DE1954226C3 - Use of a quinoxaline derivative as part of a direct feed for pets - Google Patents

Description

in which R 'and R ² = hydrogen, R ³ = hydrogen or halogen atom or methyl radical and R- * = hydrogen atom or methyl radical or R ¹ and R ² = methyl radical, R ³ = bromine atom and R ⁴ = hydrogen atom, in particular of quinoxaline -l, 4-dioxide, as a component of a direct feed for pets, the direct feed containing 0.0001 to 0.025 percent by weight of the quinoxaline derivative, or as a component of a pre-mass for pet food, the pre-mass consisting of an essentially solid carrier and 0.2 to Contains 50 percent by weight of the quinoxaline derivative.

From British patent specification 1 121 104 it is already known to use certain quinoxaline derivatives, in particular Quinoxaline di-N-oxides, the poultry feed in an amount of 1 to 60 mg / kg body weight add to combat chronic respiratory diseases in chickens. Furthermore was found that this feed additive also increased the weight of poultry and domestic animals promoted and better forage utilization is achieved.

It has been found that when using a quinoxaline derivative of the formula

\ R ⁴ ν 0 R ¹ / ' R ² R ³ / ΐ \ KJ ϊ O

in which R ¹ and R ² = hydrogen, R ³ = hydrogen or halogen atom or methyl radical and R * = hydrogen atom or methyl radical or R 'and R ² = methyl radical, R ³ = bromine atom and R ⁴ = hydrogen atom, in particular of quinoxaline 1,4-dioxide, as a component of a direct feed for pets, the direct feed containing 0.0001 to 0.025 percent by weight of the quinoxaline derivative, or as a component of a pre-mass for pet food, the pre-mass consisting of an essentially solid carrier and 0.2 to 50 Contains percent by weight of the quinoxaline derivative, an even greater weight gain of the animals and better feed utilization takes place.

in which R ¹ and R ² = hydrogen, R ³ = hydrogen or halogen atom or methyl radical and R ⁺ = hydrogen atom or methyl radical or R ¹ and R ² = methyl radical, R ³ = bromine atom and R ⁴ = hydrogen atom, in particular of quinoxaline-1, 4-dioxide, as a component of a direct feed for pets, the direct feed containing 0.0001 to 0.025 percent by weight of the quinoxaline derivative, or as a component of a pre-mass for pet food, the pre-mass consisting of an essentially solid carrier and containing 0.2 to 50% by weight of the quinoxaline derivative .

A food provided with the said additive can be used on all pets, e.g. B. poultry, pigs, Sheep and cattle.

The direct feed contains 0.0001 percent by weight (1 g / ton) to 0.025 percent by weight (250 g, ton) a quinoxaline derivative of the above. Type or 0.0001

jo weight percent (i g / ton) to 0.0025 weight percent (25 g / ton) of the preferred quinoxaline derivative. One can feed the animals with this feed for essentially their entire growing season or just part of it, preferably the initial part, their growing season feed to achieve the desired increase in the rate of growth of the animals. Such an increase in the rate of growth of the animals enables the animals in a shorter growth times than before can be brought to a desired sales weight, or that animals with a greater weight are obtained in the same growing time as before can. In addition, the subject matter of the invention leads to a better utilization of the feed, i. i.e. that animals who are fed with a feed containing a quinoxaline derivative of the above, a given Achieve weight after consuming less food than animals whose food has such a diet Does not contain quinoxaline derivative.

Certain quinoxaline derivatives that can be used according to the invention are, for. B. quinoxaline 1,4-dioxide, 6-methylquinoxaline-1,4-dioxide, 6-chloro-2,3-dimethylquinoxaline-1,4-dioxide, 6-bromo-2,3-dimethylquinoxaline-1,4-dioxide, 6,7-dimethylquinoxaline-1,4-dioxide and o-chloro-T-methylquinoxaline-1,4-dioxide, of which the preferred compound is quinoxaline 1,4-dioxide itself.

The pets can with a quinoxaline derivative of the type specified above in the form of a pre-mass for pet food, such food being fed by diluting a concentrated premass can be prepared.

As mentioned, the mass can have the form of a concentrated pre-mass, which is mixed with a full-fledged, d. H. Balanced feed can be diluted to create a feed that can be used as a Direct feed for animals can be used to increase their growth rate.

A suitable pre-mass consists, for. B. from a mixture of a quinoxaline derivative of the type indicated above with an inert edible carrier, e.g. B. kaolin, talc, calcium carbonate, fuller's earth, attapulgite clay, oyster shell meal, starch or lactose, or with a wholesome edible carrier, ζ. Κ the standard fattening diet for chickens intended for roasting, consisting of grain and grain by-products, animal protein supplemented with vitamins and minerals, or another conventional feed.

Such a premix contains 0.2 to 50 percent by weight of the quinoxaline derivative or 0.2 to 5 percent by weight the preferred quinoxaline derivative and can be diluted with a full feed, so that the final feed is 0.0001 to 0.025 percent by weight quinoxaline derivative and 0.0001 to Contains 0.0025 percent by weight of the preferred quinoxaline derivative. When diluting the premasses 500 g of pre-mix are expediently mixed with 1 ton of feed.

The direct feed for pets and the premasses can also contain other veterinary compounds, such as B. anthelmintics such as tetramisole, pyramid tartrate, thiabendazole or piperazine, coccidiostats such as methyl benzoquate, meticlorpindole, 3,5-dinitro-o-toluamide, 3,5-dinitrobenzamide, amprolium or decoquinate, or antibiotics such as bacitracin, oleandomycin or virginiamycin.

The invention is explained in more detail below purely by way of example using exemplary embodiments.

example 1

Feed premasses which are suitable for dilution with a feed can thereby be obtained be that 5, 10, 25, 50 or 100 g of quinoxaline-1,4-dioxide with a standard fattening feed for Roast certain chickens, consisting of cornmeal and fishmeal plus lysine, methionine, Vitamins and minerals mixed in such a way that a pre-mass with a weight of 500 g is obtained.

You can obtain further premixes if the quinoxaline-1,4-dioxide is replaced by 6-methylquinoxaline-1,4-dioxide, o-bromo ^ -dimethylquinoxaline-1,4-dioxide, 6,7-dimethylquinoxaline-1,4-dioxide or 6-chloro-7-methylquinoxaline-1,4-dioxide replaced.

Example 2

A direct feed for poultry can be produced in that 500 g of a pre-mass according to Example 1 can be intimately mixed with 1 ton of standard feed for chickens intended for roasting.

Example 3

Groups of 60 seven day old chicks were weighed and caged, each cage Contained 10 chicks. A group of chicks was fed a full-fledged staple for 6 days, which did not contain a growth promoting compound while fourteen other groups were with the same for 6 days Basic fodder was fed, but this was 0.0005 to 0.01 percent by weight of a quinoxaline derivative contained. After the 6 days, all chicks were weighed and their respective weight gains was ascertained. A compound with growth promoting ability caused the chicks to develop the treated groups showed an increased weight gain compared to the chicks of the control group. The difference between these weight gains - expressed as a percentage of the weight gain the control group - was considered significant if they were equal to or more than 11% above the weight gain of the control group was. The following results were obtained with the Test quinoxaline derivatives:

R ² R ³ R ⁴ percent difference test between link Weight in the feed increases in the R ¹ H H H treated and control 0.01 groups 0.005 ( ⁰ O) H 0.0025 + 34.6 H Me H 0.001 + 33.0 Me Cl H 0.0005 + 20.9 Me Br H 0.01 + 18.2 H Me Me 0.01 + 19.0 H H Cl Me 0.01 + 34.6 Me 0.01 + 25.2 Me 0.01 + 33.8 H + 42.5 H + 41.3

Example 4

In an experiment carried out essentially as in Example 3, a group of 60 received one Day-old chicks that were kept in chicken coops of 60 chicks each, a feed with quinoxaline-1,4-dioxide, and the growth rate over 8 weeks was that of a similar control group of 360 chicks compared. After the 8 weeks the following resulted:

Average weight of those fed a diet with 0.001 percent by weight quinoxaline 1,4-dioxide Chickens 1.82 kg; mean weight of the control group chickens 1.60 kg. relationship from feed consumption to chicken weight: 2.18 control group; 2.02 treated group.

Example 5

When examined with pigs in which each group contained 6 pigs, the following were obtained Results after a fattening period of 7 weeks:

Pigs: mean weight gain per animal 21.8 kg control group, 24.2 kg treated Group;

castrated pigs: average weight gain per animal 22.9 kg control group,
25.1 kg treated group.

The treated group each received a feed with 0.001 percent by weight of quinoxaline 1,4-dioxide.

The exploitation of the invention can be made possible by legal provisions, in particular by the Feed Act, be limited.

Claims (1)

Claim: Use of a quinoxaline derivative of the formula O
R ³ ! R ¹ The invention thus relates to the use of a quinoxaline derivative of the formula