DE1692478C - Growth promoting feed - Google Patents

Description

amine A and D mixtures, riboflavin supplements and such as vitamins, minerals, etc., can

other vitamin B complexes, and bone meal, lime concentrates added depending on the circumstances

as well as inorganic substances other than mineral compounds.

Suppliers. The stronger concentrates can vary somewhat, depending on the compound, with protein-containing carriers such as soy compounds in feed mixes and concentrates, bean oil meal, to concentrated supplements, depending on the compound the animals can be fed to the feed used and to the treatment to be treated. In such cases, the animal leaves. The substances are expediently eaten with the animals the usual food of maize, oat-edible carrier materials in such relative men- ίο and other cereals and the like. The proportion of gene ratios combined so that concentrates without the means can be in these supplementary foods that are easily blended with nutritionally balanced between about 0.2 and 20 g / kg of supplementary food standard feed or are added as such,
sentences to normal feed can be used. The concentrates mentioned can also be the

contain, can be prepared so that they achieve 0.10 balanced, ready-made feed that contains about 10 ⁰ Z ₀ inactive substance with a 10 to about 125 g of the claimed agents per ton of salt (sodium chloride) or other minerals ge food contains. In the case of ruminants, it should contain a mixture, the incorporation of which into the poultry - the finished feed, proteins, fat, cellulose, coal feed ration is desired. This can be adjusted according to free ao hydrates, vitamins and minerals in such amounts of choice so that with the content of contain that the need of the respective animal for this active ingredient in the mixture of each animal is satisfied. Most of these substances are given in the correct daily dose given. If the naturally occurring feed, such as prepared feed supplements, is used, then alfalfa hay or flour, ground maize, whole the material mixed with the feed can be administered »5 oats, soybean oil meal, maize fermentation feed, can be ground. Even then, a concentration of corn on the cob, wheat bran and dried molasses around 0.10 to 10% Jcs Mitteis is used in the feed. contain. Bone meal, lime, iodized salt, and acids- However, larger amounts can also be applied. Minerals are often added to make those required if the product is flavored to the poultry, minerals, and urea, to provide additional adherence. The latter can be supplied by simple attempts to deliver nitrogen.

to be established. As the skilled person knows, the feed can be a large daily dose with only a part of the daily intake, depending on the purpose, to mix the feed distribution, to a perfect habits, the species of animal, etc. Special feed is often advisable to ensure consumption of the dose. The remainder of the different purposes are in "Feeds and Feeding" of daily food ration can then after consumption 35 Morrison, The Morrison Publishing Company, of the prepared portion fed in the usual way Clinton, Iowa, 1959, compiled,
will. In the case of nichtwiederkäuenden animals, such as In the preparation of concentrates may be a swine, a suitable feed, about 50 used to plurality of carriers, the 80 ° / ₀ grain, 3 to 10 ⁰ / o animal protein, 5 to 30 ° / ₀ contain the funds mentioned. The suitable 4 ° vegetable protein, 2 to 4% minerals and additional carriers include: soybean oil flour, corn gluten- containing vitamins,
flour, cottonseed oil flour, sunflower seed- The following examples illustrate the invention, flour, linseed oil flour, corn flour, lime and corn cob flour. The carriers facilitate a uniform example 1
Distribution of the active material in the finished 45

Feed with which the concentrate is blended The effectiveness of the compounds described here

will. This is especially important because only a small fertilizer 7,8,9,10 - Tetrahydro - 6H - cyclohepta [b] chin-

Amount of effective material is required. oxaline - 5.11 - dioxide and 2,3 - dihydro - IH - cyclo-

If desired, the concentrates can be mixed with verpenta [b] quinoxaline-4,9-dioxide to promote the

different proteinaceous materials or edible 50 growths from chickens is carried out on a group of

Waxes, such as zein, microcrystalline wax, and the like, demonstrated by Vantrass white rock chicks. With these

be superficially coated to be the effective trials the day old chicks in

Wrap the component in a protective film. four groups of 25 pieces of one gender

Of course, the proportions can be divided into such and based on an electrically heated breeder

Concentrates are subject to wide fluctuations because 55 wire mesh shelves are held. Each group becomes one

the amount of effective material in the finished feed is assigned to a separate department and a basic

by blending appropriate amounts of concentrate food administered by 0.05 percent by weight

with the feed to any content of 7,8,9,10 - tetrahydro - 6H - cyclohepta [b] quinoxalin-

Supplements in the finished feed can be set 5.11 - dioxide or 2.3 - dihydro - IH - cyclopenta [b] -

can. Has been added in the preparation of strong concentrates, ⁶ Q quinoxaline-4,9-dioxide. A consortium

d. H. Premixes made by feed producers do not receive any supplements in the troll group

to ready-made food or to weaker concentrates food. Growth and feed conversion

can be blended, the content of each group can be up to an age of

the mean between about 0.2 and about 100 g / kg 8 weeks. The composition of the

Concentrate. A particularly useful con- ⁶ 5 staple is described below. the

concentrate is obtained by mixing 2 g of the supplements in the form of a food

Mi.tsls with 0.5 kg lime or 0.5 kg lime-soybean premix at the expense of yellow corn flour

oil flour mixture (1: 1). Other food supplements, added.

Component% of the mixture

Yellow cornmeal '.. 56.65

Soybean oil meal (50% protein) .. 33.75

Alfalfa flour (17% protein) 2.00

Stabilized animal fat 3.50

Dicalcium phosphate 2.00

Iodized salt 0.50

Trace mineral-vitamin premix 0.60

Lime 1.00

100.00

Trace mineral-vitamin premix

(Vitamin - 5 · / «of the feed)% of the premix

ν liamin / \ iu

Vitamin D ₃ 10

Choline chloride (25%) 35.25

Niacin (80%) 0.55

Calcium pantothenate (45%) 10

Riboflavin 0.39

B-12-60 0.2

Unidentified poultry and cattle growth factor from one

Streptomyces fermentation 30

Fine cornmeal 3.75

(Mineral mixture - 0.05% of the feed)

Manganese 24.0

Iodine 0.48

Iron 8.0

Copper 0.8

Zinc 0.0 *

Cobalt 0.08

The chicks are observed daily, weighed weekly, and the gain of each animal, the growth index and feed utilization are determined. It has been found that by 7,8,9 ' 10-Tetrahydro-6H-cycloheptate-quinoxaline-S. 11-dioxide and that by 2,3-dihydro-1H-cyclopenta [b] quinoxaline-4,9-dioxide supplemented feed a significant increase in weight gain and a substantial Causes improvement in feed conversion.

Example 2

The procedure of Example 1 is followed using 0.002, 0.01 and 0.025 weight percent,

based on the feed, to 7,8,9,10-tetrahydro-

6H-cyclohepta [b] quinoxaline-5, ll-dioxide and 2,3-di-

hydro - IH - cyclopentatbjquinoxaline - 4.9 - dioxide

observed in growth and forage utilization.
Example 3

A group of piglets is given a perfectly balanced diet, which turns out to be the highest

ao has proven useful for such animals. These animals that are weaned around the 6th to 8th day of life an introductory formula is fed for several days, which contains 60.1% skimmed milk powder, 10.1% soybean oil, 9.9% glucose

s5 hydrate, 1.1% brewer's yeast, 0.4% oxytetracycline supplement with 1.1 g oxytetracycline / kg, 16% soybean oil flour and a complete vitamin and mineral supplement contains. The basic food for some piglets of the group is made up of 7,8,9,10-tetrahydro-

oH-cycIoheptatblchinoxalin-S.ll -dioxid and 2,3-dihydro-lH-cyclopentatbJquinoxalin ^^ - dioxide supplemented in an amount of 100 g / ton of feed. This feed is given when the animals have been around for about 3 weeks are old and for a total of 4 weeks.

The supplemented feed is found to result in an economically significant weight gain and leads to a considerable improvement in feed conversion.

Claims (1)

1 2 methods that are useful is administration Claim: more convenient in animal feed, water or mineral mix. A typical conventional lining material that Growth-promoting feed can be used in solid or is said to be from about 50 to liquid form, characterized by 5 80% grain, 0 to 10% animal protein, 5 to 30% a content of ^, ^ lO-tetrahydro-oH-cyclo- vegetable protein, 2 to 4% minerals and additional hepta [b] quinoxaline-5, ll-dioxide and / or 2,3-Di- borrowed vitamin suppliers exist. hydro-lH-cyclopentaßilchinoxaline - ^ - dioxide. The addition of a small amount of one or the other two compounds described here 2,3-dihydro- lo lH-cyclopentafblquinoxaline - ^ - dioxide and 7,8,9, 10 - Tetrahydro - 6H - cycloheptaltychinoxalin-S.ll-di- oxide used in food for animals, both ruminants than non-ruminants, if these animals do that Long-term preparation in amounts of approx »Ο ι« -. ··> -ι ·· - ioo ~ _B / io ν £ <T> oraf »u / irht nrn Tap. into the. The invention relates to a growth-promoting special feed in solid or liquid form which is maintained in its active growth period and which, through th, to an acceleration of the growth pigs content of TSQlO-tetrahydro-oH-cycloheptadicity and to a better feed conversion, / u [blchinoxalin- 5, ll-dioxide and / or 2,3-dihydro-1H- the animal classes mentioned include poultry (chickens. Cyc! Openta [b] quinoxaline-4,9-dioxide is labeled. 20 ducks, turkeys). Cattle, sheep, dogs, cats., The agents according to the invention are valuable for pigs, rats, mice, horses, goats, mules, treatment of the urinary tract (healing and prophy rabbits, mink etc. The improvement achieved lax) and systemic infections in humans and in the growth rate and forage wasted animal; they are particularly useful against gram negation exceeding the results of normally tive infections, both in vitro and in vivo. 35 can be obtained with a complete food which al ^; · In addition, they are effective remedies against the "air nutrients, vitamins, minerals and others for pouch disease" of poultry; a healthy growth of such animals is necessary in an impressive manner, they accelerate the growth and contain factors. The animals reach their marrow! Improve the feed conversion of domestic animals, thus weight faster and with less feed, especially from poultry, both in the presence of the feed composition described here and in the absence of infections, have proven to be particularly useful and outstanding For the purposes described above, in the case of animals such as poultry, rats, pigs, the compounds mentioned orally and parenterally, sheep, cattle, etc., can be found. In some cases> administered, e.g. B. by subcutaneous or intra- the effect can vary depending on the C muscular injections, in doses of about 1 to about 35 badly of the animals. The products could; i 100 mg / kg body weight. In the case of parenteral administration, of course in one component of the feed or as a portion, galen of about 10 to about 100 mg / kg of body weight, evenly blended with a mixed feed, are preferred. Appropriate trays are given; They can also, as already mentioned, germ materials for paranteral injection can be used in an amount equivalent to that of the water supply; either aqueous vehicles such as water or isotonic 40 of the animals can be added. In the nutritional saline solution, isotonic dextrose solution, Ringer's solution, balanced feed, numerous feeds or non-aqueous carriers, such as fatty oils of vegetable origin, can be used. Origin (cottonseed, peanut oil, corn, sesame), the resulting new feed mixtures have Dimethyl sulfoxide and other non-aqueous vehicles have a noticeable influence on growth, the therapeutic efficacy of the preparation and feed utilization. These feed rates do not affect and in the values used, which are an extremely important factor in the quantities and proportions, are non-toxic (glycine rearing of animals can be considered as the number of kiIorin, propylene glycol, sorbitol). It is also advantageous to define grams of feed that are required to obtain preparations for the improvised preparation of a weight gain of 1 kilogram - the solutions required before administration. 50 h is. The novel feed supplements according to Such preparations, liquid diluents, allow the present invention to be used e.g. B. propylene glycol, diethyl carbonate, glycerine, sor- of high-calorie, more protein-rich feed bit, etc., buffering agents, hyaluronidase, local anesthesia to achieve improved feed-fattening ratios and inorganic salts to achieve the and the use of feed that currently desired pharmacological properties are not effectively exploited. Easier to endure. For oral administration, doses are pressed: the feed compositions according to the invention from about 1 to about 60 mg / kg body weight are preferred when they are fed to animals. This can be done in a variety of methods, more effectively converted into animal body weight, in the form of capsules, converted to previously known food supplements, pills, lozenges, liquid mixtures and compositions. Any animal feed can be prepared solutions. In the case of poultry and other domestic animals that have the usual nutritional balance, other methods such as adding energy, protein, mineral and vitamin supplies to the feed, preparing feed concentrates below, and one or more of those described herein and feed supplements can be used. Besides quinoxaline di-N-oxides. Some of the various can be diluted solutions and suspensions, 65 of which components are common grains, e.g. B. Attn 0.1 "/" strength solutions for drinking purposes administered as milled grain, and grain by-products; are sufficient animal protein substances, such as meat and ^- fish. Although the aforementioned administration by-products; vitamin-containing mixtures, e.g. B. Vit-