DE19500662C2 - Estradiolhaltiges Pflaster und seine Verwendung - Google Patents

Estradiolhaltiges Pflaster und seine Verwendung

Info

Publication number
DE19500662C2
DE19500662C2 DE19500662A DE19500662A DE19500662C2 DE 19500662 C2 DE19500662 C2 DE 19500662C2 DE 19500662 A DE19500662 A DE 19500662A DE 19500662 A DE19500662 A DE 19500662A DE 19500662 C2 DE19500662 C2 DE 19500662C2
Authority
DE
Germany
Prior art keywords
active substance
plaster according
sensitive adhesive
containing plaster
pressure sensitive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE19500662A
Other languages
German (de)
English (en)
Other versions
DE19500662A1 (de
Inventor
Reinhold Meconi
Frank Seibertz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LTS Lohmann Therapie Systeme AG
Original Assignee
LTS Lohmann Therapie Systeme AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE19500662A priority Critical patent/DE19500662C2/de
Application filed by LTS Lohmann Therapie Systeme AG filed Critical LTS Lohmann Therapie Systeme AG
Priority to AU43050/96A priority patent/AU700697B2/en
Priority to PCT/EP1995/005005 priority patent/WO1996021433A1/de
Priority to CA002209711A priority patent/CA2209711C/en
Priority to EP95941722A priority patent/EP0802789B1/de
Priority to AT95941722T priority patent/ATE181827T1/de
Priority to CZ19972121A priority patent/CZ288128B6/cs
Priority to ES95941722T priority patent/ES2137560T3/es
Priority to KR1019970704778A priority patent/KR100373451B1/ko
Priority to PL95321188A priority patent/PL321188A1/xx
Priority to DK95941722T priority patent/DK0802789T3/da
Priority to MXPA/A/1997/005291A priority patent/MXPA97005291A/xx
Priority to HU9800182A priority patent/HU226275B1/hu
Priority to DE59506370T priority patent/DE59506370D1/de
Priority to NZ297806A priority patent/NZ297806A/en
Priority to JP8521396A priority patent/JPH10511966A/ja
Priority to SK952-97A priority patent/SK281623B6/sk
Priority to US08/860,595 priority patent/US5885612A/en
Priority to SI9530313T priority patent/SI0802789T1/xx
Priority to CN95197296A priority patent/CN1172430A/zh
Priority to IL11661495A priority patent/IL116614A/xx
Priority to MYPI96000055A priority patent/MY132338A/en
Priority to ZA96223A priority patent/ZA96223B/xx
Publication of DE19500662A1 publication Critical patent/DE19500662A1/de
Priority to NO972565A priority patent/NO972565D0/no
Priority to FI972950A priority patent/FI119358B/fi
Priority to GR990402488T priority patent/GR3031397T3/el
Publication of DE19500662C2 publication Critical patent/DE19500662C2/de
Application granted granted Critical
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
DE19500662A 1995-01-12 1995-01-12 Estradiolhaltiges Pflaster und seine Verwendung Expired - Fee Related DE19500662C2 (de)

Priority Applications (26)

Application Number Priority Date Filing Date Title
DE19500662A DE19500662C2 (de) 1995-01-12 1995-01-12 Estradiolhaltiges Pflaster und seine Verwendung
SK952-97A SK281623B6 (sk) 1995-01-12 1995-12-18 Náplasť obsahujúca účinnú látku na kontrolované podávanie estradiolu a jej použitie
PCT/EP1995/005005 WO1996021433A1 (de) 1995-01-12 1995-12-18 Estradiolhaltiges pflaster
EP95941722A EP0802789B1 (de) 1995-01-12 1995-12-18 Estradiolhaltiges pflaster
AT95941722T ATE181827T1 (de) 1995-01-12 1995-12-18 Estradiolhaltiges pflaster
CZ19972121A CZ288128B6 (cs) 1995-01-12 1995-12-18 Náplast obsahující účinnou látku pro kontrolované podávání estradiolu
ES95941722T ES2137560T3 (es) 1995-01-12 1995-12-18 Parche contenedor de estradiol.
KR1019970704778A KR100373451B1 (ko) 1995-01-12 1995-12-18 에스트라디올함유패치
PL95321188A PL321188A1 (en) 1995-01-12 1995-12-18 Estradiol containing plaster
DK95941722T DK0802789T3 (da) 1995-01-12 1995-12-18 Estradiolholdigt plaster
MXPA/A/1997/005291A MXPA97005291A (en) 1995-01-12 1995-12-18 Patch that contains estrad
HU9800182A HU226275B1 (en) 1995-01-12 1995-12-18 Plaster containing estradiol and or adhesive layer containing lauric-acid
DE59506370T DE59506370D1 (de) 1995-01-12 1995-12-18 Estradiolhaltiges pflaster
NZ297806A NZ297806A (en) 1995-01-12 1995-12-18 Plaster containing estradiol
AU43050/96A AU700697B2 (en) 1995-01-12 1995-12-18 Estradiol-containing patch
CA002209711A CA2209711C (en) 1995-01-12 1995-12-18 Plaster containing estradiol
US08/860,595 US5885612A (en) 1995-01-12 1995-12-18 Recrystallization-free estradiol-containing patch
SI9530313T SI0802789T1 (en) 1995-01-12 1995-12-18 Plaster containing estradiol
CN95197296A CN1172430A (zh) 1995-01-12 1995-12-18 含雌二醇的药膏
JP8521396A JPH10511966A (ja) 1995-01-12 1995-12-18 エストラジオール含有パッチ
IL11661495A IL116614A (en) 1995-01-12 1995-12-29 Estradiol-containing patch
MYPI96000055A MY132338A (en) 1995-01-12 1996-01-08 Estradiol-containing patch
ZA96223A ZA96223B (en) 1995-01-12 1996-01-11 Estradiol-containing patch
NO972565A NO972565D0 (no) 1995-01-12 1997-06-05 Estradiolholdig plaster
FI972950A FI119358B (fi) 1995-01-12 1997-07-11 Estradiolipitoinen laastari
GR990402488T GR3031397T3 (en) 1995-01-12 1999-09-30 Plaster containing estradiol

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19500662A DE19500662C2 (de) 1995-01-12 1995-01-12 Estradiolhaltiges Pflaster und seine Verwendung

Publications (2)

Publication Number Publication Date
DE19500662A1 DE19500662A1 (de) 1996-07-18
DE19500662C2 true DE19500662C2 (de) 2001-04-26

Family

ID=7751307

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19500662A Expired - Fee Related DE19500662C2 (de) 1995-01-12 1995-01-12 Estradiolhaltiges Pflaster und seine Verwendung
DE59506370T Expired - Lifetime DE59506370D1 (de) 1995-01-12 1995-12-18 Estradiolhaltiges pflaster

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE59506370T Expired - Lifetime DE59506370D1 (de) 1995-01-12 1995-12-18 Estradiolhaltiges pflaster

Country Status (24)

Country Link
US (1) US5885612A (no)
EP (1) EP0802789B1 (no)
JP (1) JPH10511966A (no)
KR (1) KR100373451B1 (no)
CN (1) CN1172430A (no)
AT (1) ATE181827T1 (no)
AU (1) AU700697B2 (no)
CA (1) CA2209711C (no)
CZ (1) CZ288128B6 (no)
DE (2) DE19500662C2 (no)
DK (1) DK0802789T3 (no)
ES (1) ES2137560T3 (no)
FI (1) FI119358B (no)
GR (1) GR3031397T3 (no)
HU (1) HU226275B1 (no)
IL (1) IL116614A (no)
MY (1) MY132338A (no)
NO (1) NO972565D0 (no)
NZ (1) NZ297806A (no)
PL (1) PL321188A1 (no)
SI (1) SI0802789T1 (no)
SK (1) SK281623B6 (no)
WO (1) WO1996021433A1 (no)
ZA (1) ZA96223B (no)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19700913C2 (de) * 1997-01-14 2001-01-04 Lohmann Therapie Syst Lts Transdermales therapeutisches System zur Abgabe von Hormonen
DE19830651A1 (de) * 1998-07-09 2000-01-13 Lohmann Therapie Syst Lts Steroidhaltiges Pflaster, Verfahren zu seiner Herstellung und Verwendung
AU5325000A (en) 1999-06-05 2000-12-28 David Houze Solubility enhancement of drugs in transdermal drug delivery systems and methodsof use
AU3104301A (en) 2000-01-20 2001-07-31 Noven Pharmaceuticals, Inc. Compositions and methods to effect the release profile in the transdermal administration of active agents
DE10025971B4 (de) * 2000-05-25 2004-09-02 Lts Lohmann Therapie-Systeme Ag Transdermales therapeutisches System in Plasterform mit verminderter Tendenz zur Wirkstoffkristallisation und seine Verwendung
DE10025970C2 (de) * 2000-05-25 2002-04-25 Lohmann Therapie Syst Lts Estrogenhaltiges Pflaster mit einem Wirkstoffreservoir auf der Basis von Ethylcellulose und einem Ethylen-Vinylacetat-Vinylpyrrolidon-Copolymer und seine Verwendung
US20020106402A1 (en) * 2000-12-05 2002-08-08 Hartwig Rod Lawson Crystallization inhibition of drugs in transdermal drug delivery systems and methods of use
US7740481B2 (en) * 2002-06-21 2010-06-22 Politecnico Di Milano Osteointegrative interface for implantable prostheses and a method for the treatment of the osteointegrative interface
IT1390847B1 (it) 2008-07-29 2011-10-19 Milano Politecnico Trattamento biomimetico a base silicio per l'osteointegrazione di substrati in metallo.
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
ES2885523T3 (es) 2011-11-23 2021-12-14 Therapeuticsmd Inc Formulaciones y terapias de reposición hormonal de combinación naturales
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US9353453B2 (en) 2012-07-19 2016-05-31 Politecnico Di Milano Metal substrate modified with silicon based biomimetic treatment having antibacterial property for the osteointegration thereof
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
AU2015264003A1 (en) 2014-05-22 2016-11-17 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
US10286077B2 (en) 2016-04-01 2019-05-14 Therapeuticsmd, Inc. Steroid hormone compositions in medium chain oils
WO2017173071A1 (en) 2016-04-01 2017-10-05 Therapeuticsmd, Inc. Steroid hormone pharmaceutical composition
DE102018120505A1 (de) 2017-10-20 2019-04-25 Amw Gmbh Verhinderung der Kristallisation von Wirkstoffen in transdermalen Darreichungssystemen
US11633405B2 (en) 2020-02-07 2023-04-25 Therapeuticsmd, Inc. Steroid hormone pharmaceutical formulations

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4210711A1 (de) * 1991-10-31 1993-05-06 Schering Ag Berlin Und Bergkamen, 1000 Berlin, De Transdermale therapeutische systeme mit kristallisationsinhibitoren
DE4336557A1 (de) * 1993-05-06 1994-11-10 Lohmann Therapie Syst Lts Estradiolhaltiges transdermales therapeutisches System

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US3637224A (en) * 1969-02-27 1972-01-25 Fedders Corp Annular sealing ring
US4379454A (en) * 1981-02-17 1983-04-12 Alza Corporation Dosage for coadministering drug and percutaneous absorption enhancer
AU553343B2 (en) * 1981-08-10 1986-07-10 Advance Electrode Kabushikikaisya Absorbent adhesive bandage with medicament release
US4624665A (en) * 1984-10-01 1986-11-25 Biotek, Inc. Method of transdermal drug delivery
ATE95430T1 (de) * 1984-12-22 1993-10-15 Sanol Arznei Schwarz Gmbh Wirkstoffpflaster.
US4883669A (en) * 1985-02-25 1989-11-28 Rutgers, The State University Of New Jersey Transdermal absorption dosage unit for estradiol and other estrogenic steroids and process for administration
CN1021196C (zh) * 1986-12-29 1993-06-16 新泽西州州立大学(鲁杰斯) 透皮雌激素/孕激素药剂单元、系统及方法
CH674618A5 (no) * 1987-04-02 1990-06-29 Ciba Geigy Ag
DE3743946A1 (de) * 1987-09-01 1989-03-09 Lohmann Gmbh & Co Kg Vorrichtung zur abgabe von nitroglycerin an die haut, verfahren zu ihrer herstellung sowie ihre verwendung
DE3729299A1 (de) * 1987-09-02 1989-03-23 Beiersdorf Ag Transdermales therapeutisches system
US4906475A (en) * 1988-02-16 1990-03-06 Paco Pharmaceutical Services Estradiol transdermal delivery system
FR2635979B1 (fr) * 1988-09-07 1992-05-29 Lhd Lab Hygiene Dietetique Dispositif auto-adhesif d'administration d'un principe actif par voie percutanee
DE3933460A1 (de) * 1989-10-06 1991-04-18 Lohmann Therapie Syst Lts Oestrogenhaltiges wirkstoffpflaster
US5518734A (en) * 1991-09-25 1996-05-21 Beta Pharmaceuticals Co. Transdermal delivery system for estradiol and process for manufacturing said device
US5503844A (en) * 1993-05-18 1996-04-02 Mli Acquisition Corp. Ii Foam laminate transdermal patch

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4210711A1 (de) * 1991-10-31 1993-05-06 Schering Ag Berlin Und Bergkamen, 1000 Berlin, De Transdermale therapeutische systeme mit kristallisationsinhibitoren
DE4336557A1 (de) * 1993-05-06 1994-11-10 Lohmann Therapie Syst Lts Estradiolhaltiges transdermales therapeutisches System

Also Published As

Publication number Publication date
NZ297806A (en) 1998-11-25
WO1996021433A1 (de) 1996-07-18
DE19500662A1 (de) 1996-07-18
EP0802789B1 (de) 1999-07-07
NO972565L (no) 1997-06-05
SK281623B6 (sk) 2001-05-10
FI972950A (fi) 1997-07-11
CZ212197A3 (en) 1997-11-12
CN1172430A (zh) 1998-02-04
PL321188A1 (en) 1997-11-24
ES2137560T3 (es) 1999-12-16
MX9705291A (es) 1997-10-31
NO972565D0 (no) 1997-06-05
KR100373451B1 (ko) 2003-04-23
AU700697B2 (en) 1999-01-14
DE59506370D1 (de) 1999-08-12
CZ288128B6 (cs) 2001-04-11
MY132338A (en) 2007-10-31
IL116614A0 (en) 1996-03-31
FI972950A0 (fi) 1997-07-11
KR19980701389A (ko) 1998-05-15
GR3031397T3 (en) 2000-01-31
ATE181827T1 (de) 1999-07-15
SK95297A3 (en) 1998-01-14
JPH10511966A (ja) 1998-11-17
SI0802789T1 (en) 1999-12-31
FI119358B (fi) 2008-10-31
DK0802789T3 (da) 2000-01-31
AU4305096A (en) 1996-07-31
IL116614A (en) 1999-12-22
ZA96223B (en) 1996-07-26
CA2209711A1 (en) 1996-07-18
EP0802789A1 (de) 1997-10-29
CA2209711C (en) 2003-10-28
US5885612A (en) 1999-03-23
HUT77666A (hu) 1998-07-28
HU226275B1 (en) 2008-07-28

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Legal Events

Date Code Title Description
OP8 Request for examination as to paragraph 44 patent law
8127 New person/name/address of the applicant

Owner name: LTS LOHMANN THERAPIE-SYSTEME AG, 56626 ANDERNACH,

D2 Grant after examination
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee