DE202016008300U1 - Zusammensetzungen zur Kombinationstherapie mit Denguevirus und dendritischen Zellen - Google Patents

Zusammensetzungen zur Kombinationstherapie mit Denguevirus und dendritischen Zellen Download PDF

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DE202016008300U1
DE202016008300U1 DE202016008300.8U DE202016008300U DE202016008300U1 DE 202016008300 U1 DE202016008300 U1 DE 202016008300U1 DE 202016008300 U DE202016008300 U DE 202016008300U DE 202016008300 U1 DE202016008300 U1 DE 202016008300U1
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cancer
dengue virus
virus type
cells
dcs
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PrimeVax Immuno Oncology Inc
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    • C12N2770/24011Flaviviridae
    • C12N2770/24111Flavivirus, e.g. yellow fever virus, dengue, JEV
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    • C12N2770/24011Flaviviridae
    • C12N2770/24111Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24171Demonstrated in vivo effect
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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DE202016008300.8U 2015-07-02 2016-07-01 Zusammensetzungen zur Kombinationstherapie mit Denguevirus und dendritischen Zellen Expired - Lifetime DE202016008300U1 (de)

Applications Claiming Priority (2)

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US201562231351P 2015-07-02 2015-07-02
US62/231,351 2015-07-02

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DE202016008300U1 true DE202016008300U1 (de) 2017-07-14

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US (6) US9730989B2 (enExample)
EP (1) EP3316897A4 (enExample)
JP (2) JP2018522880A (enExample)
CN (1) CN107921063A (enExample)
CA (1) CA2991212A1 (enExample)
DE (1) DE202016008300U1 (enExample)
MX (1) MX2018000052A (enExample)
WO (1) WO2017004567A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2991212A1 (en) 2015-07-02 2017-01-05 PrimeVax Immuno-Oncology, Inc. Compositions and methods for combination therapy with dengue virus and dendritic cells
US10765727B2 (en) 2015-09-26 2020-09-08 PrimeVax Immuno-Oncology, Inc. Compositions and methods for producing dendritic cells
CN110139671A (zh) 2016-11-16 2019-08-16 普莱瓦克斯免疫肿瘤学公司 用于治疗癌症的组合免疫疗法
EP3565567A4 (en) 2017-01-04 2020-07-29 Primevax Immuno-Oncology, Inc. COMPOSITIONS AND METHODS OF THERAPY WITH DENGUE VIRUS
AU2018283957B2 (en) * 2017-06-12 2024-01-25 Cleveland Clinic Lerner Research Institute ZIKA virus strains for treatment of glioblastoma
KR20200023375A (ko) * 2017-06-15 2020-03-04 프라임벡스 이뮤노-온콜로지, 인크. 뎅기 바이러스 및 수지상 세포를 이용하는 암 요법을 위한 조성물 및 방법

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1015972A (en) 1905-09-25 1912-01-30 Westinghouse Electric & Mfg Co Electric switch.
US1035755A (en) 1908-07-21 1912-08-13 Glenn S Smith Draftsman's apparatus.
US6429199B1 (en) * 1994-07-15 2002-08-06 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules for activating dendritic cells
CA2321093A1 (en) 1998-02-20 1999-08-26 The Rockefeller University Apoptotic cell-mediated antigen presentation to dendritic cells
US6524587B1 (en) 1998-05-05 2003-02-25 Bruce W. Lyday Hyperthermia and immunotherapy for leukemias lymphomas, and solid tumors
US6048686A (en) * 1998-05-05 2000-04-11 Randy Kyle Brown Hyperthermia and immunotherapy for cancer
WO2000057907A2 (en) 1999-03-26 2000-10-05 Walter Reed Army Institute Of Research Multivalent dengue virus vaccine
JP2002540170A (ja) * 1999-03-26 2002-11-26 ウォルター リード アーミー インスティテュート オブ リサーチ 弱毒化デング熱2型ウイルスワクチン
CN1353575A (zh) 1999-03-31 2002-06-12 匹兹堡大学联邦制高等教育 用树状细胞一肿瘤细胞或树状细胞一病毒细胞衍生的免疫原在体外诱导抗原特异性t-销细胞
EP1484064A1 (en) 2003-06-04 2004-12-08 Gesellschaft für Biotechnologische Forschung Therapeutical composition containing dentritic cells and use thereof
AU2005257105A1 (en) * 2004-06-24 2006-01-05 Dnavec Research Inc. Anticancer agent containing minus-strand RNA virus
US8513008B2 (en) 2004-10-07 2013-08-20 Argos Therapeutics, Inc. Mature dendritic cell compositions and methods for culturing same
JP5020935B2 (ja) * 2005-04-08 2012-09-05 アルゴス セラピューティクス,インコーポレイティド 樹状細胞組成物および方法
USRE46042E1 (en) 2006-08-15 2016-06-28 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Development of dengue virus vaccine components
US8097256B2 (en) * 2006-09-28 2012-01-17 Cedars-Sinai Medical Center Cancer vaccines and vaccination methods
EP2547360A4 (en) 2010-03-15 2013-11-20 Univ Pennsylvania SYSTEM AND METHOD FOR THE PRODUCTION AND STORAGE OF ACTIVATED TIRES OF DENDRITIC CELLS
CA2837145A1 (en) 2011-05-26 2012-11-29 Glaxosmithkline Biologicals Sa Inactivated dengue virus vaccine
EP2543386A1 (en) * 2011-07-05 2013-01-09 Sotio a.s. Means and methods for active cellular immunotherapy of cancer by using tumor cells killed by high hydrostatic pressure
WO2013154778A1 (en) 2012-04-11 2013-10-17 Dana-Farber Cancer Institute, Inc. Host targeted inhibitors of dengue virus and other viruses
EP2858668A1 (en) * 2012-06-10 2015-04-15 Takeda Vaccines, Inc. Compositions and methods for administration of vaccines against dengue virus
JP6581101B2 (ja) 2014-02-14 2019-09-25 イミューン デザイン コーポレイション 局所免疫刺激及び全身免疫刺激の組み合わせによる癌の免疫療法
KR102873947B1 (ko) 2015-05-07 2025-10-22 베이롤 칼리지 오브 메드신 수지상 세포 면역요법
CA2991212A1 (en) 2015-07-02 2017-01-05 PrimeVax Immuno-Oncology, Inc. Compositions and methods for combination therapy with dengue virus and dendritic cells
US10765727B2 (en) 2015-09-26 2020-09-08 PrimeVax Immuno-Oncology, Inc. Compositions and methods for producing dendritic cells
CN110139671A (zh) 2016-11-16 2019-08-16 普莱瓦克斯免疫肿瘤学公司 用于治疗癌症的组合免疫疗法
EP3565567A4 (en) 2017-01-04 2020-07-29 Primevax Immuno-Oncology, Inc. COMPOSITIONS AND METHODS OF THERAPY WITH DENGUE VIRUS
KR20200023375A (ko) 2017-06-15 2020-03-04 프라임벡스 이뮤노-온콜로지, 인크. 뎅기 바이러스 및 수지상 세포를 이용하는 암 요법을 위한 조성물 및 방법

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Harris et al., Virology 253, 86–95 (1999)
J. Immunol. Methods 223: 77–92, 1999

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Publication number Publication date
MX2018000052A (es) 2018-05-11
US20190046622A1 (en) 2019-02-14
US20170304422A1 (en) 2017-10-26
EP3316897A1 (en) 2018-05-09
JP2021176862A (ja) 2021-11-11
WO2017004567A1 (en) 2017-01-05
EP3316897A4 (en) 2019-03-13
US10357553B2 (en) 2019-07-23
CA2991212A1 (en) 2017-01-05
US10946080B2 (en) 2021-03-16
JP2018522880A (ja) 2018-08-16
US20190247479A1 (en) 2019-08-15
US9849167B2 (en) 2017-12-26
US20180050098A1 (en) 2018-02-22
US9730989B2 (en) 2017-08-15
CN107921063A (zh) 2018-04-17
US20210187086A1 (en) 2021-06-24
US10159727B2 (en) 2018-12-25
US20170000868A1 (en) 2017-01-05

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