DE19509694A1 - Verwendung von Magnetiten zur Bestimmung der Perfusion von menschlichem Gewebe mittels MR-Diagnostik - Google Patents

Verwendung von Magnetiten zur Bestimmung der Perfusion von menschlichem Gewebe mittels MR-Diagnostik

Info

Publication number
DE19509694A1
DE19509694A1 DE19509694A DE19509694A DE19509694A1 DE 19509694 A1 DE19509694 A1 DE 19509694A1 DE 19509694 A DE19509694 A DE 19509694A DE 19509694 A DE19509694 A DE 19509694A DE 19509694 A1 DE19509694 A1 DE 19509694A1
Authority
DE
Germany
Prior art keywords
perfusion
diagnostic agents
contrast
agents according
diagnostics
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19509694A
Other languages
German (de)
English (en)
Inventor
Thomas Dr Balzer
Andreas Dr Muehler
Peter Dr Reimer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Priority to DE19509694A priority Critical patent/DE19509694A1/de
Priority to IL11737296A priority patent/IL117372A0/xx
Priority to AU51030/96A priority patent/AU5103096A/en
Priority to PCT/EP1996/000967 priority patent/WO1996027394A1/fr
Priority to ZA961919A priority patent/ZA961919B/xx
Publication of DE19509694A1 publication Critical patent/DE19509694A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
    • A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
    • A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
    • A61K49/1851—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with an organic macromolecular compound, i.e. oligomeric, polymeric, dendrimeric organic molecule
    • A61K49/1863—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with an organic macromolecular compound, i.e. oligomeric, polymeric, dendrimeric organic molecule the organic macromolecular compound being a polysaccharide or derivative thereof, e.g. chitosan, chitin, cellulose, pectin, starch

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Signal Processing (AREA)
  • Epidemiology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE19509694A 1995-03-08 1995-03-08 Verwendung von Magnetiten zur Bestimmung der Perfusion von menschlichem Gewebe mittels MR-Diagnostik Withdrawn DE19509694A1 (de)

Priority Applications (5)

Application Number Priority Date Filing Date Title
DE19509694A DE19509694A1 (de) 1995-03-08 1995-03-08 Verwendung von Magnetiten zur Bestimmung der Perfusion von menschlichem Gewebe mittels MR-Diagnostik
IL11737296A IL117372A0 (en) 1995-03-08 1996-03-05 A diagnostic composition containing magnetites
AU51030/96A AU5103096A (en) 1995-03-08 1996-03-07 Use of ferrites for determining the perfusion of human tissue by m.r. diagnosis
PCT/EP1996/000967 WO1996027394A1 (fr) 1995-03-08 1996-03-07 Utilisation de ferrites pour determiner la perfusion de tissus humains au moyen d'un diagnostic par resonance magnetique
ZA961919A ZA961919B (en) 1995-03-08 1996-03-08 Use of magnetites to determine the perfusion of human tissue with the aid of mr diagnosis

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19509694A DE19509694A1 (de) 1995-03-08 1995-03-08 Verwendung von Magnetiten zur Bestimmung der Perfusion von menschlichem Gewebe mittels MR-Diagnostik

Publications (1)

Publication Number Publication Date
DE19509694A1 true DE19509694A1 (de) 1996-09-19

Family

ID=7756943

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19509694A Withdrawn DE19509694A1 (de) 1995-03-08 1995-03-08 Verwendung von Magnetiten zur Bestimmung der Perfusion von menschlichem Gewebe mittels MR-Diagnostik

Country Status (5)

Country Link
AU (1) AU5103096A (fr)
DE (1) DE19509694A1 (fr)
IL (1) IL117372A0 (fr)
WO (1) WO1996027394A1 (fr)
ZA (1) ZA961919B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002022011A1 (fr) * 2000-09-15 2002-03-21 Institut für Diagnostikforschung GmbH an der Freien Universität Berlin Procede de representation par images et de diagnostic de thrombus par tomographie a spin nucleaire faisant appel a des agents de contraste particulaires

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1264181B1 (fr) 2000-03-06 2007-06-06 Dade Behring Marburg GmbH Supports a revetement en polysaccharides, leur preparation et leur utilisation
WO2001074245A1 (fr) * 2000-03-31 2001-10-11 Amersham Health As Procede d'imagerie par resonance magnetique
US7082326B2 (en) 2000-03-31 2006-07-25 Amersham Health As Method of magnetic resonance imaging
US6690962B2 (en) 2000-09-15 2004-02-10 Institut fur Diagnostikforshung GmbH Process for graphic visualization and diagnosis of thrombi by means of nuclear spin tomography with use of particulate contrast media
FR2861994A1 (fr) * 2003-11-12 2005-05-13 Guerbet Sa Nouvel agent de diagnostic pour l'irm dans les pathologies impliquant des proteinases

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3443251A1 (de) * 1984-11-23 1986-05-28 Schering AG, 1000 Berlin und 4709 Bergkamen Eisenoxid-komplexe fuer die nmr-diagnostik
EP0186616A1 (fr) * 1984-11-23 1986-07-02 Schering Aktiengesellschaft Particules magnétiques comme agent diagnostique
EP0525199A1 (fr) * 1991-01-19 1993-02-03 Meito Sangyo Kabushiki Kaisha Composition contenant des particules ultra fines d'oxyde de metal magnetique
EP0543020A1 (fr) * 1991-06-11 1993-05-26 Meito Sangyo Kabushiki Kaisha Composite oxyde comprenant du carboxypolysaccharide hydrosoluble et de l'oxyde de fer magnetique

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5055288A (en) * 1987-06-26 1991-10-08 Advanced Magnetics, Inc. Vascular magnetic imaging method and agent comprising biodegradeable superparamagnetic metal oxides

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3443251A1 (de) * 1984-11-23 1986-05-28 Schering AG, 1000 Berlin und 4709 Bergkamen Eisenoxid-komplexe fuer die nmr-diagnostik
EP0186616A1 (fr) * 1984-11-23 1986-07-02 Schering Aktiengesellschaft Particules magnétiques comme agent diagnostique
EP0525199A1 (fr) * 1991-01-19 1993-02-03 Meito Sangyo Kabushiki Kaisha Composition contenant des particules ultra fines d'oxyde de metal magnetique
EP0543020A1 (fr) * 1991-06-11 1993-05-26 Meito Sangyo Kabushiki Kaisha Composite oxyde comprenant du carboxypolysaccharide hydrosoluble et de l'oxyde de fer magnetique

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002022011A1 (fr) * 2000-09-15 2002-03-21 Institut für Diagnostikforschung GmbH an der Freien Universität Berlin Procede de representation par images et de diagnostic de thrombus par tomographie a spin nucleaire faisant appel a des agents de contraste particulaires

Also Published As

Publication number Publication date
IL117372A0 (en) 1996-07-23
WO1996027394A1 (fr) 1996-09-12
AU5103096A (en) 1996-09-23
ZA961919B (en) 1996-07-16

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Legal Events

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OP8 Request for examination as to paragraph 44 patent law
8130 Withdrawal