DE202014005060U1 - Right-handed lactic acid and potassium lactate-binding milk-free fermentation-containing composition - Google Patents

Abstract

A composition containing L - (+) - lactic acid and potassium in lactate binding, characterized in that the composition, based on a portion of the composition, comprises as active components: - Potassium in the range from> = 200 mg to <= 2000 mg, preferably in Range from> = 400 mg to <= 1200 mg, preferably in the range from> = 400 mg to <= 800 mg; Lactate in the range from> = 300 mg to <= 4000 mg, preferably in the range from> = 800 mg to <= 2000 mg, preferably in the range from> = 1200 mg to <= 1600 mg; L (+) lactic acid in the range from> = 200 mg to <= 3000 mg, preferably in the range from> = 400 mg to <= 2000 mg, preferably in the range from> = 800 mg to <= 1400 mg.

Description

The present invention relates to potassium in lactate form and L - (+) - lactic acid from natural, milk-free lactofermentation, vitamin B12, vitamin B1, steviol glycosides, fruit juice concentrate and Rhodiola rosea containing composition, which in particular as a dietary supplement or functional food in stress and nutritional deficiency of Potassium and B-12 as well as the support of energy metabolism, the function of nerve cells and psyche, the neurovegetative balance, the reduction of fatigue, the maintenance of normal blood pressure and a normal homocysteine metabolism and the regulation of the intestinal environment.

Every second person dies of cardiovascular disease. High blood pressure and smoking are the most important risk factors, with hypertension having overtaken smoking as the main risk factor for premature death ( GBD, 2010 ). Potassium is an essential mineral. As effective as a sodium reduction (salt reduction) is an increased potassium intake to lower blood pressure. In this case, a sufficiently high potassium intake, in contrast to a drug treatment on the cause of the complex clinical picture of hypertension. In addition, dietary or supplemental supplements in hypertensives may more than halve the risk of stroke.

Therefore, the American Heart Association and the Food and Nutrition Board recommend that adults take at least 4.7 grams of potassium daily ( FNB, 2004 ). Over 80 percent of Germans do not reach this US recommendation ( MRI, 2008 ). Although women consume more vegetables and fruits than men, they still have a potassium deficit of 1560 milligrams compared to the official US recommendation. Vegetables, herbs, fruits and nuts are good sources of potassium and at the same time contain little sodium. By switching to a vegetable and fruit rich and low-fat diet, the blood pressure can be successfully lowered ( Sacks et al., 2001 ). But only 10 percent of Germans reach the recommended by the German Society of Nutrition (DGE) five servings of vegetables and fruits a day. In the EU, the recommended daily allowance for potassium is only 2 grams. However, because of the importance that potassium has for maintaining normal blood pressure and our health, this recommendation is far too low.

Before the development of agriculture, people consumed only one gram of sodium per day, but 10 grams of potassium ( Eaton et al., 1997 ). On the other hand, according to the National Consumption Study II (NVS II), Germans absorb on average only 3.4 grams of potassium, but 3.1 grams of sodium ( MRI, 2008 and 2013 ). According to a comprehensive study by the Research Institute for Child Nutrition in Dortmund (2006), the actual sodium intake is on average 40 to 70 percent higher than the low-precision questionnaire values of the NVS II. Compared to the Stone Age diet, the ratio of potassium to sodium has increased by a factor 12 to 50 shifted to sodium.

The genome of modern man, however, does not differ significantly from that of his ancestors of a few thousand years ago, which is why the metabolism of the modern man is calibrated to the diet of that time. This can hardly handle the industrially produced food that has been prevalent for about two generations. The original diet of humans was rich in vegetable diet with many base-forming mineral compounds, such as potassium, calcium and magnesium, and low in sodium chloride. But with industrialization, the mineral content in our food has changed dramatically. Through processing and preservation, the content of sodium has increased strongly and the content of potassium has decreased. When cooking vegetables and potatoes, the losses of potassium and magnesium can be significant and reach up to 75 percent ( Bognár, 1988 ). About cooking water go very large amounts of potassium are lost.

Base-forming potassium supplements are particularly useful as they help regulate both the mineral and acid-base balance. But often they are not well tolerated in terms of taste. Alkaline potassium compounds such as potassium bicarbonate alkalize the gastrointestinal tract, which adversely affects the intestinal environment and intestinal flora.

Potassium, which is abundant in legumes, nuts, vegetables and fruits, helps normalize NO production and softens the endothelium, while salt makes it hard ( Oberleithner et al., 2007 and 2009 ).

Increased homocysteine levels are an independent risk factor for cardiovascular disease and myocardial infarction. Homocysteine is a degradation product of the amino acid methionine found in animal foods more common than in plant foods. Homocysteine leads to a reduced bioavailability of NO, which is presumably mediated by increased levels of ADMA by inhibiting the degradation enzyme ( Dayal and Lentz, 2005 ; Lentz et al. 2003 ).

B12 supports homocysteine degradation and is therefore essential for healthy vessels and the formation of NO, as homocysteine leads to elevated levels of ADMA (asymmetric dimethyl-L-arginine). The combination according to the invention of L - (+) - lactic acid, potassium lactate and vitamin B12 showed a synergy effect here. In addition, the normal function of psyche and nerves and the energy metabolism are promoted by vitamin B12. The high potassium content effectively promotes a normal blood pressure. Preferably, the active B12 compound methylcobalamin is used due to its better bioavailability.

In the prior art, both numerous lactic acid foods with fluctuating and usually low concentration of about 1% are known. They are generally considered healthy, but many consumers avoid them because they do not like the sour taste or can not tolerate the free lactic acid in the stomach.

The dextrorotatory L (+) - lactic acid is highly valued in folk and naturopathy. The multiple mechanisms of action are ultimately only partially clarified. Certainly, L (+) - lactic acid is used to restore a healthy, slightly acidic, large intestinal milieu. In an acidic large intestine, gaseous ammonia, which pollutes the energy metabolism in the liver, is excreted as a non-toxic ammonium salt. The liver is relieved and can break down better metabolic acids. In addition, the lactic acid of intestinal bacteria is degraded to the anti-cancerous butyrate. An alkaline colonic pH increases the risk of colon cancer by promoting the toxicity of bile acids to carcinogenic secondary bile acids. Lowering the pH of the colon to the slightly acidic region has various positive effects.

For chronic diseases and aging, the bicarbonate buffer reserves in venous blood are often reduced. The underlying cause is mitochondrial dysfunction, which releases less carbon dioxide and thus bicarbonate from the cells into the venous blood. After Dr. Dr. Paul Gerhardt Seeger significantly increases L (+) - lactic acid cell respiration.

Normally there is 5-20 mg / dl lactate in the blood. Lactate is utilized in the heart muscle. The heart covers up to 60% of its energy requirement through lactate during exercise. The liver is of crucial importance in lactate metabolism, with about 60-70% of the lactate being metabolized in the liver. Using energy, lactate is converted to glucose via pyruvate (gluconeogenesis).

If hepatic insufficiency exists due to limited oxygen supply, it itself covers energy consumption through anaerobic glycolysis. It thereby becomes lactate-producing organism from the lactate-consuming organ. This leads to a massive increase in the lactate level. Kidney function also affects lactate levels: About 30% are eliminated by the kidneys. The lactate level in the blood is the result of the constant production and elimination of lactate throughout the body.

Orally ingested lactic acid enters the intestine and is partially absorbed into the blood. There it acts as a signal molecule and exerts a "training effect" on erythrocytes and tissue. With regular lactic acid exposure (through diet or exercise), monocarbocylate transporters (MCT) are increasingly expressed in the erythrocyte membrane. As a result, the "trained" erythrocytes can increasingly absorb lactic acid from the plasma as required. This increases the gradient between tissue or muscle and plasma, which in turn allows an increased proton efflux from the tissue: muscle and tissue can release their acids to the plasma reinforced and deacidified. This effect results in an overall improved proton receptivity and buffering capacity of the erythrocytes. Particularly in the case of cancers, such a system can effectively remove tumor lactic acid, which protects the tumor and promotes metastasis, from the tissue and render it harmless. The MCT transport system has the highest priority in pH regulation under load because it can significantly increase its transport performance. The MCTs thus determine the real buffer capacity of a tissue. The main task of the erythrocytes is known to be the transport of oxygen and carbon dioxide. The carbon dioxide diffuses in the capillaries in the erythrocytes, where it is converted into carbonic acid with water and finally reacts to hydrogen carbonate ions and protons. L (+) - lactic acid has a vasodilating effect and can increase the performance of the sodium-potassium pumps and the membrane potential in the erythrocytes. Thus, it counteracts the formation of the roll of paper (sludge), which deteriorates the rheological properties of the blood and inhibits the oxygenation of the tissue.

Lactate is an important source of energy. Under exercise, the heart muscle and nerve cells preferably cover their energy requirements via lactate. Lactate acts as a pseudo-hormone also regulating the sympatho-adrenergic system.

Many of these positive lactic acid effects are achieved through exercise. Oral lactic acid supplementation is an alternative for people who can not or do not want enough exercise because they simulate physical training for the organism. Ingested L (+) lactic acid also has a beneficial effect on the acid-base balance by regulating the intestinal environment, improving ammonia detoxification and relieving the liver.

Surprisingly, it could be stated that the composition according to the invention with L (+) - lactic acid and potassium lactate acts synergistically in the support of the intestinal milieu by slightly acidifying the colonic medium and thus physiologically regulating, thereby relieving the urea cycle by the increased excretion of ammonia via the stool becomes.

The combination according to the invention of L - (+) - lactic acid from milk-free, natural lactofermentation and potassium lactate significantly increased the gastrointestinal compatibility compared to conventional products containing lactic acid and at the same time represented a valuable source of potassium which dissolves completely in water and thus optimally bioavailable is. The combination of the invention, the stomach is not acidified, but the intestine is easily and naturally acidified. If the combination according to the invention is consumed together with meals, gastric emptying is delayed and the blood sugar and insulin increase is flattened.

Thiamine is important for healthy heart function and energy metabolism. In the biologically active form, it is the coenzyme of pyruvate dehydrogenase E1, α-ketoglutarate dehydrogenase and transketolase and thus plays a central role in the citrate cycle and in the degradation of organic acids such as lactic acid.

The pyruvate kinase needs as cofactors potassium and magnesium to produce ATP at the end of glycolysis. This reaction also produces pyruvate. In erythrocytes pyruvate kinase is responsible for the entire energy supply. The pyruvate dehydrogenase complex is located in the mitochondrial matrix and is composed of different enzymes. Pyruvate dehydrogenase produces acetyl-CoA from pyruvate by oxidative decarboxylation, which is finally introduced into the citric acid cycle. Thus, the pyruvate dehydrogenase complex combines glycolysis with the citrate cycle, thus enabling energy production from carbohydrates. The activity of the pyruvate dehydrogenase complex is regulated in different ways. For example, pyruvate dehydrogenase E1, an enzyme of the pyruvate dehydrogenase complex, relies on thiamine pyrophosphate and magnesium as cofactors. While an apple, brown rice or the whole grain of wheat supply plenty of potassium, magnesium and vitamin B1 (thiamine) for their own metabolism, these central cofactors in soft drinks, sugar, white rice and white flour are almost completely absent.

A typical manifestation of thiamine deficiency is metabolic acidosis due to increased lactate production (lactate acidosis). Thiamine is necessary for effective lactate degradation and a useful supplement of the lactic acid concentrate according to the invention.

For daily integration into everyday life, the taste of a product is crucial. So far potassium and lactic acid-rich foods and supplements often fail. At the same time, the supply of water should be increased without adding additional energy in the form of sugar. This corresponds to the new WHO recommendations.

Surprisingly, it could be stated that the taste of the inventive composition by the combination of steviol glycosides and fruit juice concentrate, preferably from blackcurrant, led to a particularly harmonious, refreshingly fruity and subtly sweet taste without the typical, licorice-like stevia aftertaste.

The composition of L - (+) - lactic acid, potassium as lactate, vitamin B12, steviol glycosides, fruit juice concentrate and rhodiola (Rhodiola Rosea) is so highly concentrated that with only a small amount of a glass of mineral water is extremely tasty, tolerable and effective with potassium, vitamin B1 and B12 is enriched.

Rhodiola Rosea is a well-known adaptogen used for natural aromatization. In a preferred embodiment, the recipe according to the invention is rounded off with a natural elderflower aroma.

• – Kalium im Bereich von >= 200 mg bis <= 2000 mg, vorzugsweise im Bereich von >= 400 mg bis <= 1200 mg, bevorzugt im Bereich von >= 400 mg bis <= 800 mg; und
• – Laktat im Bereich von >= 300 mg bis <= 4000 mg, vorzugsweise im Bereich von >= 800 mg bis <= 2000 mg, bevorzugt im Bereich von >= 1200 mg bis <= 1600 mg; und
• – L(+)-Milchsäure im Bereich von >= 200 mg bis <= 3000 mg, vorzugsweise im Bereich von >= 400 mg bis <= 2000 mg, bevorzugt im Bereich von >= 800 mg bis <= 1400 mg; und/oder
• – Vitamin B12 im Bereich von >= 0,1 μg bis <= 1000 μg, vorzugsweise im Bereich von >= 05 μg bis <= 10 μg, bevorzugt im Bereich von >= 1 μg bis <= 3 μg; und/oder
• – Thiamin im Bereich von >= 0,05 mg bis <= 20 mg, vorzugsweise im Bereich von >= 0,3 mg bis <= 1 mg, bevorzugt im Bereich von >= 0,2 mg bis <= 0,5 mg; und/oder
• – Fruchtsaftkonzentrat im Bereich von >= 100 mg bis <= 10000 mg, vorzugsweise im Bereich von >= 1000 mg bis <= 5000 mg, bevorzugt im Bereich von >= 2500 mg bis <= 3400 mg; und/oder
• – Steviolglykoside im Bereich von >= 5 mg bis <= 300 mg, vorzugsweise im Bereich von >= 15 mg bis <= 100 mg, bevorzugt im Bereich von >= 20 mg bis <= 40 mg.
• – Rhodiola-Rosea-Extrakt im Bereich von >= 5 mg bis <= 3000 mg, vorzugsweise im Bereich von >= 20 mg bis <= 100 mg, bevorzugt im Bereich von >= 20 mg bis <= 40 mg.
• – natürliches Holunderblütenaroma im Bereich von >= 5 mg bis <= 300 mg, vorzugsweise im Bereich von >= 15 mg bis <= 100 mg, bevorzugt im Bereich von >= 20 mg bis <= 40 mg.

In preferred embodiments, the composition comprises, based on a portion of the composition, as active ingredients:

• Potassium in the range of> = 200 mg to <= 2000 mg, preferably in the range of> = 400 mg to <= 1200 mg, preferably in the range of> = 400 mg to <= 800 mg; and
• Lactate in the range of> = 300 mg to <= 4000 mg, preferably in the range of> = 800 mg to <= 2000 mg, preferably in the range of> = 1200 mg to <= 1600 mg; and
• L (+) - lactic acid in the range of> = 200 mg to <= 3000 mg, preferably in the range of> = 400 mg to <= 2000 mg, preferably in the range of> = 800 mg to <= 1400 mg; and or
• - Vitamin B12 in the range of> = 0.1 μg to <= 1000 μg, preferably in the range of> = 05 μg to <= 10 μg, preferably in the range of> = 1 μg to <= 3 μg; and or
• - Thiamine in the range of> = 0.05 mg to <= 20 mg, preferably in the range of> = 0.3 mg to <= 1 mg, preferably in the range of> = 0.2 mg to <= 0.5 mg ; and or
• - Fruit juice concentrate in the range of> = 100 mg to <= 10000 mg, preferably in the range of> = 1000 mg to <= 5000 mg, preferably in the range of> = 2500 mg to <= 3400 mg; and or
• - Steviolglykoside in the range of> = 5 mg to <= 300 mg, preferably in the range of> = 15 mg to <= 100 mg, preferably in the range of> = 20 mg to <= 40 mg.
• - Rhodiola rosea extract in the range of> = 5 mg to <= 3000 mg, preferably in the range of> = 20 mg to <= 100 mg, preferably in the range of> = 20 mg to <= 40 mg.
• - Natural elderflower flavor in the range of> = 5 mg to <= 300 mg, preferably in the range of> = 15 mg to <= 100 mg, preferably in the range of> = 20 mg to <= 40 mg.

• – 600 mg Kalium
• – 1367,5 mg Laktat
• – 1.056 mg L-(+)-Milchsäure
• – 1,5 μg Vitamin B12
• – 0,42 mg Thiamin
• – 2.854 mg Schwarzer Johannisbeersaftkonzentrat
• – 26,5 mg Steviolglykoside 97%
• – 33,51 mg Rhodiola-Rosea-Extrakt
• – 33,5 mg natürliches Holunderblütenaroma

In particularly preferred embodiments, the composition comprises, based on a portion of the composition, as active constituents the substances:

• - 600 mg of potassium
• - 1367.5 mg lactate
• - 1.056 mg L - (+) - lactic acid
• - 1.5 μg of vitamin B12
• - 0.42 mg of thiamine
• - 2,854 mg blackcurrant juice concentrate
• - 26.5 mg steviol glycosides 97%
• - 33.51 mg rhodiola rosea extract
• - 33.5 mg natural elderflower aroma

The following example serves to illustrate the present invention: Food supplement Liquid concentrate for the preparation of a beverage ingredient per 100 ml mg / 5 ml potassium 12,000 mg 600 mg lactate 27,350 mg 1367.5 mg L - (+) - lactic acid 21,120 mg 1056 mg Demineralized water 12,000 mg 600 mg B12 as methylcobalamin 30 μg 1.5 μg thiamine hydrochloride 8.4 mg 0.42 mg Blackcurrant juice concentrate 57,084 mg 2854 mg Steviol glycosides 97% 530 mg 26.5 mg Rhodiola rosea-extract 670 mg 33.51 mg natural elderflower aroma 670 mg 33.50 mg 131.4 mg 6571.43 mg

A serving of 5 ml of liquid concentrate is prepared in 250-400 ml of water. Two portions (daily dose) are consumed per day. A ready-made beverage can be prepared simply on the basis of this concentrate (300 to 400 ml per 5 ml of the example described above).

QUOTES INCLUDE IN THE DESCRIPTION

This list of the documents listed by the applicant has been generated automatically and is included solely for the better information of the reader. The list is not part of the German patent or utility model application. The DPMA assumes no liability for any errors or omissions.

Cited non-patent literature

• GBD, 2010 [0002]
• FNB, 2004 [0003]
• MRI, 2008 [0003]
• Sacks et al., 2001 [0003]
• Eaton et al., 1997 [0004]
• MRI, 2008 and 2013 [0004]
• Bognár, 1988 [0005]
• Oberleithner et al., 2007 and 2009 [0007]
• Dayal and Lentz, 2005 [0008]
• Lentz et al. 2003 [0008]

Claims (10)

A composition containing L - (+) - lactic acid and potassium lactate, characterized in that the composition comprises, based on a portion of the composition, as active ingredients: potassium in the range of> = 200 mg to <= 2000 mg, preferably in Range of> = 400 mg to <= 1200 mg, preferably in the range of> = 400 mg to <= 800 mg; Lactate in the range of> = 300 mg to <= 4000 mg, preferably in the range of> = 800 mg to <= 2000 mg, preferably in the range of> = 1200 mg to <= 1600 mg; L (+) - lactic acid in the range of> = 200 mg to <= 3000 mg, preferably in the range of> = 400 mg to <= 2000 mg, preferably in the range of> = 800 mg to <= 1400 mg. A composition according to claim 1, characterized in that the L (+) - lactic acid in the lactic acid and in the potassium lactate is preferably derived from dairy-free fermentation. Composition according to one of claims 1 and 2, characterized in that the composition additionally contains vitamin B12, preferably as methylcobalamin: - Vitamin B12 in the range of> = 0.1 μg to <= 1000 μg, preferably in the range of> = 0 , 5 μg to <= 10 μg, preferably in the range of> = 1 μg to <= 3 μg. Composition according to one of claims 1-3, characterized in that the composition additionally contains vitamin B1: - thiamine in the range of> = 0.05 mg to <= 20 mg, preferably in the range of> = 0.3 mg to <= 1 mg, preferably in the range of> = 0.2 mg to <= 0.5 mg. A composition according to any one of claims 1 to 4, characterized in that the composition additionally contains steviol glycosides as sweetener: steviol glycosides in the range of> = 5 mg to <= 300 mg, preferably in the range of> = 15 mg to <= 100 mg, preferably in the range of> = 20 mg to <= 40 mg. A composition according to any one of claims 1 to 5, characterized in that the composition additionally contains juice concentrate, preferably from black currant, aronia berry, elderberry or pomegranate: fruit juice concentrate in the range of> = 100 mg to <= 10000 mg, preferably in the range of> = 1000 mg to <= 5000 mg, preferably in the range of> = 2500 mg to <= 3400 mg. A composition according to any one of claims 1 to 6, characterized in that the composition additionally contains Rhodiola rosea extract: - Rhodiola rosea extract in the range of> = 5 mg to <= 3000 mg, preferably in the range of> = 20 mg to <= 100 mg, preferably in the range of> = 20 mg to <= 40 mg. Composition according to any one of Claims 1 to 7, characterized in that the composition additionally contains natural elderflower aroma: - natural elderflower aroma in the range of> = 5 mg to <= 300 mg, preferably in the range of> = 15 mg to <= 100 mg, preferably in the range of> = 20 mg to <= 40 mg. Liquid concentrate for the preparation of a drink and finished drinks containing a composition according to any one of claims 1 to 9. Liquid concentrate for the preparation of a drink and ready-to-drink beverages according to claim 9, characterized in that the composition, based on a daily dose of the composition, as active ingredients comprises the substances: - 600 mg potassium - 1367.5 mg lactate - 1.056 mg L - (+) -Lactic acid - 1.5 μg vitamin B12 - 0.42 mg thiamine - 2.854 mg blackcurrant juice concentrate - 26.5 mg steviol glycosides 97%