DE69528103T2 - Verwendung von Riminophenazin zur Behandlung von MDR-Resistenz - Google Patents

Verwendung von Riminophenazin zur Behandlung von MDR-Resistenz

Info

Publication number
DE69528103T2
DE69528103T2 DE69528103T DE69528103T DE69528103T2 DE 69528103 T2 DE69528103 T2 DE 69528103T2 DE 69528103 T DE69528103 T DE 69528103T DE 69528103 T DE69528103 T DE 69528103T DE 69528103 T2 DE69528103 T2 DE 69528103T2
Authority
DE
Germany
Prior art keywords
alkyl
hydrogen
treatment
halogen atom
riminophenazine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69528103T
Other languages
English (en)
Other versions
DE69528103D1 (de
Inventor
Constance Elizabeth Medlen
Ronald Anderson
John Francis O'sullivan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Technology Finance Corp Pty Ltd
Original Assignee
University of Pretoria
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Pretoria filed Critical University of Pretoria
Application granted granted Critical
Publication of DE69528103D1 publication Critical patent/DE69528103D1/de
Publication of DE69528103T2 publication Critical patent/DE69528103T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/46—Phenazines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Paper (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Glass Compositions (AREA)
  • Silicon Polymers (AREA)
DE69528103T 1994-04-05 1995-03-16 Verwendung von Riminophenazin zur Behandlung von MDR-Resistenz Expired - Lifetime DE69528103T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ZA942363 1994-04-05
ZA949352 1994-11-24

Publications (2)

Publication Number Publication Date
DE69528103D1 DE69528103D1 (de) 2002-10-17
DE69528103T2 true DE69528103T2 (de) 2003-05-15

Family

ID=66553352

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69528103T Expired - Lifetime DE69528103T2 (de) 1994-04-05 1995-03-16 Verwendung von Riminophenazin zur Behandlung von MDR-Resistenz

Country Status (7)

Country Link
EP (1) EP0676201B1 (de)
JP (1) JPH07277982A (de)
KR (1) KR950031076A (de)
AT (1) ATE223718T1 (de)
AU (1) AU696324B2 (de)
CA (1) CA2144783A1 (de)
DE (1) DE69528103T2 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU704048B2 (en) * 1995-01-31 1999-04-15 Universiteit Van Pretoria Anti-parasitic activity
KR970704704A (ko) * 1995-05-22 1997-09-06 오쓰카 아키히코 디하이드로펜아진 유도체, 이의 제조 방법, 및 결핵균 및 비정형 항산균용 약물(Dihydrophenazine derivative, process for producing the same and drug for tubercle bacilli and atypical acid-fast bacilli)
WO1997045120A1 (en) * 1996-05-24 1997-12-04 University Of Pretoria Use of riminophenazines as antimicrobial and antimalarial agents
US6426415B1 (en) 1997-09-03 2002-07-30 Guilford Pharmaceuticals Inc. Alkoxy-substituted compounds, methods and compositions for inhibiting parp activity
US6635642B1 (en) 1997-09-03 2003-10-21 Guilford Pharmaceuticals Inc. PARP inhibitors, pharmaceutical compositions comprising same, and methods of using same
US6346536B1 (en) 1997-09-03 2002-02-12 Guilford Pharmaceuticals Inc. Poly(ADP-ribose) polymerase inhibitors and method for treating neural or cardiovascular tissue damage using the same
US6514983B1 (en) 1997-09-03 2003-02-04 Guilford Pharmaceuticals Inc. Compounds, methods and pharmaceutical compositions for treating neural or cardiovascular tissue damage
US6197785B1 (en) 1997-09-03 2001-03-06 Guilford Pharmaceuticals Inc. Alkoxy-substituted compounds, methods, and compositions for inhibiting PARP activity
US6291425B1 (en) 1999-09-01 2001-09-18 Guilford Pharmaceuticals Inc. Compounds, methods and pharmaceutical compositions for treating cellular damage, such as neural or cardiovascular tissue damage
US6395749B1 (en) 1998-05-15 2002-05-28 Guilford Pharmaceuticals Inc. Carboxamide compounds, methods, and compositions for inhibiting PARP activity
US6387902B1 (en) * 1998-12-31 2002-05-14 Guilford Pharmaceuticals, Inc. Phenazine compounds, methods and pharmaceutical compositions for inhibiting PARP
US6723733B2 (en) 2000-05-19 2004-04-20 Guilford Pharmaceuticals, Inc. Sulfonamide and carbamide derivatives of 6(5H)phenanthridinones and their uses
AU2001275085A1 (en) 2000-06-01 2001-12-11 Guilford Pharmaceuticals Inc. Methods, compounds and compositions for treating gout
AUPR644301A0 (en) * 2001-07-17 2001-08-09 Unisearch Limited Method and composition for treatment of cancer
JP2016164125A (ja) * 2013-07-02 2016-09-08 国立大学法人帯広畜産大学 バベシア症の治療剤及び予防剤
CN107382882B (zh) * 2017-07-26 2022-03-25 浙江华海药业股份有限公司 一种氯法齐明的精制方法

Also Published As

Publication number Publication date
JPH07277982A (ja) 1995-10-24
KR950031076A (ko) 1995-12-18
EP0676201B1 (de) 2002-09-11
AU1498295A (en) 1995-10-12
EP0676201A3 (de) 1996-06-12
EP0676201A2 (de) 1995-10-11
AU696324B2 (en) 1998-09-10
ATE223718T1 (de) 2002-09-15
CA2144783A1 (en) 1995-10-06
DE69528103D1 (de) 2002-10-17

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: TECHNOLOGY FINANCE CORP. (PTY.) LTD., SANDTON, ZA

8364 No opposition during term of opposition