DE19375061I2 - Hexadecylphosphocolin enthaltende arzneimittel mit antitumorwirkung. - Google Patents

Hexadecylphosphocolin enthaltende arzneimittel mit antitumorwirkung.

Info

Publication number
DE19375061I2
DE19375061I2 DE19375061C DE19375061C DE19375061I2 DE 19375061 I2 DE19375061 I2 DE 19375061I2 DE 19375061 C DE19375061 C DE 19375061C DE 19375061 C DE19375061 C DE 19375061C DE 19375061 I2 DE19375061 I2 DE 19375061I2
Authority
DE
Germany
Prior art keywords
pct
hexadecylphosphocolin
antitumoric
effect
containing medicament
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE19375061C
Other languages
German (de)
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asta Medica GmbH
Original Assignee
Asta Medica GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Medica GmbH filed Critical Asta Medica GmbH
Application granted granted Critical
Publication of DE19375061I2 publication Critical patent/DE19375061I2/de
Active legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/08—Ethers or acetals acyclic, e.g. paraformaldehyde
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2458—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of aliphatic amines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Respiratory Apparatuses And Protective Means (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Steroid Compounds (AREA)
  • Electrically Operated Instructional Devices (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
DE19375061C 1985-12-04 1986-12-04 Hexadecylphosphocolin enthaltende arzneimittel mit antitumorwirkung. Active DE19375061I2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE3542893 1985-12-04
DE3606631 1986-02-28
PCT/EP1986/000705 WO1987003480A2 (en) 1985-12-04 1986-12-04 Medicament with anti-tumoral action containing hexadecylphosphocholine
DE8686906829T DE3679908D1 (de) 1985-12-04 1986-12-04 Hexadecylphosphocolin enthaltende arzneimittel mit antitumorwirkung.

Publications (1)

Publication Number Publication Date
DE19375061I2 true DE19375061I2 (de) 2008-11-20

Family

ID=25838509

Family Applications (4)

Application Number Title Priority Date Filing Date
DE19375061C Active DE19375061I2 (de) 1985-12-04 1986-12-04 Hexadecylphosphocolin enthaltende arzneimittel mit antitumorwirkung.
DE19863641491 Withdrawn DE3641491A1 (de) 1985-12-04 1986-12-04 Arzneimittel mit antitumorwirkung
DE19863641379 Withdrawn DE3641379A1 (de) 1985-12-04 1986-12-04 Arzneimittel
DE8686906829T Expired - Lifetime DE3679908D1 (de) 1985-12-04 1986-12-04 Hexadecylphosphocolin enthaltende arzneimittel mit antitumorwirkung.

Family Applications After (3)

Application Number Title Priority Date Filing Date
DE19863641491 Withdrawn DE3641491A1 (de) 1985-12-04 1986-12-04 Arzneimittel mit antitumorwirkung
DE19863641379 Withdrawn DE3641379A1 (de) 1985-12-04 1986-12-04 Arzneimittel
DE8686906829T Expired - Lifetime DE3679908D1 (de) 1985-12-04 1986-12-04 Hexadecylphosphocolin enthaltende arzneimittel mit antitumorwirkung.

Country Status (15)

Country Link
US (2) US4837023A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (4) EP0248062B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (2) JPH0637393B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (2) ATE64529T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (2) CA1338627C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (4) DE19375061I2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (2) DK172954B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (2) ES2038215T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (2) FI873363A0 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GR (2) GR3002487T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (2) HU208143B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IE (2) IE59777B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (2) NO175620C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PT (2) PT83872B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
WO (2) WO1987003480A2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (43)

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US5916884A (en) * 1985-12-04 1999-06-29 Max-Planck-Gesellschaft Zur Foederung Der Wissenschaften Compositions containing a mixture of phosphorus compounds and alkylglycerols
CA2001401A1 (en) * 1988-10-25 1990-04-25 Claude Piantadosi Quaternary amine containing ether or ester lipid derivatives and therapeutic compositions
EP0412941B1 (en) * 1989-08-10 1996-05-15 Sandoz Ltd. Phospholipids for the treatment of multiple sclerosis
US5182271A (en) * 1989-08-10 1993-01-26 Sandoz Ltd. Thioether, keto-ester and alkyl phospholipids useful in treating multiple sclerosis
US5290769A (en) * 1989-09-27 1994-03-01 Asta Pharma Aktiengesellschaft Use of hexadecylphosphocholine for the treatment of psoriasis
EP0916343A1 (de) * 1989-09-27 1999-05-19 ASTA Medica Aktiengesellschaft Verwendung von Alkylphosphorsäure-Verbindungen zur Bekämpfung von Psoriasis-Erkrankungen
DE4111105A1 (de) * 1991-04-05 1992-10-08 Max Planck Gesellschaft Neue erucyl-, brassidyl- und nervonylderivate
US5369097A (en) * 1991-04-25 1994-11-29 The University Of British Columbia Phosphonates as anti-cancer agents
US5506217A (en) * 1991-04-25 1996-04-09 The University Of British Columbia Phosphonates as anti-cancer agents
DK0521297T3 (da) * 1991-07-04 1998-05-04 Asta Medica Ag Fremgangsmåde til fremstilling af alkylphosphocholiner og rensning heraf
US5298655A (en) * 1991-09-27 1994-03-29 Merck & Co., Inc. Farnesyl pyrophosphate analogs
US6254879B1 (en) 1991-09-27 2001-07-03 Max-Planck-Gessellschaft zun Förderung der Wissenschaften e.V. Methods of treating protozoal diseases
DE4132344A1 (de) * 1991-09-27 1993-04-01 Max Planck Gesellschaft Verfahren zur herstellung eines arzneimittels zur oralen oder topischen verabreichung bei der behandlung von leishmaniasis
US6172050B1 (en) 1992-07-11 2001-01-09 Asta Medica Aktiengesellschaft Phospholipid derivatives
DE4222910A1 (de) * 1992-07-11 1994-01-13 Asta Medica Ag Neue Phospholipidderivate
DE4235911A1 (de) * 1992-10-23 1994-04-28 Asta Medica Ag Stabilisierte Hexadecylphosphocholinlösungen in Glycerinalkylethern
DE69431596D1 (de) * 1993-06-10 2002-11-28 Wake Forest University Winston (phospho)lipide zum bekämpfen einer hepatitis b-infektion
US6551623B1 (en) 1993-09-09 2003-04-22 Lorus Therapeutics Inc. Immunomodulating compositions from bile
US6280774B1 (en) 1993-09-09 2001-08-28 Lorus Therapeutics Inc. Immunomodulating compositions from bile
US7135584B2 (en) * 1995-08-07 2006-11-14 Wake Forest University Lipid analogs for treating viral infections
WO1996006620A2 (en) * 1994-08-29 1996-03-07 Wake Forest University Lipid analogs for treating viral infections
US5574025A (en) * 1994-10-26 1996-11-12 Merck & Co., Inc. Inhibitors of prenyl-protein transferases
AU1573495A (en) * 1995-02-10 1996-08-27 University Of British Columbia, The {4-hexadecyl-3-methoxy-butyl} phosphonic acid and its protienconjugates useful as anti-cancer agents
EP0814821A1 (en) 1995-03-16 1998-01-07 Imutec Pharma Inc. Immunomodulating compositions from bile for the treatment of immune system disorders
KR100499190B1 (ko) * 1996-03-29 2006-04-17 교와 핫꼬 고교 가부시끼가이샤 육모제
US20040101569A1 (en) * 1996-05-16 2004-05-27 Lorus Therapeutics Inc. Immunomodulating compositions from bile
US6121245A (en) * 1997-01-29 2000-09-19 Firshein; Richard N. Method of treating cancer using alkylglycerols in conjunction with chemotherapy
SE9701912D0 (sv) * 1997-05-22 1997-05-22 Interhealth Ab Pharmaceutical composition and use thereof
US7582678B2 (en) * 1997-07-09 2009-09-01 D-Pharm Limited Use of branched-chain fatty acids and derivatives thereof for the treatment of pain
DE69804865T2 (de) * 1998-01-22 2002-11-07 Zentaris Ag Feste miltefosin enthaltende arzneimittel zur oralen verabreichung bei der behandlung von leishmaniasis
US7026469B2 (en) * 2000-10-19 2006-04-11 Wake Forest University School Of Medicine Compositions and methods of double-targeting virus infections and cancer cells
IL137672A0 (en) 2000-08-03 2001-10-31 Dpharm Ltd Derivatives of branched-chain lipophilic molecules and uses thereof
US7309696B2 (en) 2000-10-19 2007-12-18 Wake Forest University Compositions and methods for targeting cancer cells
US6960738B2 (en) * 2001-05-29 2005-11-01 Koninklijke Philips Electronics N.V. Metal-ceramic bond
CN100469131C (zh) * 2001-08-31 2009-03-11 汤姆森许可公司 实现条件存取系统和传输、接收及处理内容的方法和设备
WO2003090757A1 (en) * 2002-04-26 2003-11-06 Rudolf Perl Pharmaceutical compositions of phospholipid derivatives
US20050187191A1 (en) * 2004-02-20 2005-08-25 Kucera Louis S. Methods and compositions for the treatment of respiratory syncytial virus
UY30042A1 (es) 2005-12-19 2007-07-31 Zentaris Gmbh Nuevos derivados de alquilfosfolípidos con citotoxicidad reducida y usos de los mismos.
US8637688B2 (en) * 2006-12-20 2014-01-28 Julia Diederichs Topical dosage form comprising tri-substituted glycerol compounds
JP2011057647A (ja) * 2009-09-14 2011-03-24 Adeka Corp 化粧料
WO2012178108A1 (en) 2011-06-24 2012-12-27 Glycoregimmune, Inc. Prevention and treatment of inflammatory conditions
CN102491994B (zh) * 2011-12-07 2014-10-15 宁波九胜创新医药科技有限公司 一种胆碱磷酸烷基酯的制备方法
WO2016094226A1 (en) * 2014-12-09 2016-06-16 Glycoregimmune, Inc. Prevention and treatment of inflammatory conditions

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3225227A1 (de) * 1982-07-06 1984-01-12 Max Planck Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Derivate des n.n-bis-(2-chlor-aethyl)-phosphorsaeureamids
JPS5984824A (ja) * 1982-11-08 1984-05-16 Takeda Chem Ind Ltd 抗腫瘍剤
US4690935A (en) * 1983-03-31 1987-09-01 Wayne State University Inhibition of tumor growth and metastasis with calcium channel blocker compounds
JPS60184092A (ja) 1984-03-01 1985-09-19 Kao Corp リン酸エステルおよびその製法

Also Published As

Publication number Publication date
EP0248062A1 (de) 1987-12-09
HU208143B (en) 1993-08-30
ATE75608T1 (de) 1992-05-15
HUT44441A (en) 1988-03-28
JP2857084B2 (ja) 1999-02-10
WO1987003478A2 (en) 1987-06-18
DK393187A (da) 1987-07-28
DK398587A (da) 1987-07-30
GR3005168T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1993-05-24
ES2038215T3 (es) 1993-07-16
HU203201B (en) 1991-06-28
GR3002487T3 (en) 1992-12-30
WO1987003478A3 (en) 1987-09-24
FI873364A7 (fi) 1987-08-03
FI873363L (fi) 1987-08-03
IE863177L (en) 1987-06-04
EP0248047A1 (de) 1987-12-09
HUT44431A (en) 1988-03-28
NO873244D0 (no) 1987-08-03
CA1338627C (en) 1996-10-01
DE3641491A1 (de) 1987-09-17
EP0230575A3 (de) 1987-12-02
NO873243D0 (no) 1987-08-03
DK393187D0 (da) 1987-07-28
US4837023A (en) 1989-06-06
EP0225608A3 (de) 1987-10-28
PT83872A (de) 1987-01-01
PT83872B (pt) 1989-01-17
JPH0859677A (ja) 1996-03-05
EP0225608A2 (de) 1987-06-16
US5049552A (en) 1991-09-17
WO1987003480A3 (en) 1988-02-25
DK398587D0 (da) 1987-07-30
NO175620C (no) 1994-11-09
FI873363A7 (fi) 1987-08-03
PT83873A (de) 1987-01-01
FI873363A0 (fi) 1987-08-03
EP0248047B1 (de) 1991-06-19
DE3641379A1 (de) 1987-09-03
EP0248062B1 (de) 1992-05-06
ES2032755T3 (es) 1993-03-01
IE59778B1 (en) 1994-04-06
CA1280369C (en) 1991-02-19
NO174877C (no) 1994-07-27
FI873364A0 (fi) 1987-08-03
NO873243L (no) 1987-10-02
EP0230575A2 (de) 1987-08-05
IE863176L (en) 1987-06-04
PT83873B (pt) 1989-01-17
JPH0637393B2 (ja) 1994-05-18
NO873244L (no) 1987-10-01
NO174877B (no) 1994-04-18
DE3679908D1 (de) 1991-07-25
JPS63501719A (ja) 1988-07-14
ATE64529T1 (de) 1991-07-15
IE59777B1 (en) 1994-04-06
WO1987003480A2 (en) 1987-06-18
DK172954B1 (da) 1999-10-18
NO175620B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1994-08-01

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