DE19541967A1 - Combination, useful as deodorant for personal care - Google Patents

Abstract

Active agent combination comprises one or more monoesters (I) of mono-, di- or tri- glycerine monocarboxylic or mono-, di- or tri- glycerine dicarboxylic acid, and one or more aryl compounds of formula (II). R1-R5 = H, CH3, OCH3 or NH2; m = 1-10; y = 0 or 1; q = 0-10; A, B = H, OH or 1-10C alkyl.

Description

The present invention relates to the use of substances known per se as substances effective against bacteria, mycota and viruses. In a special version The present invention relates to cosmetic and dermatological forms Preparations containing such substances.

The healthy warm-blooded organism, especially the healthy human skin, is populated with a large number of non-pathogenic microorganisms. This so-called Microflora of the skin is not only harmless, it provides important protection Defense against opportunistic or pathogenic germs.

Bacteria are prokaryotic unicellular organisms. You can roughly follow theirs Shape (ball, cylinder, curved cylinder) as well as after the construction of their cell wall (gram positive, gram negative). Wear finer subdivisions also take into account the physiology of organisms. So aerobic, anaerobic exist like facultative anaerobic bacteria. Some individuals are in their capacity as pa thogenic germs of medical importance, others are perfect harmless.

Substances effective against bacteria have been known for some time. The term "Antibiotics" for example, which does not act on all antimicrobial substances applicable, can be dated to 1941, although the first findings for penicillin were found as early as 1929. Antibiotics in today's sense are not suitable for all medical and certainly not cosmetic applications net, since often the warm-blooded organism, e.g. the sick patient, also Use in any way impaired in its metabolic functions becomes.  

An object of the present invention was therefore the state of the art in this To enrich direction, in particular to make substances available, which are effective against gram-positive and / or gram-negative bacteria, without that with the application of the substances an unacceptable impairment of the Ge health of the user.

Gram-negative germs are, for example, Escherichia coli, Pseudomonas species and Enterobacteriaceen, such as Citrobacter.

Gram-positive germs also play a role in cosmetics and dermatology. In the Impure skin, for example, is a bacterial secondary, among other influences infections of etiological importance. One of the most important microorganisms in Related to blemished skin is Propionibacterium acnes.

Impure skin and / or comedones affect the well-being of those affected but even in mild cases. Since practically every or every young person from un pure skin of any kind is affected, there is a need for many people, to remedy this condition.

It was therefore a particular object of the present invention, one against immature ne skin or Propionibacterium acnes active substance or combination of substances to fin the.

In a further embodiment, the present invention relates to cosmetic des odorants. Such formulations serve to eliminate body odor, which ent stands when the odorless fresh sweat decomposes by microorganisms becomes. The usual cosmetic deodorants have different active principles underlying.

Both liquid deodorants, for example aerosol, are known and customary sprays, roll-ons and the like as well as solid preparations, for example deodorant sticks te ("sticks"), powder, powder sprays, intimate cleansers, etc.  

In so-called antiperspirants, astringents - mainly aluminum salts such as aluminum hydroxychloride (aluminum chlorohydrate) - the formation of sweat and be connected. Apart from the denaturation of the skin proteins, they work there for substances used, depending on their dosage, drastically in the heat in the armpit region and should only be used in exceptional cases the.

By using antimicrobial substances in cosmetic deodorants, the Bacterial flora on the skin can be reduced. Ideally, only the smell causing microorganisms can be effectively reduced. In practice, however emphasized that the entire microflora of the skin can be affected.

The sweat flow itself is not affected by this, ideally only the micro Biological decomposition of the sweat temporarily stopped.

Also the combination of astringents with antimicrobial substances in one and the same composition is common. The disadvantages of both classes of active ingredients cannot be completely eliminated in this way.

Finally, body odor can also be masked by fragrances, a method which least suits the aesthetic needs of the consumer as the Mixture of body odor and perfume smells rather unpleasant.

However, most cosmetic deodorants, like most Kos Metika as a whole, scented, even if it contains deodorizing agents. Perfuming can also serve to improve consumer acceptance of a cosmetic To increase the product or to give a product a certain flair.

Perfuming cosmetic agents containing active ingredients, in particular cosmetic des odorants, however, is not infrequently problematic because of active ingredients and perfumes components occasionally react with one another and render each other ineffective.

Deodorants should meet the following conditions:

• 1) They should cause reliable deodorization.
• 2) The natural biological processes of the skin must not be caused by the Desodo guarantees are affected.  
• 3) The deodorants do not have to be determined in the event of an overdose or other be harmless in accordance with the intended use.
• 4) They should not accumulate on the skin after repeated use.
• 5) They should be easy to incorporate into common cosmetic formulations.

Another object of the present invention was therefore cosmetic deodorant tien develop that do not have the disadvantages of the prior art. In particular in particular, the deodorants should largely protect the microflora of the skin, the number of the microorganisms that are responsible for body odor, selectively re reduce.

Furthermore, it was an object of the invention to remove cosmetic deodorants wrap, which are characterized by good skin tolerance. Under no circumstances should they deodorizing principles accumulate on the skin.

Another task was to develop cosmetic deodorants, which with a the greatest possible variety of common cosmetic auxiliaries and additives harmony ren, especially those with a deodorant or antiperspirant effect Formulations of significant perfume ingredients.

Yet another object of the invention was to provide cosmetic deodorants to ask, which over a longer period, in the order of magnitude of at least half a day, are effective without their effects noticeably after leaves.

Finally, an object of the present invention was deodorant cosmetic Develop principles that are as universal as possible in a wide variety of dosage forms Shapes of cosmetic deodorants can be incorporated without any or few special dosage forms.

Mushrooms, also fungi [fungus = Latin mushroom], Mycota [µνκηζ = Greek mushroom] or Mycobionten in contrast to the bacteria belong to the eucaryotes. Eucaryotes are Living beings whose cells (eucytes) are in contrast to those of the so-called proca ryonten (Procyten) through a through nuclear envelope and nuclear membrane from the rest of the Cyto  plasma-delimited cell nucleus. The cell nucleus contains the genetic information in chro mosomes saved.

Representatives of the mycobionts include, for example, yeasts (Protoascomycetes), Mold (Plectomycetes), powdery mildew (Pyrenomycetes), downy mildew (Phyco mycetes) and the mushrooms (Basidiomycetes).

Fungi, not even the Basidiomycetes, are not plant organisms, but they do like this a cell wall, vacuoles filled with cell juice and a microscopic one that is clearly visible Plasma flow. They contain no photosynthetic pigments and are C-hetero troph. They grow under aerobic conditions and gain energy through oxidation organic substances. However, some representatives, such as yeasts, are facultative active anaerobes and capable of generating energy through fermentation processes.

Dermatomycoses are diseases in which certain types of fungi, especially dermatos phytes, penetrate the skin and hair follicles. The symptoms of dermatomycoses For example, vesicles, exfoliation, rhagades and erosion are usually associated with Itching or allergic eczema.

Dermatomycoses can essentially be divided into the following four groups: Dermatophytia (e.g. epidermophytia, favus, microsporie, trichophytia), yeast mycoses (e.g. pityriasis and other pityrosporum-related mycoses, Candida infections, Bla stomycose, Busse-Buschke disease, torulose, piedra alba, torulopsidosis, trichospo rose), mold mycoses (e.g. aspergillosis, cephalosporidosis, phycomycosis and Sko pulariopsidosis), system mycoses (e.g. chromomycosis, coccidiomycosis, histoplasmo se).

Pathogenic and facultatively pathogenic germs include, for example, from Group of the yeast Candida species (e.g. Candida albicans) and those of the Pityro family sporum. Pityrosporum species, especially Pityrosporum ovale, are for skin diseases genes such as pityriasis versicolor, seborrhea in the forms Seborrhoea oleosa and Sebor rhoea sicca, which are mainly expressed as seborrhea capitis (= dandruff), se blame borrheic eczema and pityrosporum folliculitis. A beta Pityrosporum ovale's involvement in the development of psoriasis is recognized by experts discussed.  

All areas of human skin can be affected by dermatomycoses. Dermatophytia almost exclusively affect skin, hair and nails. Hefemycoses can Mucous membranes and internal organs are also affected, system mycoses extend regularly on whole organ systems.

The areas of the body that are affected by clothing, Jewelry or shoes can accumulate moisture and heat. So the foot belongs mushroom to the best known and most widespread dermatomycoses. Especially fungal diseases of the finger and toenail areas continue to be uncomfortable.

Furthermore, super infections of the skin by fungi and bacteria are not uncommon.

If there is a primary infection, d. that is, the normal germ colonization of the skin Tending new infection with high bacterial counts of one or more often physiological Pathogens, for example staphylococci, but often also unphysiological pathogens, for example Candida albicans, can coincide with unfavorable influences a "superinfection" of the affected skin occurs. The normal microflora of the skin (or another body organ) is literally caused by the secondary pathogen overgrown.

Such superinfections can, depending on the germ in question favorable cases in unpleasant skin symptoms (itching, un beautiful external appearance). In unfavorable cases, However, they lead to extensive destruction of the skin, in the worst case culminate even in the death of the patient.

Superinfections of the type described above are e.g. B. often in the full screen of AIDS secondary diseases occurring. In itself - at least in low germ densities - un harmful, but possibly also extremely pathogenic germs In this way, the healthy skin flora is preserved. However, there are others with AIDS Body organs affected by super infections.

Such superinfections are also common in a variety of dermatological conditions diseases, e.g. B. atopic eczema, neurodermatitis, acne, seborrheic dermatitis  or psoriasis observed. Also many medical and therapeutic measures e.g. B. the radio or chemotherapy of tumor diseases, as a side effect Called, drug-induced immunosuppression or systemic Antibiotic treatment, as well as external chemical or physical influences (e.g. pollution, smog), promote the occurrence of super infections external and internal organs, especially the skin and mucous membranes.

In individual cases, it is easily possible to cause super infections with antibiotics fight, but mostly such substances have the disadvantage of being more unpleasant Side effects. For example, patients are often allergic to penicillins because appropriate treatment would be prohibited in such a case.

Furthermore, topically administered antibiotics have the disadvantage that they damage the skin flora not only rid of the secondary pathogen, but also the physiological itself Skin flora severely impair and the natural healing process in this way is braked again.

The object of the present invention was to overcome the disadvantages of the prior art eliminate and substances and preparations containing such substances for To make available, which can be used to cure super infections NEN, the physiological skin flora does not suffer any significant losses.

In contrast to the prokaryotic and eukaryotic cellular organisms are viruses [virus = lat. poison] biological structures which are essential for biosynthesis Need host cell. Extracellular viruses (also called "virions") consist of egg ner single or double stranded nucleic acid sequence (DNA or RNA) and one Protein coat (called capsid), optionally an additional lipid-containing shell (Envelope) surrounded. The whole of nucleic acid and capsid is also Nu called cleocapsid. The viruses were classified classically according to clinical ones Criteria, but today mostly according to their structure, their morphology, in particular special but according to the nucleic acid sequence.

Medically important virus types are, for example, influenza viruses (family of the Orthomyxoviridae), Lyssaviruses (e.g. rabies, family of the rhabdoviruses) Enteroviruses  (e.g. hepatitis A, family Picornaviridae), hepadnaviruses (e.g. hepatitis B, family the Hepadnaviridae).

There are no virucides, i.e. virus-killing substances in the actual sense, since Vi do not have their own metabolism. It was for that reason too discusses whether viruses should be classified as living beings. Pharmacological Interventions without damage to the unaffected cells is difficult in any case. Possible Mechanisms of action in the fight against viruses are primarily the disruption their replication, e.g. B. by blocking the enzymes important for replication, that are present in the host cell. Furthermore, the release of the viral nucleic acids be prevented into the host cell. As part of the disclosure presented herewith is used under terms such as "antiviral" or "effective against viruses", "virucidal" or similar understood the property of a substance, a single or multicellular organ against harmful consequences of a viral infection, be it prophylactic or thera peutisch, to protect, regardless of what the actual mechanism of action the substance in individual cases.

However, the prior art lacks substances which are active against viruses, which, moreover, does not harm the host organism or only does so to a reasonable extent gene.

An object of the present invention was therefore to remedy this problem, So to find substances that are effective in a single or multicellular organism against harmful consequences of a viral infection, be it prophylactic or therapeutic, to protect.

It has been found, surprisingly, and that is the solution to all of these Tasks that drug combinations consisting of

• (I) one or more substances selected from the group of Monoglycerin-monocarboxylic acid monoester, the diglycerin monocarboxylic acid monoester, the triglycerol monocarboxylic acid monoester, the monoglycerin-dicarboxylic acid monoester, the diglycerin dicarboxylic acid monoester and the triglycerol dicarboxylic acid monoester such as  
• (II) one or more aryl compounds of the general structural formula where R¹ can represent: H, CH₃, OCH₃, NH₂, and where up to five identical or different radicals R¹ or any combination of the same and different such radicals can occur within a molecule, corresponding to n = 1-5. The index m can take values from 1-10, the index y can take the values 0 or 1, the index q can take values from 0-10, A and B independently represent H, OH, and branched and unbranched alkyl radicals with 1-10 carbon atoms,
  In particular, cosmetic deodorants or preparations which are effective against foot odor or against bacteria, fungi or viruses and contain such combinations of active ingredients, remedy the disadvantages of the prior art.

The monoglycerol mono- or dicarboxylic acid monoesters according to the invention are by the general formula

reproduced, wherein R is a branched or unbranched acyl radical Represents 6-14 carbon atoms. R is advantageously selected from the group of unbranched acyl residues. The fatty acids on which these esters are based or Monocarboxylic acids are the

Hexanoic acid (caproic acid) (R = -C (O) -C₅H₁₁),
Heptanoic acid (enanthic acid) (R = -C (O) -C₆H₁₃),
Octanoic acid (caprylic acid) (R = -C (O) -C₇H₁₅),
Nonanoic acid (pelargonic acid) (R = -C (O) -C₈H₁₇),
Decanoic acid (capric acid) (R = -C (O) -C₉H₁₉),
Undecanoic acid (R = -C (O) -C₁₀H₂₁),
Dodecanoic acid (lauric acid) (R = -C (O) -C₁₁ H₂₃),
Tridecanoic acid (R = -C (O) -C₁₂H₂₅),
Tetradecanoic acid (myristic acid) (R = -C (O) -C₁₃H₂₇).

R is particularly advantageously the octanoyl residue (caprylic acid residue) or the deca noyl residue (capric acid residue), is therefore represented by the formulas

R = -C (O) -C₇H₁₅) or R = -C (O) -C₉H₁₉

represents.

In this document, especially in the examples, the abbreviation GMCy for Gly cerinmonocaprylate and the abbreviation GMC used for glycerol monocaprinate.

In the case of the glycerol esters esterified in the 1-position of the glycerol, the 2-position is an asymmetry center. Active according to the invention and equally advantageous are the 2S and 2R configurations.

It has turned out to be favorable to use racemic mixtures of the stereoisomers to use.

The content of GMCy and / or in the dermatological preparations is GMC advantageously 0.1-10.0% by weight, preferably 0.5 to 7.5% by weight, particularly preferably 1.5-5.0 wt .-%, each based on the total weight of the respective wording.

According to the invention, the di- or triglycerol units are diglycerol mono- or dicarboxylic acid monoesters or Triglycerol mono- or dicarboxylic acid monoesters as linear, unbranched Molecules, i.e. etherified via the respective OH groups in the 1- or 3-position "Monoglycerin molecules" before.  

A small proportion of cyclic di- or triglycerol units as well as the Glycerol molecules etherified in the 2-position by OH groups can be tolerated. It is however, it is advantageous to keep such impurities as low as possible.

The mono- or dicarboxylic acid monoesters of diglycerol according to the invention are preferably characterized by the following structure (substitution positions specified):

where R 'is a hydrocarbon residue, advantageously a branched or un represents branched alkyl or alkenyl radical of 5 to 17 carbon atoms.

The mono- or dicarboxylic acid monoesters of triglycerol according to the invention are preferably characterized by the following structure (substitution positions specified):

where R '' is a hydrocarbon residue, advantageously a branched or un branched alkyl or alkenyl radical represents alkyl radical of 5 to 17 carbon atoms.

The monocarboxylic acids on which these esters are based are

Hexanoic acid (caproic acid) (R ′ or R ′ ′ = -C₅H₁₁),
Heptanoic acid (enanthic acid) (R ′ or R ′ ′ = -C₆H₁₃),
Octanoic acid (caprylic acid) (R ′ or R ′ ′ = -C₇H₁₅),
Nonanoic acid (pelargonic acid) (R ′ or R ′ ′ = -C₈H₁₇),
Decanoic acid (capric acid) (R ′ or R ′ ′ = -C₉H₁₉),
Undecanoic acid (R ′ or R ′ ′ = -C₁₀H₂₁),
10-undecenoic acid (undecylenic acid) (R ′ or R ′ ′ = -C₁₀H₁₉),
Dodecanoic acid (lauric acid) (R ′ or R ′ ′ = -C₁₁ H₂₃),
Tridecanoic acid (R ′ or R ′ ′ = -C₁₂H₂₅),
Tetradecanoic acid (myristic acid) (R ′ or R ′ ′ = -C₁₃H₂₇),
Pentadecanoic acid (R ′ or R ′ ′ = -C₁₄H₂₉),
Hexadecanoic acid (palmitic acid) (R ′ or R ′ ′ = -C₁₅H₃₁),
Heptadecanoic acid (margaric acid) (R ′ or R ′ ′ = -C₁₆H₃₃),
Octadecanoic acid (stearic acid) (R 'or R''= -C₁₇H₃₅).

R 'and R' 'are particularly favorable selected from the group of unbranched Alkyl radicals with odd carbon numbers, especially with 9, 11 and 13 carbon atoms.

In general, the monocarboxylic acid monoesters of diglycerol are those of Triglycerins preferred.

Are very particularly cheap

Diglycerol monocaprinate (DMC) R ′ = 9,
Triglycerol monolaurate (TML) R ′ ′ = 11,
Diglycerol monolaurate (DML) R ′ = 11,
Triglycerol monomyristate (TMM) R ′ ′ = 13.

As a preferred monocarboxylic acid monoester of diglycerol according to the invention diglycerol monocaprinate (DMC) has been shown.

The monocarboxylic acid monoesters of diglycerol according to the invention are preferably in the 1-position, the monofatty acid esters according to the invention Triglycerins preferably esterified in the 2'-position.

According to an advantageous embodiment of the present invention, a additional proportion of di- or triglycerol esterified in other places, likewise such as a share in the various diesters of the di- or Triglycerins used.

Particularly advantageous are those monocarboxylic acid esters which have a Processes are available, as described in DE-OS 38 18 293.

The dicarboxylic acids on which the esters according to the invention are based preferably selected from the group of α, ω-alkanedicarboxylic acids, in particular preferably selected from the group of α, ω-alkanedicarboxylic acids, so that the Residues R, R 'and R' 'in the given case from the generic formula

-OOC- (CH₂) _k -COOH

are described and where k can take numbers from 0 to 8.

The diglycerol esters, which are two, and the triglycerol esters, which are characterized by three centers of asymmetry are in all their configurations effective according to the invention. The diglycerol esters have four, the triglycerol esters eight stereoisomers.

In the diglycerol esters, the 2- and the 2'-position are centers of asymmetry. Erfin active according to the invention and equally advantageous are the 2S2′S-, the 2R2′S-, the 2S2′R and 2R2′R configurations.

In the triglycerol esters are the 2-, the 2 'and the 2' '- position Asymmetry centers. Active and equally advantageous according to the invention the 2S2′S2′′S-, the 2R2′S2′′S-, the 2S2′R2′′S-, the 2R2′R2′′S-, the 2S2′S2′′R, the 2R2′S2′′R-, the 2S2′R2′′R- and the 2R2′R2′′R configuration.

It has turned out to be favorable to use racemic mixtures of the stereoisomers to use.

Aryl compounds preferred according to the invention are selected from the group Phenoxyethanol, anise alcohol, 2-methyl-5-phenyl-pentan-1-ol, 2-methyl-4-phenylbutan-2-ol.

Phenoxyethanol is characterized by the structural formula

Anise alcohol is characterized by the structural formula

2-Methyl-5-phenyl-pentan-1-ol is characterized by the structural formula

2-Methyl-4-phenylbutan-2-ol is characterized by the structural formula

It is known from DE-OS 37 40 186, phenoxyethanol (also: Phenoxe tol) as a component of cosmetic deodorants. Furthermore, on specified locations also combinations of phenoxyethanol and Gly cerinmonolaurate. However, the state of the art could not help points to the synergistic acting according to the invention Give active ingredient combinations with partial glycerides.

The preparations according to the invention are particularly advantageous thereby indicates that the mono- or dicarboxylic acid monoester of the mono- Di- and / or triglycerol in concentrations of 0.01-10.00% by weight, preferably 0.05-5.00% by weight, particularly preferably 0.1-3.00% by weight, in each case based on the total weight of the composition, is or are present.

The preparations according to the invention are also particularly advantageous characterized in that the aryl compound or the aryl compounds in Concentrations of 0.01-10.00% by weight, preferably 0.05-5.00% by weight, particularly preferably 0.1-3.00% by weight, in each case based on the total weight of the composition, is or are present.

It is advantageous to reduce the (i) mono-, di- and / or triglycerol-mono- or dicarboxylic acid monoester and (ii) aryl compound so that ratios (i): (ii) like 10: 1 to 1:10, in particular like about 5: 1 to 1: 5, whole particularly advantageous as about 2: 1 to 1: 2: 5 arise.

Preparations according to the invention, the action according to the invention Combinations of substances are particularly advantageous characterized in that the active ingredient combinations according to the invention in Concentrations of 0.05-10.00% by weight, preferably 0.1-5.0% by weight, are present gene, each based on the total weight of the preparations.

Dermatological preparations according to the invention can be in the form of Aerosols, i.e. from aerosol containers, squeeze bottles or through one  Pump device sprayable preparations are present or in the form of means However, roll-on devices apply liquid compositions in the form of W / O or can be applied from normal bottles and containers Q / W emulsions e.g. B. creams or lotions. Furthermore, the Zu Preparations advantageous in the form of tinctures, shampoos, washing, showering or Bath preparations or powders are available.

As usual cosmetic carriers for the production of the invention In addition to water, ethanol and dermatological preparations Isopropanol, glycerin and propylene glycol skin-caring fat or fat-like Substances such as oleic acid decyl ester, cetyl alcohol, cetylstearyl alcohol and 2-octyl dodecanol, used in the proportions customary for such preparations as well as slime-forming substances and thickeners, e.g. B. hydroxyethyl or Hydroxypropyl cellulose, polyacrylic acid, polyvinyl pyrrolidone, but next to it also in small amounts cyclic silicone oils (polydimethylsiloxanes) as well liquid low viscosity polymethylphenylsiloxanes.

As a propellant for derma according to the invention, sprayable from aerosol containers Tological preparations are the usual known volatile, liquefied propellants, for example hydrocarbons (propane, butane, iso butane), which are used alone or in a mixture with one another can. Compressed air can also be used advantageously.

Of course, the expert knows that there are non-toxic propellant gases per se that would be suitable in principle for the present invention, but to which nevertheless because of harmful effects on the environment or other accompanying factors should be avoided, especially chlorofluorocarbons (CFCs).

As emulsifiers for the production of the dermatological additives according to the invention preparations, there have been non-ionic types, such as polyoxyethylene fat alcohol ether, e.g. B. Cetylstearyl alcohol polyethylene glycol ether with 12 or 20 attached ethylene oxide units per molecule, cetostearyl alcohol and Sor bitanester and sorbitan ester ethylene oxide compounds (e.g. Sorbitan monostearate and polyoxyethylene sorbitan monostearate) and long chain High molecular weight waxy polyglycol ethers have been found to be suitable.  

In addition to the components mentioned, the inventive matological preparations, the pH of which is preferably, for. B. by usual Buffer mixtures is set to 4.0 to 7.5, in particular 5.0 to 6.5, Perfume, dyes, antioxidants, suspending agents, buffer mixtures or other common cosmetic or dermatological ingredients are added will.

According to the invention, all of the cosmetic antioxidants can be cheap and / or dermatological applications suitable or customary Antioxidants are used.

The antioxidants are advantageously selected from the group consisting of Amino acids (e.g. glycine, histidine, tyrosine, tryptophan) and their derivatives, Imidazoles (e.g. urocanic acid) and their derivatives, peptides such as D, L-carnosine, D-carnosine, L-carnosine and their derivatives (e.g. anserine), carotenoids, carotenes (e.g. α-carotene, β-carotene, lycopene) and their derivatives, lipoic acid and their Derivatives (e.g. dihydrolipoic acid), aurothioglucose, propylthiouracil and others Thiols (e.g. thioredoxin, glutathione, cysteine, cystine, cystamine and their Glycosyl, N-acetyl, methyl, ethyl, propyl, amyl, butyl and lauryl, palmitoyl, Oleyl, γ-linoleyl, cholesteryl and glyceryl esters) and their salts, Dilauryl thiodipropionate, distearyl thiodipropionate, thiodipropionic acid and their Derivatives (esters, ethers, peptides, lipids, nucleotides, nucleosides and salts) as well Sulfoximine compounds (e.g. buthionine sulfoximines, homocysteine sulfoximine, Bu thionine sulfones, penta-, hexa-, heptathionine sulfoximine) in very low compatible dosages (e.g. pmol to µmol / kg), also (metal) chelators (e.g. α-hydroxy fatty acids, palmitic acid, phytic acid, lactoferrin), α-Hy hydroxy acids (e.g. citric acid, lactic acid, malic acid), humic acid, Bile acid, bile extracts, bilirubin, biliverdin, EDTA, EGTA and their Derivatives, unsaturated fatty acids and their derivatives (e.g. γ-linolenic acid, linol acid, oleic acid), folic acid and its derivatives, ubiquinone and ubiquinol and their derivatives, vitamin C and derivatives (e.g. ascorbyl palmitate, Mg-Ascor byl phosphate, ascorbyl acetate), tocopherols and derivatives (e.g. vitamin E-ace tat), vitamin A and derivatives (vitamin A palmitate) and konyferyl benzoate of benzoin, rutinic acid and its derivatives, ferulic acid and its Derivatives, butylated hydroxytoluene, butylated hydroxyanisole, nordihydroguajakh resin acid, Nordihydroguajaretic acid, trihydroxybutyrophenon, uric acid and their De derivatives, mannose and their derivatives, zinc and its derivatives (e.g. ZnO,  ZnSO₄) selenium and its derivatives (e.g. selenium methionine), stilbene and their Derivatives (e.g. stilbene oxide, trans-stilbene oxide) and those according to the invention suitable derivatives (salts, esters, ethers, sugars, nucleotides, nucleosides, Peptides and lipids) of these active ingredients.

The amount of antioxidants (one or more compounds) in the preparation tion is preferably 0.001 to 30 wt .-%, particularly preferred 0.05-20% by weight, in particular 1-10% by weight, based on the total weight the preparation.

If vitamin E and / or its derivatives, the antioxidant (s) represent is advantageous, their respective concentrations from the range of 0.001-10% by weight, based on the total weight of the formulation len.

If vitamin A, or vitamin A derivatives, or carotenes or their derivatives the antioxidant (s) are advantageous, their respective Concentrations in the range of 0.001-10 wt .-%, based on the Total weight of the formulation to choose.

It is advantageous for the present invention that the pH of the Invention according to dermatological preparations is less than 8. pH values that easily are higher than 7, but less than 7.5 can generally be tolerated will. In any case, is for a given fatty acid mixture in individual cases simply trying it out, without doing anything inventive, easy to determine which one the exact upper pH limit must be observed.

The pH of the formulations according to the invention in acid is advantageous set to a very weakly alkaline range of less than 8, preferably from 4.0-7.5, particularly preferably from 5.0-6.5.

The amounts of auxiliary additives and carriers to be used and ge possibly perfume depending on the type of each Product can be easily determined by a specialist simply by trying it out.

The dermatological preparations according to the invention are produced apart from special preparations, each in the examples  are noted separately, in the usual way, mostly by simple mixing with stirring, if necessary with gentle heating. It doesn't offer Difficulties. For emulsions fat phase and the water phase are e.g. B. prepared separately, optionally with heating and then emulsified.

Otherwise, the usual rules for putting together galenic formulations to be observed, which are familiar to the expert.

If the combinations according to the invention are to be incorporated into powder, the suspension bases for this can advantageously be selected from the group
Silicic acid gels (e.g. those available under the trade name Aerosil®), diatomaceous earth, talc, modified starch, titanium dioxide, silk powder, nylon powder, polyethylene powder and related substances.

Advantageous exemplary embodiments of the present invention follow. The Quantities always refer to% by weight, unless otherwise is specified.  

example 1

Example 2

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Example 17

Example 18

Example 19

Example 20

Example 21

Example 22

The liquid phase obtained by mixing the respective components together together with a propane-butane mixture (2: 7) in a ratio of 39: 61 in Filled aerosol container.  

Example 23

Example 24

Example 25

Example 26

Claims (4)

1. Active ingredient combinations consisting of

• (I) one or more substances selected from the group consisting of the monoglycerol monocarboxylic acid monoesters, the diglycerol monocarboxylic acid monoesters, the triglycerol monocarboxylic acid monoesters, the monoglycerol dicarboxylic acid monoesters, the diglycerol dicarboxylic acid monoesters and the triglycerol monoester acids such as
• (II) one or more aryl compounds of the general structural formula where R¹ can represent: H, CH₃, OCH₃, NH₂, and where up to five identical or different radicals R¹ or any combination of the same and different such radicals can occur within a molecule, corresponding to n = 1-5, the index m values can be from 1-10, the index y can take the values 0 or 1, the index q can take the values 0-10 and A and B independently of one another H, OH, and branched and unbranched alkyl radicals with 1-10 carbon atoms, can represent.

2. Active substance combinations according to claim 1, characterized in that the Substance or the substances of the group of monoglycerol monocarboxylic acid monoesters, the diglycerol monocarboxylic acid monoesters and the triglycerol monocarboxylic acid monoester is selected from the group glycerol mono caprylate, glycerol monocaprinate, diglycerol monocaprinate, triglycerol monolaurate, Diglycerol monolaurate, triglycerol monomyristate.   3. Active substance combinations according to claim 1, characterized in that as Aryl compound that 2-methyl-4-phenylbutan-1-ol is selected. 4. Use of active ingredient combinations according to claim 1 for combating of body odors.