DE2118636A1 - 3-Nucleotide von Lincomycin und deren Analogen, Verfahren zu ihrer Herstellung und ihre Verwendung in therapeutischen Präparaten - Google Patents
3-Nucleotide von Lincomycin und deren Analogen, Verfahren zu ihrer Herstellung und ihre Verwendung in therapeutischen PräparatenInfo
- Publication number
- DE2118636A1 DE2118636A1 DE19712118636 DE2118636A DE2118636A1 DE 2118636 A1 DE2118636 A1 DE 2118636A1 DE 19712118636 DE19712118636 DE 19712118636 DE 2118636 A DE2118636 A DE 2118636A DE 2118636 A1 DE2118636 A1 DE 2118636A1
- Authority
- DE
- Germany
- Prior art keywords
- radical
- nucleoside
- formula
- compound according
- phosphate group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002773 nucleotide Substances 0.000 title claims description 90
- 238000000034 method Methods 0.000 title claims description 40
- 238000002360 preparation method Methods 0.000 title claims description 35
- 230000001225 therapeutic effect Effects 0.000 title claims description 8
- 229960005287 lincomycin Drugs 0.000 title description 22
- OJMMVQQUTAEWLP-KIDUDLJLSA-N lincomycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@@H](C)O)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 OJMMVQQUTAEWLP-KIDUDLJLSA-N 0.000 title description 19
- OJMMVQQUTAEWLP-UHFFFAOYSA-N Lincomycin Natural products CN1CC(CCC)CC1C(=O)NC(C(C)O)C1C(O)C(O)C(O)C(SC)O1 OJMMVQQUTAEWLP-UHFFFAOYSA-N 0.000 title description 17
- 230000008569 process Effects 0.000 title description 12
- 150000001875 compounds Chemical class 0.000 claims description 77
- 238000000855 fermentation Methods 0.000 claims description 38
- 230000004151 fermentation Effects 0.000 claims description 38
- -1 alkyl radical Chemical group 0.000 claims description 36
- DRTQHJPVMGBUCF-XVFCMESISA-N Uridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-XVFCMESISA-N 0.000 claims description 32
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 claims description 30
- 150000003839 salts Chemical class 0.000 claims description 29
- 239000000460 chlorine Substances 0.000 claims description 28
- 150000003254 radicals Chemical class 0.000 claims description 28
- 239000002777 nucleoside Substances 0.000 claims description 26
- 150000003833 nucleoside derivatives Chemical class 0.000 claims description 26
- NYHBQMYGNKIUIF-UUOKFMHZSA-N Guanosine Chemical compound C1=NC=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O NYHBQMYGNKIUIF-UUOKFMHZSA-N 0.000 claims description 17
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- DRTQHJPVMGBUCF-UHFFFAOYSA-N uracil arabinoside Natural products OC1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-UHFFFAOYSA-N 0.000 claims description 16
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- 238000009826 distribution Methods 0.000 claims description 11
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- MWEQTWJABOLLOS-UHFFFAOYSA-L disodium;[[[5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-oxidophosphoryl] hydrogen phosphate;trihydrate Chemical compound O.O.O.[Na+].[Na+].C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP([O-])(=O)OP(O)([O-])=O)C(O)C1O MWEQTWJABOLLOS-UHFFFAOYSA-L 0.000 claims description 2
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- 108020004774 Alkaline Phosphatase Proteins 0.000 description 21
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- 125000003729 nucleotide group Chemical group 0.000 description 18
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
- C07H15/16—Lincomycin; Derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3025470A | 1970-04-20 | 1970-04-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2118636A1 true DE2118636A1 (de) | 1971-11-04 |
Family
ID=21853299
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19712118636 Pending DE2118636A1 (de) | 1970-04-20 | 1971-04-17 | 3-Nucleotide von Lincomycin und deren Analogen, Verfahren zu ihrer Herstellung und ihre Verwendung in therapeutischen Präparaten |
Country Status (4)
| Country | Link |
|---|---|
| BE (1) | BE766008A (enrdf_load_stackoverflow) |
| DE (1) | DE2118636A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2092060B1 (enrdf_load_stackoverflow) |
| GB (1) | GB1298295A (enrdf_load_stackoverflow) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7164011B2 (en) | 2002-08-15 | 2007-01-16 | Vicuron Pharmaceuticals, Inc. | Lincomycin derivatives possessing antibacterial activity |
| US7199105B2 (en) | 2002-08-15 | 2007-04-03 | Vicuron Pharmaceuticals, Inc. | Lincomycin derivatives possessing antibacterial activity |
| JP2007516172A (ja) * | 2003-06-17 | 2007-06-21 | ビキュロン・ファーマシューティカルズ・インコーポレイテッド | 抗菌活性を有する新規リンコマイシン誘導体 |
| US7256177B2 (en) | 2003-06-17 | 2007-08-14 | Vicuron Pharmaceuticals, Inc. | Lincomycin derivatives possessing antibacterial activity |
| US7199106B2 (en) | 2003-06-17 | 2007-04-03 | Vicuron Pharmaceuticals, Inc. | Lincomycin derivatives possessing antimicrobial activity |
| US7361743B2 (en) | 2004-02-11 | 2008-04-22 | Pfizer Inc | Lincomycin derivatives possessing antibacterial activity |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3544552A (en) * | 1968-10-18 | 1970-12-01 | Upjohn Co | 3-phosphate esters of lincomycin |
-
1971
- 1971-04-17 DE DE19712118636 patent/DE2118636A1/de active Pending
- 1971-04-19 FR FR7113813A patent/FR2092060B1/fr not_active Expired
- 1971-04-19 GB GB2565571A patent/GB1298295A/en not_active Expired
- 1971-04-20 BE BE766008A patent/BE766008A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BE766008A (fr) | 1971-09-16 |
| FR2092060A1 (enrdf_load_stackoverflow) | 1972-01-21 |
| GB1298295A (en) | 1972-11-29 |
| FR2092060B1 (enrdf_load_stackoverflow) | 1974-10-18 |
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| Date | Code | Title | Description |
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| OHN | Withdrawal |