DE212016000276U1 - Hydrogel dressing for the treatment of burn wounds and trophic ulcers - Google Patents

Abstract

A hydrogel dressing for the treatment of burn wounds and trophic ulcers, comprising a gel-based graft-based composition based on acrylamide and water, characterized in that the netting is thermo-treated and made from synthetic, for example polypropylene fibers.

Description

The present invention relates to medicine, in particular the dressings for the treatment of burn wounds and trophic ulcers, especially in the stages of granulation tissue formation and epithelization.

As for the essential features, the closest to the present dressing is a hydrogel dressing for the treatment of burn wounds and trophic ulcers which comprises a net-attached gel-forming composition based on acrylamide and water [Invention Patent No. 2157243, RF, MPK 7 A61L15 / 22, publ 10.10.2000]. In the mentioned device, the gel-forming composition is poured and applied to a net-like backing to increase the strength of the dressing.

The aforementioned bandage has insufficient strength, which causes it to tear away from the wound as it is removed, which does not preclude additional trauma to the wound and pain sensation in the injured.

In addition, due to the high toughness of the hydrogel, in many cases it is not possible to obtain a hydrogel dressing on a mesh pad with the necessary strength and effectiveness due to limited penetration of drugs from the dressing into the wound, which substantially reduces its healing effect.

As for the essential features, the closest to the present process is a process for producing a hydrogel dressing for the treatment of burn wounds and trophic ulcers, which comprises the preparation of a gel-forming composition based on acrylamide and water and their connection to a netting [Invention Patent No. 2157243, RF , MPK 7 A61L15 / 22, published 10.10.2000]. In the mentioned method, the gel-forming composition is poured and applied to a net-like backing to increase the strength of the dressing.

The dressing obtained by this method has insufficient strength, which causes it to tear away from the wound as it is removed, which does not preclude additional trauma to the wound and pain sensation in the injured.

In addition, due to the high toughness of the hydrogel, in many cases it is not possible to obtain a hydrogel dressing on a mesh pad with the necessary strength and effectiveness due to limited penetration of drugs from the dressing into the wound, which substantially reduces its healing effect.

Object of the present invention is to propose a hydrogel dressing for the treatment of burns and trophic ulcers, which make it possible to obtain a hydrogel dressing with greater strength, a longer residence time on the wound, and the intended before use by the attending physician for a specific Ill (patients) may have or acquire predetermined characteristics, which may be particularly anesthetic and / or hemostatic, for example, to use it under conditions of emergency medical aid, for example, to help an injured person in a traffic accident.

The stated object is achieved by providing the conditions for increasing the strength of the dressing and extending its duration of action by forming hydrogel with a polymer backbone attached to the planar polymer surfaces of a thermo-treated synthetic fiber network, as well as the possibility of obtaining additional beneficial properties achieved by the dressing, namely an improved initial moisture in its storage and its transport, but with the possibility of its impregnation with medicinal or pharmaceutical liquids to increase its moisture and obtaining properties that are determined by the attending physician, directly before its application to the wound or the ulcer.

The proposed as well as the known hydrogel dressing for the treatment of burn wounds and trophic ulcers comprises a net-attached gel-forming composition based on acrylamide and water, but according to the invention the mesh is thermo-treated, made of threads based on synthetic, for example polypropylene fibers.

A special feature of the present hydrogel dressing is that the outer surfaces of the dressing are saturated with salubrious clays, for example, with nanoparticles of Kremnevite and / or bentonite.

A peculiarity of the present hydrogel dressing is that it has a humidity of 75-95%, is impregnated with a drug and is placed in a hermetically sealed sterile package.

A peculiarity of the present association is that it deals with the possibility of its saturation with solutions of medicinal Prepared preparations, has a thickness of 0.5-3.0 mm and a moisture content of the composition of 9-12%.

The proposed as well as the known method for producing a hydrogel dressing for the treatment of burns and trophic ulcers comprises the preparation of a gel-forming composition based on acrylamide and water and their connection to a network, but according to the invention, the net is made of threads on before Basis of synthetic, for example, polypropylene fibers is bound, this cleaned of the impurities, arranged in a frame in the stretched state, and a thermal treatment of the network is carried out by its heating in the thermostat to a temperature of +40 - +140 ° C, the Holding net at this temperature for 20-45 minutes and then cooled to room temperature together with the thermostat and its activation carried out in an environment of peroxide or ozone or chromium oxide or acid, the net obtained is placed in a frame in a plane-parallel shape into which the gel-forming Zu composition is removed, the air is removed from the mold and the mold is left in the mold with the gel-forming composition and netting at a temperature of 75-85 ° C for 14-15 hours until a hydrogel plate is formed which is removed from the mold when the hydrogel plate formed is removed from the frame, the plate is cleaned of the low molecular weight compounds, washed by gel collapse with 40-60% ethyl alcohol, dehydrated to a moisture level of the composition of 8-12%, and becomes a hydrogel plate with a thickness of 0.5-3.0 mm, and the cleaned and dehydrated hydrogel plate is sterilized to obtain the hydrogel dressing.

The peculiarity of the present method is that before use, the hydrogel dressing is saturated either with drug solutions or with emulsions or with distilled water, wherein the hydrogel dressing is immersed in a corresponding solution or emulsion or distilled water, and the dressing to increase its Moisture value to 75-95% is left in it.

Another peculiarity of the present method is that prior to use, the outer surfaces of the hydrogel dressing are saturated with salubrious clays, such as nanoparticles of Kremnevite and / or bentonite.

When the mesh is heated up to the melting temperature limit of the synthetic material, there is a substantial increase in the density of the parallel fibers and, consequently, the strength of the filaments made from the fibers mentioned and the mesh as a whole, thus rendering the present hydrogel dressing more durable than a dressing which is produced by the prototype process.

Depending on the temperature profiles, a network with different predetermined elasticity parameters is obtained. Elasticity is the ability of a material to undergo opposite deformations and strains.

The gel-forming composition of the dressing produced by the present process is intended for the formation of a hydrogel with a polymer backbone attached to the planar polymer surfaces of the synthetic fiber network.

The gelling composition includes, for example, acrylamide, bis-acrylamide, potassium acrylate, potassium persulfate, polyethylene glycol, and water in the following ratio of ingredients (in% by mass): Acrylamide - 1.0 - 25.0 Bis-acrylamide - 0.05 - 2.0 Potassium acrylate - 0.5 - 15.0 Polyethylene glycol - 2,0 - 20,0 Potassium persulfate - 0.0025-0.010 Water - Rest.

The present composition is determined experimentally and for prolonging the time for drying the gel, increasing its ability to saturate with drugs, and reducing the likelihood of adherence of the hydrogel dressing to the wound surface even after completion of the residence time prescribed by the attending physician the wound provided.

• Akrylamid - Basisbauteil des Polymer-Makromoleküls,
• Bisakrylamid - Verbindungskomponente des Polymer-Makromoleküls,
• Kaliumakrylat - Bauteil des Polymer-Makromoleküls, welcher ihm Festigkeit verleiht,
• Polyethylenglykol - verleiht dem Verband Elastizität und traumabekämpfende Wirkung,
• Kaliumpersulfat - Initiator der Polymerisationsreaktion.

Determination of the constituents of the gel-forming composition:

• Acrylamide - basic component of the polymer macromolecule,
• Bis-acrylamide - compound component of the polymer macromolecule,
• Potassium acrylate - component of the polymer macromolecule, which gives it strength,
• Polyethylene glycol - gives the bandage elasticity and trauma control,
• Potassium persulfate - Initiator of the polymerization reaction.

• - eine Verringerung der Menge an Bisakrylamid führt zur Erhöhung der Geschwindigkeit des Aufsaugens der Sekrete aus der Wunde, was eine sehr wichtige Funktion für die blutstillenden Verbände ist;
• - eine Verringerung von Kaliumakrylat führt zur Möglichkeit der Verstärkung des Aufsaugens der Sekrete aus der Wunde, was eine wichtige Funktion für Wunden ist, die lange nicht heilen.

The composition and ratio of ingredients may vary depending on the technological possibilities of the manufacturer. An optimal composition and an optimal ratio of the components are tested on the test track. Attention is paid to the following:

• a reduction in the amount of bis-acrylamide leads to an increase in the rate of suction of the secretions from the wound, which is a very important function for the hemostatic bandages;
• a reduction of potassium acrylate leads to the possibility of enhancing the suction of secretions from the wound, which is an important function for wounds that do not heal for a long time.

The gel forming composition components also provide the conditions for their saturation with solutions of substances having anesthetic or hemostatic or anti-inflammatory or anti-inflammatory and anesthetic and healing properties, including the possibility of prolonged delivery of a medical or pharmaceutical substance from the dressing as determined by the treating physician to offer to the wound.

The use of the present method makes it possible to provide a dressing which allows a flexible realization of the healing properties of the substances with which the gel-forming composition is saturated or impregnated, whereby it is possible, just before the application of the dressing for a concrete Patients find optimal components of a drug and thanks to the gel-forming composition of the present ingredients to extend the time of their emergence on the wound.

The saturation of the outer surfaces of the dressing with salutary clays, such as Kremnevite and / or bentonite nanoparticles, increases its contractive, anti-inflammatory and healing properties and at the same time extends the drying time of the gel, thereby prolonging the dressing's on-wound duration, the traumatizing effect of the dressing is reduced both in its application to the wound and in its removal from the wound.

While conducting patent information analysis in the preparation of the present application, the author did not discover that hydrogel dressings for the treatment of burn wounds and trophic ulcers, and a method of making them with the above-mentioned abundance of essential features, proved that the technical solutions applied for were in accordance with the invention criterion correspond to the "novelty".

The technical result obtained by the practice of the present invention is the ability to obtain a high strength dressing which has the ability to be impregnated with medicinal and / or pharmaceutical liquids prior to use to increase its moisture content and to obtain characteristics required by the attending physician for a specific patient.

The cited technical result was not discovered by the author in the known technical solutions, which belong to the state of the art, which is why the present hydrogel dressing for the treatment of burns and trophic ulcers can be considered as the inventive criterion of "inventiveness".

The present hydrogel dressing for the treatment of burn wounds and trophic ulcers consists of the known components, and the method for its production includes the currently known technological approaches, means and materials. The present hydrogel dressing for the treatment of burn wounds and trophic ulcers can be used in various fields of economics, in medicine, in cosmetics and in the prophylaxis of various diseases, from which it can be concluded that the present solutions comply with the criterion of "industrial applicability".

Example. A hydrogel dressing was prepared for the treatment and anesthesia of a trophic ulcer of the lower leg, which was a recurrent complication of deep leg vein varicosis. Previously, a bandage was made of synthetic polypropylene threads, the net cleaned of the impurities. It was carried out a thermal attachment of the network by heating in the thermostat to a temperature of 40-140 ° C, this at this temperature for 20-45 minutes left and cooled to room temperature together with the thermostat. To activate the network, an activation process by polyperoxide was used. The activation of the network can also be carried out with ozone or chromium oxide or acid by the activation method [Kuleznev V.N., Scherschwev, V.A. Chemistry and physics of polymers. Teaching aid for chem.-technol. Universities - M .: Vyssch. Sch., 1988. p. 312: III.]. Activation of the mesh gives the polypropylene mesh the ability to covalently bond to the gel-forming composition and form a solid gel plate with a solid and at the same time elastic scaffold.

• Akrylamid - 10,0
• Bisakrylamid - 1,0
• Kaliumakrylat - 1,5
• Polyethylenglykol - 15,0
• Kaliumpersulfat - 0,002
• Wasser - Rest
• Zusammen - 100.

The gel-forming composition comprised acrylamide, bis-acrylamide, potassium acrylate, polyethylene glycol, potassium persulfate and water in the following ratio of the components (in% by mass):

• Acrylamide - 10.0
• Bis-acrylamide - 1.0
• Potassium acrylate - 1.5
• Polyethylene glycol - 15.0
• Potassium persulfate - 0.002
• Water - rest
• Together - 100.

To form a solid gel slab, said components were mixed and emptied into a plane-parallel shape with a thermo-treated net made from polypropylene fiber-based yarns. The air was removed from the mold and the mold and composition mold was heated to a temperature of 75-85 ° C for 14-15 hours. The resulting hydrogel was purified from the low molecular weight compounds, purified by gel collapse with 40-60% ethyl alcohol, dehydrated to the prescribed 9-12% moisture content of the composition, and a plate of 0.5-3.0 thickness was obtained mm received. The prepared plate was sterilized and a hydrogel dressing was obtained, which can be stored in a hermetically sealed package for a long period of time until use. Prior to use, the hydrogel dressing was removed from the hermetically sealed package and impregnated with a solution of lidocaine hydrochloride in distilled water at the first stage of anesthesia and treatment of the trophic ulcer of the lower leg. For this purpose, a calculated amount of a 3% solution of lidocaine hydrochloride was prepared. The plate was dipped in the mentioned solution and left therein for 30-40 minutes. During this time, the hydrogel absorbed the mentioned solution and its moisture level increased to 85-95%. Then, the outer surfaces of the dressing were impregnated with nanoparticles of salutary clays, such as Kremnevite and / or bentonite. The ready-to-use dressing was applied without pressure on the trophic ulcer and secured for 3-5 days. For example, in the next stage of anesthesia and treatment of the trophic ulcer of the lower leg, the hydrogel dressing may be impregnated with epinephrine with a 2% solution of lidocaine hydrochloride in distilled water [1:50,000 - 1: 100,000]. In this case, 2% solution of lidocaine hydrochloride epinephrine in the ratio of 1 potassium 0.1% solution of epinephrine is added to 10 ml of a 2% solution of lidocaine. The epinephrine contributes to the delay of the absorption of the lidocaine and prolongs its action. Saturation of the hydrogel dressing with microcide is also possible.

In contrast to the prototype dressing, the present hydrogel dressing was twice longer on the ulcer without drying out - 110-120 hours (nearly 5 days), which made it possible, thanks to the longer duration of action and less trauma to the wound Applying as well as removing it to achieve a positive result - substantial reduction of pain sensations in the patient during the stay of the bandage. Specifically, epithelial growth from the wound edge was noted as early as 5-7 days after application of the hydrogel dressing to the wound.

The present hydrogel dressing for the treatment of burn wounds and trophic ulcers, in contrast to the prototype dressing, has a high strength and a long exposure time thanks to the use of a network of increased strength in it. Such a dressing has increased elasticity and is easy to model in deep wounds and on wounds with a difficult relief on the surface.

The present invention may be used for the preparation of dressings intended for the efficient treatment of wounds against various injuries, including diabetic foot syndrome wounds, bedsores, etc.

The present hydrogel dressings, having a moisture content of 75-95% impregnated with certain medicines and placed in hermetically sealed sterile packages, which need only be removed from the package and attached to the wound for use, are particularly valuable and efficient under conditions immediate medical assistance.

In this way, the present invention makes it possible to produce hydrogel dressings with a flexible realization of the healing properties of the substances with which they are impregnated, and with the possibility of their immediate application even under field conditions.

Claims (4)

A hydrogel dressing for the treatment of burn wounds and trophic ulcers, comprising a gel-based graft-based composition based on acrylamide and water, characterized in that the netting is thermo-treated and made from synthetic, for example polypropylene fibers. Hydrogel dressing for the treatment of burns and trophic ulcers Claim 1 , characterized in that the outer surfaces of the dressing are saturated with nanoparticles of Kremnevite and / or Bentonite. Hydrogel dressing for the treatment of burns and trophic ulcers Claim 1 , characterized in that it is made with the possibility of its impregnation with solutions of medicaments, has a thickness of 0.5-3.0 mm and a moisture content of the composition of 9-12%. Hydrogel dressing for the treatment of burns and trophic ulcers Claim 1 , characterized in that it has a humidity of 75-95%, impregnated with a medicament and arranged in a hermetically sealed sterile package.