DE19951671A1 - 2-(4,6-Dimethyl-pyrimidin-2-yloxy)-3-(2-(3,4-dimethoxyphenyl)ethoxy)-3,3-diphenylpropionssäure-Natriumsalz und seine Verwendung als Endothelinantagonist - Google Patents
2-(4,6-Dimethyl-pyrimidin-2-yloxy)-3-(2-(3,4-dimethoxyphenyl)ethoxy)-3,3-diphenylpropionssäure-Natriumsalz und seine Verwendung als EndothelinantagonistInfo
- Publication number
- DE19951671A1 DE19951671A1 DE19951671A DE19951671A DE19951671A1 DE 19951671 A1 DE19951671 A1 DE 19951671A1 DE 19951671 A DE19951671 A DE 19951671A DE 19951671 A DE19951671 A DE 19951671A DE 19951671 A1 DE19951671 A1 DE 19951671A1
- Authority
- DE
- Germany
- Prior art keywords
- dimethoxyphenyl
- ethoxy
- compound
- yloxy
- sodium salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000002308 endothelin receptor antagonist Substances 0.000 title abstract description 5
- HTRPIHRNVLLBGC-UHFFFAOYSA-M sodium;3-[2-(3,4-dimethoxyphenyl)ethoxy]-2-(4,6-dimethylpyrimidin-2-yl)oxy-3,3-diphenylpropanoate Chemical compound [Na+].C1=C(OC)C(OC)=CC=C1CCOC(C=1C=CC=CC=1)(C=1C=CC=CC=1)C(C([O-])=O)OC1=NC(C)=CC(C)=N1 HTRPIHRNVLLBGC-UHFFFAOYSA-M 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims abstract description 15
- 239000007787 solid Substances 0.000 claims abstract description 6
- 239000004480 active ingredient Substances 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 208000006673 asthma Diseases 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- 229940118365 Endothelin receptor antagonist Drugs 0.000 abstract description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 6
- 239000000203 mixture Substances 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- 208000001647 Renal Insufficiency Diseases 0.000 description 3
- 239000003112 inhibitor Substances 0.000 description 3
- 201000006370 kidney failure Diseases 0.000 description 3
- 102000005962 receptors Human genes 0.000 description 3
- 108020003175 receptors Proteins 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 239000003826 tablet Substances 0.000 description 3
- UUUHXMGGBIUAPW-UHFFFAOYSA-N 1-[1-[2-[[5-amino-2-[[1-[5-(diaminomethylideneamino)-2-[[1-[3-(1h-indol-3-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbon Chemical compound C1CCC(C(=O)N2C(CCC2)C(O)=O)N1C(=O)C(C(C)CC)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C1CCC(=O)N1 UUUHXMGGBIUAPW-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 102000004270 Peptidyl-Dipeptidase A Human genes 0.000 description 2
- 108090000882 Peptidyl-Dipeptidase A Proteins 0.000 description 2
- 239000008346 aqueous phase Substances 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- -1 flow regulators Substances 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 230000036454 renin-angiotensin system Effects 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000005541 ACE inhibitor Substances 0.000 description 1
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- 229940123413 Angiotensin II antagonist Drugs 0.000 description 1
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- 201000006474 Brain Ischemia Diseases 0.000 description 1
- 206010007558 Cardiac failure chronic Diseases 0.000 description 1
- 206010008120 Cerebral ischaemia Diseases 0.000 description 1
- 102000002045 Endothelin Human genes 0.000 description 1
- 108050009340 Endothelin Proteins 0.000 description 1
- 206010014824 Endotoxic shock Diseases 0.000 description 1
- 208000010228 Erectile Dysfunction Diseases 0.000 description 1
- 206010061459 Gastrointestinal ulcer Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010061216 Infarction Diseases 0.000 description 1
- 206010027476 Metastases Diseases 0.000 description 1
- 208000019695 Migraine disease Diseases 0.000 description 1
- 206010053159 Organ failure Diseases 0.000 description 1
- 206010033645 Pancreatitis Diseases 0.000 description 1
- 206010040070 Septic Shock Diseases 0.000 description 1
- 208000032851 Subarachnoid Hemorrhage Diseases 0.000 description 1
- 206010047163 Vasospasm Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 238000002399 angioplasty Methods 0.000 description 1
- 239000002333 angiotensin II receptor antagonist Substances 0.000 description 1
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000006793 arrhythmia Effects 0.000 description 1
- 206010003119 arrhythmia Diseases 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 150000001735 carboxylic acids Chemical class 0.000 description 1
- 206010008118 cerebral infarction Diseases 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 239000002872 contrast media Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 description 1
- 239000002158 endotoxin Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
- 201000001881 impotence Diseases 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000007574 infarction Effects 0.000 description 1
- 230000035987 intoxication Effects 0.000 description 1
- 231100000566 intoxication Toxicity 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 230000000302 ischemic effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- AFRJJFRNGGLMDW-UHFFFAOYSA-N lithium amide Chemical compound [Li+].[NH2-] AFRJJFRNGGLMDW-UHFFFAOYSA-N 0.000 description 1
- 229940126601 medicinal product Drugs 0.000 description 1
- 201000008806 mesenchymal cell neoplasm Diseases 0.000 description 1
- 230000009401 metastasis Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 206010027599 migraine Diseases 0.000 description 1
- 210000004165 myocardium Anatomy 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000012454 non-polar solvent Substances 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 239000012074 organic phase Substances 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 206010038464 renal hypertension Diseases 0.000 description 1
- 239000002461 renin inhibitor Substances 0.000 description 1
- 229940086526 renin-inhibitors Drugs 0.000 description 1
- 208000037803 restenosis Diseases 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 239000007885 tablet disintegrant Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (17)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19951671A DE19951671A1 (de) | 1999-10-27 | 1999-10-27 | 2-(4,6-Dimethyl-pyrimidin-2-yloxy)-3-(2-(3,4-dimethoxyphenyl)ethoxy)-3,3-diphenylpropionssäure-Natriumsalz und seine Verwendung als Endothelinantagonist |
| KR1020027005457A KR20020047301A (ko) | 1999-10-27 | 2000-10-17 | 소듐2-(4,6-디메틸-피리미딘-2-일옥시)-3-(2-(3,4-디메톡시페닐)에톡시)-3,3-디페닐프로피오네이트 및 엔도텔린길항제로서의 그의 용도 |
| BR0015112-2A BR0015112A (pt) | 1999-10-27 | 2000-10-17 | Composto, método para uso do mesmo, e, produto farmacêutico |
| IL14931200A IL149312A0 (en) | 1999-10-27 | 2000-10-17 | Sodium 2-(4,6-dimethyl-pyrimidin-2-yloxy)-3-(2-(3,4-dimethoxyphenyl)ethoxy)-3,3-diphenylpropionate and use thereof as endothelin antagonist |
| MXPA02004071A MXPA02004071A (es) | 1999-10-27 | 2000-10-17 | 2-(4,6-dimetil -pirimidin-2-iloxi) -3-(2-(3,4 -dimetoxifenil) etoxi) -3, 3-difenil propionato de sodio y su uso como antagonista de endotelina. |
| CA002389012A CA2389012A1 (en) | 1999-10-27 | 2000-10-17 | Sodium 2-(4,6-dimethyl-pyrimidin-2-yloxy)-3-(2-(3,4-dimethoxyphenyl)ethoxy)-3,3-diphenylpropionate and use thereof as endothelin antagonist |
| AU12727/01A AU1272701A (en) | 1999-10-27 | 2000-10-17 | Sodium 2-(4,6-dimethyl-pyrimidin-2-yloxy)-3-(2-(3,4- dimethoxyphenyl)ethoxy)-3,3-diphenylpropionate and use thereof as endothelin antagonist |
| EP00974404A EP1228047A1 (de) | 1999-10-27 | 2000-10-17 | 2-(4,6-dimethyl-pyrimidin-2-yloxy)-3-(2-(3,4-dimethoxyphenyl)ethoxy)-3,3-diphenylpropionsäure-natriumsalz und seine verwendung als endothelin-antagonist |
| SK596-2002A SK5962002A3 (en) | 1999-10-27 | 2000-10-17 | Sodium 2-(4,6-dimethyl-pyrimidin-2-yloxy)-3-(2-(3,4- dimethoxyphenyl)ethoxy)-3,3-diphenylpropionate and use thereof as endothelin antagonist |
| CZ20021485A CZ20021485A3 (cs) | 1999-10-27 | 2000-10-17 | 2-(4,6-Dimethylpyrimidinyl-2-oxy)-3-[2-(3,4-dimethoxyfenyl)ethoxy]-3,3-difenylpropionát sodný a jeho použití jako endothelinového antagonistu |
| JP2001533121A JP2003512460A (ja) | 1999-10-27 | 2000-10-17 | ２−（４，６−ジメチル−ピリミジン−２−イルオキシ）−３−（２−（３，４−ジメトキシフェニル）エトキシ）−３，３−ジフェニルプロピオン酸−ナトリウム塩及びエンドセリンアンタゴニストとしてのその使用 |
| HU0203476A HUP0203476A3 (en) | 1999-10-27 | 2000-10-17 | Sodium 2-(4,6-dimethyl-pyrimidin-2-yloxy)-3-(2-(3,4-dimethoxyphenyl)ethoxy)-3,3-diphenylpropionate, use thereof and pharmaceutical composition containing the same |
| CN00814871A CN1384822A (zh) | 1999-10-27 | 2000-10-17 | 2－(4,6－二甲基嘧啶基－2－氧基)－3－[2－(3,4－二甲氧基苯基)乙氧基]－3,3－二苯基丙酸钠及其作为内皮素拮抗剂的用途 |
| PCT/EP2000/010202 WO2001030767A1 (de) | 1999-10-27 | 2000-10-17 | 2-(4,6-dimethyl-pyrimidin-2-yloxy)-3-(2-(3,4-dimethoxyphenyl)ethoxy)-3,3-diphenylpropionsäure-natriumsalz und seine verwendung als endothelinantagonist |
| TR2002/01169T TR200201169T2 (tr) | 1999-10-27 | 2000-10-17 | 2-(4,6-Dimetilpirimidinil-2-oksi)-3- [2-(3,4-dimetoksifenil)etoksi]-3,3-difenilpropiyonat ve endotelin antagonist olarak kullanılması |
| NO20021986A NO20021986L (no) | 1999-10-27 | 2002-04-26 | Natrium-2-(4,6-dimetyl-pyrimidin-2-yloksy)-3-(2-(3,4- dimetoksyfenyl)etoksy)-3,3-difenylpropionat og anvendelse deravsom endothelin-antagonist |
| BG106700A BG106700A (en) | 1999-10-27 | 2002-05-14 | Sodium 2-(4,6-dimethylpyrimidin-2-yloxy)-3-(2-(3,4-dimethoxyphenyl) ethoxy-3,3-diphenylpropionate and use thereof as endothelin antagonist |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19951671A DE19951671A1 (de) | 1999-10-27 | 1999-10-27 | 2-(4,6-Dimethyl-pyrimidin-2-yloxy)-3-(2-(3,4-dimethoxyphenyl)ethoxy)-3,3-diphenylpropionssäure-Natriumsalz und seine Verwendung als Endothelinantagonist |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE19951671A1 true DE19951671A1 (de) | 2001-05-03 |
Family
ID=7927001
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19951671A Withdrawn DE19951671A1 (de) | 1999-10-27 | 1999-10-27 | 2-(4,6-Dimethyl-pyrimidin-2-yloxy)-3-(2-(3,4-dimethoxyphenyl)ethoxy)-3,3-diphenylpropionssäure-Natriumsalz und seine Verwendung als Endothelinantagonist |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP1228047A1 (cs) |
| JP (1) | JP2003512460A (cs) |
| KR (1) | KR20020047301A (cs) |
| CN (1) | CN1384822A (cs) |
| AU (1) | AU1272701A (cs) |
| BG (1) | BG106700A (cs) |
| BR (1) | BR0015112A (cs) |
| CA (1) | CA2389012A1 (cs) |
| CZ (1) | CZ20021485A3 (cs) |
| DE (1) | DE19951671A1 (cs) |
| HU (1) | HUP0203476A3 (cs) |
| IL (1) | IL149312A0 (cs) |
| MX (1) | MXPA02004071A (cs) |
| NO (1) | NO20021986L (cs) |
| SK (1) | SK5962002A3 (cs) |
| TR (1) | TR200201169T2 (cs) |
| WO (1) | WO2001030767A1 (cs) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2532650A3 (en) | 2004-06-24 | 2013-11-06 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19636046A1 (de) * | 1996-09-05 | 1998-03-12 | Basf Ag | Neue Carbonsäurederivate, ihre Herstellung und Verwendung als gemischte ET¶A¶/ET¶B¶-Rezeptorantagonisten |
-
1999
- 1999-10-27 DE DE19951671A patent/DE19951671A1/de not_active Withdrawn
-
2000
- 2000-10-17 TR TR2002/01169T patent/TR200201169T2/xx unknown
- 2000-10-17 CZ CZ20021485A patent/CZ20021485A3/cs unknown
- 2000-10-17 IL IL14931200A patent/IL149312A0/xx unknown
- 2000-10-17 WO PCT/EP2000/010202 patent/WO2001030767A1/de not_active Application Discontinuation
- 2000-10-17 BR BR0015112-2A patent/BR0015112A/pt not_active IP Right Cessation
- 2000-10-17 SK SK596-2002A patent/SK5962002A3/sk unknown
- 2000-10-17 EP EP00974404A patent/EP1228047A1/de not_active Withdrawn
- 2000-10-17 AU AU12727/01A patent/AU1272701A/en not_active Abandoned
- 2000-10-17 CN CN00814871A patent/CN1384822A/zh active Pending
- 2000-10-17 HU HU0203476A patent/HUP0203476A3/hu unknown
- 2000-10-17 KR KR1020027005457A patent/KR20020047301A/ko not_active Ceased
- 2000-10-17 CA CA002389012A patent/CA2389012A1/en not_active Abandoned
- 2000-10-17 JP JP2001533121A patent/JP2003512460A/ja not_active Abandoned
- 2000-10-17 MX MXPA02004071A patent/MXPA02004071A/es unknown
-
2002
- 2002-04-26 NO NO20021986A patent/NO20021986L/no not_active Application Discontinuation
- 2002-05-14 BG BG106700A patent/BG106700A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA02004071A (es) | 2002-10-11 |
| NO20021986D0 (no) | 2002-04-26 |
| AU1272701A (en) | 2001-05-08 |
| SK5962002A3 (en) | 2002-09-10 |
| BR0015112A (pt) | 2002-10-29 |
| HUP0203476A3 (en) | 2003-07-28 |
| KR20020047301A (ko) | 2002-06-21 |
| CZ20021485A3 (cs) | 2003-06-18 |
| JP2003512460A (ja) | 2003-04-02 |
| NO20021986L (no) | 2002-04-26 |
| BG106700A (en) | 2003-02-28 |
| WO2001030767A1 (de) | 2001-05-03 |
| HUP0203476A2 (en) | 2003-05-28 |
| CA2389012A1 (en) | 2001-05-03 |
| EP1228047A1 (de) | 2002-08-07 |
| TR200201169T2 (tr) | 2002-09-23 |
| CN1384822A (zh) | 2002-12-11 |
| IL149312A0 (en) | 2002-11-10 |
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| 8127 | New person/name/address of the applicant |
Owner name: ABBOTT GMBH & CO. KG, 65205 WIESBADEN, DE |
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| 8139 | Disposal/non-payment of the annual fee |