DE19643586A1 - Topical sterol formulation for use as deodorant - Google Patents

Abstract

Formulation containing at least one sterol or sterol derivative and its use to combat microorganisms, viruses, parasites and protozoa.

Description

The present invention relates to the use of some known substances zen than against bacteria, mycota, protozoa and viruses, d. H. so against micro substances effective for organisms, viruses, parasites and protozoa. In particular The present invention relates to cosmetic and embodiments thereof dermatological preparations containing such substances.

The healthy warm-blooded organism, especially the healthy human skin, is colonized with a large number of non-pathogenic microorganisms. This so-called microflora of the skin is not only harmless, it also creates one important protection for the defense against opportunistic or pathogenic germs.

Bacteria belong to the group of prokaryotic unicellular organisms. You can roughly follow their shape (sphere, cylinder, curved cylinder) as well as their structure their cell wall (gram-positive, gram-negative). Finer ones Subdivisions also take into account the physiology of the organisms. So there are aerobic, anaerobic and facultative anaerobic bacteria. Some In their capacity as pathogenic germs, organisms are of medical importance Meaning, others are completely harmless.

Substances effective against bacteria have been known for some time. Of the The term "antibiotics", for example, does not apply to all antimicrobial agents Substances can be dated to 1941, although the first findings on penicillin were found in 1929. Antibiotics in today's sense are not medical for everyone, least of all Cosmetic applications suitable, as the warm-blooded org nism, i.e. the sick patient, when used in some way its metabolic functions are impaired.

One object of the present invention was therefore to provide the prior art in to enrich this direction, in particular, therefore, substances available to provide which is effective against gram-positive and / or gram-negative bacteria sam are, without the application of the substances being unacceptable Impairment of the health of the user would be connected.

Gram-negative germs are, for example, Escherichia coli, Pseudomonas- Species as well as Enterobacteriaceae such as Citrobacter.

Gram-positive germs also play a role in cosmetics and dermatology. In the case of impure skin, for example, there are bacteri among other influences all secondary infections of etiological importance. One of the most important Propi is the microorganism associated with blemished skin onibacterium acnes.

Impure skin and / or comedones impair the well-being of the Be but hit even in mild cases. Practically everyone or every youngster that is affected by blemished skin of any kind exists in many People need to remedy this condition.

A particular object of the present invention was to counter to find impure skin or Propionibacterium acnes effective active ingredient.

In a further embodiment, the present invention relates to cosmetic products Deodorants. Such formulations are used to eliminate body odor gen, which arises when the odorless fresh sweat by in particular whose gram-positive microorganisms are decomposed. The usual cosmetic Deodorants are based on different principles of action.

Both liquid deodorants, for example, are known and in use Aerosol sprays, roll-ons and the like as well as solid preparations For example, deodorant sticks, powders, powder sprays, intimate cleansers, etc.

In so-called antiperspirants, astringents - mainly aluminum nium salts such as aluminum hydroxychloride (aluchlorohydrate) - the formation of the Sweat can be prevented. Apart from the denaturation of the skin However, proteins affect the substances used for this, depending on their dose tion, drastically in the heat balance of the armpit region and should at best may be used in exceptional cases.

By using antimicrobial substances in cosmetic deodorants the bacterial flora on the skin can be reduced. Ideally, you should only the odor-causing microorganisms are effectively reduced. In In practice, however, it has been found that the entire microflora of the skin can be affected.

The flow of sweat itself is not influenced by this, in the ideal case only the microbial decomposition of sweat temporarily stopped.

The combination of astringents with antimicrobial substances in one and the same composition is common. The disadvantages of both However, classes of active substances cannot be completely eliminated in this way gene.

Finally, body odor can also be masked by fragrances, a Method that least meets the aesthetic needs of the consumer is fair, as the mixture of body odor and perfume scent is rather unpleasant take smell.

However, most cosmetic deodorants, as well as the mei Most cosmetics overall, perfumed, even if they have deodorant ingredients include. Perfuming can also serve to increase consumer acceptance to increase a cosmetic product or a specific product To give flair.

The perfuming of active ingredient-containing cosmetic agents, in particular cosmetics shear deodorants, is not infrequently problematic because active ingredients and perfume ingredients occasionally react with one another and have no effect on one another can do sam.

Deodorants should meet the following conditions:

• 1) They should cause reliable deodorization.
• 2) The natural biological processes of the skin must not be affected by the Deodorants are affected.
• 3) The deodorants do not have to be determined in the event of an overdose or other be harmless if used as directed.
• 4) They should not rub against the skin after repeated use to cherish.
• 5) You should be able to familiarize yourself with common cosmetic formulations sen.

A further object of the present invention was therefore to provide cosmetic des To develop odorants that do not have the disadvantages of the prior art point. In particular, the deodorants should farge the microflora of the skin The number of microorganisms responsible for body odor is conserved are responsible, selectively reduce.

It was also an object of the invention to provide cosmetic deodorants develop, which are characterized by good skin tolerance. Under no circumstance the deodorizing active principles should accumulate on the skin.

Another task was to develop cosmetic deodorants, which with the greatest possible number of customary cosmetic auxiliaries and additives ovens harmonize, especially with those currently in deodorant or antitran inspiring formulations with important perfume ingredients.

Yet another object of the invention was to provide cosmetic deodorants To make available, which over a longer period of time, in the Order of magnitude of at least half a day, are effective without their Effect noticeably diminishes.

Finally, it was an object of the present invention to provide deodorizing kos to develop metic principles that are as universal as possible in the various Most dosage forms of cosmetic deodorants are incorporated can without being restricted to one or a few special dosage forms be.

Fungi, also fungi [fungus = Latin mushroom], mycota [µκηζ = Greek mushroom] or mycobion In contrast to bacteria, they are called eucaryotes. Eucaryotes are living beings whose cells (eucytes) are in contrast to them the so-called procaryotes (procytes) through a nuclear membrane cell nucleus separated from the rest of the cytoplasm. The nucleus contains the genetic information is stored in chromosomes.

Representatives of the mycobionts include, for example, yeasts (Protoascomycetes), Mold (Plectomycetes), powdery mildew (Pyrenomycetes), downy mildew (Phycomycetes) and the mushrooms (Basidiomycetes).

Fungi, not even the Basidiomycetes, are not plant organisms but like this one cell wall, cell sap-filled vacuoles and one microscopic clearly visible plasma flow. They do not contain photosynthetic pigments and are carbon heterotrophic. They grow in aerobic conditions and gain energy through the oxidation of organic substances. Some representatives, for example yeasts, however, are facultative anaerobes and for energy levels extraction through fermentation processes.

Dermatomycoses are diseases that affect certain types of fungus, in particular Dermatophytes, invading the skin and hair follicles. The symptoms of the matomycoses are for example vesicles, exfoliation, rhagades and erosion, usually associated with itching or allergic eczema.

Dermatomycoses can essentially be divided into the following four groups become: dermatophytias (e.g. epidermophytia, favus, microsporia, trichophytia), Yeast mycoses (e.g. pityriasis and other mycoses caused by pityrosporum, Can dida infections, blastomycosis, Busse-Buschke disease, torulosis, piedra alba, torulopsidosis, trichospurosis), mold mycoses (e.g. aspergillosis, Cephalosporidosis, phycomycosis and scopulariopsidosis), systemic mycoses (e.g. Chromomycosis, coccidiomycosis, histoplasmosis).

The pathogenic and facultative pathogenic germs include, for example from the group of the yeasts Candida species (e.g. Candida albicans) and those of the Pityrosporum family. Pityrosporum species, especially Pityrosporum ovale, are in the forms for skin diseases like pityriasis versicolor, seborrhea Seborrhoea oleosa and Seborrhoea sicca, which are mainly called seborrhoea express capitis (= dandruff), seborrheic eczema and pityrosporum folli to blame culitis. Involvement of Pityrosporum ovale in the The development of psoriasis is discussed by experts.

Dermatomycoses can affect all areas of the human skin the. Dermatophytias almost exclusively affect the skin, hair and nails. Yeast mycoses can also affect mucous membranes and internal organs, system myco sen regularly extend to entire organ systems.

The areas of the body that are affected by Clothing, jewelry or shoes can accumulate moisture and heat. So athlete's foot is one of the best known and most widespread derma tomycosen. Fungal diseases of the fingers are still particularly unpleasant. and toenail areas (onychomycosis).

Furthermore, superinfections of the skin by fungi and bacteria are not uncommon.

If there is a primary infection, i. H. the normal colonization of germs in the skin, occurring new infection with high bacterial counts of one or more often phy siological pathogens, for example staphylococci, but often also unphysio logical pathogen, for example Candida albicans, can occur when they meet If unfavorable influences cause a "superinfection" of the affected skin to occur. The normal microflora of the skin (or any other body organ) is involved literally overgrown by the secondary pathogen.

Such superinfections can develop, depending on the germ concerned, in favorable cases, in unpleasant skin conditions (Itching, unsightly external appearance). In unfavorable conditions In some cases, however, they can lead to extensive destruction of the skin in the worst case, culminating in the patient's death.

Superinfections of the type described above are z. B. in the full picture of AIDS frequently occurring secondary diseases. In itself - at least in small ways Germ densities - harmless, but under certain circumstances also pronounced In this way, pathogenic germs overgrow the healthy skin flora. at AIDS, however, other organs of the body are also affected by superinfections fen.

Such superinfections are also dermatological in a large number of cases Diseases, e.g. B. atopic eczema, neurodermatitis, acne, seborrheic Dermatitis or psoriasis observed. Also many medical and therapeuti cal measures, e.g. B. radio- or chemotherapy of tumor diseases gen, drug-induced immunosupply caused as a side effect pression or systemic antibiotic treatment, as well as external chemical or physical influences (e.g. environmental pollution, smog), promote the occurrence of superinfections of the external and internal organs, especially the skin and mucous membranes.

In individual cases it is easily possible to treat superinfections with antibiotics to combat drugs, but mostly such substances have the disadvantage unpleasant side effects. Often, for example, patients are against Pe nicilline allergic, which is why an appropriate treatment is in one would forbid such a trap.

Furthermore, topically administered antibiotics have the disadvantage that they affect the skin not only free flora from the secondary pathogen, but also the phy itself Significantly affect the biological skin flora and the natural healing process is braked again in this way.

The object of the present invention was to address the disadvantages of the prior art Technique to eliminate and substances and preparations, such substances containing, to make available, through their use superinfection can be cured, although the physiological skin flora does not suffers significant losses.

Protozoa are parasitic unicellular organisms with a clearly demarcated nucleus, the reproduce asexually (through division and budding), or else gender (gameto, gamonto and autogamy). The food intake from of the environment occurs through permeation and through pinocytosis or phagocytosis. Most protozoa can in addition to vegetative, mostly motile state also form cysts (so-called trophozoites) under unfavorable circumstances train them as permanent forms.

Depending on the type of locomotion and apparatus, protozoa are divided into four different groups:

• (a) Mastigophora (flagellates with flagella)
• (b) Sarcodina / Rhizopoda (amoeboid movement pattern due to plasma protrusions pings)
• (c) Sporozoa (meandering or sliding movement pattern)
• (d) Ciliata / Ciliophora (cilia or flagellation).

Parasitic protozoa are found in subtropical and tropical areas often by stinging and sucking insects, but also dirt and Smear infection as well as transmitted through the food chain.

Some medically and dermatologically relevant protozoonoses are: Tricho moniasis (caused by Trichomonas vaginalis), dysentery (caused due to lamblia intestinalis), visceral as well as cutaneous and mucosal leishma niose (caused for example by Leishmania donovanii, L.tropica, L.brasiliensis, L.mexicana, L.diffusa or L.pifanoi), trypanosmiasis (causes by various Trypanosoma species), amoebic dysentery and amoebiasis (caused for example by different Entamoeba species, Jodamoeba butschlii or Naegleria fowleri), coccidosis (by Isospora belli) and Balanti denruhr (caused by Balantidium coli).

Medical and dermatological diseases caused by protozoonoses nomes impair, sometimes considerably, human wellbeing. It there is therefore a considerable need for the persons concerned, this To remedy conditions. It was therefore an object of the present invention to to find effective principles of action against protozoa.

Parasites are single or multicellular plants or animals that relate to (= ectopa rasites) or in (= endoparasites) other living beings at their expense with (= pathogenic parasites) or without (apathogenic parasites) Causing symptoms of illness. The way of life is either too aprophytic or purely parasitic, possibly only as periodic, temporary or stationary parasite. The development of parasites is one or more rere bound different host organisms, with humans being the intermediate host or be the final host.

Medically and dermatologically significant parasites are, for example Helminths, which in turn are subdivided into Trematodae, Cestodae and Nematodae structure. Helminth pants that affect human well-being are for example schistosomiasis (caused by Schistosoma species), tapeworms fall from the intestines and other internal organs (caused by, for example Taenia species and Echinococcus species), Ascariasis (caused by Ascaris lumbricoides), Enterobiasis (caused by Enterobium vermicularis), Parago nimiasis (caused by Paragonium species), filariasis (caused e.g. wise by Wucheria bancrofti) and other nematode infestations (for example caused by Trichuris trichura or Trichinella spiralis).

In addition, a large number are parasitic on or in humans and animals of living insect species or arachnids, the medical and dermatological cause cal changes in the host organisms. In this regard for the Parasitoses responsible for impairment of human well-being are for example accrodermatitis (caused by grain mites, for example wise Pediculoides ventricosus), scabies (caused by Sarcoptes scabii), Fly and / or fly larvae infestation (caused for example by Glossina Stomoxys-, Tabanus-, Chrysops-, Lucilia-, Chrysomya-, Cochliamya-, Wohlfar tia, Cordylobia or Dermatobia species), mosquito and / or mosquito larvae infestation (caused for example by Aedes-Culex, Anopheles, Phlebotomus Culicuides, Sumilium or Haemagoges species), tick infestation (caused by for example by Argas persicus and other Argas species, Ornithodorus erra ticus and other Ornithodorus species, Orobius Rhiphocephalus, Dermacentor, Haemaphysalis, Amblyomma, Ixodes species), porocephalosis (caused by Porocephalus species), flea infestation (caused by, for example, Pulex irritans, Ctenocephalides canis, Xenopsylla cheopsis, Nosophyllus fasciatus or Sar copsylla penetrans), lice infestation (caused for example by Phthirius pubis, Pediculosus humanus or Pediculosuscaptits), bedbugs (caused for example by Cimex lectularius, Cimex hemipterus, Panstron gylus megistus, Rhodnius prolixus, Triatoma dimidata, Triatoma infestans, Tria toma sordida or Triatoma brasiliensis) and mite infestation (caused by for example by Demodexfolliculorum and other Demodex species as well as by Dermamyskus species Glyciphagus domesticus, Pyemotes species, Sarcoptes species or Trombicula species).

It is of additional importance that the on or in the human Orga living parasites in turn are carriers of bacteria, mycota, Protozoa and viruses can affect the health and wellbeing of the Host organism, for example humans, can sustainably affect nen. There was therefore a need for active principles of action against parasitosis to find what the medical or dermatological appearance to be are able to improve. Satisfying this need was therefore another challenge the present invention.

In contrast to the prokaryotic and eukaryotic cellular organs nisms are viruses [virus = Latin poison] biological structures that contribute to biosyn these require a host cell. Extracellular viruses (also called "virions") consist of a single or double-stranded nucleic acid sequence (DNA or RNA) and a protein coat (called a capsid), possibly one additional lipid-containing envelope (envelope). The entirety Nucleic acid and capsid is also called nucleocapsid. The classification the viruses were classically based on clinical criteria, but nowadays mostly according to their structure, their morphology, but especially according to the Nucleic acid sequence.

Medically important virus types are, for example, influenza viruses (Orthomyxoviridae family), Lyssaviruses (e.g. rabies, Rhabdo family viruses) enteroviruses (e.g. hepatitis A, family of the Picornaviridae), hepadnaviruses (e.g. hepatitis B, family of the Hepadnaviridae).

There are no virucidal substances, i.e. substances that kill viruses in the strict sense of the word, because viruses do not have their own metabolism. It became from the For this reason it is also discussed whether viruses can be classified as living beings should. Pharmacological interventions without harming the unaffected In any case, cells are difficult. Possible mechanisms of action in the fight against the viruses are primarily the disruption of their replication, e.g. B. by blocking Ren the enzymes that are important for replication and are present in the host cell. Furthermore, the release of the viral nucleic acids into the host cell can be prevented be changed. In the context of the disclosure presented here, under Terms such as "antiviral" or "effective against viruses", "virucidal" or similar, understood the property of a substance, a unicellular or multicellular Or ganism against the harmful consequences of a viral infection, be it prophylactic or therapeutic, to protect, regardless of what the actual Mechanism of action of the substance in individual cases.

However, the state of the art lacks virus-effective sub punch, which also does not affect the host organism or is not justifiable Damage dimensions.

One object of the present invention was therefore to address these disadvantages remedy, i.e. to find substances which are effective for one or more cellular organism from the harmful consequences of a viral infection, be it pro phylactically or therapeutically, protect.

The invention relates to the use of one or more compounds Compounds from the group of sterols and sterol derivatives as antimicrobial, antiviral, antiparasitic and antiparasitic agents against protozoa against microorganisms, viruses, parasites and protozoa.

The invention also relates to the use of a compound or meh rer compounds from the group of sterols and sterol derivatives than antimi crobial, antiviral, antiparasitic, and antiparasitic to protozoa Active ingredients against microorganisms, viruses, parasites and protozoa as Part of preparations.

The invention also relates to preparations with a content of one Compound or more compounds from the group of the sterols and Sterol derivatives with antimicrobial, antiviral, antiparasitic and opposite Protozoa antiparasitic effect against microorganisms, viruses, parasites and protozoa.

The active ingredients and preparations according to the invention can be used prophylactically are used and cause only minor and no disturbance the accumulation of microorganisms, viruses, parasites and protozoa form, or they also eliminate existing microorganisms, viruses, Parasites and protozoa and thus reduce their number.

The stated objects are achieved according to the invention. The invention ßen active ingredients have the inventive, mentioned effects on micro organisms, viruses, parasites and protozoa and are used to treat the mentioned disorders and diseases.

Suitable sterols and sterol derivatives are, for example:
A) natural, nature-identical and synthetically accessible sterols
B) natural and synthetic steroid hormones with a sterol structure, and
C) Natural substances and mixtures of natural substances that contain compounds with a sterol structure.

Well-suited sterols (also referred to as "sterols") A) are, for. B. Zoosterols, Phytosterols and mycosterols.

Preferred zoosterols are cholesterol, dihydrocholesterol and 7-dehydrochols sterol, lanosterol, dihydrolanosterol, spongosterol and stellasterol.

Preferred phytosterols are ergosterol, sitosterol, stigmasterol, fucosterol, Brassicasterol and campesterol.

Preferred mycosterols are ergosterol, fungisterol and zymosterol.

Preferred compounds are in particular cholesterol, 7-dehydrocholesterol, Dihydrocholesterol, lanosterol, dihydrolanosterol, spongosterol, coprosterol, Phytosterols, cholesteryl oleate and cholesteryl sulfate.

Cholecalciferol, ergocalciferol and calciferol are also very suitable.

Suitable steroid hormones B) are, for example, androgens, estrogens, Progestins, corticoids, mineral corticoids and ecdysone.

Preferred natural substances and natural substance mixtures C) are wool wax and wool wax alcohols, soy sterols, tall oil sterols and natural substances with steroid structures, for example:

• - Cardenolides (e.g. digoxygenin, digitoxin, digoxin, gitoxin, gitoxygenin, Digitoxygenin),
• - bufadienolides (e.g. scillarenin, scillaren),
• - steroid sapogenins (e.g. digitogenin, gitogenin, tigogenin),
• - Bile acids and their derivatives (e.g. cholic acid, glycolic acid, taurocholic acid, deoxycholic acid, lithocholic acid, chenodeoxycholic acid, cholanic acid), and
  Steroid alkaloids (e.g. Solanidine, Tomatidine, Strophanitn, Conessin).

The invention also relates to the hydrogenated derivatives of the sterols Groups A, B and C, especially group A.

You can e.g. B. hydrogenated in the 5/6 position, 7/8 position and / or 8/9 position be.

The dihydro derivatives, in particular the 5/6 dihydro derivatives, are preferred.

Furthermore, the dehydro derivatives of the sterols of groups A, B and C are also available suitable, especially the 7-dehydro derivatives.

Dihydrocholesterol, dihydrolanosterol and 7-dehydrochole are preferred sterol.

Suitable derivatives of the compounds of groups A, B and C, which are also in the hydrogenated forms, especially dihydroforms, or the dehydroforms are also those derivatives which, by substituting the 3-hydroxy group of sterols are available and in the following also referred to as D who the. These derivatives of compounds of group A are preferred.

These 3-OH groups with inorganic or organic are preferred Acids or reacted with alcohols, i.e. esterified or etherified, or else reacted with amines, with a replacement of the sterol-3-OH group substituted 3-amino group of the sterol backbone results.

• a) The sterol-3-OH group can, for example, with inorganic acids such as Sulfuric acid or phosphoric acid can be esterified. Preferred are the Sulphates, especially the sulphates of the compounds of group A, e.g. B. Chole steryl-3-sulfate.
• b) The 3-OH group can be esterified with carboxylic acids. Suitable are e.g. B. branched or unbranched, saturated or unsaturated, preferably mono- to 5-fold, in particular mono- or di-unsaturated, carboxylic acids having 1-40, preferably 1-20 carbon atoms.
  Cholesteryl formate, cholesteryl isostearate, cholesteryl oleate and beta-sitosterylacetate are preferred.
  The said carboxylic acid esters of soy sterol, in particular soy sterol acetate, are particularly preferred.
  Furthermore, the said carboxylic acid esters of phytosterols and Dihy drophytosterols are preferred, especially the octadecanoates, eg. B. Dihydrophyto steryloctadecanoate.
• c) The 3-OH group can also be esterified with hydroxylated carboxylic acids. Suitable are e.g. B. one to five times hydroxylated carboxylic acids, e.g. B. as described under b). Mono- and dihydroxycarboxylic acids are preferred.
  Preference is given to cholesteryl hydroxystearates, preferably the monohydroxy stearates, preferably cholesteryl α-hydroxystearate.
• d) The 3-OH group can also be present in etherified form with alcohols. Are suitable z. B. straight-chain or branched, saturated or one to fivefold, preferably mono- or di-unsaturated monoalcohols with 1-40, in particular 1-20 Carbon atoms.
• e) The 3-OH group can also be etherified with polyols. Straight-chain or branched, saturated or mono- to five-fold, preferably mono- or di-unsaturated polyhydroxyalkanols with 2-8, preferably 2-6, in particular 2 or 3, hydroxyl groups are suitable.
  Glyceryl lanolate and the sterol ethers obtainable with sorbitol, mannitol or xylitol, in particular those of cholesterol, are preferred.
• f) The 3-OH group can also be etherified with cycloalkyl groups, which can optionally be substituted by one or two or more hydroxyl groups.
  The cycloalkyl groups can have 4-8, in particular 6, carbon atoms and optionally carry a hydroxyl group on each carbon atom.
• g) The 3-OH group can still contain glycosidically bound sugar residues be substituted, for example mono-, di- or oligosaccharides with preference wise 2 or 3 sugar residues. Suitable saccharides, especially mono saccharides, are trioses, tetroses, pentoses or hexoses, of which in particular others the pentoses and hexoses. Glucose and fructose become special preferred. In particular, cholesteryl glucoside is preferred.
• h) Suitable 3-OH derivatives are also the ethoxylates, e.g. B. those with Ethy Lenoxide chains with an E / O number of 1-200, in particular 5-150. Preferred become Choleth-20, Dihydrocholet-30, Laneth-5 to -50, PEG-50-Lanolin to PEG-150 lanolin, PEG-5 soy sterol to PEG-50 soy sterol, PEG-5 tall oil sterol ether.
• i) Suitable 3-OH derivatives are also the propoxylates, e.g. B. those with a P / O number of 1-200, especially 5-30. PPG-5-lanolin- Wax, PPG-5-Lanonlin-Alcohol-Ether to P PG-30-Lanolin-Alcohol-Ether.
• j) The mixed ethoxylates-propoxylates of the 3-OH group are also suitable. Suitable ethoxylate or propoxylate radicals can each have 1-100, preferably 10-100, of these radicals. Preferred mixed (E / O) _n - (P / O) _m - chains with the numerical values given above for n and m are PPG-12-PEG-50-lanolin and PPG-40-PEG-60-lanolin oil.
• k) Preferred sterols substituted on the 3-OH group are also the sulfo succinate. Di-sodium sitostereth-14-sulfosuccinate is preferred.
• l) Furthermore, the reaction products of the 3-OH group of the sterols, ins particular of cholesterol, with the amino groups of amino acids preferred, where z. B. in a condensation reaction with elimination of water, the 3-OH- Group is replaced by the amino residue of the amino acid, whereby the 3- Amino derivatives of the C-3 atom of the sterol ring system are formed. Particularly preferred is the amine obtainable in this way, the by Reaction of glutamic acid with cholesterol is available.

The Deri described above under a) to l) are particularly preferred vate D of cholesterol.

The following sterols and sterol derivatives according to the invention are particularly preferred:

The active ingredients according to the invention are prepared according to the person skilled in the art common, customary methods. Active ingredients according to the invention are commercially available available or known or can be obtained by known methods.

The active ingredients are against the mentioned microorganisms, viruses, Parasites and protozoa excellently effective and used to treat the mentioned diseases and conditions.

The active ingredients according to the invention act in particular in the sense of disinfection ornamental active ingredients, e.g. B. one the microorganisms, viruses, and parasites Protozoanic effect or z. B. in a growth inhibition for these. These principles of action are in particular also with the terms antimicrobial, antiviral, antiparasitic and anti-protozoal antiparasi tary effect against microorganisms, viruses, parasites and protozoa and should apply in the same way to these active ingredients.

It has been found in an astonishing way that the invention Active ingredients the growth of gram-positive and gram-negative bacteria, Prevent mycobionts, protozoa, parasites and viruses. The Active ingredients according to the invention in a synergistic manner, ie superadditive in with regard to the individual components.

In particular, the active ingredients according to the invention are capable of promoting growth of yeasts, in particular of the Pityrosporum species, namely Pityrosporum oval, to prevent.

It has also been found that the active ingredients according to the invention the Bil prevent seborrheic symptoms, especially dandruff as well as pre-existing seborrheic manifestations, in particular Dandruff, eliminate.

The active ingredients according to the invention are also well suited for the Ver Use as a deodorizing agent in cosmetic deodorants as well against blemished skin, mild forms of acne or Propionibacterium acnes.

Finally, it has been found that the active ingredients according to the invention the Decay of organic matter, especially cosmetic and dermatological Preparations due to infestation with gram-positive and gram-negative bacteria, Mycobionts, protozoa, parasites and viruses can prevent the sen preparations are added.

A method for combating mycobion is thus also in accordance with the invention th, characterized in that the active ingredients according to the invention are given optionally in a suitable cosmetic or dermatological carrier with brought into contact with the area contaminated by mycobionts, as well as a method to protect organic products from infestation with Mycobionts, characterized in that these organic products the Active ingredients according to the invention are added in an effective amount.

The prior art consequently did not provide the slightest indication of the inven- tive Proper use as an antimycotic principle of action.

It was also astonishing that the active ingredients according to the invention are particularly good are effective against those responsible for the development of dandruff Germ Pityrosporum oval and related germs. A preferred embodiment form of the present invention are therefore to be used against dandruff Formulations such as anti-dandruff shampoos.

According to the invention, the active ingredients are preferably in cosmetic or derma tological compositions used, with a content of 0.1-50 Wt .-%, in particular 5-35 wt .-%, based on the total weight of the zu composition. The compositions advantageously contain 10, in particular their 10.1, -25 wt .-% of the active ingredients according to the invention.

The active ingredients can be used topically, percutaneously, transdermally, parenterally, be carried out orally or intravascularly.

Preparations which contain active ingredients according to the invention can be topical Be preparations, for example cosmetic and dermatological topical Preparations or also conventional pharmaceutical dosage forms. Before are added deodorants or deodorant body cleansing products or Personal care products. The active ingredients can also be used in disinfectants and / or cleaning agents that are not only used to treat the Body or skin, but also for cleaning and disinfection adorn hard surfaces, medical materials, devices, instruments ten, furniture and walls.

Detergents, disinfectants and detergents intended for the body can also be used to treat the skin, just like the ones topical preparations. But they are preferably used to treat Body cavities, wounds and also the mouth and throat area as well as the nose.

The active compounds according to the invention can be converted into common ones without difficulty Incorporate cosmetic or dermatological formulations, advantageously in Pump sprays, aerosol sprays, creams, ointments, tinctures, lotions, nail care products (e.g. nail polish, nail polish remover, nail balms) and the like.

It is also possible and possibly advantageous to use the active substances according to the invention to combine substances with other active ingredients, for example with other anti microbial, antimycotic or antiviral substances.

It is advantageous to buffer the compositions according to the invention. A pH range of 3.5-7.5 is advantageous. It is particularly beneficial to adjust the pH to choose in a range of 4.0-6.5.

The cosmetic and / or dermatological formulations according to the invention genes can be composed as usual and used to treat the skin and / or the hair in terms of a dermatological treatment or a Treatment in the sense of caring cosmetics. But you can also use Make-up products are used in decorative cosmetics.

The cosmetic and / or derma according to the invention are used ecological formulations in the manner customary for cosmetics and dermatics applied to the skin and / or hair in sufficient quantity.

Those cosmetic and dermatological preparations are advantageous which are disclosed in are in the form of a sunscreen. Advantageously contain these additionally at least one UVA filter and / or at least one UVB filter and / or at least one inorganic pigment.

Cosmetic preparations according to the invention for protecting the skin from UV Rays can be in various forms, such as. B. usually can be used for this type of preparation. So you can z. Legs Solution, an emulsion of the water-in-oil (W / O) type or of the oil-in-water type (O / W), or multiple emulsions, for example of the water-in-oil-in Water (W / O / W), a gel, a hydrodispersion, a solid stick or even a Represent aerosol.

The cosmetic preparations according to the invention can be cosmetic auxiliaries contain substances that are commonly used in such preparations the, z. B. preservatives, bactericides, antioxidants, perfumes, agents for Prevent foaming, dyes, pigments that have a coloring effect have, thickeners, surfactants, emulsifiers, soft making substances, moisturizing and / or moisturizing substances, fat te, oils, waxes or other common constituents of a cosmetic formulation tion such as alcohols, polyols, polymers, foam stabilizers, electrolytes, organi cal solvents or silicone derivatives.

If the cosmetic or dermatological preparation is a solution or lotion, the following solvents can be used:

• - water or aqueous solutions,
• - Oils, such as triglycerides of capric or caprylic acid, but preferably Castor oil,
• - Fats, waxes and other natural and synthetic fatty substances preferably esters of fatty acids with alcohols of low carbon number, e.g. B. with Isopropanol, propylene glycol or glycerin, or esters of fatty alcohols with Alkanoic acids with a low carbon number or with fatty acids,
• - Alcohols, diols or polyols with a low carbon number, as well as their ethers, preferably wise ethanol, isopropanol, propylene glycol, glycerin, ethylene glycol, ethyl lenglycol monoethyl or monobutyl ether, propylene glycol monomethyl, monoethyl or monobutyl ether, diethylene glycol monomethyl or -monoethyl ether and analogous products.

In particular, mixtures of the abovementioned solvents are used turns. In the case of alcoholic solvents, water can be an additional component be.

According to the invention, all beneficial antioxidants for cosmetic and / or dermatological applications suitable or common anti oxidants are used.

The antioxidants are advantageously selected from the group consisting of amino acids (e.g. glycine, histidine, tyrosine, tryptophan) and their derivatives, imidazoles (e.g. urocanic acid) and their derivatives, peptides such as D, L-carnosine, D- Carnosine, L-carnosine and their derivatives (e.g. anserine), carotenoids, carotenes (e.g. α-carotene, β-carntene, lycopene) and their derivatives, lipoic acid and their derivatives (e.g. dihydrolipoic acid), Aurothioglucose, propylthiouracil and other thiols (e.g. thioredoxin, glutathione, cysteine, cystine, cystamine and their glycosyl, N-acetyl, methyl, ethyl, propyl, amyl, butyl and lauryl, palmitoyl -, oleyl, γ-linoleyl, cholesteryl and glyceryl esters) as well as their salts, dilauryl thiodipropionate, distearyl thiodipropionate, thiodipropionic acid and their derivatives (esters, ethers, peptides, lipids, nucleotides, nucleosides and salts) as well as sulfoxamine compounds (e.g. Buthioninsulfoximine, Homocysteineulfoximin, Buthionin sulfone, Penta-, Hexa-, Heptathioninsulfoxim in) in very low tolerable doses (e.g. B. pmol to µmol / kg), furthermore (metal) chelators (e.g. α-hydroxy fatty acids, palmitic acid, phytic acid, lactoferrin), α-hydroxy acids (e.g. citric acid, lactic acid, malic acid), humic acid, bile acid, Bile extracts, bilirubin, biliverdin, EDTA, EGTA and their derivatives, unsaturated fatty acids and their derivatives (e.g. γ-linolenic acid, linoleic acid, oleic acid), folic acid and their derivatives, ubiquinone and ubiquinol and their derivatives, vitamin C and derivatives (e.g. ascorbyl palmitate, Mg-ascorbyl phosphate, ascorbyl acetate), tocopherols and derivatives (e.g. vitamin E acetate), vitamin A and derivatives (vitamin A palmitate) and coniferyl benzoate of benzoin, rutic acid and its derivatives, ferulic acid and their derivatives, butylhydroxytoluene, butyl hydroxyanisole, nordihydroguajak resin acid, nordihydroguajaretic acid, trihydroxy butyrophenone, uric acid and its derivatives, mannose and its derivatives, zinc and its derivatives (e.g. ZnO, ZnSO ₄ ) selenium and its derivatives (e.g. selenium methionine) ), P tilbene and their derivatives (e.g. B. stilbene oxide, trans-stilbene oxide) and the derivatives suitable according to the invention (salts, esters, ethers, sugars, Nukleo tide, nucleosides, peptides and lipids) of these active ingredients.

The amount of antioxidants (one or more compounds) in the preparation tion is preferably 0.001 to 30 wt .-%, particularly preferably 0.05- 20% by weight, in particular 1-10% by weight, based on the total weight of the Preparation.

Provided that vitamin E and / or its derivatives represent the antioxidant (s) len, it is advantageous to have their respective concentrations in the range of 0.001- 10.0% by weight, based on the total weight of the formulation, to be selected.

If vitamin A, or vitamin A derivatives, or carotenes or their derivatives the one or more antioxidants is advantageous, their respective concentra ions from the range of 0.001-10% by weight, based on the total weight the formulation to choose.

Emulsions according to the invention are advantageous and contain, for. B. the mentioned Fats, oils, waxes and other fatty substances, as well as water and an emulsifier, as is commonly used for such type of formulation.

Gels according to the invention usually contain alcohols of low carbon number, z. B. ethanol, isopropanol, 1,2-propanediol, glycerol and water or a vorste hend called oil in the presence of a thickener, which is used in oily alcohol gels preferably silicon dioxide or an aluminum silicate, in the case of aqueous alcoholic or alcoholic gels is preferably a polyacrylate.

Fixed pens according to the invention contain e.g. B. natural or synthetic Waxes, fatty alcohols or fatty acid esters. Lip balm sticks are preferred and deodorant sticks ("deodorant sticks").

As a propellant for kos according to the invention, which can be sprayed from aerosol containers metallic or dermatological preparations are the customary known ones volatile, liquefied propellants, e.g. B. Hydrocarbons (propane, Butane, isobutane) are suitable, used alone or in a mixture with one another can be. It is also advantageous to use compressed air.

Of course, the person skilled in the art knows that there are propellant gases which are nontoxic per se would be suitable in principle for the present invention, but to which nevertheless because of a questionable effect on the environment or other accompanying circumstances should be avoided, especially fluorocarbons and fluorochlorine hydrocarbons (CFC).

The preparations according to the invention can also preferably contain substances contain that absorb UV radiation in the UVB range, the total amount of filter substances z. B. 0.1 wt .-% to 30 wt .-%, preferably 0.5 to 10 wt .-%, in particular 1 to 6 wt .-%, based on the Ge total weight of the preparation in order to make cosmetic preparations available Put the skin away from the entire range of ultraviolet radiation protection. They can also serve as sunscreens.

The UVB filters can be oil-soluble or water-soluble. As oil-soluble Substan zen are z. B. to name:

• - 3-Benzylidencamphor and its derivatives, z. B. 3- (4-methylbenzylidene) - camphor,
• - 4-aminobenzoic acid derivatives, preferably 4- (dimethylamino) benzene acid (2-ethylhexyl) ester, 4- (dimethylamino) benzoic acid amyl ester;
• - Esters of cinnamic acid, preferably 4-methoxycinnamic acid (2-ethylhexyl) ester, Isopentyl 4-methoxycinnamate;
• - Esters of salicylic acid, preferably salicylic acid (2-ethylhexyl) ester, Sali cylic acid (4-isopropylbenzyl) ester, salicylic acid homomenthyl ester;
• - Derivatives of benzophenone, preferably 2-hydroxy-4-methoxybenzo phenone, 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2,2'-dihydroxy-4- methoxybenzophenone;
• - Esters of benzalmalonic acid, preferably 4-methoxybenzalmalonic acid redi (2-ethylhexyl) ester;
• - 2,4,6-trianilino- (p-carbo-2'-ethyl-1'-hexyloxy) -1,3,5-triazine.

As water-soluble substances are advantageous:

• - 2-phenylbenzimidazole-5-sulfonic acid and its salts, e.g. B. Sodium, Potassium or triethanolammonium salts,
• - sulfonic acid derivatives of benzophenones, preferably 2-hydroxy-4- methoxybenzophenone-5-sulfonic acid and its salts;
• - Sulphonic acid derivatives of 3-benzylidenecamphor, such as. B. 4- (2-Oxo-3-boron nylidenemethyl) benzenesulfonic acid, 2-methyl-5- (2-oxo-3-bornylidenme thyl) sulfonic acid and its salts.

The list of the UVB filters mentioned which are used according to the invention can, of course, not be limiting.

It can also be advantageous to use UVA filters in preparations according to the invention use, usually in cosmetic and / or dermatological Preparations are included. Such substances are preferred wise to derivatives of dibenzoylmethane, in particular to 1- (4'- tert-butylphenyl) -3- (4'-methoxyphenyl) propane-1,3-dione and around 1-phenyl-3- (4'-iso propylphenyl) propane-1,3-dione. Even preparations that make these combinations are the subject of the invention. It can be the same amounts of UVA filter substances are used, which for UVB filter substances were called.

Cosmetic and / or dermatological preparations according to the invention can They also contain inorganic pigments that are commonly used in cosmetics can be used to protect the skin from UV rays. It is about to oxides of titanium, zinc, iron, zirconium, silicon, manganese, aluminum ums, cers and mixtures thereof, as well as modifications in which the oxides the active agents are. Pigments are particularly preferred based on titanium dioxide. It can be used for the above combinations mentioned amounts can be used.

Cosmetic preparations for hair care are, for example wise to shampoo, preparations that are used when rinsing the hair or after shampooing, before or after the permanent wave treatment, before or after coloring or bleaching the hair to be applied Preparations for blow-drying or inserting the hair, preparations for coloring or bleaching to a hairdressing and treatment lotion, a hair lacquer or to Permanent waving.

The cosmetic preparations contain active ingredients and auxiliaries like them usually for this type of hair care and hair care preparations act can be used.

Preservatives, surface-active substances, sub punches to prevent foaming, emulsifiers, thickeners, fats, Oils, waxes, organic solvents, bactericides, perfumes, or dyes Pigments, the task of which is to color the hair or the preparation itself, Electrolytes, anti-greasy hair preparations.

Cosmetic preparations that contain a shampoo or detergent, Represent shower or bath preparation, preferably contain at least an anionic, non-ionic or amphoteric surfactant or Mixtures thereof, active ingredients according to the invention and auxiliaries as they are usual can be used for this.

Examples of surface-active substances that are advantageously ver according to the invention can be used are conventional soaps, e.g. B. fatty acid salts of Sodium, alkyl sulfates, alkyl ether sulfates, alkane and alkyl benzene sulfonates, sulfo acetate, sulfobetaines, sarcosinates, amidosulfobetaines, sulfosuccinates, sulfo succinic acid half-esters, alkyl ether carboxylates, protein-fatty acid condensates, Alkyl betaines and amido betaines, fatty acid alkanolamides, polyglycol ether derivatives father.

The surface-active substance can be used in a concentration between 1% by weight and 50 wt .-% in the shampoo, or the detergent, shower or Bath preparations are available.

If the cosmetic or dermatological preparation is in the form of a lotion before that rinsed and z. B. before or after decolorization, before or after Shampooing, between two shampooing steps, before or after Permanent wave treatment is applied, it is z. B. to water rige or aqueous-alcoholic solutions, which may be surface-active Contain substances, preferably non-ionic or cationic surface-active ve substances whose concentration is between 0.1 and 10% by weight, preferably between 0.2 and 5% by weight. This cosmetic or dermatologi cal preparation can also be an aerosol with the commonly used for this present aids.

A cosmetic preparation in the form of a lotion that is not rinsed out, in particular a lotion for inserting the hair, a lotion that is used when blow-drying the hair is used, a hairdressing and treatment lotion, in general mean an aqueous, alcoholic or aqueous-alcoholic solution and contains at least one cationic, anionic, non-ionic or amphoteric res polymer or mixtures thereof, as well as active ingredients according to the invention. The amount of active ingredients according to the invention used is, for. B. between 0.1 and 10% by weight, preferably between 0.1 and 3% by weight.

Cosmetic and dermatological preparations for the treatment and care of Hair which contain the active ingredients according to the invention can be used as emulsions which are of the nonionic or anionic type. Non-ionic In addition to water, emulsions contain oils or fatty alcohols, for example can be polyethoxylated or polypropoxylated, or mixtures of the two organic components. These emulsions optionally contain cationic surfactants. Anionic emulsions are preferred wise of the soap type and contain at least one according to the invention ethoxylated or propoxylated organic compound with anionic or non-ionic character.

Cosmetic and dermatological preparations for the treatment and care of Hair can be in the form of gels which, in addition to active ingredients according to the invention and solvents usually used for this or organic thickening medium, e.g. B. gum arabic, xanthan gum, sodium alginate, cellulose derivatives, preferably methyl cellulose, hydroxymethyl cellulose, hydroxyethyl cellulose, Hydroxypropyl cellulose, hydroxypropylmethyl cellulose or inorganic ver thickener, e.g. B. aluminum silicates such as bentonite, or a Mixture of polyethylene glycol and polyethylene glycol stearate or distearate, contain. The thickener is in the gel, for. B. in an amount between 0.1 and 30% by weight, preferably between 0.5 and 15% by weight.

The amount of the active ingredients according to the invention in one is preferably for the hair determined means 0.01 wt .-% to 10 wt .-%, in particular 0.5 wt .-% up to 5% by weight, based on the total weight of the preparations.

Unless otherwise stated, the amounts and percentages relate to details ben and parts on the weight, in particular on the total weight of the respective gen mixture or preparation.

The following examples are intended to represent the embodiments of the present inventions clarify. The data always relate to% by weight, if not other information can be provided.

The following examples are intended to represent the embodiments of the present inventions clarify. The numerical values given are% by weight.

example 1 W / O cream

Paraffin oil 10.00 Ozokerite 4.00 vaseline 4.00 vegetable oil 10.00 Wool wax alcohol 2.00 Aluminum stearate 0.40 Dihydrocholesteryl octyl decanoate 12.00 Perfume, preservatives q. s. Water, VES ad 100.00

The above example can also be used with an identical amount of glyceryl lanolate, Chole steryl isostearate or Laneth-10 instead of dihydrocholesteryl octyl decanoate be formulated.

Example 2 W / O lotion

Paraffin oil 25.00 Silicone oil 2.00 Ceresin 1.50 Wool wax alcohol 0.50 Glucose sesquiisostearate 2.50 Dihydrocholesteryl octyl decanoate 15.00 Perfume, preservatives q. s. Water, VES ad 100.00

The above example can also be used with an identical amount of Dihydrocholet-5, Chole sterol or cholecalciferol instead of dihydrophytosteryl octyl decanoate formu be lured.

Example 3 O / W lotion

Paraffin oil 5.00 Isopropyl palmitate 5.00 Cetyl alcohol 2.00 Beeswax 2.00 Ceteareth-20 2.00 PEG-20 glyceryl stearate 1.50 Glycerin 3.00 Lanosterol 12.00 Perfume, preservatives q.s. Water, VES ad 100.00

The above example can also be used with an identical amount of PPG-5-Lanolin Wax, PEG-25 phytosterol or PEG-40 soya sterol instead of PEG-20 glyceryl stea council to be formulated.

Example 4 O / W cream

Vegetable oil 10.00 Cetyl alcohol 2.00 Glycerol monostearate 1.50 PEG-30 glyceryl stearate 2.00 Glycerin 3.00 Isopropyl palmitate 5.00 Carbopol 980 (neutralized) 0.30 PPG-10 Lanolin Alcohol Ether 5.00 Perfume, preservatives q.s. Water, VES ad 100.00

The above example can also be used with an identical amount of PEG-10 lanolin, PEG-20 Soya Sterol or Tall Oil Sterol instead of PPG-10 Lanolin Alcohol Ether can be formulated.

Example 5 ointment

vaseline 36.00 Ceresin 10.00 zinc oxide 4.00 Vegetable oil 20.00 Wool wax alcohol 10.00 Perfume, preservatives q.s. Paraffin oil ad 100.00

The above example can also be used with an identical amount of lanosterol, PEG-25- Phytosterol or cholesteryl oleate instead of wool wax alcohol who are formulated the.

Example 6 Skin oil

Cetyl palmitate 3.00 C _12-15 alkyl benzoate 2.00 Polyisobutene 10.00 Squalane 2.00 β-sitosterol 15.00 Perfume, preservatives q.s. Paraffin oil ad 100.00

The above example can also be used with an identical amount of dihydrocholesterol, Disodium sitostereth-14-sulfosuccinate or PEG-10-soya sterol instead of β-sitosterol can be formulated.

Example 7 Bath oil

Paraffin oil 20.00 PEG-40 hydrogenated castor oil 5.00 Cholesteryl hydroxystearate 11.00 Perfume, preservatives q.s. Soybean oil ad 100.00

The above example can also be used with an identical amount of Laneth-20, PPG-5 Lanolin wax or PEG-25 phytosterol instead of cholesteryl hydroxystearate be formulated.

Example 8 lipstick

Ceresin 8.00 Beeswax 4.00 Carnauba wax 2.00 vaseline 40.00 Hydrogenated castor oil 4.00 Cholesterol 7.50 Perfume, preservatives q.s. Paraffin oil ad 100.00

The above example can also be used with an identical amount of cholesteryl oleate, Lanosterol or soy sterol can be formulated instead of cholesterol.

Example 9 Care mask

PEG-50 lanolin 0.50 Glyceryl stearate 2.00 Sunflower seed oil 3.00 Bentonite 8.00 kaolin 35.00 Tin oxide 5.00 PEG-5 phytosterol 5.00 Perfume, preservatives q.s. Water, VES ad 100.00

The above example can also be used with an identical amount of PEG-5 lanolate, PPG-5-Lanolin Wax or Soya Sterol Acetate instead of PEG-5-Phytosterol be formulated.

Example 10 Gel containing liposomes

Lecithin 6.00 Vegetable oil 12.50 Hydrolyzed collagen 2.00 Xanthan gum 1.40 Butylene glycol 3.00 Lanosterol 10.00 Perfume, preservatives q.s. Water, VES ad 100.00

The above example can also be used with an identical amount of wool wax alcohol, Whoever formulated cholesteryl isostearate or glyceryl lanolate instead of lanosterol the.

Example 11 Shower preparation with refatting agent

Cocoamidodiacetate 10.00 Sodium lauryl sulfate 2500 Potassium Cocyl Hydrolyzed Collagen 5.00 Macadamia nut oil 5.00 Sodium chloride 0.60 Disodium sitostereth-14 sulfosuccinate 20.00 Perfume, preservatives q.s. Water, VES ad 100.00

The above example can also be used with an identical amount of PPG-12-PEG-50- Lanolin, cholesteryl hydroxystearate, or dihydrocholeth-15 instead of Disodium sitostereth-14-sulfosuccinate can be formulated.

Example 12 Bar of soap

Na salt from sebum fatty acids 60.00 Na salt from coconut oil 28.00 Sodium chloride 0.50 Wool wax alcohol 10.00 Perfume, preservatives q.s. Water, VES ad 100.00

The above example can also be used with an identical amount of glyceryl lanolate, Lanosterol or Soy Sterol can be formulated instead of wool wax alcohol.

Example 13 Syndet soap

Sodium lauryl sulfate 30.00 Sodium sulfosuccinate 10.00 Potassium cocoyl hydrolyzed collagen 2.00 Dimethicone copolyol 2.00 paraffin 2.00 Cornstarch 10.00 Talc 10.00 Glycerin 3.00 Wool wax alcohol 15.00 Perfume, preservatives q. s. Water, VES ad 100.00

The above example can also be used with an identical amount of glyceryl lanolate, Lanosterol or Soy Sterol can be formulated instead of wool wax alcohol.

Example 14 Hair care products

TEA-Cocoyl hydrolyzed collagen 30.00 Monoethanolamine lauryl sulfate 25.00 almond oil 2.00 Sodium chloride 1.00 Cholecalciferol 7.50 Perfume, preservatives q. s. Water, VES ad 100.00

The above example can also be used with an identical amount of β-sitosterol, Chole sterol or stearyl glycyrrhetinate can be formulated instead of cholecalciferol.

Example 15 Care shampoo

Disodium lauryl sulfosuccinate 6.00 Cocoamidopropyl betaine 10.00 Glycol distearate 5.00 7-dehydrocholesterol 12.00 Perfume, preservatives q. s. Water, VES ad 100.00

The above example can also be used with an identical amount of Lanosterol, Glyce ryl lanolate or stearyl glycyrrhetinate formulated instead of 7-dehydrocholesterol will.

Example 16 Hair treatment

Cetyl alcohol 5.00 Caprylic / Capric Triglyceride 3.00 Petrolatum 2.00 Wool wax alcohol 0.50 Glyceryl lanolate 12.50 Perfume, preservatives q. s. Water, VES ad 100.00

The above example can also be used with an identical amount of Cholesteryl Isostea rat, cholesteryl oleate or dihydrolanosterol instead of glyceryl lanolate formu be lured.

Example 17 hair conditioner

Cocoamidopropyl betaine 5.00 Cetyl alcohol 2.00 Propylene glycol 2.00 Citric acid 0.30 Glyceryl lanolate 10.00 Perfume, preservatives q. s. Water, VES ad 100.00

The above example can also be used with an identical amount of Soya Sterol, Chole steryl hydroxystearate or Laneth-10 instead of glyceryl lanolate the.

Example 18 Hair setting

Polyvinyl pyrrolidone / vinyl acetate / vinyl propionate copolymer 5.00 Ethanol 45.00 β-sitosterol 7.50 Perfume, preservatives q. s. Water, VES ad 100.00

The above example can also be used with an identical amount of ergocalciferol, Laneth-15 or PPG-5-Lanolin Wax can be formulated instead of β-sitosterol.

Example 19 Hairdressing cream

vaseline 4.00 Cetearyl alcohol 4.00 PEG-40 hydrogenated castor oil 2.00 Isopropyl palmitate 5.00 Citric acid 1.00 7-dehydrocholesterol 5.00 Perfume, preservatives q. s. Water, VES ad 100.00

The above example can also be used with an identical amount of cholesterol, wool Wax alcohol or soy sterol instead of 7-dehydrocholesterol who are formulated the.

Example 20 shaving cream

Stearic acid 7.00 Sodium lauryl sulfate 3.00 Stearyl alcohol 1.00 Glycerin 5.00 Triethanolamine 3.60 Soy sterol 5.00 Perfume, preservatives q. s. Water, VES ad 100.00

The above example can also be used with an identical amount of cholesterol, wool waxy alcohol or glyceryl lanolate can be formulated instead of soy sterol.

Example 21 Foot cream

Soluan 5 2.00 Methyl salicylate 5.00 Caprylic / Capric Triglyceride 10.00 Stearic acid 5.00 Cetyl alcohol 1.00 Glycerin 2.00 Dimethicone 1.00 Carbopol 984 0.50 Triethanolamine 1.50 Wool wax alcohol 12.50 Perfume, preservatives q. s. Water, VES ad 100.00

The above example can also be used with an identical amount of dihydrocholesterol, Dihydrolanosterol or Soya Sterol formulated instead of wool wax alcohol will.

Example 22 Aerosol spray

Octyldodecanol 0.50 7-dehydrocholesterol 5.00 Perfume, preservatives q. s. Ethanol ad 100.00

The above example can also be used with an identical amount of wool wax alcohol, Formulated glyceryl lanolate or soya sterol instead of 7-dehydrocholesterol will.

The liquid obtained by mixing the respective components together Phase is used together with a propane-butane mixture (2: 7) in the ratio 39: 61 filled into aerosol containers.

Example 23 Pump spray

PEG-40 Hydrogenated Castor Oil 2.00 Glycerin 1.00 Dihydrophytosteryl octyl decanoate 10.00 Perfume, preservatives q. s. Water, VES ad 100.00

The above example can also be used with an identical amount of 7-dehydrochole sterol, cholesteryl oleate or cholesteryl isostearate instead of dihydrophyto steryl octyl decanoate.

Example 24 Roll-on gel

1,3-butylene glycol 2.00 PEG-40 Hydrogenated Castor Oil 2.00 Hydroxyethyl cellulose 0.50 Dihydrolanosterol 10.00 Perfume, preservatives q. s. Water, VES ad 100.00

The above example can also be used with an identical amount of glyceryl lanolate, Formulated Soya Sterol or Dihydrocholeth-20 instead of Dihydrolanosterol will.

Example 25 Roll-on emulsion

Triceteareth phosphate 0.30 Octyldodecanol 2.00 C _12-15 alkyl benzoate 2.00 C _10-30 alkyl acrylate 0.15 Dihydrocholeth-20 12.00 Perfume, preservatives q. s. Water, VES ad 100.00

The above example can also be used with an identical amount of Laneth-15, PPG-40- PEG-60 Lanolin Oil or Tall Oil Sterol formulated instead of Dihydrocholeth-20 will.

Example 26 Wax pencil

Hydrogenated castor oil 5.00 Beeswax 6.00 Ceresin 30.00 C _12-15 alkyl benzoate 17.00 Wool wax alcohol 20.00 Perfume, preservatives q. s. Octyldodecanol ad 100.00

The above example can also be used with an identical amount of β-sitosterol, Chole sterol or glyceryl lanolate can be formulated instead of wool wax alcohol.

Example 27 Manufacture of capsules

Capsules containing the ingredients listed below will be produced according to known working methods. These are for the treatment of the for the above purposes in dosage amounts of one capsule each time or suitable several times a day:

Cholecalciferol 0.50 g; or
Ergocalciferol 0.50 g.

The above example can also be used with an identical amount of Soya Sterol, β-Sito sterol or glycyrrhecitic acid instead of cholecalciferol or ergocalciferol be formulated.

The figures in the above examples are% by weight.

Example 28 Aerosol spray

Octyldodecanol 0.50 7-dehydrocholesterol 5.00 Perfume, preservatives q. s. Ethanol ad 100.00

The above example can also be used with an identical amount of Soya Sterol, Chole steryl oleate or cholesteryl palmitoleate instead of 7-dehydrocholesterol formu be lured.

The liquid obtained by mixing the respective components together Phase is used together with a propane-butane mixture (2: 7) in the ratio 39: 61 filled into aerosol containers.

Example 29 Pump spray

PEG-40 Hydrogenated Castor Oil 2.00 Glycerin 1.00 Glyceryl lanolate 7.50 Perfume, preservatives q. s. Water, VES ad 100.00

The above example can also be used with an identical amount of PEG-25 Soya Sterol, Formulated dihydrolanosterol or wool wax alcohol instead of glyceryl lanolate will.

The figures given in the examples are percentages by weight.

The active ingredients according to the invention can be used particularly advantageously in microemulsions. Cosmetic and dermatological preparations according to the invention can be particularly advantageous as

• a) unthickened,
• b) classic, e.g. B. by adding polyoxamers, pluronics, carrageenans or thickened vegetable gums,
• c) by adding A-B-A triblock copolymers (e.g. PEG-150 distearate, Fa. Akzo Nobel) or alpha, omega-bis-polyethoxylated silanes or silicones) thickened,
• d) by adding star polymers (e.g. PEG-300 pentaerythrityl tetrastearate or hydrophobically modified tetrakis-polyethoxylated silanes and silicones) thickened,
• e) by adding A-B-A-B multiblock copolymers, starburst polymers, Dendrimers and other supramolecular crosslinkers (e.g. Rheodol TWIS 399, from KAO, or PEG-120-methylglucose dioleate) thickened oil-in Water (O / W), bicontinuous, or water-in-oil (W / O) micro find emulsions use.

Example 30

1,3-di (2-ethylhexyl) cyclohexane 35.00 Glyceryl lanolate 10.00 Sorbitan monolaurate 10.00 Water (+ citric acid up to pH 5.5) 45.00

The above example can also be used with an identical amount of dihydrolanosterol, Dihydrophytosteryl octyl decanoate or cholesteryl oleate instead of glyceryl lanolate.

Example 31

1,3-di (2-ethylhexyl) cyclohexane 33.00 Laneth 10 Acetate 10.00 Sorbitan monolaurate 10.00 Water (+ citric acid up to pH 5.5) 45.00 PEG-150 distearate 2.00

The above example can also be used with an identical amount of Choleth-20, Laneth-5 or PPG-10-Lanolin Alcohol Ether instead of Sorbitan Monolaurate will.

Example 32

Steareth-15 4.80 Glycerin monostearate 2.40 Glyceryl lanolate 7.50 Cyclomethicone 3.30 Cetearyl octanoate 1.70 water 85.30

The above example can also be used with an identical amount of Cholesteryl Isostea rat, glycyrrhetinyl stearate or soya sterol acetate instead of glyceryl lanolate be formulated.

Example 33

Steareth-15 4.80 Glycerin monostearate 2.40 Cholesteryl hydroxystearate 7.50 Cyclomethicone 3.30 Cetearyl octampate 17.00 water 83.30 PEG-150 distearate 2.00

The above example can also be used with an identical amount of β-sitosteryl acetate, Cholesteryl oleate or dihydrophytosteryl octyl decanoate instead of chole steryl hydroxystearate.

Claims (6)

1. Using one or more compounds from the group of sterols and sterol derivatives as antimicrobial, antiviral, and antiparasitic active substances antiparasitic against protozoa against microorganisms, Viruses, Parasites and Protozoa. 2. Use of one or more compounds from the group of sterols and sterol derivatives as antimicrobial, antiviral, and antiparasitic active substances antiparasitic against protozoa against microorganisms, Viruses, parasites and protozoa as part of preparations. 3. Preparations containing one or more compounds formulations from the group of sterols and sterol derivatives with antimicrobial, antivi ral, anti-parasitic and anti-parasitic action against protozoa about microorganisms, viruses, parasites and protozoa. 4. Uses or preparations according to claims 1-3, characterized shows that the sterols and sterol derivatives are selected from the group Cholesterol, 7-dehydrocholesterol, dihydrocholesterol, lanosterol, dihydrolano sterol, spongosterol, coprosterol, phytosterols, cholesteryl oleate and choles steryl sulfate. 5. Preparations according to claims 1-4, characterized in that it is are topical preparations. 6. Use of the active ingredients according to claims 1-4 as active ingredients in Desodo guarantees.