
| BE (1) | BE770558A (enExample) |
| DE (1) | DE2137043B2 (enExample) |
| FR (1) | FR2099348A5 (enExample) |
| GB (1) | GB1361387A (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5972668A (en) | 1994-06-28 | 1999-10-26 | Henkel Kommanditgesellschaft Auf Aktien | Production of multi-enzyme granules |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4016041A (en) * | 1975-02-12 | 1977-04-05 | Lever Brothers Company | Process of making granular enzymes of reduced stickiness |
| US4176079A (en) | 1977-04-20 | 1979-11-27 | The Procter & Gamble Company | Water-soluble enzyme-containing article |
| US4115292A (en) | 1977-04-20 | 1978-09-19 | The Procter & Gamble Company | Enzyme-containing detergent articles |
| DE4329463A1 (de) * | 1993-09-01 | 1995-03-02 | Cognis Bio Umwelt | Mehrenzymgranulate |
| DE69519944T2 (de) * | 1994-11-18 | 2001-06-13 | Genencor International, Inc. | Umhüllte enzymgranulate |
| DE19615776A1 (de) | 1996-04-20 | 1997-10-23 | Henkel Kgaa | Löslichkeitsverbessertes Enzymgranulat |
| DE19651446A1 (de) | 1996-12-11 | 1998-06-18 | Henkel Kgaa | Umhüllte Enzymzubereitung mit verbesserter Löslichkeit |
| DE10142124A1 (de) | 2001-08-30 | 2003-03-27 | Henkel Kgaa | Umhüllte Wirkstoffzubereitung für den Einsatz in teilchenförmigen Wasch- und Reinigungsmitteln |
| US6841185B2 (en) | 2001-10-19 | 2005-01-11 | The Procter & Gamble Co. | Flavored coffee compositions and methods of making the same |
| GB201106408D0 (en) | 2011-04-15 | 2011-06-01 | Revolymer Ltd | Novel composite |
| GB201106391D0 (en) | 2011-04-15 | 2011-06-01 | Reckitt & Colman Overseas | Novel composite |
| GB201106409D0 (en) | 2011-04-15 | 2011-06-01 | Revolymer Ltd | Novel composite |
-
1970
- 1970-07-28 GB GB3656370A patent/GB1361387A/en not_active Expired
-
1971
- 1971-07-24 DE DE19712137043 patent/DE2137043B2/de not_active Ceased
- 1971-07-27 BE BE770558A patent/BE770558A/xx not_active IP Right Cessation
- 1971-07-28 FR FR7127646A patent/FR2099348A5/fr not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5972668A (en) | 1994-06-28 | 1999-10-26 | Henkel Kommanditgesellschaft Auf Aktien | Production of multi-enzyme granules |
Also Published As
| Publication number | Publication date |
|---|---|
| GB1361387A (en) | 1974-07-24 |
| BE770558A (fr) | 1972-01-27 |
| FR2099348A5 (enExample) | 1972-03-10 |
| DE2137043A1 (de) | 1972-02-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OD | Request for examination | ||
| 8235 | Patent refused |